Arabica coffee (Coffea arabica L.) ground nanoparticles contain phenolics compounds that have anti-inflammatory effects, so they can be used as sources of active compounds in anti-inflammatory gel preparations. This study aims to determine the optimum formulation of anti-inflammatory gel preparations using Arabica coffee ground nanoparticles as active compounds. Treatment optimization was performed using a Response Surface Methodology according to the Box-Behnken Design with a quadratic model in the Design Expert Version 10.0.3.0 software. In this study we used three factors (x): carbopol 940, triethanolamine (TEA), and nanoparticles, each of which consists of three levels, the response (y) observed including the acidity degree (pH), spreadability, viscosity and total phenolic content. ANOVA analysis results show that the quadratic model is very appropriate since it produces a high R2 value and a low PRESS value for all responses, as well as significant p-values ( 5%). The optimum formulations for the gel preparations of the Arabica coffee ground nanoparticles obtained in this study are carbopol 940 (0.569%), TEA (0.468%), and nanoparticles (3.000%), which have values w/o an interval (0.994) and a desirable (0.981) response to acidity (5.212), spreadability (5.850 cm), viscosity (3734.244 cps) and total phenolic content (669.227 µgGAE/g).

The development of membrane technology is rapidly increasing due to its numerous advantages, including its ease of use, chemical resistant properties, reduced energy consumption, and limited need for chemical additives. Polyurethane membranes (PUM) are a particular type of membrane filter, synthesized using natural organic materials containing hydroxy (-OH) groups, which can be used for water filtration, e.g., ammonia removal. Red seaweed (Rhodophyta) has specific molecules which could be used for PUM. This study aimed to ascertain PUM synthesis from red seaweed biomass (PUM-RSB) by using toluene diisocyanate via the phase inversion method. Red seaweed biomass with a particle size of 777.3 nm was used as starting material containing abundant hydroxy groups visible in the FTIR spectrum. The PUM-RSB produced was elastic, dry, and sturdy. Thermal analysis of the membrane showed that the initial high degradation temperature was 290.71 °C, while the residue from the thermogravimetric analysis (TGA) analysis was 4.88%. The PUM-RSB section indicates the presence of cavities on the inside. The mechanical properties of the PUM-RSB have a stress value of 53.43 MPa and a nominal strain of 2.85%. In order to optimize the PUM-RSB synthesis, a Box–Behnken design of Response Surface Methodology was conducted and showed the value of RSB 0.176 g, TDI 3.000 g, and glycerin 0.200 g, resulting from the theoretical and experimental rejection factor, i.e., 31.3% and 23.9%, respectively.

Oriental Journal of Chemistry is a peer reviewed quarterly research journal of pure and applied chemistry. It publishes standard research papers in almost all thrust areas of current chemistry of academic and commercial importance. It provides a platform for rapid publication of quality research papers, reviews and chemistry letters. Oriental Journal of Chemistry is abstracted and indexed in almost all reputed National and International agencies.

Polyurethane membranes are widely developed polymers by researchers because they can be made from synthetic materials or natural materials. Red seaweed (Gracilaria verrucosa Greville) is a natural material that can be developed as a raw material for polyurethane membranes. This study used red seaweed biomass (RSB) as a raw material to manufacture polyurethane as an adsorptive membrane for removing ammonia in water. The membrane composition was determined using the Box–Behnken design from Response Surface Methodology with three factors and three levels. In the ammonia adsorption process, the adsorption isotherm was determined by varying the concentration, while the adsorption kinetics was determined by varying the contact time. Red seaweed biomass-based polyurethane membrane (PUM-RSB) can adsorb ammonia in water with an adsorption capacity of 0.233 mg/g and an adsorption efficiency of 16.2%. The adsorption efficiency followed the quadratic model in the Box–Behnken design, which resulted in the optimal composition of RSB 0.15 g, TDI 3.0 g, and glycerin 0.4 g with predicted and actual adsorption capacities of 0.224 mg/g and 0.226 mg/g. The ammonia adsorption isotherm using PUM-RSB follows the Freundlich isotherm, with a high correlation coefficient (R²) of 0.977, while the Langmuir isotherm has a low R² value of 0.926. The Freundlich isotherm indicates that ammonia is adsorbed on the surface of the adsorbent as multilayer adsorption. In addition, based on the analysis of adsorption kinetics, the adsorption phenomenon follows pseudo-order II with a chemisorption mechanism, and it is assumed that the bond that occurs is between the anion –SO₄²⁻ with the NH₄⁺ cation to form ammonium sulfate (NH₄)₂SO₄ and between isocyanates (NCO) with NH₄⁺ cations to form substituted urea.

Background: Arabica coffee ground nanoparticles gel is known to possess good physicochemical properties and high phenolic contents in which the phenolics are famous for their anti-inflammatory activities. Objectives: : This study aimed to investigate the anti-inflammatory activities of the arabica coffee ground nanoparticles gel on carrageenan-induced male mice for 6 h. The positive control was commercial medicine (Voltaren gel), and the control negative was base gel. Methods: The inflammatory inhibition of arabica coffee ground nanoparticles gel is determined by measuring the edema volume of the carrageenan-induced mice foot using a plethysmometer. Anti-inflammatory activities of arabica coffee ground nanoparticles gel were optimized using Box-Behnken Design of the response surface methodology. Results: The anti-inflammatory activities or inflammatory inhibition of arabica coffee ground nanoparticles gel was determined by measuring the edema volume of the carrageenan-induced mice foot. The increase of edema volume of the mice foot from the first to 180th min was caused by the release of inflammation mediator such as histamine, prostaglandins, bradykinins, and serotonin on the tissue; meanwhile, at the 240th min, the edema of the mice foot experienced a decrease due to the inhibition of prostaglandins synthesis to the tissue. The obtained results indicated that the arabica coffee ground nanoparticles gel has average value of anti-inflammatory activities of 27.75%. The obtained optimum formulation is 0.500% Carbopol 940, 0.400% triethanolamine, and 2.313% nanoparticle, giving 29.360% and 29.670% for the predicted and experimental inflammatory inhibition values, with 0.812 desirability value, respectively. Conclusions: The Box-Behnken design can be used to determine the optimal gel formulation of arabica coffee grounds for inflammatory inhibition.