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Prof. Matthias Kohl
Institute of Precision Medicine, Medical and Life Sciences Faculty, Furtwangen University, Jakob-Kienzle-Straße 17, 78054 Villingen-Schwenningen, Germany

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0 Bioinformatics
0 Biostatistics
0 Image Analysis
0 Precision Medicine
0 Data science for life science

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Bioinformatics
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Statistical/machine learning

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Journal article
Published: 12 July 2021 in Evidence-based Complementary and Alternative Medicine : eCAM
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To examine the effects of warm footbaths with thermogenic medicinal powders on vitality and heart rate variability in healthy adults. Intervention and Outcome. Seventeen healthy young adults (22.1 ± 2.4 years, 11 females) received three footbaths (WA: warm water only; GI: warm water and ginger; MU: warm water and mustard) in randomized order with a crossover design. We assessed vitality with the Basler Befindlichkeit questionnaire (BBS) and heart rate variability (HRV) before (t0), immediately after (t1), and 10 minutes following footbaths (t2). The primary outcome measure was self-reported vitality, measured via the BBS, at t1. The primary outcome measure, self-reported vitality, was higher after GI and tended to be higher after MU compared to WA with medium effect sizes (GI vs. WA, mean difference −2.47 (95% CI −5.28 to 0.34), padj=0.048, dadj = 0.74), MU vs. WA, −2.35 (−5.32 to 0.61), padj=0.30, dadj = 0.50). At t2, the standard deviation of beat-to-beat intervals (SDNN) of HRV increased, and the stress index tended to decrease after all three footbath conditions with small to medium effect sizes (0.42–0.66). There is preliminary evidence that footbaths with thermogenic agents GI and MU may increase self-reported vitality during a short-time period with a more pronounced effect with GI. After a short follow-up, all three conditions tended to shift the autonomic balance towards relaxation. Future research should investigate these effects in clinical samples with a larger, more diverse sample size.

ACS Style

Jan Vagedes; Silja Kuderer; Eduard Helmert; Matthias Kohl; Florian Beissner; Henrik Szöke; Stefanie Joos; Ursula Wolf. Warm Footbaths with Sinapis nigra or Zingiber officinale Enhance Self-Reported Vitality in Healthy Adults More than Footbaths with Warm Water Only: A Randomized, Controlled Trial. Evidence-based Complementary and Alternative Medicine : eCAM 2021, 2021, 1 .

AMA Style

Jan Vagedes, Silja Kuderer, Eduard Helmert, Matthias Kohl, Florian Beissner, Henrik Szöke, Stefanie Joos, Ursula Wolf. Warm Footbaths with Sinapis nigra or Zingiber officinale Enhance Self-Reported Vitality in Healthy Adults More than Footbaths with Warm Water Only: A Randomized, Controlled Trial. Evidence-based Complementary and Alternative Medicine : eCAM. 2021; 2021 ():1.

Chicago/Turabian Style

Jan Vagedes; Silja Kuderer; Eduard Helmert; Matthias Kohl; Florian Beissner; Henrik Szöke; Stefanie Joos; Ursula Wolf. 2021. "Warm Footbaths with Sinapis nigra or Zingiber officinale Enhance Self-Reported Vitality in Healthy Adults More than Footbaths with Warm Water Only: A Randomized, Controlled Trial." Evidence-based Complementary and Alternative Medicine : eCAM 2021, no. : 1.

Brief report
Published: 25 May 2021 in International Journal of Environmental Research and Public Health
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Whole-body electromyostimulation (WB-EMS), an innovative training technology, is considered as a joint-friendly, highly customizable and particularly time-effective option for improving muscle strength and stability, body composition and pain relief. The aim of the present study was to determine the effect of 16 weeks of once-weekly WB-EMS on maximum isometric trunk (MITS), leg extensor strength (MILES), lean body mass (LBM) and body-fat content. A cohort of 54 male amateur golfers, 18 to 70 years old and largely representative for healthy adults, were randomly assigned to a WB-EMS (n = 27) or a control group (CG: n = 27). Bipolar low-frequency WB-EMS combined with low-intensity movements was conducted once per week for 20 min at the participants’ locations, while the CG maintained their habitual activity. The intention to treat analysis with multiple imputation was applied. After 16 weeks of once-weekly WB-EMS application with an attendance rate close to 100%, we observed significant WB-EMS effects on MITS (p< 0.001), MILES (p = 0.001), LBM (p = 0.034), but not body-fat content (p = 0.080) and low-back pain (LBP: p ≥ 0.078). In summary, the commercial setting of once-weekly WB-EMS application is effective to enhance stability, maximum strength, body composition and, to a lower extent, LBP in amateur golfers widely representative for a healthy male cohort.

ACS Style

Carina Zink-Rückel; Matthias Kohl; Sebastian Willert; Simon von Stengel; Wolfgang Kemmler. Once-Weekly Whole-Body Electromyostimulation Increases Strength, Stability and Body Composition in Amateur Golfers. A Randomized Controlled Study. International Journal of Environmental Research and Public Health 2021, 18, 5628 .

AMA Style

Carina Zink-Rückel, Matthias Kohl, Sebastian Willert, Simon von Stengel, Wolfgang Kemmler. Once-Weekly Whole-Body Electromyostimulation Increases Strength, Stability and Body Composition in Amateur Golfers. A Randomized Controlled Study. International Journal of Environmental Research and Public Health. 2021; 18 (11):5628.

Chicago/Turabian Style

Carina Zink-Rückel; Matthias Kohl; Sebastian Willert; Simon von Stengel; Wolfgang Kemmler. 2021. "Once-Weekly Whole-Body Electromyostimulation Increases Strength, Stability and Body Composition in Amateur Golfers. A Randomized Controlled Study." International Journal of Environmental Research and Public Health 18, no. 11: 5628.

Brief report
Published: 01 May 2021 in Nutrients
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The present study aimed to determine the effect of detraining on muscle quality (MQ) in older men with osteosarcopenia. Forty-three community-dwelling older men (78 ± 4 years) were randomly allocated to a consistently supervised high-intensity resistance exercise training (HIRT) group (n = 21) or a control group (CG, n = 22). The HIRT scheduled a periodized single set protocol twice weekly. After the intervention, the men were subjected to six months of detraining. Muscle quality (MQ), defined as maximum isokinetic hip/leg extensor strength per unit of mid-thigh intra-fascia volume, was determined by magnetic resonance imaging (MRI) or per unit of thigh muscle mass assessed by dual-energy X-ray absorptiometry (DXA). Intention-to-treat analysis with multiple imputations was applied. We observed significant exercise effects for MQ (p = 0.001). During detraining, the HIRT group lost about one-third of the intervention-induced gain and displayed significantly (p = 0.001) higher MQ reductions compared to the CG. Nevertheless, after training and detraining, the overall intervention effect on MQ remained significant (p ≤ 0.004). In summary, six months of absence from HIRT induce a significant deleterious effect on MQ in older osteosarcopenic men. We conclude that intermitted training programs with training breaks of six months and longer should be replaced by largely continuous exercise programs, at least when addressing MQ parameters.

ACS Style

Mansour Ghasemikaram; Klaus Engelke; Matthias Kohl; Simon von Stengel; Wolfgang Kemmler. Detraining Effects on Muscle Quality in Older Men with Osteosarcopenia. Follow-Up of the Randomized Controlled Franconian Osteopenia and Sarcopenia Trial (FrOST). Nutrients 2021, 13, 1528 .

