Human dipeptidyl peptidase IV (hDDP-IV) has a considerable importance in inactivation of glucagon-like peptide-1, which is related to type 2 diabetes. One approach for the treatment is the development of small hDDP-IV inhibitors. In order to design better inhibitors, we analyzed 5-(aminomethyl)-6-(2,4-dichlrophenyl)-2-(3,5-dimethoxyphenyl)pyrimidin-4-amine and a set of 24 molecules found in the BindingDB web database for model designing. The analysis of their molecular properties allowed the design of a multiple linear regression model for activity prediction. Their docking analysis allowed visualization of the interactions between the pharmacophore regions and hDDP-IV. After both analyses were performed, we proposed a set of nine molecules in order to predict their activity. Four of them displayed promising activity, and thus, had their docking performed, as well as, the pharmacokinetic and toxicological study. Two compounds from the proposed set showed suitable pharmacokinetic and toxicological characteristics, and therefore, they were considered promising for future synthesis and in vitro studies.

A pandemia do COVID-19 modificou o cronograma de atividades propostas para o ano letivo de 2020-21, a partir da substituição das aulas presenciais pelo ensino remoto emergencial (ERE). Para os professores do ensino superior, embora as boas práticas de ensino sejam uma preocupação constante das universidades, surgiram desafios diante do modo repentino de transição e implementação do ERE. Nesse sentido, este estudo objetivou investigar as principais dificuldades encontradas por docentes do ensino superior no Brasil, frente ao ERE durante a pandemia de COVID-19. A coleta de dados ocorreu entre dezembro de 2020 e fevereiro de 2021, utilizando-se um questionário eletrônico constituído por 21 questões objetivas. Participaram do estudo 234 docentes. Deste total, 77,4% dos participantes apresentaram dificuldades durante o processo de adaptação para o ERE, sendo estas relacionadas a falta de capacitação ou de recursos tecnológicos por parte das instituições; problemas com o uso de tecnologias digitais (ferramentas e softwares); influência de dificuldades psicológicas; dificuldades associadas à burocracia administrativa ou com Segurança de Dados. Elucida-se que a transição deve ser realizada com planejamento e investimento na formação adequada dos professores, para que a educação em contexto virtual alcance o mesmo sucesso dos encontros presenciais.

Endometrial cancer (EC) is a prevalent malignancy in women, and those who are proficient in the DNA mismatch repair (pMMR) pathway may have a family history (FH) that meets the criteria for a hereditary neoplastic condition (HNS). This study aimed to estimate the risk of HNS in women with pMMR endometrial tumors by analyzing their FH. To achieve this, we collaborated with a primary study and collected FH information by telephone. The final sample comprised 42 women who responded to the Primary Screening Questionnaire. Their family pedigrees were drawn and categorized according to internationally standardized criteria for the risk of HNS. Results showed that 26 women (61%) were found to be at risk for HNS, with Bethesda criteria being met by 23%, Amsterdam criteria by 15%, and 4% met the attenuated familial adenomatous polyposis criteria. Our results emphasize the importance of FH and the need to encourage healthcare professionals to collect and document FH more frequently, even if it is self-reported. By identifying individuals with HNS, we can improve their outcomes and reduce the burden of cancer in families with a predisposition to cancer.

Objective: to analyze the complexity of care for patients admitted to a Clinical Oncology Unit of a university hospital. Methods: this is an epidemiological, quantitative descriptive, retrospective cross-sectional study, with data collected from the medical records of patients admitted from January to December 2019. The data was analyzed using descriptive statistics of centrality, dispersion, and bivariate analysis for measures of association between variables. Results: a total of 555 medical records of cancer patients were analyzed, with a predominance of males (57.3%). Patients admitted for clinical management had greater care complexity and length of stay compared to those admitted for oncological treatment. 360 (64.9%) had associated comorbidities, however, there was no significant correlation between comorbidities and complexity of care, comorbidities, and length of stay. The length of hospital stay ranged from 1 to 42 days, with 356 (64.1%) episodes of readmissions. Conclusion: this study concluded that cancer patients who were hospitalized for clinical management had greater complexity of care and length of stay, showing a functional decline. Furthermore, associated comorbidities and complications inherent to oncological treatment and disease progression can influence readmission episodes and greater care needs.