'Mode 3' allows and emphasises the co-existence and co-evolution of different knowledge and innovation paradigms: the competitiveness and superiority of a knowledge system is highly determined by its adaptive capacity to combine and integrate different knowledge and innovation modes via co-evolution, co-specialisation and co-opetition knowledge stock and flow dynamics. The 'Quadruple Helix' emphasises the importance of also integrating the perspective of the media-based and culture-based public. What results is an emerging fractal knowledge and innovation ecosystem, well-configured for the knowledge economy and society.

This article develops an inter-disciplinary and trans-disciplinary framework of analysis that relates knowledge, innovation and the environment (natural environments) to each other. For that purpose the five-helix structure model of the Quintuple Helix is being introduced. The Triple Helix model, designed by Etzkowitz and Leydesdorff (2000), focuses on the relations of universities, industry and governments. The Quadruple Helix (Carayannis & Campbell, 2009) blends in the perspective of a media-based and culture-based public. The Quintuple Helix finally frames knowledge and innovation in the context of the environment (natural environments). Therefore, the Quintuple Helix can be interpreted as an approach in line with sustainable development and social ecology. “Eco-innovation” and “eco-entrepreneurship” should be processed in such a broader understanding of knowledge and innovation.

The Triple Helix innovation model focuses on university-industry-government relations. The Quadruple Helix embeds the Triple Helix by adding as a fourth helix the ‘media-based and culture-based public’ and ‘civil society’. The Quintuple Helix innovation model is even broader and more comprehensive by contextualizing the Quadruple Helix and by additionally adding the helix (and perspective) of the ‘natural environments of society’. The Triple Helix acknowledges explicitly the importance of higher education for innovation. However, in one line of interpretation it could be argued that the Triple Helix places the emphasis on knowledge production and innovation in the economy so it is compatible with the knowledge economy. The Quadruple Helix already encourages the perspective of the knowledge society, and of knowledge democracy for knowledge production and innovation. In a Quadruple Helix understanding, the sustainable development of a knowledge economy requires a coevolution with the knowledge society. The Quintuple Helix stresses the necessary socioecological transition of society and economy in the twenty-first century; therefore, the Quintuple Helix is ecologically sensitive. Within the framework of the Quintuple Helix innovation model, the natural environments of society and the economy also should be seen as drivers for knowledge production and innovation, therefore defining opportunities for the knowledge economy. The European Commission in 2009 identified the socioecological transition as a major challenge for the future roadmap of development. The Quintuple Helix supports here the formation of a win-win situation between ecology, knowledge and innovation, creating synergies between economy, society, and democracy. Global warming represents an area of ecological concern, to which the Quintuple Helix innovation model can be applied with greater potential.

The concept of Society 5.0 and Industry 5.0 is not a simple chronological continuation or alternative to Industry 4.0 paradigm. Society 5.0 aims to place human beings at the midpoint of innovation, exploiting the impact of technology and Industry 4.0 results with the technological integration to improve quality of life, social responsibility and sustainability. This ground-breaking perspective has common points with the objectives of the United Nations Sustainable Development Goals. It also has major implication for universities transformations. Universities are called upon producing knowledge for new technologies and social innovation. In our paper, we argue that digitalisation opens new perspectives for universities and can become one of the main drivers of their change. Incorporating the assumptions of Society 5.0 and Industry 5.0 into the universities practices and policies will allow both universities and societies to fully benefit from digital transformation. Making the human-oriented innovation as the universities trademark and developing new cooperative models will also help to achieve sustainable priorities. The use of the Quintuple Helix Model (QHM) might foster the process of necessary transformations capacities as it integrates different perspectives and sets the stage for sustainability priorities and considerations. As far as the practical goal is concerned, the paper proposes a set of recommendations for universities aiming at developing new forms and channels of distribution of education, research and innovation within in the context of QHM and Society 5.0. We call them socially and digitally engaged model.