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Hydrodynamic cavitation is a promising technique for water disinfection. In the present paper, the disinfection characteristics of an advanced hydrodynamic cavitation reactor (ARHCR) in pilot scale were studied. The effects of various flow rates (1.4–2.6 m3/h) and rotational speeds (2600–4200 rpm) on the removal of Escherichia coli (E. coli) were revealed and analyzed. The variation regularities of the log reduction and reaction rate constant at various cavitation numbers were established. A disinfection rate of 100% was achieved in only 4 min for 15 L of simulated effluent under 4200 rpm and 1.4 m3/h, with energy efficiency at 0.0499 kWh/L. A comprehensive comparison with previously introduced HCRs demonstrates the superior performance of the presented ARHCR system. The morphological changes in E. coli were studied by scanning electron microscopy. The results indicate that the ARHCR can lead to serious cleavage and surface damages to E. coli, which cannot be obtained by conventional HCRs. Finally, a possible damage mechanism of the ARHCR, including both the hydrodynamical and sonochemical effects, was proposed. The findings of the present study can provide strong support to the fundamental understanding and applications of ARHCRs for water disinfection.
Xun Sun; Zhengquan Wang; Xiaoxu Xuan; Li Ji; Xuewen Li; Yang Tao; Grzegorz Boczkaj; Shan Zhao; Joon Yong Yoon; Songying Chen. Disinfection characteristics of an advanced rotational hydrodynamic cavitation reactor in pilot scale. Ultrasonics Sonochemistry 2021, 73, 105543 .
AMA StyleXun Sun, Zhengquan Wang, Xiaoxu Xuan, Li Ji, Xuewen Li, Yang Tao, Grzegorz Boczkaj, Shan Zhao, Joon Yong Yoon, Songying Chen. Disinfection characteristics of an advanced rotational hydrodynamic cavitation reactor in pilot scale. Ultrasonics Sonochemistry. 2021; 73 ():105543.
Chicago/Turabian StyleXun Sun; Zhengquan Wang; Xiaoxu Xuan; Li Ji; Xuewen Li; Yang Tao; Grzegorz Boczkaj; Shan Zhao; Joon Yong Yoon; Songying Chen. 2021. "Disinfection characteristics of an advanced rotational hydrodynamic cavitation reactor in pilot scale." Ultrasonics Sonochemistry 73, no. : 105543.
The environment of a large-scale vegetable production area can be exposed to antibiotic residues and antibiotic-resistant bacteria (ARB) via animal manure and irrigation with contaminated water, which can facilitate the dissemination of ARB. However, the occurrence of ARB in plantation areas and their dissemination in this environment remain largely unexplored. In total, 382 samples including those from vegetable (n = 106), soil (n = 87), well water (n = 24), river water (n = 20), river sediments (n = 20), farmer feces (n = 58) and farmer hands (n = 67) were collected in 2019 from a large-scale cultivation area in Shandong, China. Selective agar plates were used to screen for carbapenem-resistant Enterobacteriaceae (CRE) and whole-genome sequencing and Southern blotting were used to characterise isolates and mobile genetic elements carrying carbapenem resistance determinants. A total of nine NDM-5-producing isolates of Escherichia coli, Klebsiella pneumoniae, and Citrobacter spp. were identified from environmental sources and human feces, all of which were multidrug-resistant. Single nucleotide polymorphism analysis suggested clonal transmission of carbapenem-resistant Citrobacter sedlakii within greenhouse soils in the area. Eight of the isolates carried closely related or identical IncX3 plasmids carrying blaNDM-5, which were shown to be conjugative via filter mating experiments, indicating the highly transmissible nature of this genetic element. Isolates of E. coli and Citrobacter freundii were detected in the feces of local farm workers and contained similar IncX3 plasmids with blaNDM-5 environmental isolates, suggesting a potential risk of CRE transfer from the work environment to the farm workers. Thus, further research is required to investigate the potential health risks associated with environmental exposure to CRE in vegetable cultivation areas.
Qian Zhao; Björn Berglund; Huiyun Zou; Ziyu Zhou; Huiyu Xia; Ling Zhao; Lennart E. Nilsson; Xuewen Li. Dissemination of blaNDM-5 via IncX3 plasmids in carbapenem-resistant Enterobacteriaceae among humans and in the environment in an intensive vegetable cultivation area in eastern China. Environmental Pollution 2021, 273, 116370 .
AMA StyleQian Zhao, Björn Berglund, Huiyun Zou, Ziyu Zhou, Huiyu Xia, Ling Zhao, Lennart E. Nilsson, Xuewen Li. Dissemination of blaNDM-5 via IncX3 plasmids in carbapenem-resistant Enterobacteriaceae among humans and in the environment in an intensive vegetable cultivation area in eastern China. Environmental Pollution. 2021; 273 ():116370.
Chicago/Turabian StyleQian Zhao; Björn Berglund; Huiyun Zou; Ziyu Zhou; Huiyu Xia; Ling Zhao; Lennart E. Nilsson; Xuewen Li. 2021. "Dissemination of blaNDM-5 via IncX3 plasmids in carbapenem-resistant Enterobacteriaceae among humans and in the environment in an intensive vegetable cultivation area in eastern China." Environmental Pollution 273, no. : 116370.