AMA Style

Mansour Ghasemikaram, Klaus Engelke, Matthias Kohl, Simon von Stengel, Wolfgang Kemmler. Detraining Effects on Muscle Quality in Older Men with Osteosarcopenia. Follow-Up of the Randomized Controlled Franconian Osteopenia and Sarcopenia Trial (FrOST). Nutrients. 2021; 13 (5):1528.

Chicago/Turabian Style

Mansour Ghasemikaram; Klaus Engelke; Matthias Kohl; Simon von Stengel; Wolfgang Kemmler. 2021. "Detraining Effects on Muscle Quality in Older Men with Osteosarcopenia. Follow-Up of the Randomized Controlled Franconian Osteopenia and Sarcopenia Trial (FrOST)." Nutrients 13, no. 5: 1528.

Original research
Published: 01 April 2021 in Clinical Interventions in Aging
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Purpose: Temporary cessation of exercise but maintenance of habitual physical activity might be a frequent situation in older people’s lives. Particularly the COVID-19 induced lockdown of exercise training facilities with individual outdoor activities still being allowed might be a blueprint for this potentially harmful scenario. Thus, the aim of the present study was to determine the effects of 6 months of detraining after 18 months of high-intensity resistance exercise (HIT-RT) on body composition and cardiometabolic outcomes in predominately obese older men with osteosarcopenia. Materials and Methods: Community-dwelling predominately obese men 72– 91 years old with low muscle and bone mass (n=43) were randomly assigned to an 18-month HIT-RT (EG: n=21) or a non-training control group (CG, n=22). After the intervention, participants of the EG discontinued HIT-RT for 6 months, but increased their habitual physical activity. Study outcomes were group differences in detraining changes (“effects”) for lean body mass (LBM), total and abdominal body fat rate (determined by dual-energy x-ray absorptiometry) and the Metabolic Syndrome Z-Score (MetSZ). We applied an intention-to-treat analysis with multiple imputation to analyze the data. Results: After the 18-month HIT-RT, we observed significant positive training effects for LBM, total and abdominal body fat rate and the MetSZ (all p< 0.001). Abrupt cessation of HIT-RT for 6 months resulted in significantly higher unfavorable changes in the HIT-RT compared with the CG for LBM (p=0.001), total body fat (p=0.003) and the MetSZ (p=0.003), apart from abdominal body fat (p=0.059). However, significant overall effects were still present after 24 months for LBM and body fat indices but not for the MetSZ. Conclusion: The present study clearly indicates the unfavorable effects of 6 months of detraining after HIT-RT. Correspondingly, exercise protocols particularly for older people should focus on continuous exercise with short regeneration periods rather than on intermitted protocols with pronounced training breaks.

ACS Style

Wolfgang Kemmler; Daniel Schoene; Matthias Kohl; Simon von Stengel. Changes in Body Composition and Cardiometabolic Health After Detraining in Older Men with Osteosarcopenia: 6-Month Follow-Up of the Randomized Controlled Franconian Osteopenia and Sarcopenia Trial (FrOST) Study. Clinical Interventions in Aging 2021, ume 16, 571 -582.

AMA Style

Wolfgang Kemmler, Daniel Schoene, Matthias Kohl, Simon von Stengel. Changes in Body Composition and Cardiometabolic Health After Detraining in Older Men with Osteosarcopenia: 6-Month Follow-Up of the Randomized Controlled Franconian Osteopenia and Sarcopenia Trial (FrOST) Study. Clinical Interventions in Aging. 2021; ume 16 ():571-582.

Chicago/Turabian Style

Wolfgang Kemmler; Daniel Schoene; Matthias Kohl; Simon von Stengel. 2021. "Changes in Body Composition and Cardiometabolic Health After Detraining in Older Men with Osteosarcopenia: 6-Month Follow-Up of the Randomized Controlled Franconian Osteopenia and Sarcopenia Trial (FrOST) Study." Clinical Interventions in Aging ume 16, no. : 571-582.

Clinical trial report
Published: 01 January 2021 in Clinical Interventions in Aging
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The menopausal transition is a critical period in women’s lives. Exercise might be the most promising non-pharmaceutic intervention to address the large variety of risk factors related to the pronounced estradiol decline during peri- and early-postmenopause. The aim of this study was to determine the effect of an 18-month multipurpose exercise program on risk factors and symptoms related to the menopausal transition. Fifty-four women 1– 5 years postmenopause with osteopenia or osteoporosis were randomly assigned 1) to a high impact weight-bearing/high-intensity/velocity resistance training group (EG: n=27) exercising three times a week or 2) to an attendance control group (CG: n=27) that performed low-intensity exercise once a week. Both groups were supplemented with cholecalciferol and calcium. The primary study endpoint was bone mineral density (BMD) at lumbar spine (LS) and total hip, secondary outcomes were lean body mass (LBM), total and abdominal body percentage, metabolic syndrome Z-Score (MetS-Z), menopausal symptoms and muscle strength and power. Due to COVID-19, the study was stopped after 13 months. We observed significant effects for BMD-LS (EG: 0.002± .018 versus CG: − .009± 0.018 mg/cm2, p=0.027) but not for BMD total hip (EG: − 0.01± .016 versus CG: − .009± 0.020 mg/cm2, p=0.129). LBM improved significantly in the EG and decreased in the CG (0.39± 1.08 vs − 0.37± 1.34 kg, p=0.026). Total and abdominal body fat improved significantly in the EG and was maintained in the CG (− 1.44± 1.49 vs − 0.02± 1.55 kg, p=0.002 and -1.50± 2.33 vs 0.08± 2.07 kg, p=0.011). Significant effects in favor of the EG were also determined for menopausal symptoms (p=0.029), hip/leg extension strength (p< 0.001) and power (p< 0.001). However, changes of the MetS-Z did not differ significantly (p=0.149) between EG and CG. In summary, with minor exceptions, we demonstrated the effectiveness of a multipurpose exercise protocol dedicated to early-postmenopausal women on various risk factors and complaints related to the menopausal transition.

ACS Style

Michael Hettchen; Simon von Stengel; Matthias Kohl; Marie H Murphy; Mahdieh Shojaa; Mansour Ghasemikaram; Laura Bragonzoni; Francesco Benvenuti; Claudio Ripamonti; Maria Grazia Benedetti; Mikko Julin; Tapani Risto; Wolfgang Kemmler. Changes in Menopausal Risk Factors in Early Postmenopausal Osteopenic Women After 13 Months of High-Intensity Exercise: The Randomized Controlled ACTLIFE-RCT. Clinical Interventions in Aging 2021, ume 16, 83 -96.

AMA Style

Michael Hettchen, Simon von Stengel, Matthias Kohl, Marie H Murphy, Mahdieh Shojaa, Mansour Ghasemikaram, Laura Bragonzoni, Francesco Benvenuti, Claudio Ripamonti, Maria Grazia Benedetti, Mikko Julin, Tapani Risto, Wolfgang Kemmler. Changes in Menopausal Risk Factors in Early Postmenopausal Osteopenic Women After 13 Months of High-Intensity Exercise: The Randomized Controlled ACTLIFE-RCT. Clinical Interventions in Aging. 2021; ume 16 ():83-96.

Chicago/Turabian Style

Michael Hettchen; Simon von Stengel; Matthias Kohl; Marie H Murphy; Mahdieh Shojaa; Mansour Ghasemikaram; Laura Bragonzoni; Francesco Benvenuti; Claudio Ripamonti; Maria Grazia Benedetti; Mikko Julin; Tapani Risto; Wolfgang Kemmler. 2021. "Changes in Menopausal Risk Factors in Early Postmenopausal Osteopenic Women After 13 Months of High-Intensity Exercise: The Randomized Controlled ACTLIFE-RCT." Clinical Interventions in Aging ume 16, no. : 83-96.

