Ti-Cu alloys have broad application prospects in the biomedical field due to their excellent properties. The properties of Ti-Cu alloys are strongly dependent on Cu content, microstructures, its Ti₂Cu phase and its preparation process. The aim of this work is to investigate the effect of Cu content on the precipitation behaviors, mechanical and corrosion properties of the as-cast Ti-Cu alloys. The microstructures and phase evolution were characterized by SEM and TEM, and the properties were studied by tensile and electrochemical test. The results show that the volume fraction of Ti₂Cu phase increases with the increase of Cu content. The Ti₂Cu phase presents a variety of microscopic morphologies with different Cu content, such as rod, granular, lath and block shaped. The crystal orientation relationships between the Ti₂Cu and α-Ti matrix in Ti-4Cu and Ti-10Cu alloys are (103)_Ti2Cu//(0[1$\overline{1}$11)_α-Ti, [$\overline{3}$01]_Ti2Cu//[2$\overline{1}\overline{1}$0]_α-Ti, and (103)_Ti2Cu//(0002)_α-Ti, [$\overline{3}$31]_Ti2Cu//[1$\overline{2}$10]_α-Ti, respectively. The tensile strength, Vickers hardness and Young’s modulus of the Ti-Cu alloys increase with the increase of Cu content, whereas the elongation decreases. The fracture morphologies of these alloys reveal ductile, ductile-brittle hybrid, and cleavage brittle mode, respectively. The corrosion resistance of the Ti-Cu alloys in SBF solution can be described as: Ti-4Cu alloy > Ti-10Cu alloy > Ti-7Cu alloy. The volume fraction of Ti₂Cu phases and the “protective barrier” provided by the fine lath Ti₂Cu phases strongly affected the electrochemical performances of the alloys.