Infections caused by carbapenem-resistant Enterobacteriaceae are a growing concern worldwide. Raoultella ornithinolytica is a species in the Enterobacteriaceae family which can cause hospital-acquired infections and is sporadically reported as carbapenem-resistant from human and environmental sources. In this study, we firstly report on an NDM-1-producing R. ornithinolytica, Rao166, isolated from drinking water in an animal cultivation area in China. In addition to carbapenem-resistance, Rao166 was resistant to several other antibiotics including gentamicin, sulfamethoxazole-trimethoprim, tetracycline and fosfomycin. Rao166 carried a novel IncFIC-type megaplasmid, 382,325 bp in length (pRAO166a). A multidrug resistance region, 60,600 bp in length, was identified in the plasmid containing an aac(3)-IId-like gene, aac(6′)-Ib-cr, blaDHA-1, blaTEM-1B, blaCTX-M-3, blaOXA-1, blaNDM-1, qnrB4, catB3, arr-3, sul1, and tet(D). Results from virulence assays implied that Rao166 has considerable pathogenic potential. Although pRAO166a was found to be non-transmissible, dissemination of the NDM-1 producing strain may occur from well water to humans or animals through cross-contamination during food preparation or directly via drinking water, and potentially lead to difficult-to-treat infections. Thus, contamination of well water by this carbapenem-resistant and presumptively virulent strain of R. ornithinolytica should be considered a potential public health risk.
Huiyun Zou; Björn Berglund; Hao Xu; Xiaohui Chi; Qian Zhao; Ziyu Zhou; Huiyu Xia; Xuewen Li; Beiwen Zheng. Genetic characterization and virulence of a carbapenem-resistant Raoultella ornithinolytica isolated from well water carrying a novel megaplasmid containing blaNDM-1. Environmental Pollution 2020, 260, 114041 .
AMA StyleHuiyun Zou, Björn Berglund, Hao Xu, Xiaohui Chi, Qian Zhao, Ziyu Zhou, Huiyu Xia, Xuewen Li, Beiwen Zheng. Genetic characterization and virulence of a carbapenem-resistant Raoultella ornithinolytica isolated from well water carrying a novel megaplasmid containing blaNDM-1. Environmental Pollution. 2020; 260 ():114041.
Chicago/Turabian StyleHuiyun Zou; Björn Berglund; Hao Xu; Xiaohui Chi; Qian Zhao; Ziyu Zhou; Huiyu Xia; Xuewen Li; Beiwen Zheng. 2020. "Genetic characterization and virulence of a carbapenem-resistant Raoultella ornithinolytica isolated from well water carrying a novel megaplasmid containing blaNDM-1." Environmental Pollution 260, no. : 114041.
A new variant of the blaOXA-546 gene, namely blaOXA-894, was identified on the chromosome of Shewanella xiamenensis isolated from pig wastewater in rural China. OXA-894 differs from OXA-546 (A46V, I219del) and OXA-48 (T167I, I219del) with two amino acid substitutions, respectively. The isolate was resistant to ampicillin, aztreonam, imipenem, meropenem and fosfomycin. Carba NP test confirmed S. xiamenensis strain sx20 as a carbapenemase-producer. The blaOXA-894 gene was located between the gene encoding a LysR family transcriptional regulator and the C15 gene. Its gene environment was similar to other S. xiamenensis with chromosome-located blaOXA-48-like genes. The T24H and T94V amino acid substitutions of LuxS protein were predicted to be deleterious, which may affect the virulence phenotype. The occurrence and potential health risk of carbapenem-resistant S. xiamenensis in a water environment is of concern.
Huiyun Zou; Ziyu Zhou; Huiyu Xia; Qian Zhao; Xuewen Li. Characterization of Chromosome-Mediated BlaOXA-894 in Shewanella xiamenensis Isolated from Pig Wastewater. International Journal of Environmental Research and Public Health 2019, 16, 3768 .
AMA StyleHuiyun Zou, Ziyu Zhou, Huiyu Xia, Qian Zhao, Xuewen Li. Characterization of Chromosome-Mediated BlaOXA-894 in Shewanella xiamenensis Isolated from Pig Wastewater. International Journal of Environmental Research and Public Health. 2019; 16 (19):3768.
Chicago/Turabian StyleHuiyun Zou; Ziyu Zhou; Huiyu Xia; Qian Zhao; Xuewen Li. 2019. "Characterization of Chromosome-Mediated BlaOXA-894 in Shewanella xiamenensis Isolated from Pig Wastewater." International Journal of Environmental Research and Public Health 16, no. 19: 3768.
Antibiotic resistance among gram-negative bacteria is increasingly becoming a problem of global concern. Particularly problematic is the emergence of resistance to last-resort antibiotics such as carbapenems and colistin. The increasing number of reports on the plasmid-mediated colistin resistance gene mcr-1 in isolates worldwide is raising concerns for the future usefulness of this class of antibiotics. Dissemination of mcr-1 is believed to have originated mainly from animal breeding, however, the role of the environment as a transmission source is not yet fully understood. In the current study, 89 extended-spectrum β-lactamase-producing Escherichia coli isolated from 231 samples from different environmental sources in 12 villages in a rural area of Shandong, China, were screened for mcr-1.17 (19.1%) mcr-1-positive isolates were found from different environmental sources, aggregated in 6 villages. Plasmids of three different Inc-groups carrying mcr-1 were confirmed, indicating that the widespread geographical distribution of mcr-1 in the local area is due to a number of different plasmids. Additionally, almost a third (29.4%) of the isolates carried virulence factors associated to intestinal pathogenic E. coli. These results illustrate the high complexity of the transmission patterns of mcr-1 among different environmental matrices on a local scale and the potential for the environment to facilitate dissemination and emergence of antibiotic-resistant and virulent strains of bacteria.
