Buildings are vulnerable to collapse incidents. We adopt a workflow to detect unusual vertical surface motions before building collapses based on PS-InSAR time series analysis and spatiotemporal data mining techniques. Sentinel-1 ascending and descending data are integrated to decompose vertical deformation in the city of Alexandria, Egypt. Collapsed building data were collected from official sources, and overlayed on PS-InSAR vertical deformation results. Time series deformation residuals are used to create a space–time cube in the ArcGIS software environment and analyzed by emerging hot spot analysis to extract spatiotemporal patterns for vertical deformation around collapsed buildings. Our results show two spatiotemporal patterns of new cold spot or new hot spot before the incidents in 66 out of 68 collapsed buildings between May 2015 and December 2018. The method was validated in detail on four collapsed buildings between January and May 2019, proving the applicability of this workflow to create a temporal vulnerability map for building collapse monitoring. This study is a step forward to create a PS-InSAR based model for building collapse prediction in the city.