The countries of Central Asia are collectively known as the five ''-stans'': Uzbekistan, Kyrgyzstan, Turkmenistan, Tajikistan and Kazakhstan. In recent times, the Central Asian region has been affected by the shrinkage of the Aral Sea, widespread desertification, soil salinization, biodiversity loss, frequent sand storms, and many other ecological disasters. This paper is a review article based upon the collection, identification and collation of previous studies of environmental changes and regional developments in Central Asia in the past 30 years. Most recent studies have reached a consensus that the temperature rise in Central Asia is occurring faster than the global average. This warming trend will not only result in a higher evaporation in the basin oases, but also to a significant retreat of glaciers in the mountainous areas. Water is the key to sustainable development in the arid and semi-arid regions in Central Asia. The uneven distribution, over consumption, and pollution of water resources in Central Asia have caused severe water supply problems, which have been affecting regional harmony and development for the past 30 years. The widespread and significant land use changes in the 1990s could be used to improve our understanding of natural variability and human interaction in the region. There has been a positive trend of trans-border cooperation among the Central Asian countries in recent years. International attention has grown and research projects have been initiated to provide water and ecosystem protection in Central Asia. However, the agreements that have been reached might not be able to deliver practical action in time to prevent severe ecological disasters. Water management should be based on hydrographic borders and ministries should be able to make timely decisions without political intervention. Fully integrated management of water resources, land use and industrial development is essential in Central Asia. The ecological crisis should provide sufficient motivation to reach a consensus on unified water management throughout the region.

Understanding the impacts and extent of both climate change and human activities on ecosystems is crucial to sustainable development. With low anti-interference ability, arid and semi-arid ecosystems are particularly sensitive to disturbances from both climate change and human activities. We investigated how and to what extent climate variation and human activities influenced major indicators that are related to ecosystem functions and conditions in the past decades in Xinjiang, a typical arid and semi-arid region in China. We analyzed the changing trends of evapotranspiration (ET), gross primary productivity (GPP) and leaf area index (LAI) derived from the Moderate-Resolution Imaging Spectroradiometer (MODIS) satellite product and the Breathing Earth System Simulator (BESS) model in Xinjiang for different climate zones. We separated and quantified the contributions of climate forcing and human activities on the trends of the studied ecosystem indicators using the residual analysis method for different climate zones in Xinjiang. The results show that GPP and LAI increased and ET decreased from 2001 to 2015 in Xinjiang. Factors that dominate the changes in ecosystem indicators vary considerably across different climate zones. Precipitation plays a positive role in impacting vegetation indicators in arid and hyper-arid zones and temperature has a negative correlation with both GPP and LAI in hyper-arid zones in Xinjiang. Results based on residual analysis indicate that human activities could account for over 72% of variation in the changes in each ecosystem indicator. Human activities have large impacts on each vegetation indicator change in hyper-arid and arid zones and their relative contribution has a mean value of 79%. This study quantifies the roles of climate forcing and human activities in the changes in ecosystem indicators across different climate zones, suggesting that human activities largely influence ecosystem processes in the arid and semi-arid regions of Xinjiang in China.

Flagellin is recognized by both Toll-like receptor (TLR)5 and NAIP5/NLRC4 inflammasome receptors. We hypothesized that the flagellins derived from different bacteria might differentially activate TLR5 and/or NAIP5/NLRC4 signal pathways. To test this, the immune recognition of recombinant flagellins derived from pathogenic Salmonella Typhi (SF) and the nonpathogenic Escherichia coli K12 strain MG1655 (KF) were examined by the activation of TLR5 and NLRC4 pathways in various cell types. While flagellins SF and KF were not distinguishable in activating the TLR5 pathway, KF induced significantly less interleukin-1β production and pyroptotic cell death in peritoneal macrophages than SF, and showed markedly lower efficiency in activating caspase-1 through the NLRC4 pathway than SF. Macrophages may differentially recognize flagellins by intracellular sensors and thereby initiate the immune response to invading pathogenic bacteria. Our findings suggest an active role of flagellin as an important determinant in host differential immune recognition and for the control of bacteria infection.