Journal article
Published: 26 November 2020 in Bone
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Detraining after dedicated exercise programs might be a frequent situation in older people's exercise patterns. The aim of the present study was thus to determine the effects of 6 months of detraining after 18 months of high intensity resistance exercise (HIT-RT) on musculoskeletal outcomes in older men with sarcopenia. Community-dwelling men aged 72 years and older with osteosarcopenia (n=43) were randomly assigned to an 18-month HIT-RT (EG: n=21) or a non-training control group (CG, n=22). After the intervention, participants of the EG stopped HIT-RT for 6 months, but continued their habitual physical activity. Study outcomes were skeletal muscle mass index, bone mineral density (BMD) at the lumbar-spine and total-hip, maximum hip/leg-extensor strength, handgrip strength and gait velocity. We applied an intention-to-treat analysis with multiple imputation. Changes in the HIT-RT were much more pronounced during the detraining period compared with the CG, although this effect was only significant for skeletal muscle mass index and hip-/leg-extensor strength (p=.002 and p=.013), but not for lumbar-spine BMD (p=.068), total-hip BMD (p=.069), handgrip strength (p=.066) or gait velocity (p=.067). Apart from total-hip BMD (p=.055), handgrip strength (p=.069) and gait velocity (p=.881) values of the HIT-RT group decreased significantly during detraining. However, after 24 months, overall effects (p<.001) were still observed for skeletal muscle mass index and hip-/leg-extensor strength. Although unable to state from which point in time relevant detraining effects emerge, we conclude that health care providers should focus on continuous rather than intermitted exercise programs for older people. Clinical trial number: clinicalTrials.gov: NCT03453463; NCT04444661.

ACS Style

Wolfgang Kemmler; Matthias Kohl; Michael Fröhlich; Daniel Schoene; Simon von Stengel. Detraining effects after 18 months of high intensity resistance training on osteosarcopenia in older men—Six-month follow-up of the randomized controlled Franconian Osteopenia and Sarcopenia Trial (FrOST). Bone 2020, 142, 115772 .

AMA Style

Wolfgang Kemmler, Matthias Kohl, Michael Fröhlich, Daniel Schoene, Simon von Stengel. Detraining effects after 18 months of high intensity resistance training on osteosarcopenia in older men—Six-month follow-up of the randomized controlled Franconian Osteopenia and Sarcopenia Trial (FrOST). Bone. 2020; 142 ():115772.

Chicago/Turabian Style

Wolfgang Kemmler; Matthias Kohl; Michael Fröhlich; Daniel Schoene; Simon von Stengel. 2020. "Detraining effects after 18 months of high intensity resistance training on osteosarcopenia in older men—Six-month follow-up of the randomized controlled Franconian Osteopenia and Sarcopenia Trial (FrOST)." Bone 142, no. : 115772.

Methodology
Published: 10 September 2020 in Journal of Nanobiotechnology
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Fast point-of-care (POC) diagnostics represent an unmet medical need and include applications such as lateral flow assays (LFAs) for the diagnosis of sepsis and consequences of cytokine storms and for the treatment of COVID-19 and other systemic, inflammatory events not caused by infection. Because of the complex pathophysiology of sepsis, multiple biomarkers must be analyzed to compensate for the low sensitivity and specificity of single biomarker targets. Conventional LFAs, such as gold nanoparticle dyed assays, are limited to approximately five targets—the maximum number of test lines on an assay. To increase the information obtainable from each test line, we combined green and red emitting quantum dots (QDs) as labels for C-reactive protein (CRP) and interleukin-6 (IL-6) antibodies in an optical duplex immunoassay. CdSe-QDs with sharp and tunable emission bands were used to simultaneously quantify CRP and IL-6 in a single test line, by using a single UV-light source and two suitable emission filters for readout through a widely available BioImager device. For image and data processing, a customized software tool, the MultiFlow-Shiny app was used to accelerate and simplify the readout process. The app software provides advanced tools for image processing, including assisted extraction of line intensities, advanced background correction and an easy workflow for creation and handling of experimental data in quantitative LFAs. The results generated with our MultiFlow-Shiny app were superior to those generated with the popular software ImageJ and resulted in lower detection limits. Our assay is applicable for detecting clinically relevant ranges of both target proteins and therefore may serve as a powerful tool for POC diagnosis of inflammation and infectious events.

ACS Style

Christoph Ruppert; Lars Kaiser; Lisa Johanna Jacob; Stefan Laufer; Matthias Kohl; Hans-Peter Deigner. Duplex Shiny app quantification of the sepsis biomarkers C-reactive protein and interleukin-6 in a fast quantum dot labeled lateral flow assay. Journal of Nanobiotechnology 2020, 18, 1 -11.

AMA Style

Christoph Ruppert, Lars Kaiser, Lisa Johanna Jacob, Stefan Laufer, Matthias Kohl, Hans-Peter Deigner. Duplex Shiny app quantification of the sepsis biomarkers C-reactive protein and interleukin-6 in a fast quantum dot labeled lateral flow assay. Journal of Nanobiotechnology. 2020; 18 (1):1-11.

Chicago/Turabian Style

Christoph Ruppert; Lars Kaiser; Lisa Johanna Jacob; Stefan Laufer; Matthias Kohl; Hans-Peter Deigner. 2020. "Duplex Shiny app quantification of the sepsis biomarkers C-reactive protein and interleukin-6 in a fast quantum dot labeled lateral flow assay." Journal of Nanobiotechnology 18, no. 1: 1-11.

Journal article
Published: 24 August 2020 in International Journal of Molecular Sciences
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Assessment of hematotoxicity from environmental or xenobiotic compounds is of notable interest and is frequently assessed via the colony forming unit (CFU) assay. Identification of the mode of action of single compounds is of further interest, as this often enables transfer of results across different tissues and compounds. Metabolomics displays one promising approach for such identification, nevertheless, suitability with current protocols is restricted. Here, we combined a hematopoietic stem and progenitor cell (HSPC) expansion approach with distinct lineage differentiations, resulting in formation of erythrocytes, dendritic cells and neutrophils. We examined the unique combination of pathway activity in glycolysis, glutaminolysis, polyamine synthesis, fatty acid oxidation and synthesis, as well as glycerophospholipid and sphingolipid metabolism. We further assessed their interconnections and essentialness for each lineage formation. By this, we provide further insights into active metabolic pathways during the differentiation of HSPC into different lineages, enabling profound understanding of possible metabolic changes in each lineage caused by exogenous compounds.

ACS Style

Lars Kaiser; Helga Weinschrott; Isabel Quint; Markus Blaess; René Csuk; Manfred Jung; Matthias Kohl; Hans-Peter Deigner. Metabolite Patterns in Human Myeloid Hematopoiesis Result from Lineage-Dependent Active Metabolic Pathways. International Journal of Molecular Sciences 2020, 21, 6092 .

AMA Style

Lars Kaiser, Helga Weinschrott, Isabel Quint, Markus Blaess, René Csuk, Manfred Jung, Matthias Kohl, Hans-Peter Deigner. Metabolite Patterns in Human Myeloid Hematopoiesis Result from Lineage-Dependent Active Metabolic Pathways. International Journal of Molecular Sciences. 2020; 21 (17):6092.