Xiang Ji; Beiwen Zheng; Björn Berglund; Huiyun Zou; Qiang Sun; Xiaohui Chi; Jakob Ottoson; Xuewen Li; Cecilia Stålsby Lundborg; Lennart E. Nilsson. Dissemination of extended-spectrum β-lactamase-producing Escherichia coli carrying mcr-1 among multiple environmental sources in rural China and associated risk to human health. Environmental Pollution 2019, 251, 619 -627.
AMA StyleXiang Ji, Beiwen Zheng, Björn Berglund, Huiyun Zou, Qiang Sun, Xiaohui Chi, Jakob Ottoson, Xuewen Li, Cecilia Stålsby Lundborg, Lennart E. Nilsson. Dissemination of extended-spectrum β-lactamase-producing Escherichia coli carrying mcr-1 among multiple environmental sources in rural China and associated risk to human health. Environmental Pollution. 2019; 251 ():619-627.
Chicago/Turabian StyleXiang Ji; Beiwen Zheng; Björn Berglund; Huiyun Zou; Qiang Sun; Xiaohui Chi; Jakob Ottoson; Xuewen Li; Cecilia Stålsby Lundborg; Lennart E. Nilsson. 2019. "Dissemination of extended-spectrum β-lactamase-producing Escherichia coli carrying mcr-1 among multiple environmental sources in rural China and associated risk to human health." Environmental Pollution 251, no. : 619-627.
The wide spread of carbapenemase-producing Enterobacteriaceae (CPE) in the environment is an emerging environmental issue with potentially-serious public health implications. However, carbapenemase-producing Citrobacter from environment has rarely been investigated. Here we report the isolation and comparative genomics of carbapenemase-producing Citrobacter isolates from river sediment in China. Potential CPE was isolated by selective MacConkey agar plates containing 2 mg/L meropenem. The presence of carbapenemase genes was detected by PCR and sequencing. The clonal relatedness of Klebsiella pneumoniae carbapenemase (KPC-2)-producing Citrobacter isolates was assessed by pulsed-field gel electrophoresis (PFGE) and multilocus sequence typing. Plasmid analysis of KPC-2-producing Citrobacter isolates was performed by S1-PFGE, Southern blotting, and whole genome sequencing. A total of four KPC-2-producing Citrobacter and three Aeromonas isolates were recovered from 54 sediment cultures of Shifeng River. Notably, all KPC-producing isolates were isolated from sampling sites near a waste water treatment plant. Antimicrobial susceptibility testing showed that three of the four sequenced isolates (C1710, C191, and C196) resistant to multiple antibiotics. Genotyping and pan-genome analyses revealed that the C191 and C196 C. freundii isolates exhibited a high level of genetic similarity. Plasmid analysis confirmed that the bla gene is located on either IncF or IncN3 plasmids in all isolates. The bla gene of C1710, C181 and C191 was successfully transferred with E. coli EC600 as the recipient strain. In silico analysis further suggested that pKPC-191 is a novel IncF plasmid, with 99% identity to two previously described IncFII plasmids at 71% coverage. We report here the presence of diverse conjugative bla plasmids from environmental Citrobacter isolates, which poses the possible dissemination of antimicrobial resistance into clinical isolates. To our knowledge, this is the first study to culture and characterize KPC-2-producing Citrobacter isolates from river sediments in China.
Hao Xu; Xin Wang; Xiao Yu; Jing Zhang; Lihua Guo; Chen Huang; Xiawei Jiang; Xuewen Li; YouJun Feng; Beiwen Zheng. First detection and genomics analysis of KPC-2-producing Citrobacter isolates from river sediments. Environmental Pollution 2018, 235, 931 -937.
AMA StyleHao Xu, Xin Wang, Xiao Yu, Jing Zhang, Lihua Guo, Chen Huang, Xiawei Jiang, Xuewen Li, YouJun Feng, Beiwen Zheng. First detection and genomics analysis of KPC-2-producing Citrobacter isolates from river sediments. Environmental Pollution. 2018; 235 ():931-937.
Chicago/Turabian StyleHao Xu; Xin Wang; Xiao Yu; Jing Zhang; Lihua Guo; Chen Huang; Xiawei Jiang; Xuewen Li; YouJun Feng; Beiwen Zheng. 2018. "First detection and genomics analysis of KPC-2-producing Citrobacter isolates from river sediments." Environmental Pollution 235, no. : 931-937.
