Dr. Cecília R. Santos
CICS-UBI- Health Sciences Research Centre, University of Beira Interior
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Academic Career Length
32Years (1995-Present)
(Calculated once Scilit publication data is synced: current year − year of first publication + 1)
Representative Publications
View All Publications1 September 2000 in General and Comparative Endocrinology
Journal Article
DPDeborah Mary Power
Deborah Mary PowerNEN.P. Elias
N.P. Elias
Samantha RichardsonJMJ. Mendes
J. Mendes
CSClaudio Soares
Claudio SoaresCecília R. Santos1 May 2012 in Molecular Cancer Research
Journal Article
The human 6-transmembrane epithelial antigen of prostate (STEAP) family comprises STEAP1, STEAP2, STEAP3, and STEAP4. All of these proteins are unique to mammals and share an innate activity as metalloreductases, indicating their importance in metal metabolism. Overall, they participate in a wide range of biologic processes, such as molecular trafficking in the endocytic and exocytic pathways and control of cell proliferation and apoptosis. STEAP1 and STEAP2 are overexpressed in several types of human cancers, namely prostate, bladder, colon, pancreas, ovary, testis, breast, cervix, and Ewing sarcoma, but their clinical significance and role in cancer cells are not clear. Still, their localization in the cell membrane and differential expression in normal and cancer tissues make STEAP proteins potential candidates as biomarkers of several cancers, as well as potential targets for new immunotherapeutic strategies for disease attenuation or treatment. This review brings together the current knowledge about each STEAP protein, giving an overview of the roles of this family of proteins in human physiology and disease, and analyzes their potential as immunotherapeutic agents in cancer research. Mol Cancer Res; 10(5); 573–87. ©2012 AACR.
1 November 2017 in Neurobiology of Disease
Journal Article
FMFernanda Marques
Fernanda MarquesJSJoão Carlos Sousa
João Carlos SousaMBMaria Brito
Maria Brito
Jens PahnkeCecília R. SantosJPJoana Almeida Palha
Joana Almeida Palha +1
1 June 2007 in General and Comparative Endocrinology
Journal Article
IMI. Morgado
I. MorgadoCecília R. SantosRJR. Jacinto
R. Jacinto
DPDeborah Mary Power
Deborah Mary Power1 June 2004 in Journal of Biological Chemistry
Journal Article
TETherese Eneqvist
Therese Eneqvist
ELErik Lundberg
Erik Lundberg
AKAnders Karlsson
Anders Karlsson
SHShenghua Huang
Shenghua Huang
Cecília R. SantosASA. Elisabeth Sauer-Eriksson
A. Elisabeth Sauer-Eriksson +1
Transthyretin (TTR) is an extracellular transport protein involved in the distribution of thyroid hormones and vitamin A. So far, TTR has only been found in vertebrates, of which piscine TTR displays the lowest sequence identity with human TTR (47%). Human and piscine TTR bind both thyroid hormones 3,5,3′-triiodo-l-thyronine (T3) and 3,5,3′,5′-tetraiodo-l-thyronine (thyroxine, T4). Human TTR has higher affinity for T4 than T3, whereas the reverse holds for piscine TTR. X-ray structures of Sparus aurata (sea bream) TTR have been determined as the apo-protein at 1.75 Å resolution and bound to ligands T3 and T4, both at 1.9 Å resolution. The apo structure is similar to human TTR with structural changes only at β-strand D. This strand forms an extended loop conformation similar to the one in chicken TTR. The piscine TTR·T4 complex shows the T4-binding site to be similar but not identical to human TTR, whereas the TTR·T3 complex shows the I3′ halogen situated at the site normally occupied by the hydroxyl group of T4. The significantly wider entrance of the hormone-binding channel in sea bream TTR, in combination with its narrower cavity, provides a structural explanation for the different binding affinities of human and piscine TTR to T3 and T4.
1 October 2020 in Trends in Endocrinology & Metabolism
Journal Article
ACAna R. Costa
Ana R. CostaMOMariana Lança de Oliveira
Mariana Lança de Oliveira
ICInês Cruz
Inês Cruz
IGIsabel Goncalves
Isabel GoncalvesJCJosé Cascalheira
José CascalheiraCecília R. SantosAbout Me
Dr Cecilia Santos (orcid.org/0000-0001-6074-7825) is associate professor with habilitation in biomedicine and the responsible for the Oncobiology classes at the University of Beira Interior and has been leading a group focused in CP physiology for the last 17 years. She published 60 papers published in peer-review journals, 3 book chapters, has h-index of 22, (Scopus, September 2020) and was PI of three FCT funded projects (finished), and is currently member of the research team in five ongoing projects. On the lead of these and other studies, Dr Santos supervised 3 post-doctoral grants; 7 doctoral and 25 master thesis and is currently supervising 2 PhD thesis and 2 master thesis.
Major research outputs were the demonstration that the choroid plexus is highly responsive to sex hormones with pronounced differences between rat males and females, the finding that the choroid plexus harbours a circadian clock and is a source of the hormone melatonin. More recently we found that the choroid plexus contains a vast variety of taste and odorant receptors with unknown functions but very likely involved in the chemical surveillance operated by this organ. Other interests include research in cancer biology most related to the tumor-blood barrier and a generalised interest in the blood-brain barrier.