Chicago/Turabian Style

Lars Kaiser; Helga Weinschrott; Isabel Quint; Markus Blaess; René Csuk; Manfred Jung; Matthias Kohl; Hans-Peter Deigner. 2020. "Metabolite Patterns in Human Myeloid Hematopoiesis Result from Lineage-Dependent Active Metabolic Pathways." International Journal of Molecular Sciences 21, no. 17: 6092.

Journal article
Published: 05 August 2020 in Nutrients
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The present study aimed to evaluate the effect of high intensity dynamic resistance exercise (HIT-DRT) and whey protein supplementation (WPS) on bone mineral density (BMD) and sarcopenia parameters in osteosarcopenic men. Men ≥ 72 years with osteosarcopenia (n = 43) were randomly assigned to a HIT-RT (HIT-RT: n = 21) or a non-training control group (n = 22). Supervised HIT-RT twice/week was applied for 18 months, while the control group maintained their habitual lifestyle. Supplying WPS, total protein intake amounted to 1.5–1.6 (HIT-RT) and 1.2 g/kg/body mass/d (control). Both groups were supplied with calcium and vitamin D. Primary study outcomes were BMD and the sarcopenia Z-score. After adjusting for multiplicity, we observed significant positive effects for sarcopenia Z-score (standardized mean difference (SMD): 1.40), BMD at lumbar spine (SMD: 0.72) and total hip (SMD: 0.72). In detail, effect sizes for skeletal muscle mass changes were very pronounced (1.97, p < 0.001), while effects for functional sarcopenia parameters were moderate (0.87, p = 0.008; handgrip strength) or low (0.39, p = 0.209; gait velocity). Apart from one man who reported short periods of temporary worsening of existing joint pain, no HIT-RT/WPS-related adverse effects or injuries were reported. We consider HIT-RT supported by whey protein supplementation as a feasible, attractive, safe and highly effective option to fight osteosarcopenia in older men.

ACS Style

Wolfgang Kemmler; Matthias Kohl; Franz Jakob; Klaus Engelke; Simon Von Stengel. Effects of High Intensity Dynamic Resistance Exercise and Whey Protein Supplements on Osteosarcopenia in Older Men with Low Bone and Muscle Mass. Final Results of the Randomized Controlled FrOST Study. Nutrients 2020, 12, 2341 .

AMA Style

Wolfgang Kemmler, Matthias Kohl, Franz Jakob, Klaus Engelke, Simon Von Stengel. Effects of High Intensity Dynamic Resistance Exercise and Whey Protein Supplements on Osteosarcopenia in Older Men with Low Bone and Muscle Mass. Final Results of the Randomized Controlled FrOST Study. Nutrients. 2020; 12 (8):2341.

Chicago/Turabian Style

Wolfgang Kemmler; Matthias Kohl; Franz Jakob; Klaus Engelke; Simon Von Stengel. 2020. "Effects of High Intensity Dynamic Resistance Exercise and Whey Protein Supplements on Osteosarcopenia in Older Men with Low Bone and Muscle Mass. Final Results of the Randomized Controlled FrOST Study." Nutrients 12, no. 8: 2341.

Original research
Published: 01 June 2020 in Clinical Interventions in Aging
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Purpose: Whole-body electromyostimulation (WB-EMS) especially in combination with a high-protein supplementation has been established as an efficient treatment against sarcopenia. However, there are several case reports of rhabdomyolysis after WB-EMS application. Thus, we asked if this training could potentially lead to deteriorations of the cardiac as well as the renal function. Materials and Methods: One hundred sarcopenic obese men aged 70 years and older were randomly balanced (1-1-1) and allocated to one of the three study arms. During 16 weeks of intervention, these groups either performed WB-EMS and took a protein supplement (WB-EMS&P), solely received the protein supplement (Protein) or served as control group (CG). WB-EMS consisted of 1.5× 20 min (85 Hz, 350 μs, 4 s of strain to 4 s of rest) applied with moderate-to-high intensity while moving. We further generated a daily protein intake of 1.7– 1.8 g/kg/body mass per day. At baseline and 8– 10 days after completion of the intervention, blood was drawn and biomarkers of muscle, cardiac and renal health were assessed. Results: Hereby, we found slight but significant elevations of creatine kinase (CK) levels in the WB-EMS group pointing to minor damages of the skeletal muscle (140 U/l [81– 210], p < 0.001). This was accompanied by a significant, low-grade increase of creatine kinase–muscle brain (CK-MB, 0.43 ng/mL [− 0.29– 0.96], p < 0.01) and high-sensitivity troponin T (hsTnT, 0.001 ng/mL. [0.000– 0.003], p < 0.001) but without a higher risk of developing heart failure according to N-terminal prohormone of brain natriuretic peptide (NT-proBNP, − 5.7 pg/mL [− 38.8– 24.6], p = 0.17). Estimated glomerular filtration rate (eGFR) was impaired neither by the high-protein supplementation alone nor in combination with WB-EMS (CG 76.0 mL/min/1.73 m2 [71.9– 82.2] vs Protein 73.2 mL/min/1.73 m2 [63.0– 78.9] vs WB-EMS&P 74.6 mL/min/1.73 m2 [62.8– 84.1], p = 0.478). Conclusion: In conclusion, even in the vulnerable group of sarcopenic obese seniors, the combination of WB-EMS with a high-protein intake revealed no short-term, negative impact on the eGFR, but potential consequences for the cardiovascular system need to be addressed in future studies.

ACS Style

Wolfgang Kemmler; Simon von Stengel; Matthias Kohl; Nicolas Rohleder; Thomas Bertsch; Cornel C. Sieber; Ellen Freiberger; Robert Kob. Safety of a Combined WB-EMS and High-Protein Diet Intervention in Sarcopenic Obese Elderly Men. Clinical Interventions in Aging 2020, ume 15, 953 -967.

AMA Style

Wolfgang Kemmler, Simon von Stengel, Matthias Kohl, Nicolas Rohleder, Thomas Bertsch, Cornel C. Sieber, Ellen Freiberger, Robert Kob. Safety of a Combined WB-EMS and High-Protein Diet Intervention in Sarcopenic Obese Elderly Men. Clinical Interventions in Aging. 2020; ume 15 ():953-967.

Chicago/Turabian Style

Wolfgang Kemmler; Simon von Stengel; Matthias Kohl; Nicolas Rohleder; Thomas Bertsch; Cornel C. Sieber; Ellen Freiberger; Robert Kob. 2020. "Safety of a Combined WB-EMS and High-Protein Diet Intervention in Sarcopenic Obese Elderly Men." Clinical Interventions in Aging ume 15, no. : 953-967.