To investigate the occurrence of antibiotic residues in different types of environmental samples including water samples in rural Shandong province, China. Further, to characterize the potential ecological risk for development of antibiotic resistance in the environment, and the potential direct human health risk of exposure to antibiotics via drinking water and vegetables. Environmental samples (n = 214) (river water, waste water, drinking water, sediments, manure, soil and edible parts of vegetables) were collected in twelve villages in Shandong province in eastern China. High performance liquid chromatography–tandem mass spectrometry (HPLC–MS/MS) was used to determine the concentration of antibiotic residues. The ratio of the measured environmental concentrations (MEC) to the predicted no-effect concentrations (PNEC) was used to evaluate the ecological risk (risk quotient, RQ) for development of antibiotic resistance. The potential risks to human health through exposure to antibiotics in drinking water were assessed by comparing measured environmental concentrations (MEC) and predicted no-effect concentration in drinking water (PNECDW), and in vegetables by comparing estimated daily intake (EDI) to ADI. Sulfapyridine, sulfamethoxazole, ciprofloxacin, enrofloxacin, levofloxacin, norfloxacin, chloramphenicol, florfenicol, doxycycline, and metronidazole were detected at concentrations ranging between 0.3 and 3.9 ng/L in river water, 1.3 and 12.5 ng/L in waste water, 0.5 and 21.4 ng/L in drinking water, 0.31 and 1.21 μg/kg in river sediment, 0.82 and 1.91 μg/kg in pig manure, 0.1 and 11.68 μg/kg in outlet sediment, 0.5 and 2.5 μg/kg in soil, and 6.3 and 27.2 μg/kg in vegetables. The RQs for resistance development were >1 for enrofloxacin, levofloxacin, and ranged between 0.1 and 1 for ciprofloxacin. MECs/PNECDW ratios were <1 from exposure to antibiotics through drinking water for both adults and children. EDI/ADI ratios were <0.1 from exposure to antibiotics by vegetable consumption. Antibiotic pollutants were ubiquitous in various environmental compartments of Shandong province of China. Risk estimates indicated a potential for the measured levels of enrofloxacin, levofloxacin and ciprofloxacin in waste water to pose an ecological risk for resistance selection, and further studies are needed to validate this finding. The investigated antibiotics did not appear to pose an appreciable direct human health risk from environmental exposure through drinking water or vegetables consumption. However, they might still pose a risk for resistance development.
Nada Hanna; Pan Sun; Qiang Sun; Xuewen Li; Xiwei Yang; Xiang Ji; Huiyun Zou; Jakob Ottoson; Lennart E. Nilsson; Björn Berglund; Oliver James Dyar; Ashok J. Tamhankar; Cecilia Stålsby Lundborg. Presence of antibiotic residues in various environmental compartments of Shandong province in eastern China: Its potential for resistance development and ecological and human risk. Environment International 2018, 114, 131 -142.
AMA StyleNada Hanna, Pan Sun, Qiang Sun, Xuewen Li, Xiwei Yang, Xiang Ji, Huiyun Zou, Jakob Ottoson, Lennart E. Nilsson, Björn Berglund, Oliver James Dyar, Ashok J. Tamhankar, Cecilia Stålsby Lundborg. Presence of antibiotic residues in various environmental compartments of Shandong province in eastern China: Its potential for resistance development and ecological and human risk. Environment International. 2018; 114 ():131-142.
Chicago/Turabian StyleNada Hanna; Pan Sun; Qiang Sun; Xuewen Li; Xiwei Yang; Xiang Ji; Huiyun Zou; Jakob Ottoson; Lennart E. Nilsson; Björn Berglund; Oliver James Dyar; Ashok J. Tamhankar; Cecilia Stålsby Lundborg. 2018. "Presence of antibiotic residues in various environmental compartments of Shandong province in eastern China: Its potential for resistance development and ecological and human risk." Environment International 114, no. : 131-142.
The emergence and spread of the mobile colistin resistance gene (mcr-1) has become a major global public health concern. So far, this gene has been widely detected in food animals, pets, food, and humans. However, there is little information on the contamination of mcr-1-containing bacteria in farming soils. In August 2016, a survey of ESBL-producing Escherichia coli isolated from farming soils was conducted in Shandong Province, China. We observed colistin resistance in 12 of 53 (22.6%) ESBL-producing Enterobacteriaceae isolates from farming soil. Six mcr-1-positive E. coli strains originating from a livestock-intensive area were found. The isolates belonged to four different STs (ST2060, ST3014, ST6756, and ST1560) and harbored extensive additional resistance genes. An E. coli with blaNDM-1 was also detected in a soil sample from the same area. Comparative whole genome sequencing and S1-PFGE analysis indicated that mcr-1 was chromosomally encoded in four isolates and located on IncHI2 plasmids in two isolates. To our knowledge, we report the first isolation of mcr-1 in ESBL-producing E. coli from farming soils. This work highlights the importance of active surveillance of colistin-resistant organisms in soil. Moreover, investigations addressing the influence of animal manure application on the transmission of mcr-1-producing bacteria are also warranted.
Beiwen Zheng; Chen Huang; Hao Xu; Lihua Guo; Jing Zhang; Xin Wang; Xiawei Jiang; Xiao Yu; Linfeng Jin; Xuewen Li; YouJun Feng; Yonghong Xiao; Lanjuan Li. Occurrence and Genomic Characterization of ESBL-Producing, MCR-1-Harboring Escherichia coli in Farming Soil. Frontiers in Microbiology 2017, 8, 2510 .
AMA StyleBeiwen Zheng, Chen Huang, Hao Xu, Lihua Guo, Jing Zhang, Xin Wang, Xiawei Jiang, Xiao Yu, Linfeng Jin, Xuewen Li, YouJun Feng, Yonghong Xiao, Lanjuan Li. Occurrence and Genomic Characterization of ESBL-Producing, MCR-1-Harboring Escherichia coli in Farming Soil. Frontiers in Microbiology. 2017; 8 ():2510.
