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Shuaishuai Xu
Hunan Provincial Key Laboratory of Clinical Epidemiology, Xiangya School of Public Health, Central South University, 110 Xiangya Road, Changsha, Hunan 410078, China

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Review article
Published: 07 July 2021 in Chemosphere
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Microalgal biomass and its fine chemical production from microalgae have pioneered algal bioprocess technology with few limitations such as lab-to-industry. However, laboratory-scale transitions and industrial applications are hindered by a plethora of limitations comprising expensive in culturing methods. Therefore, to emphasize the profitable benefits, the algal culturing techniques appropriately employed for large-scale microalgal biomass yield necessitates intricate assessment to emphasize the profitable benefits. The present review holistically compiles the culturing strategies for improving microalgal biomass production based on appropriate factors like designing better bioreactor designs. On the other hand, synthetic biology approaches for abridging the effective industrial transition success explored recently. Prospects in synthetic biology for enhanced microalgal biomass production based on cultivation strategies and various mechanistic modes approach to enrich cost-effective and viable output are discussed. The State-of-the-art culturing techniques encompassing enhancement of photosynthetic activity, designing bioreactor design, and potential augmenting protocols for biomass yield employing indoor cultivation in both (Open and or/closed) methods are enumerated. Further, limitations hindering the microalgal bioproducts development are critically evaluated for improving culturing techniques for microalgal cell factories, subsequently escalating the cost-benefit ratio in bioproducts synthesis from microalgae. The comprehensive analysis could provide a rational and deeper detailed insight for microalgal entrepreneurs through alternative culturing technology viz., synthetic biology and genome engineering in an Industrial perspective arena.

ACS Style

Maruthanayagam Veerabadhran; Sivakumar Natesan; Davoodbasha MubarakAli; Shuaishuai Xu; Fei Yang. Using different cultivation strategies and methods for the production of microalgal biomass as a raw material for the generation of bioproducts. Chemosphere 2021, 285, 131436 .

AMA Style

Maruthanayagam Veerabadhran, Sivakumar Natesan, Davoodbasha MubarakAli, Shuaishuai Xu, Fei Yang. Using different cultivation strategies and methods for the production of microalgal biomass as a raw material for the generation of bioproducts. Chemosphere. 2021; 285 ():131436.

Chicago/Turabian Style

Maruthanayagam Veerabadhran; Sivakumar Natesan; Davoodbasha MubarakAli; Shuaishuai Xu; Fei Yang. 2021. "Using different cultivation strategies and methods for the production of microalgal biomass as a raw material for the generation of bioproducts." Chemosphere 285, no. : 131436.

Review
Published: 31 October 2020 in Toxins
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Cyanobacterial blooms triggered by eutrophication and climate change have become a global public health issue. The toxic metabolites microcystins (MCs) generated by cyanobacteria can accumulate in food chain and contaminate water, thus posing a potential threat to human and animals health. Studies have suggested that aside liver, the kidney may be another target organ of MCs intoxication. Therefore, this review provides various evidences on the nephrotoxicity of MCs. The review concludes that nephrotoxicity of MCs may be related to inhibition of protein phosphatases and excessive production of reactive oxygen species, cytoskeleton disruption, endoplasmic reticulum stress, DNA damage and cell apoptosis. To protect human from MCs toxic consequences, this paper also puts forward some directions for further research.

ACS Style

Shuaishuai Xu; Xiping Yi; Wenya Liu; Chengcheng Zhang; Isaac Massey; Fei Yang; Li Tian. A Review of Nephrotoxicity of Microcystins. Toxins 2020, 12, 693 .

AMA Style

Shuaishuai Xu, Xiping Yi, Wenya Liu, Chengcheng Zhang, Isaac Massey, Fei Yang, Li Tian. A Review of Nephrotoxicity of Microcystins. Toxins. 2020; 12 (11):693.

Chicago/Turabian Style

Shuaishuai Xu; Xiping Yi; Wenya Liu; Chengcheng Zhang; Isaac Massey; Fei Yang; Li Tian. 2020. "A Review of Nephrotoxicity of Microcystins." Toxins 12, no. 11: 693.

Journal article
Published: 10 December 2019 in International Journal of Environmental Research and Public Health
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Microcystin-LR (MC-LR) is a potent hepatotoxin, but a few studies suggested that it might also induce nephrotoxicity. However, nephrotoxicity induced by prolonged oral exposure to MC-LR is unknown. The aim of this study was to evaluate the potential influence of MC-LR on the kidney in mice following chronic exposure to MC-LR. In this study, we evaluated the nephrotoxicity of MC-LR in mice drinking water at different concentrations (1, 30, 60, 90, and 120 μg/L) for 6 months for the first time. The results showed that the kidney weights and the kidney indexes of mice were not altered in the MC-LR treated mice, compared with the control group. In addition, the renal function indicators revealed that the serum creatinine (SCr) levels were not significant changes after exposure to MC-LR. The blood urea nitrogen (BUN) levels were markedly decreased after exposure to 90 and 120 μg/L MC-LR for 3 months. The BUN levels were lower than that of the control group after exposure to 120 μg/L MC-LR for 6 months. The histopathological investigation revealed enlarged renal corpuscles, widened of kidney tubules, and lymphocyte infiltration in the interstitial tissue and the renal pelvis after exposure to 60, 90, and 120 μg/L MC-LR. Consequently, our results suggested that long-term exposure to MC-LR might be one important risk of kidney injury, which will provide important clues for the prevention of renal impairment.

ACS Style

Xiping Yi; Shuaishuai Xu; Feiyu Huang; Cong Wen; Shuilin Zheng; Hai Feng; Jian Guo; Jihua Chen; Xiangling Feng; And Fei Yang. Effects of Chronic Exposure to Microcystin-LR on Kidney in Mice. International Journal of Environmental Research and Public Health 2019, 16, 5030 .

AMA Style

Xiping Yi, Shuaishuai Xu, Feiyu Huang, Cong Wen, Shuilin Zheng, Hai Feng, Jian Guo, Jihua Chen, Xiangling Feng, And Fei Yang. Effects of Chronic Exposure to Microcystin-LR on Kidney in Mice. International Journal of Environmental Research and Public Health. 2019; 16 (24):5030.

Chicago/Turabian Style

Xiping Yi; Shuaishuai Xu; Feiyu Huang; Cong Wen; Shuilin Zheng; Hai Feng; Jian Guo; Jihua Chen; Xiangling Feng; And Fei Yang. 2019. "Effects of Chronic Exposure to Microcystin-LR on Kidney in Mice." International Journal of Environmental Research and Public Health 16, no. 24: 5030.