Review
Published: 12 May 2020 in Osteoporosis International
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This systematic review and meta-analysis set out to determine the effect of dynamic resistance exercise (DRT) on areal bone mineral density (aBMD) in postmenopausal women and derive evidence-based recommendations for optimized training protocols. A systematic review of the literature according to the PRISMA statement included (a) controlled trials, (b) of isolated DRT with at least one exercise and one control group, (c) with intervention durations ≥ 6 months, (d) aBMD assessments at lumbar spine or proximal femur, (e) in cohorts of postmenopausal women. We searched eight electronic databases up to March 2019 without language restrictions. The meta-analysis was performed using a random-effects model. Standardized mean differences (SMD) for BMD changes at lumbar spine (LS), femoral neck (FN), and total hip (TH) were defined as outcome measures. Moderators of the exercise effects, i.e., “intervention length,” “type of DRT,” “training frequency,” “exercise intensity,” and “exercise volume,” were addressed by sub-group analyses. The study was registered in the international prospective register of systematic reviews (PROSPERO) under ID: CRD42018095097. Seventeen articles with 20 exercise and 18 control groups were eligible. SMD average is 0.54 (95% CI 0.22–0.87) for LS-BMD, 0.22 (0.07–0.38) for FN-BMD, and 0.48 (0.22–0.75) for TH-BMD changes (all p ≤ 0.015). While sub-group analysis for FN-BMD revealed no differences within categories of moderators, lower training frequency (< 2 sessions/week) resulted in significantly higher BMD changes at LS and TH compared to higher training frequency (≥ 2 sessions/week). Additionally, free weight training was significantly superior to DRT devices for improving TH-BMD. This work provided further evidence for significant, albeit only low–moderate, effects of DRT on LS-, FN-, and TH-BMD. Unfortunately, sub-analysis results did not allow meaningful exercise recommendations to be derived. This systematic review and meta-analysis observed a significant low–moderate effect of dynamic resistance exercise on bone mineral density changes in postmenopausal women. However, sub-group analyses focusing on exercise characteristics found no results that enable the derivation of meaningful exercise recommendations in the area of exercise and osteoporosis prevention or therapy.

ACS Style

M. Shojaa; S. Von Stengel; Matthias Kohl; Daniel Schoene; W. Kemmler. Effects of dynamic resistance exercise on bone mineral density in postmenopausal women: a systematic review and meta-analysis with special emphasis on exercise parameters. Osteoporosis International 2020, 31, 1427 -1444.

AMA Style

M. Shojaa, S. Von Stengel, Matthias Kohl, Daniel Schoene, W. Kemmler. Effects of dynamic resistance exercise on bone mineral density in postmenopausal women: a systematic review and meta-analysis with special emphasis on exercise parameters. Osteoporosis International. 2020; 31 (8):1427-1444.

Chicago/Turabian Style

M. Shojaa; S. Von Stengel; Matthias Kohl; Daniel Schoene; W. Kemmler. 2020. "Effects of dynamic resistance exercise on bone mineral density in postmenopausal women: a systematic review and meta-analysis with special emphasis on exercise parameters." Osteoporosis International 31, no. 8: 1427-1444.

Clinical trial
Published: 09 April 2020 in Journal of Bone and Mineral Research
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Dynamic resistance exercise (DRT) might be the most promising agent for fighting sarcopenia in older people. However, the positive effect of DRT on osteopenia/osteoporosis in men has still to be confirmed. In order to evaluate the effect of low volume/high intensity (HIT)‐DRT on bone mineral density (BMD) and skeletal muscle mass index (SMI) in men with osteosarcopenia, we initiated the Franconian Osteopenia and Sarcopenia Trial (FrOST). Forty‐three sedentary community dwelling older men (73‐91 years) with osteopenia/osteoporosis and SMI‐based sarcopenia were randomly assigned to a HIT‐RT exercise (EG: n=21) or a control group (CG, n=22). HIT‐RT provided a progressive, periodized single set DRT on machines with high intensity, effort and velocity twice a week, while CG maintained their lifestyle. Both groups were adequately supplemented with whey protein, Vit‐D and calcium. Primary study endpoint was integral lumbar spine (LS) BMD as determined by quantitative computed tomography. Core secondary study endpoint was skeletal muscle mass index (SMI) as determined by dual‐energy‐x‐ray absorptiometry. Additional study endpoints were BMD at the total hip and maximum isokinetic hip‐/leg‐extensor strength (leg press). After 12 months of exercise, LS‐BMD was maintained in the EG and decreased significantly in the CG, resulting in significant between group differences (p<.001, standardized mean difference (SMD): .90). In parallel, SMI increased significantly in the EG and decreased significantly in the CG (p<.001, SMD: 1.95). Total hip BMD changes did not differ significantly between the groups (p=.064, SMD=0.65), while changes in maximum hip‐/leg‐extensor strength were much more prominent (p<.001, SMD=1.92) in the EG. Considering dropout (n=2), attendance rate (95%) and unintended side effects/injuries (n=0), we believe our HIT‐RT protocol to be feasible, attractive and safe. In summary, we conclude that our combined low‐threshold HIT‐RT/protein/Vit‐D/calcium intervention was feasible, safe and effective for tackling sarcopenia and osteopenia/osteoporosis in older men with osteosarcopenia. This article is protected by copyright. All rights reserved.

ACS Style

Wolfgang Kemmler; Matthias Kohl; Michael Fröhlich; Franz Jakob; Klaus Engelke; Simon Von Stengel; Daniel Schoene. Effects of High‐Intensity Resistance Training on Osteopenia and Sarcopenia Parameters in Older Men with Osteosarcopenia—One‐Year Results of the Randomized Controlled Franconian Osteopenia and Sarcopenia Trial ( FrOST ). Journal of Bone and Mineral Research 2020, 35, 1634 -1644.

AMA Style

Wolfgang Kemmler, Matthias Kohl, Michael Fröhlich, Franz Jakob, Klaus Engelke, Simon Von Stengel, Daniel Schoene. Effects of High‐Intensity Resistance Training on Osteopenia and Sarcopenia Parameters in Older Men with Osteosarcopenia—One‐Year Results of the Randomized Controlled Franconian Osteopenia and Sarcopenia Trial ( FrOST ). Journal of Bone and Mineral Research. 2020; 35 (9):1634-1644.

Chicago/Turabian Style

Wolfgang Kemmler; Matthias Kohl; Michael Fröhlich; Franz Jakob; Klaus Engelke; Simon Von Stengel; Daniel Schoene. 2020. "Effects of High‐Intensity Resistance Training on Osteopenia and Sarcopenia Parameters in Older Men with Osteosarcopenia—One‐Year Results of the Randomized Controlled Franconian Osteopenia and Sarcopenia Trial ( FrOST )." Journal of Bone and Mineral Research 35, no. 9: 1634-1644.

Correction
Published: 13 February 2020 in Supportive Care in Cancer
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The Acknowledgement Statement was incorrect in the original publication of this article [1] and the previous correction note [2]. The correct statement is as follows.

ACS Style

P. Schalk; Matthias Kohl; H. J. Herrmann; R. Schwappacher; M. E. Rimmele; Andrea Buettner; J. Siebler; M. F. Neurath; Y. Zopf. Correction to: Influence of cancer and acute inflammatory disease on taste perception: a clinical pilot study. Supportive Care in Cancer 2020, 28, 2431 -2431.

AMA Style

P. Schalk, Matthias Kohl, H. J. Herrmann, R. Schwappacher, M. E. Rimmele, Andrea Buettner, J. Siebler, M. F. Neurath, Y. Zopf. Correction to: Influence of cancer and acute inflammatory disease on taste perception: a clinical pilot study. Supportive Care in Cancer. 2020; 28 (5):2431-2431.

Chicago/Turabian Style

P. Schalk; Matthias Kohl; H. J. Herrmann; R. Schwappacher; M. E. Rimmele; Andrea Buettner; J. Siebler; M. F. Neurath; Y. Zopf. 2020. "Correction to: Influence of cancer and acute inflammatory disease on taste perception: a clinical pilot study." Supportive Care in Cancer 28, no. 5: 2431-2431.

