Issam KHNEISSER

Issam KHNEISSER

orcid

Research Focus & Metrics

Academic Career Length

25Years (2002-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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Bradford Leon TherrellBradford Leon Therrell
Bradford Leon Therrell
CPCarmencita Padilla
Carmencita Padilla
Gustavo BorrajoGustavo Borrajo
Gustavo Borrajo
IKIssam KHNEISSER
Issam KHNEISSER
Peter SchielenPeter Schielen
Peter Schielen
MKMarika Kristiina Kase
Marika Kristiina Kase
Newborn bloodspot screening (NBS) began in the early 1960s based on the work of Dr. Robert “Bob” Guthrie in Buffalo, NY, USA. His development of a screening test for phenylketonuria on blood absorbed onto a special filter paper and transported to a remote testing laboratory began it all. Expansion of NBS to large numbers of asymptomatic congenital conditions flourishes in many settings while it has not yet been realized in others. The need for NBS as an efficient and effective public health prevention strategy that contributes to lowered morbidity and mortality wherever it is sustained is well known in the medical field but not necessarily by political policy makers. Acknowledging the value of national NBS reports published in 2007, the authors collaborated to create a worldwide NBS update in 2015. In a continuing attempt to review the progress of NBS globally, and to move towards a more harmonized and equitable screening system, we have updated our 2015 report with information available at the beginning of 2024. Reports on sub-Saharan Africa and the Caribbean, missing in 2015, have been included. Tables popular in the previous report have been updated with an eye towards harmonized comparisons. To emphasize areas needing attention globally, we have used regional tables containing similar listings of conditions screened, numbers of screening laboratories, and time at which specimen collection is recommended. Discussions are limited to bloodspot screening.

1 December 2015 in European Journal of Medical Genetics
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Journal Article
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JCJose-Mario Capo-Chichi
Jose-Mario Capo-Chichi
CMCybel Mehawej
Cybel Mehawej
VDValerie Delague
Valerie Delague
CCCatherine Caillaud
Catherine Caillaud
IKIssam KHNEISSER
Issam KHNEISSER
AMAndré Mégarbané
André Mégarbané

Verified
Journal Article
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VSVictor Skrinska
Victor Skrinska
IKIssam KHNEISSER
Issam KHNEISSER
Peter SchielenPeter Schielen
Peter Schielen
GLGerard Loeber
Gerard Loeber
This special edition of the International Journal of Neonatal Screening includes the presentations of the fourth Meeting of the Middle East North Africa (MENA) Region of the International Society for Neonatal Screening (ISNS) held in Limassol, Cyprus, March 8–11, 2020

21 November 2008 in Journal of Inherited Metabolic Disease
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IKIssam KHNEISSER
Issam KHNEISSER
SAS. M. Adib
S. M. Adib
AMA. Megarbane
A. Megarbane
ZLZ. Lukacs
Z. Lukacs

1 March 2006 in Journal of Medical Screening
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Journal Article
Open access
IKIssam KHNEISSER
Issam KHNEISSER
SASalim M Adib
Salim M Adib
JLJacques Loiselet
Jacques Loiselet
AMAndré Mégarbané
André Mégarbané
The incidence of glucose-6-phosphate dehydrogenase (G6PD) deficiency in Lebanon is estimated at 10 per 1000 in men and 0.4 per 1000 in women. A community-based cluster sampling survey was conducted in 15 villages in all areas in Lebanon. The survey found 36 cases of G6PD deficiency among 3000 men aged 14 years and above, yielding a cumulative incidence rate of 12 per 1000. Of those 36 cases, 28 (77.8%) knew of their problem since they had already suffered at least one severe anaemia crisis in their childhood following the ingestion of raw green fava beans. The remaining 22.2% were not aware at all of their defect. These findings confirm that G6PD is a common genetic problem in Lebanon. The efficiency of early screening programmes in terms of preventing severe, at times potentially lethal, haemolytic crises is currently being investigated.

1 April 2002 in Pathogens and Global Health
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Journal Article
Closed access
GMGhassan Matar
Ghassan Matar
DAD. Abdo
D. Abdo
IKIssam KHNEISSER
Issam KHNEISSER
MYM. Youssef
M. Youssef
HZH. Zouheiry
H. Zouheiry
HHH. S. Harakeh
H. S. Harakeh
In several hospitals in Beirut, Lebanon, 77 isolates of Escherichia coli were successfully derived from the stools of patients with diarrhoeal diseases, by culture on MacConkey or MacConkey-sorbitol agar. When the isolates were screened, using a multiplex PCR, 14 (from 14 different patients) were each found positive for one of the various genes defining the enterotoxigenic (five), enteroinvasive (four), enteroaggregative (three) or enteropathogenic (two) groups. Genotyping of these 14 diarrhoeagenic isolates, by pulsed-field gel electrophoresis, indicated that all were genomically distinct with the exception of two of the enteroaggregative isolates (which were of the same genotype). The E. coli apparently involved in diarrhoeal disease in Beirut therefore belong to at least four different diarrhoeagenic groups and show strain variation within each group. Diarrhoea in the absence of diarrhoeagenic E. coli may be the result of infection with bacteria other than E. coli or viral or parasitic enteropathogens.