Chicago/Turabian StyleBeiwen Zheng; Chen Huang; Hao Xu; Lihua Guo; Jing Zhang; Xin Wang; Xiawei Jiang; Xiao Yu; Linfeng Jin; Xuewen Li; YouJun Feng; Yonghong Xiao; Lanjuan Li. 2017. "Occurrence and Genomic Characterization of ESBL-Producing, MCR-1-Harboring Escherichia coli in Farming Soil." Frontiers in Microbiology 8, no. : 2510.
We report on the coexistence of mcr-1 and bla CTX-M in multidrug-resistant, extended-spectrum β-lactamase-producing Escherichia coli belonging to the sequence type 10 complex isolated from well water in rural China. Raoultella ornithinolytica with bla KPC-2 was also detected in well water from the same area. This study shows that genes coding for resistance to last-resort antibiotics are present in wells in rural China, indicating a potential source of antibiotic resistance.
Pan Sun; Zhenwang Bi; Maud Nilsson; Beiwen Zheng; Björn Berglund; Cecilia Stålsby Lundborg; Stefan Börjesson; Xuewen Li; Baoli Chen; Hong Yin; Lennart E. Nilsson. Occurrence of bla KPC-2 , bla CTX-M , and mcr-1 in Enterobacteriaceae from Well Water in Rural China. Antimicrobial Agents and Chemotherapy 2017, 61, e02569-16 .
AMA StylePan Sun, Zhenwang Bi, Maud Nilsson, Beiwen Zheng, Björn Berglund, Cecilia Stålsby Lundborg, Stefan Börjesson, Xuewen Li, Baoli Chen, Hong Yin, Lennart E. Nilsson. Occurrence of bla KPC-2 , bla CTX-M , and mcr-1 in Enterobacteriaceae from Well Water in Rural China. Antimicrobial Agents and Chemotherapy. 2017; 61 (4):e02569-16.
Chicago/Turabian StylePan Sun; Zhenwang Bi; Maud Nilsson; Beiwen Zheng; Björn Berglund; Cecilia Stålsby Lundborg; Stefan Börjesson; Xuewen Li; Baoli Chen; Hong Yin; Lennart E. Nilsson. 2017. "Occurrence of bla KPC-2 , bla CTX-M , and mcr-1 in Enterobacteriaceae from Well Water in Rural China." Antimicrobial Agents and Chemotherapy 61, no. 4: e02569-16.
The elevation and dissipation of pollutants after the ignition of fireworks in different functional areas of a valley city were investigated. The Air Quality Index (AQI) as well as inter-day and intra-day concentrations of various air pollutants (PM10, PM2.5, SO2, NO2, CO, O3) were measured during two episodes that took place during Chinese New Year festivities. For the special terrain of Jinan, the mean concentrations of pollutants increased sharply within 2–4 h of the firework displays, and concentrations were 4–6 times higher than the usual levels. It took 2–3 d for the pollutants to dissipate to background levels. Compared to Preliminary Eve (more fireworks are ignited on New Year’s Eve, but the amounts of other human activities are also lesser), the primary pollutants PM2.5, PM10, and CO reached higher concentrations on New Year’s Eve, and the highest concentrations of these pollutants were detected in living quarters. All areas suffered from serious pollution problems on New Year’s Eve (rural = urban for PM10, but rural > urban for PM2.5). However, SO2 and NO2 levels were 20%–60% lower in living quarters and industrial areas compared to the levels in these same areas on Preliminary Eve. In contrast to the other pollutants, O3 concentrations fell instead of rising with the firework displays. Interactions between firework displays and other human activities caused different change trends of pollutants. PM2.5 and PM10 were the main pollutants, and the rural living quarter had some of the highest pollution levels.
Yang Song; XiaoMing Wan; Shuoxin Bai; Dong Guo; Ci Ren; Yu Zeng; Yirui Li; Xuewen Li. The Characteristics of Air Pollutants during Two Distinct Episodes of Fireworks Burning in a Valley City of North China. PLOS ONE 2017, 12, e0168297 .
AMA StyleYang Song, XiaoMing Wan, Shuoxin Bai, Dong Guo, Ci Ren, Yu Zeng, Yirui Li, Xuewen Li. The Characteristics of Air Pollutants during Two Distinct Episodes of Fireworks Burning in a Valley City of North China. PLOS ONE. 2017; 12 (1):e0168297.
Chicago/Turabian StyleYang Song; XiaoMing Wan; Shuoxin Bai; Dong Guo; Ci Ren; Yu Zeng; Yirui Li; Xuewen Li. 2017. "The Characteristics of Air Pollutants during Two Distinct Episodes of Fireworks Burning in a Valley City of North China." PLOS ONE 12, no. 1: e0168297.