Research article
Published: 31 January 2020 in Evidence-Based Complementary and Alternative Medicine
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Objective. To analyze the thermogenic effects of footbaths with medicinal powders in adolescents with anorexia nervosa (AN) in comparison to healthy controls (HCs). Intervention and Outcomes. Forty-one female participants (21 AN, 20 HCs; 14.22 ± 1.54 years) received three footbaths—warm water and mustard (MU, Sinapis nigra), warm water and ginger (GI, Zingiber officinale), or warm water only (WA), in random order within a crossover design. Data were collected before (t1), immediately after foot immersion (maximum 20 minutes) (t2), and after 10 minutes subsequently (t3). Actual skin temperature (high resolution thermography) and perceived warmth (HeWEF questionnaire) were assessed at each time point for various body parts. The primary outcome measure was self-perceived warmth at the feet at t3. Secondary outcome measures were objective skin temperature and subjective warmth at the face, hands, and feet. Results. Perceived warmth at the feet at t3 was significantly higher after GI compared to WA (mean difference −1.02) and MU (−1.07), with no differences between those with AN and HC (−0.29). For the secondary outcome measures, a craniocaudal temperature gradient for the skin temperature (thermography) was noted at t1 for patients with AN and HC (AN with colder feet). The craniocaudal gradient for subjective warmth was only seen for patients with AN. Conclusion. Footbaths with ginger increased warmth perception at the feet longer than with mustard or warm water only for adolescents with AN as well as for HC. The impact of ginger footbaths on recovery of thermoregulatory disturbances in patients with AN repeated over extended periods merits further investigation.

ACS Style

S. Kuderer; E. Helmert; H. Szöke; S. Joos; M. Kohl; J. Svaldi; F. Beissner; F. Andrasik; J. Vagedes. Increasing Warmth in Adolescents with Anorexia Nervosa: A Randomized Controlled Crossover Trial Examining the Efficacy of Mustard and Ginger Footbaths. Evidence-Based Complementary and Alternative Medicine 2020, 2020, 1 -14.

AMA Style

S. Kuderer, E. Helmert, H. Szöke, S. Joos, M. Kohl, J. Svaldi, F. Beissner, F. Andrasik, J. Vagedes. Increasing Warmth in Adolescents with Anorexia Nervosa: A Randomized Controlled Crossover Trial Examining the Efficacy of Mustard and Ginger Footbaths. Evidence-Based Complementary and Alternative Medicine. 2020; 2020 ():1-14.

Chicago/Turabian Style

S. Kuderer; E. Helmert; H. Szöke; S. Joos; M. Kohl; J. Svaldi; F. Beissner; F. Andrasik; J. Vagedes. 2020. "Increasing Warmth in Adolescents with Anorexia Nervosa: A Randomized Controlled Crossover Trial Examining the Efficacy of Mustard and Ginger Footbaths." Evidence-Based Complementary and Alternative Medicine 2020, no. : 1-14.

Research article
Published: 30 December 2019 in PLOS ONE
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Accumulating evidence indicates that there is an interaction between the gut microbiota and endometriotic lesions. The new formation of these lesions is associated with stem cell recruitment, angiogenesis and inflammation, which may affect the composition of the gut microbiota. To test this hypothesis, we herein induced endometriotic lesions by transplantation of uterine tissue fragments from green fluorescent protein (GFP)+ donor mice into the peritoneal cavity of GFP- C57BL/6 wild-type mice. Sham-transplanted animals served as controls. Fecal pellets of the animals were collected 3 days before as well as 7 and 21 days after the induction of endometriosis to analyze the composition of the gut microbiota by means of 16S ribosomal RNA gene sequencing. The transplantation of uterine tissue fragments resulted in the establishment of endometriotic lesions in all analyzed mice. These lesions exhibited a typical histomorphology with endometrial glands surrounded by a vascularized stroma. Due to their bright GFP signal, they could be easily differentiated from the surrounding GFP- host tissue. Bacterial 16S rRNA genes were successfully PCR-amplified from the DNA extracts of all obtained mice fecal samples. However, no significant effect of endometriosis induction on the composition of the bacterial microbiota was detected with our experimental setup. Our findings allow careful speculation that endometriosis in mice does not induce pronounced dysbiosis during the acute phase of lesion formation.

ACS Style

Josefine Hantschel; Severin Weis; Karl-Herbert Schäfer; Michael D. Menger; Matthias Kohl; Markus Egert; Matthias W. Laschke. Effect of endometriosis on the fecal bacteriota composition of mice during the acute phase of lesion formation. PLOS ONE 2019, 14, e0226835 .

AMA Style

Josefine Hantschel, Severin Weis, Karl-Herbert Schäfer, Michael D. Menger, Matthias Kohl, Markus Egert, Matthias W. Laschke. Effect of endometriosis on the fecal bacteriota composition of mice during the acute phase of lesion formation. PLOS ONE. 2019; 14 (12):e0226835.

Chicago/Turabian Style

Josefine Hantschel; Severin Weis; Karl-Herbert Schäfer; Michael D. Menger; Matthias Kohl; Markus Egert; Matthias W. Laschke. 2019. "Effect of endometriosis on the fecal bacteriota composition of mice during the acute phase of lesion formation." PLOS ONE 14, no. 12: e0226835.

Journal article
Published: 29 November 2019 in npj Parkinson's Disease
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Parkinson’s disease (PD) is one of the most common neurodegenerative disorders. PD patients suffer from gastrointestinal dysfunctions and alterations of the autonomous nervous system, especially its part in the gut wall, i.e., the enteric nervous system (ENS). Such alterations and functional gastrointestinal deficits often occur years before the classical clinical symptoms of PD appear. Until now, only little is known about PD-associated changes in gut microbiota composition and their potential implication in PD development. In order to increase knowledge in this field, fecal samples of 34 PD patients and 25 healthy, age-matched control persons were investigated. Here, the V4 and V5 hypervariable region of bacterial 16S rRNA genes was PCR-amplified and sequenced using an Ion Torrent PGM platform. Within the PD group, we observed a relative decrease in bacterial taxa which are linked to health-promoting, anti-inflammatory, neuroprotective or other beneficial effects on the epithelial barrier, such as Faecalibacterium and Fusicatenibacter. Both taxa were lowered in PD patients with elevated levels of the fecal inflammation marker calprotectin. In addition, we observed an increase in shares of the Clostridiales family XI and their affiliated members in these samples. Finally, we found that the relative abundances of the bacterial genera Peptoniphilus, Finegoldia, Faecalibacterium Fusicatenibacter, Anaerococcus, Bifidobacterium, Enterococcus, and Ruminococcus were significantly influenced by medication with L-dopa and entacapone, respectively. Our data confirm previously reported effects of COMT inhibitors on the fecal microbiota of PD patients and suggest a possible effect of L-dopa medication on the relative abundance of several bacterial genera.

ACS Style

Severin Weis; Andreas Schwiertz; Marcus M. Unger; Anouck Becker; Klaus Fassbender; Stefan Ratering; Matthias Kohl; Sylvia Schnell; Karl-Herbert Schäfer; Markus Egert. Effect of Parkinson’s disease and related medications on the composition of the fecal bacterial microbiota. npj Parkinson's Disease 2019, 5, 1 -9.

AMA Style

Severin Weis, Andreas Schwiertz, Marcus M. Unger, Anouck Becker, Klaus Fassbender, Stefan Ratering, Matthias Kohl, Sylvia Schnell, Karl-Herbert Schäfer, Markus Egert. Effect of Parkinson’s disease and related medications on the composition of the fecal bacterial microbiota. npj Parkinson's Disease. 2019; 5 (1):1-9.

Chicago/Turabian Style

Severin Weis; Andreas Schwiertz; Marcus M. Unger; Anouck Becker; Klaus Fassbender; Stefan Ratering; Matthias Kohl; Sylvia Schnell; Karl-Herbert Schäfer; Markus Egert. 2019. "Effect of Parkinson’s disease and related medications on the composition of the fecal bacterial microbiota." npj Parkinson's Disease 5, no. 1: 1-9.

