Nanosheets of transition metal dichalcogenide (TMDs), the graphene-like two-dimensional (2D) materials, exhibit a unique combination of properties and have attracted enormous research interest for a wide range of applications including catalysis, functional electronics, solid lubrication, photovoltaics, energy materials and most recently in biomedical applications. Their potential for use in biosensors, drug delivery, multimodal imaging, antimicrobial agents and tissue engineering is being actively studied. However, the commercial translation of exfoliated TMDs has been limited due to the low aqueous solubility, non-uniformity, lack of control over the layer thickness, and the long-term colloidal stability of the exfoliated material. There is wide interest in the synthesis and exfoliation of TMDs resulting in the reporting of increasing numbers of new methods and their biomedical applications. The unique physicochemical characteristics of the TMD nanosheets have been exploited to tether them with biological payload to achieve selective localized delivery in vivo. The large surface-to-volume ratio, good cytocompatibility, ease of surface modification, tunable bandgap, strong spin–orbit coupling, and high optical and thermal conversion efficiency of TMD nanosheets make them favorable over traditional nanomaterials for biomedical research. Moreover, the presence of abundant active edge sites on the 2D TMDs makes them suitable for catalytic activities, while the large surface area and the interspace between layers are particularly conducive to ion or small molecule intercalation, making them useful for energy storage applications with rapid redox reaction capabilities. One of the major limitations of the exfoliated TMDs has been their limited colloidal stability in aqueous media. In this review, we summarize the recent advances in the exfoliation and synthesis of single-layered TMDs, their biomedical efficacy in terms of cytotoxicity, combinatorial therapy and diagnostic imaging, as well as antimicrobial activity. We highlight the current challenges in the field and propose strategies for the future.

Recently, research on polymer has drawn much attention mainly due to the ever increasing application of these polymeric materials in several areas such as food packaging industry, agricultural industry and biomedical research. However, increasing industrial use of polymers has led to the environmentally critical issue of waste disposal. Further, the successful implication of polymeric materials in biomedical applications depends on the biodegradability of the concerned polymer. Various enzymes play an important role in the biodegradation of polymers. The present review describes the enzyme mediated biodegradation of various polymers including synthetic, natural and blends of these materials. Detailed examples of enzymatic degradation of polymers are illustrated from current scientific literature with the discussion on various factors that can influence the degradation. In addition, different techniques that are generally applied to assess the degradation process as well as degradation products have been described. Finally, a special emphasis is given to the investigation of the kinetics of polymer degradation by enzymes.

Metastable β Ti alloys are widely projected for manufacturing the next generation of biomedical implants. The primary applications of these materials are envisaged in orthopedic, cardiovascular, and orthodontic biomedical devices. Development of an alloyprogresses through stages of compositional design, thermo-mechanical processing, and evaluation of material performance. This review tracks the progress at these three stages of alloy development particularly for use in orthopedic devices. The strategies to design low modulus compositions of β Ti alloys are critically reviewed. This is followed by the processing routes employed to achieve high strength to modulus ratio suitable for orthopedic applications. The effect of processing on performance metrics of these alloys vis-à-vis fatigue resistance, tribological response, corrosion behaviour, and biocompatibility are reviewed. In the end, targeted research areas for the future are highlighted along with encouraging strategies, with the aim to ensue clinical application of β Ti alloys.