Antibiotics are normally regarded as safe to aquatic ecosystems when their contamination concentrations are lower than the toxic threshold. This study observed the hazard of ciprofloxacin, sulfamethoxazole and their binary mixture to the aquatic environment at environmentally relevant concentrations lower than the toxic threshold, due to the stimulation on the bloom of Microcystis aeruginosa. The enhanced growth of M. aeruginosa, coupled with elevated photosynthesis activity, was exerted by 50 - 200 ng/L of ciprofloxacin, 100 - 200 ng/L of sulfamethoxazole and 20 - 100 ng/L of the binary antibiotic mixture. Stimulated production and release of microcystins were observed at even lower concentrations. The up-regulation of transcription-related proteins, cell division-related proteins, a gas vesicle protein, a global nitrogen regulator (ntcA), two microcystin synthetases (mcyC and mcyH) and ATP-binding cassette transporters provided direct proteomic evidence for the regulation of target antibiotics on M. aeruginosa bloom. Cytochrome P450 was an essential component involved in stress responses and antibiotics biodegradation. Proteomic responses to antibiotic exposure presented a shift in the energy metabolism of M. aeruginosa towards the excitation of photosynthesis, an increase of carbohydrate biosynthesis and the inhibition of carbohydrate catabolism. Superoxide dismutase, enolase and D1 protein were candidate target proteins of different antibiotics in M. aeruginosa. The antibiotic mixture showed a greater hazard than single antibiotics, and a safe threshold of 5 ng/L was suggested for each target antibiotic under the coexistence condition. This article is protected by copyright. All rights reserved.
Ying Liu; Shi Chen; Jian Zhang; Xuewen Li; Baoyu Gao. Stimulation effects of ciprofloxacin and sulphamethoxazole inMicrocystis aeruginosaand isobaric tag for relative and absolute quantitation-based screening of antibiotic targets. Molecular Ecology 2016, 26, 689 -701.
AMA StyleYing Liu, Shi Chen, Jian Zhang, Xuewen Li, Baoyu Gao. Stimulation effects of ciprofloxacin and sulphamethoxazole inMicrocystis aeruginosaand isobaric tag for relative and absolute quantitation-based screening of antibiotic targets. Molecular Ecology. 2016; 26 (2):689-701.
Chicago/Turabian StyleYing Liu; Shi Chen; Jian Zhang; Xuewen Li; Baoyu Gao. 2016. "Stimulation effects of ciprofloxacin and sulphamethoxazole inMicrocystis aeruginosaand isobaric tag for relative and absolute quantitation-based screening of antibiotic targets." Molecular Ecology 26, no. 2: 689-701.
Antibiotic resistance is a complex global health challenge. The recent Global Action Plan on antimicrobial resistance highlights the importance of adopting One Health approaches that can cross traditional disciplinary boundaries. We report on the early experiences of a multisectoral Sino-Swedish research project that aims to address gaps in our current knowledge and seeks to improve the situation through system-wide interventions. Our research project is investigating antibiotic use and resistance in a rural area of China through a combination of epidemiological, health systems and laboratory investigations. We reflect here on the challenges inherent in conducting long distance cross-disciplinary collaborations, having now completed data and sample collection for a baseline situation analysis. In particular, we recognise the importance of investing in aspects such as effective communication, shared conceptual frameworks and leadership. We suggest that our experiences will be instructive to others planning to develop similar international One Health collaborations.
Otto Cars; Yonghong Xiao; Cecilia Stålsby Lundborg; Lennart E Nilsson; Jianzhong Shen; Qiang Sun; Zhenqiang Bi; Stefan Börjesson; Christina Greko; Yang Wang; Yuqing Liu; Jakob Ottoson; Xuewen Li; Maud Nilsson; Hong Yin; Zhenwang Bi; Beiwen Zheng; Xi Xia; Baoli Chen; Lilu Ding; Pan Sun; Oliver James Dyar; Anette Hulth; Göran Tomson. Building bridges to operationalise one health - A Sino-Swedish collaboration to tackle antibiotic resistance. One Health 2016, 2, 139 -143.
AMA StyleOtto Cars, Yonghong Xiao, Cecilia Stålsby Lundborg, Lennart E Nilsson, Jianzhong Shen, Qiang Sun, Zhenqiang Bi, Stefan Börjesson, Christina Greko, Yang Wang, Yuqing Liu, Jakob Ottoson, Xuewen Li, Maud Nilsson, Hong Yin, Zhenwang Bi, Beiwen Zheng, Xi Xia, Baoli Chen, Lilu Ding, Pan Sun, Oliver James Dyar, Anette Hulth, Göran Tomson. Building bridges to operationalise one health - A Sino-Swedish collaboration to tackle antibiotic resistance. One Health. 2016; 2 ():139-143.
Chicago/Turabian StyleOtto Cars; Yonghong Xiao; Cecilia Stålsby Lundborg; Lennart E Nilsson; Jianzhong Shen; Qiang Sun; Zhenqiang Bi; Stefan Börjesson; Christina Greko; Yang Wang; Yuqing Liu; Jakob Ottoson; Xuewen Li; Maud Nilsson; Hong Yin; Zhenwang Bi; Beiwen Zheng; Xi Xia; Baoli Chen; Lilu Ding; Pan Sun; Oliver James Dyar; Anette Hulth; Göran Tomson. 2016. "Building bridges to operationalise one health - A Sino-Swedish collaboration to tackle antibiotic resistance." One Health 2, no. : 139-143.
