Nathalie Bernoud-Hubac

Dr. Nathalie Bernoud-Hubac

Contact and Structure Mechanics Laboratory LaMCoS, UMR 5259 INSA Lyon – CNRS, Institut Multidisciplinaire de Biochimie des Lipides, Campus LyonTech La Doua - INSA Lyon, 69621 Villeurbanne, France
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Research Focus & Metrics

Academic Career Length

23Years (2004-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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4 June 2015 in Molecular Neurobiology
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Journal Article
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Mayssa HachemMayssa Hachem
Mayssa Hachem
AGAlain Géloën
Alain Géloën
AVAmanda Lo Van
Amanda Lo Van
BFBaptiste Foumaux
Baptiste Foumaux
LTLaurence Tilloy-Fenart
Laurence Tilloy-Fenart
NBNathalie Bernoud-Hubac
Nathalie Bernoud-Hubac

1 November 2016 in Biochimie
Verified
Journal Article
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AVAmanda Lo Van
Amanda Lo Van
NSNobuyuki Sakayori
Nobuyuki Sakayori
Mayssa HachemMayssa Hachem
Mayssa Hachem
MBMounir Belkouch
Mounir Belkouch
MPMadeleine Picq
Madeleine Picq
NBNathalie Bernoud-Hubac
Nathalie Bernoud-Hubac

29 May 2013 in PLOS ONE
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Journal Article
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JLJennifer Lefils-Lacourtablaise
Jennifer Lefils-Lacourtablaise
MSMairobys Socorro
Mairobys Socorro
AGAlain Géloën
Alain Géloën
PDPatricia Daira
Patricia Daira
CDCyrille Debard
Cyrille Debard
NBNathalie Bernoud-Hubac
Nathalie Bernoud-Hubac
The intake of ω-3 polyunsaturated fatty acids (PUFAs), which are abundant in marine fish meat and oil, has been shown to exert many beneficial effects. The mechanisms behind those effects are numerous, including interference with the arachidonic acid cascade that produces pro-inflammatory eicosanoids, formation of novel bioactive lipid mediators, and change in the pattern of secreted adipocytokines. In our study, we show that eicosapentaenoic acid (EPA) increases secreted adiponectin from 3T3-L1 adipocytes and in plasma of mice as early as 4 days after initiation of an EPA-rich diet. Using 3T3-L1 adipocytes, we report for the first time that 15-deoxy-δ12,14-PGJ3 (15d-PGJ3), a product of EPA, also increases the secretion of adiponectin. We demonstrate that the increased adiponectin secretion induced by 15d-PGJ3 is partially peroxisome proliferator-activated receptor-gamma (PPAR-γ)-mediated. Finally, we show that 3T3-L1 adipocytes can synthesize 15d-PGJ3 from EPA. 15d-PGJ3 was also detected in adipose tissue from EPA-fed mice. Thus, these studies provide a novel mechanism(s) for the therapeutic benefits of ω-3 polyunsaturated fatty acids dietary supplementation.

1 November 2004 in Free Radical Biology and Medicine
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Journal Article
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NBNathalie Bernoud-Hubac
Nathalie Bernoud-Hubac
LFLaurent B. Fay
Laurent B. Fay
VAVenkataraman Armarnath
Venkataraman Armarnath
MGMichel Guichardant
Michel Guichardant
SBSandrine Bacot
Sandrine Bacot
MLMichel Lagarde
Michel Lagarde

23 May 2024 in Antioxidants
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NBNathalie Bernoud-Hubac
Nathalie Bernoud-Hubac
AVAmanda Lo Van
Amanda Lo Van
ALAdina-Nicoleta Lazar
Adina-Nicoleta Lazar
MLMichel Lagarde
Michel Lagarde
Stroke is a devastating neurological disorder that is characterized by the sudden disruption of blood flow to the brain. Lipids are essential components of brain structure and function and play pivotal roles in stroke pathophysiology. Dysregulation of lipid signaling pathways modulates key cellular processes such as apoptosis, inflammation, and oxidative stress, exacerbating ischemic brain injury. In the present review, we summarize the roles of lipids in stroke pathology in different models (cell cultures, animal, and human studies). Additionally, the potential of lipids, especially polyunsaturated fatty acids, to promote neuroprotection and their use as biomarkers in stroke are discussed.

21 May 2010 in British Journal of Nutrition
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Journal Article
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JLJennifer Lefils
Jennifer Lefils
AGAlain Géloën
Alain Géloën
HVHubert Vidal
Hubert Vidal
MLMichel Lagarde
Michel Lagarde
NBNathalie Bernoud-Hubac
Nathalie Bernoud-Hubac
Consumption of DHA has numerous beneficial effects, but little is known about these effects during the first few days of the DHA dietary intake. The main objectives of the present study were to determine the time course of DHA incorporation into phospholipids in different mouse tissues and the effects of DHA supplementation on adiponectin and leptin secretion. Mice were fed either a control diet or a DHA-rich diet, and some were killed on days 0, 4, 8, 16 and 32. Some mice were fed the DHA-rich diet for 16 d, and were then maintained on the control diet for sixteen more days (washout period). DHA supplementation increased plasma adiponectin secretion by 2·4-fold as early as 4 d after the initiation of the DHA-rich diet feeding. The adiponectin concentration remained 1·6-fold higher after the 16 d washout period. Plasma leptin levels were significantly lower after 4 d of feeding with DHA. These effects were associated with a significant increase in DHA incorporation in phosphatidylethanolamine and phosphatidylcholine of all analysed tissues (liver, heart and white adipose tissues). DHA mainly got incorporated at the expense ofn-6 arachidonic acid. The present data show that DHA rapidly improved the profile of secreted adipokines, and that these protective effects were long lasting.