Clinical study
Published: 29 September 2019 in BioMed Research International
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Background. Low back pain (LBP) affects almost everyone at least once in their lifetime. Various meta-analyses show promising effects on pain reduction for conventional exercise. However, the lack of time and, especially for pain patients, a fear of movement (“kinesiophobia”) as well as functional limitations often oppose participation in such activities. In contrast, the advantage of novel training technologies like whole-body electromyostimulation (WB-EMS) lies particularly in a joint-friendly, time-effective, and highly customized training protocol and might be an alternative option for LBP patients. A meta-analysis of individual patient data and a comparison of WB-EMS against a passive control group confirmed the proof principle. Thus, the aim of this randomized controlled trial is to compare WB-EMS with a recognized back-strengthening exercise protocol to determine the corresponding effects on chronic, nonspecific LBP in people suffering from this. Methods and Findings. This randomized, controlled multicenter study is focused on novel and time-effective training technologies and LBP. In this contribution, the focus is primarily on the comparison of WB-EMS against a comparable conventional exercise training (CT). One hundred ten nonspecific chronic LBP patients, 40–70 years old, were randomly allocated to the intervention arms (WB-EMS: 55 vs. CT: 55). Both groups completed a 12-week program (WB-EMS: 1 × 20 min/week vs. CT: 1 × 45 min/week) specifically dedicated to LBP. The selection of the content of the active control group was based on the principles of WB-EMS training, which uses electrical stimulation to train mainly strength and stabilization in a very short time. Exercises were similar in all groups, with the focus on strengthening and stabilizing the trunk. Outcome measures were assessed by a four-week pain diary (before and during the last four weeks of intervention) as well as an isometric maximum strength measurement of the trunk muscles at baseline and after 12 weeks of intervention. Primary study endpoint was average pain intensity at the lumbar spine. Secondary study endpoints were maximum isometric strength of the back and the abdominals. The mean pain intensity of LBP decreased significantly in both groups (WB-EMS: −22.3 ± 20.9% vs. CT: −30.2 ± 43.9%; p < 0.001 ), however, without significant intergroup difference ( p = 0.160 ). A similar result was observed for “maximum isometric strength of trunk muscles.” The increase in back strength (WB-EMS: 15.6 ± 24.9% vs. CT: 23.0 ± 30.9%) was highly significant in both groups ( p = 0.001 ), and similar changes were observed for the trunk flexors (WB-EMS: 17.6 ± 24.8% vs. CT: 18.1 ± 24.8%). Also, at the secondary endpoint, no significant difference in pairwise comparison was observed in both cases (extension: p = 0.297 ; flexion: p = 0.707 ). Conclusion. In summary, both, WB-EMS and conventional back-strengthening protocol are comparably effective in reducing nonspecific chronic LBP in this dedicated cohort. The result is particularly positive in terms of time effectiveness and offers an adequate alternative for people with limited time resources or other barriers to conventional training methods.

ACS Style

Anja Weissenfels; Nicolas Wirtz; Ulrike Dörmann; Heinz Kleinöder; Lars Donath; Matthias Kohl; Michael Fröhlich; Simon von Stengel; Wolfgang Kemmler. Comparison of Whole-Body Electromyostimulation versus Recognized Back-Strengthening Exercise Training on Chronic Nonspecific Low Back Pain: A Randomized Controlled Study. BioMed Research International 2019, 2019, 1 -9.

AMA Style

Anja Weissenfels, Nicolas Wirtz, Ulrike Dörmann, Heinz Kleinöder, Lars Donath, Matthias Kohl, Michael Fröhlich, Simon von Stengel, Wolfgang Kemmler. Comparison of Whole-Body Electromyostimulation versus Recognized Back-Strengthening Exercise Training on Chronic Nonspecific Low Back Pain: A Randomized Controlled Study. BioMed Research International. 2019; 2019 ():1-9.

Chicago/Turabian Style

Anja Weissenfels; Nicolas Wirtz; Ulrike Dörmann; Heinz Kleinöder; Lars Donath; Matthias Kohl; Michael Fröhlich; Simon von Stengel; Wolfgang Kemmler. 2019. "Comparison of Whole-Body Electromyostimulation versus Recognized Back-Strengthening Exercise Training on Chronic Nonspecific Low Back Pain: A Randomized Controlled Study." BioMed Research International 2019, no. : 1-9.

Originalarbeit
Published: 12 September 2019 in Osteologie
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ZusammenfassungKörperliches Training kann alle Größen des Frakturrisikos positiv beeinflussen, ein direkter Nachweis des frakturreduktiven Potentials fehlt indes. Ziel dieser Übersicht ist es, den frakturpräventiven Effekt körperlichen Trainings zu belegen und die trainings-wissenschaftlich/organisatorische Vorgehensweise am Beispiel der Erlanger Fitness- und Osteoporose Präventions-Studie zu diskutieren.137 früh-postmenopausale Frauen mit Osteopenie verteilten sich 1998 auf die Trainings- (TG) und die Kontrollgruppe (KG) der Studie. Primärer Endpunkt war die Häufigkeit niedrig-traumatischer klinischer Frakturen.Nach 16-jähriger Studiendauer wurden 105 Teilnehmerinnen mit 1680 Teilnehmerjahren in die Analyse eingeschlossen. Die Frakturrate niedrig-traumatischer Frakturen (0,42; 95 % CI: 0,20–0,86) sowie osteoporotischer Hauptfrakturen (0,37; 0,14–0,88) lagen in der TG signifikant niedriger als in der KG. Die Knochendichte an Lendenwirbelsäule (TG: –1,5 ± 5,0 % vs. KG: –5,8 ± 6,4 %) und Schenkelhals (TG: –6,5 ± 4,6 % vs. KG: –9,6 ± 5,0 %) nahm in beiden Gruppen z.T. signifikant ab, die Reduktion in der KG war jedoch für beide Regionen signifikant (p ≤ .001) deutlicher. Im Rahmen der EFOPS durchgeführte Substudien zu trainingswissenschaftlichen Aspekten zeigten weiterhin, dass (1) ein schnellkräftig durchgeführtes (Kraft-)Training signifikant günstigere Effekte auf die Knochendichte ausübt als ein mit moderater oder langsamer Bewegungsgeschwindigkeit durchgeführtes Training. (2) Eine Trainingsperiodisierung im Vergleich zur simplen Progression der Belastung günstigere Effekte auf Muskelkraft, Knochendichte und Teilnehmer-Compliance hat und (3) dass eine Trainingsfrequenz von weniger als zwei Trainingseinheiten/Woche auch bei hoher Reizintensität und -rate keinerlei positive Effekte auf die Knochendichte auslöst.Das unter besonderer Berücksichtigung physiologischer und trainingswissenschaftlicher Prinzipien sowie Vorgaben des ambulanten Rehabilitationssports durchgeführte Projekt belegt den klinisch hochrelevanten, frakturpräventiven Effekt eines körperlichen Trainings bei früh-postmenopausalen Frauen.

ACS Style

Wolfgang Kemmler; Matthias Kohl; Klaus Engelke; Simon Von Stengel. Körperliches Training zur Frakturprophylaxe des älteren Menschen. Osteologie 2019, 28, 192 -201.

AMA Style

Wolfgang Kemmler, Matthias Kohl, Klaus Engelke, Simon Von Stengel. Körperliches Training zur Frakturprophylaxe des älteren Menschen. Osteologie. 2019; 28 (3):192-201.