Large numbers of livestock and poultry feces are continuously applied into soils in intensive vegetable cultivation areas, and then some veterinary antibiotics are persistent existed in soils and cause health risk. For the spatial heterogeneity of antibiotic residues, developing a suitable technique to interpolate soil antibiotic residues is still a challenge. In this study, we developed an effective interpolator, high accuracy surface modeling (HASM) combined vegetable types, to predict the spatial patterns of soil antibiotics, using 100 surface soil samples collected from an intensive vegetable cultivation area located in east of China, and the fluoroquinolones (FQs), including ciprofloxacin (CFX), enrofloxacin (EFX) and norfloxacin (NFX), were analyzed as the target antibiotics. The results show that vegetable type is an effective factor to be combined to improve the interpolator performance. HASM achieves less mean absolute errors (MAEs) and root mean square errors (RMSEs) for total FQs (NFX+CFX+EFX), NFX, CFX and EFX than kriging with external drift (KED), stratified kriging (StK), ordinary kriging (OK) and inverse distance weighting (IDW). The MAE of HASM for FQs is 55.1 μg/kg, and the MAEs of KED, StK, OK and IDW are 99.0 μg/kg, 102.8 μg/kg, 106.3 μg/kg and 108.7 μg/kg, respectively. Further, RMSE simulated by HASM for FQs (CFX, EFX and NFX) are 106.2 μg/kg (88.6 μg/kg, 20.4 μg/kg and 39.2 μg/kg), and less 30% (27%, 22% and 36%), 33% (27%, 27% and 43%), 38% (34%, 23% and 41%) and 42% (32%, 35% and 51%) than the ones by KED, StK, OK and IDW, respectively. HASM also provides better maps with more details and more consistent maximum and minimum values of soil antibiotics compared with the measured data. The better performance can be concluded that HASM takes the vegetable type information as global approximate information, and takes local sampling data as its optimum control constraints.
Wen-Jiao Shi; Tian-Xiang Yue; Zheng-Ping Du; Zong Wang; Xue-Wen Li. Surface modeling of soil antibiotics. Science of The Total Environment 2016, 543, 609 -619.
AMA StyleWen-Jiao Shi, Tian-Xiang Yue, Zheng-Ping Du, Zong Wang, Xue-Wen Li. Surface modeling of soil antibiotics. Science of The Total Environment. 2016; 543 ():609-619.
Chicago/Turabian StyleWen-Jiao Shi; Tian-Xiang Yue; Zheng-Ping Du; Zong Wang; Xue-Wen Li. 2016. "Surface modeling of soil antibiotics." Science of The Total Environment 543, no. : 609-619.
Steroid hormones released from manure agricultural application are a matter of global concern. The residual levels of steroid hormones were studied in a typical intensive vegetable cultivation area in northeast China, with a long history of heavy manure application. Seven steroids (estrone, 17α-estradiol, 17β-estradiol, estriol, testosterone, androstendione and progesterone) were analyzed from soil sampled from vegetable greenhouses, from sediments and water from the adjacent drainage ditch and from the groundwater. The results showed that target steroids were detected in the soil samples, with detection frequencies varying from 3.13 to 100%. The steroid concentrations varied substantially in soils, ranging from below the detection limit to 109.7μg·kg(-1). Three steroids-progesterone, androstendione and estrone-were found to have relatively high residue concentrations in soil, with maximum concentrations of 109.7, 9.83 and 13.30μg·kg(-1), respectively. In adjacent groundwater, all the steroids, with the exception of estrone, were detected in one or more of the 13 groundwater samples. The concentrations of steroids in groundwater ranged from below the method detection limit to 2.38ng·L(-1). Six of the seven (excluding androstendione) were detected in drainage ditch water samples, with concentrations ranging from below the detection limit to 14ng·L(-1). Progesterone, androstendione and estrone accumulated relatively easily in soils; their concentrations in groundwater were lower than those of other steroids. The concentrations of testosterone and estriol were relatively low in soil, while in groundwater were higher than those of other steroids. The residual levels of steroids in soil and groundwater showed a clear spatial variation in the study area. The residual levels of steroid hormones in soil varied substantially between differently planted greenhouses.
Feng-Song Zhang; Yun-Feng Xie; Xuewen Li; Dai-Yi Wang; Lin-Sheng Yang; Zhi-Qiang Nie. Accumulation of steroid hormones in soil and its adjacent aquatic environment from a typical intensive vegetable cultivation of North China. Science of The Total Environment 2015, 538, 423 -430.
AMA StyleFeng-Song Zhang, Yun-Feng Xie, Xuewen Li, Dai-Yi Wang, Lin-Sheng Yang, Zhi-Qiang Nie. Accumulation of steroid hormones in soil and its adjacent aquatic environment from a typical intensive vegetable cultivation of North China. Science of The Total Environment. 2015; 538 ():423-430.
Chicago/Turabian StyleFeng-Song Zhang; Yun-Feng Xie; Xuewen Li; Dai-Yi Wang; Lin-Sheng Yang; Zhi-Qiang Nie. 2015. "Accumulation of steroid hormones in soil and its adjacent aquatic environment from a typical intensive vegetable cultivation of North China." Science of The Total Environment 538, no. : 423-430.