Chicago/Turabian Style

Wolfgang Kemmler; Matthias Kohl; Klaus Engelke; Simon Von Stengel. 2019. "Körperliches Training zur Frakturprophylaxe des älteren Menschen." Osteologie 28, no. 3: 192-201.

Journal article
Published: 05 September 2019 in Marine Drugs
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There is a variety of antineoplastic drugs that are based on natural compounds from ecological niches with high evolutionary pressure. We used two cell lines (Jurkat J16 and Ramos) in a screening to assess 300 different naturally occurring compounds with regard to their antineoplastic activity. The results of the compounds 4,6-dibromo-2-(2',4'-dibromophenoxy)phenol (P01F03), 4,5,6-tribromo-2-(2',4'-dibromophenoxy)phenol (P01F08), and 5-epi-nakijinone Q (P03F03) prompted us to perform further research. Using viability and apoptosis assays on the cell lines of primary human leukemic and normal hematopoietic cells, we found that P01F08 induced apoptosis in the cell lines at IC50 values between 1.61 and 2.95 μM after 72 h. IC50 values of peripheral blood mononuclear cells (PBMNCs) from healthy donors were higher, demonstrating that the cytotoxicity in the cell lines reached 50%, while normal PBMNCs were hardly affected. The colony-forming unit assay showed that the hematopoietic progenitor cells were not significantly affected in their growth by P01F08 at a concentration of 3 μM. P01F08 showed a 3.2-fold lower IC50 value in primary leukemic cells [acute myeloid leukemia (AML)] compared to the PBMNC of healthy donors. We could confirm the antineoplastic effect of 5-epi-nakijinone Q (P03F03) on the cell lines via the induction of apoptosis but noted a similarly strong cytotoxic effect on normal PBMNCs.

ACS Style

Saskia Mayer; Marie Prechtl; Pia Liebfried; Ron-Patrick Cadeddu; Fabian Stuhldreier; Matthias Kohl; Folker Wenzel; Björn Stork; Sebastian Wesselborg; Peter Proksch; Ulrich Germing; Rainer Haas; Paul Jäger. First Results from a Screening of 300 Naturally Occurring Compounds: 4,6-dibromo-2-(2',4'-dibromophenoxy)phenol, 4,5,6-tribromo-2-(2',4'-dibromophenoxy)phenol, and 5-epi-nakijinone Q as Substances with the Potential for Anticancer Therapy. Marine Drugs 2019, 17, 521 .

AMA Style

Saskia Mayer, Marie Prechtl, Pia Liebfried, Ron-Patrick Cadeddu, Fabian Stuhldreier, Matthias Kohl, Folker Wenzel, Björn Stork, Sebastian Wesselborg, Peter Proksch, Ulrich Germing, Rainer Haas, Paul Jäger. First Results from a Screening of 300 Naturally Occurring Compounds: 4,6-dibromo-2-(2',4'-dibromophenoxy)phenol, 4,5,6-tribromo-2-(2',4'-dibromophenoxy)phenol, and 5-epi-nakijinone Q as Substances with the Potential for Anticancer Therapy. Marine Drugs. 2019; 17 (9):521.

Chicago/Turabian Style

Saskia Mayer; Marie Prechtl; Pia Liebfried; Ron-Patrick Cadeddu; Fabian Stuhldreier; Matthias Kohl; Folker Wenzel; Björn Stork; Sebastian Wesselborg; Peter Proksch; Ulrich Germing; Rainer Haas; Paul Jäger. 2019. "First Results from a Screening of 300 Naturally Occurring Compounds: 4,6-dibromo-2-(2',4'-dibromophenoxy)phenol, 4,5,6-tribromo-2-(2',4'-dibromophenoxy)phenol, and 5-epi-nakijinone Q as Substances with the Potential for Anticancer Therapy." Marine Drugs 17, no. 9: 521.

Original research article
Published: 12 August 2019 in Frontiers in Physiology
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Purpose: Overweight and obesity are an increasing problem worldwide. However, most studies that focus on weight reduction by energy restriction and/or aerobic exercise reported considerable loss of muscle mass as well. Increased protein intake and/or resistance exercise might inhibit this detrimental effect during a negative energy balance. Whole-body electromyostimulation (WB-EMS), a time effective, joint-friendly, and highly customizable training technology, showed similar hypertrophic effects compared with high-intensity resistance training. The aim of this study is to evaluate the effect of WB-EMS on body composition during negative energy balance with maintained/increased protein intake in overweight premenopausal women. Patients and Methods: Ninety premenopausal, 25–50-year-old, overweight women were randomly assigned to three groups (n = 30 each). (1) Negative energy balance (−500 kcal/day) by energy restriction with compensatory protein intake (CG). (2) Negative energy balance (−500 kcal/day) by energy restriction (−250 kcal/day) and increased physical activity (−250 kcal/day) with increased protein intake (PA). (3) Negative energy balance (−500 kcal/day) due to energy restriction and increased physical activity with increased protein intake plus WB-EMS. The duration of the intervention was 16 weeks. Participants underwent restrictions in kcal per days and supplementation of protein (CG: 1.2 or PA/WB-EMS: 1.7 g/kg body mass/day) where needed. Bipolar WB-EMS was applied 1.5× week for 20 min (85 Hz; 350 μs; intermittent 6 s impulse, 4 s rest; rectangular). The primary study endpoint “lean body mass” (LBM) and secondary endpoint body fat mass (BFM) were assessed by bio-impedance analysis (BIA). Results: LBM decreased in the CG and PA group (CG: −113 ± 1,872 g; PA: −391 ± 1,832 g) but increased in the WB-EMS group (387 ± 1,769 g). However, changes were not significant (p > 0.05). Comparing the groups by ANOVA, no significant differences were observed (p = 0.070). However, pairwise adjusted comparisons determined significant differences between WB-EMS and PA (p = 0.049). BFM decreased significantly (p < 0.001) in all groups (CG: −2,174 ± 4,331 g; PA: −3,743 ± 4,237 g; WB-EMS: −3,278 ± 4,023 g) without any significant difference between the groups (ANOVA: p = 0.131). Conclusion: WB-EMS is an efficient, joint-friendly, and highly customizable training technology for maintaining muscle mass during energy restriction and can thus be considered as an alternative to more demanding resistance exercise protocols.

ACS Style

Sebastian Willert; Anja Weissenfels; Matthias Kohl; Simon von Stengel; Michael Fröhlich; Heinz Kleinöder; Daniel Schöne; Marc Teschler; Wolfgang Kemmler. Effects of Whole-Body Electromyostimulation on the Energy-Restriction-Induced Reduction of Muscle Mass During Intended Weight Loss. Frontiers in Physiology 2019, 10, 1012 .

AMA Style

Sebastian Willert, Anja Weissenfels, Matthias Kohl, Simon von Stengel, Michael Fröhlich, Heinz Kleinöder, Daniel Schöne, Marc Teschler, Wolfgang Kemmler. Effects of Whole-Body Electromyostimulation on the Energy-Restriction-Induced Reduction of Muscle Mass During Intended Weight Loss. Frontiers in Physiology. 2019; 10 ():1012.

Chicago/Turabian Style

Sebastian Willert; Anja Weissenfels; Matthias Kohl; Simon von Stengel; Michael Fröhlich; Heinz Kleinöder; Daniel Schöne; Marc Teschler; Wolfgang Kemmler. 2019. "Effects of Whole-Body Electromyostimulation on the Energy-Restriction-Induced Reduction of Muscle Mass During Intended Weight Loss." Frontiers in Physiology 10, no. : 1012.