Prediction of antibiotic pollution and its consequences is difficult, due to the uncertainties and complexities associated with multiple related factors. This article employed domain knowledge and spatial data to construct a Bayesian network (BN) model to assess fluoroquinolone antibiotic (FQs) pollution in the soil of an intensive vegetable cultivation area. The results show: (1) The relationships between FQs pollution and contributory factors: Three factors (cultivation methods, crop rotations, and chicken manure types) were consistently identified as predictors in the topological structures of three FQs, indicating their importance in FQs pollution; deduced with domain knowledge, the cultivation methods are determined by the crop rotations, which require different nutrients (derived from the manure) according to different plant biomass. (2) The performance of BN model: The integrative robust Bayesian network model achieved the highest detection probability (pd) of high-risk and receiver operating characteristic (ROC) area, since it incorporates domain knowledge and model uncertainty. Our encouraging findings have implications for the use of BN as a robust approach to assessment of FQs pollution and for informing decisions on appropriate remedial measures.
Xuewen Li; Yunfeng Xie; Lianfa Li; Xunfeng Yang; Ning Wang; Jinfeng Wang. Using robust Bayesian network to estimate the residuals of fluoroquinolone antibiotic in soil. Environmental Science and Pollution Research 2015, 22, 17540 -17549.
AMA StyleXuewen Li, Yunfeng Xie, Lianfa Li, Xunfeng Yang, Ning Wang, Jinfeng Wang. Using robust Bayesian network to estimate the residuals of fluoroquinolone antibiotic in soil. Environmental Science and Pollution Research. 2015; 22 (22):17540-17549.
Chicago/Turabian StyleXuewen Li; Yunfeng Xie; Lianfa Li; Xunfeng Yang; Ning Wang; Jinfeng Wang. 2015. "Using robust Bayesian network to estimate the residuals of fluoroquinolone antibiotic in soil." Environmental Science and Pollution Research 22, no. 22: 17540-17549.
The role of combined arsenic and antibiotics pollution in the environment has recently gained more attention. In this study, a new approach to eliminate tetracycline antibiotics (TCs) from water, via the fern species Pteris vittata (L.), an arsenic hyperaccumulator, was investigated. The encouraging results showed that more than half of the TCs could be removed from the water solution (with the starting concentration of TCs about 1.0 mg kg−1 respectively) after one day of treatment. No TCs (less than 0.01 mg kg−1) were detected in the solution after five days of treatment. The results showed that Pteris vittata has high ability to eliminate TCs, which makes it suitable for practical application. Further research found that TCs concentrations were very low in both the roots and the pinnae of Pteris vittata, which indicates that accumulation in the fronds is not the main removal mechanism and that degradation in the fronds might be the main cause. Present results provide a feasible method for simultaneous removal of arsenic and TCs from livestock-polluted wastewater. However, more research work should be done before any real-world application is made.
Xuewen Li; Xiwei Yang; Ning Wang; Yunfeng Xie. Potential ofPteris vittatato Remove Tetracycline Antibiotics from Aquatic Media. International Journal of Phytoremediation 2015, 17, 895 -899.
AMA StyleXuewen Li, Xiwei Yang, Ning Wang, Yunfeng Xie. Potential ofPteris vittatato Remove Tetracycline Antibiotics from Aquatic Media. International Journal of Phytoremediation. 2015; 17 (9):895-899.
Chicago/Turabian StyleXuewen Li; Xiwei Yang; Ning Wang; Yunfeng Xie. 2015. "Potential ofPteris vittatato Remove Tetracycline Antibiotics from Aquatic Media." International Journal of Phytoremediation 17, no. 9: 895-899.
Malaria is a highly climate-sensitive vector-borne infectious disease that still represents a significant public health problem in Huaihe River Basin. However, little comprehensive information about the burden of malaria caused by flooding and waterlogging is available from this region. This study aims to quantitatively assess the impact of flooding and waterlogging on the burden of malaria in a county of Anhui Province, China. A mixed method evaluation was conducted. A case-crossover study was firstly performed to evaluate the relationship between daily number of cases of malaria and flooding and waterlogging from May to October 2007 in Mengcheng County, China. Stratified Cox models were used to examine the lagged time and hazard ratios (HRs) of the risk of flooding and waterlogging on malaria. Years lived with disability (YLDs) of malaria attributable to flooding and waterlogging were then estimated based on the WHO framework of calculating potential impact fraction in the Global Burden of Disease study. A total of 3683 malaria were notified during the study period. The strongest effect was shown with a 25-day lag for flooding and a 7-day lag for waterlogging. Multivariable analysis showed that an increased risk of malaria was significantly associated with flooding alone [adjusted hazard ratio (AHR) = 1.467, 95% CI = 1.257, 1.713], waterlogging alone (AHR = 1.879, 95% CI = 1.696, 2.121), and flooding and waterlogging together (AHR = 2.926, 95% CI = 2.576, 3.325). YLDs per 1000 of malaria attributable to flooding alone, waterlogging alone and flooding and waterlogging together were 0.009 per day, 0.019 per day and 0.022 per day, respectively. Flooding and waterlogging can lead to higher burden of malaria in the study area. Public health action should be taken to avoid and control a potential risk of malaria epidemics after these two weather disasters.
Guoyong Ding; Lu Gao; Xuewen Li; Maigeng Zhou; Qiyong Liu; Hongyan Ren; Baofa Jiang. A Mixed Method to Evaluate Burden of Malaria Due to Flooding and Waterlogging in Mengcheng County, China: A Case Study. PLOS ONE 2014, 9, e97520 .
AMA StyleGuoyong Ding, Lu Gao, Xuewen Li, Maigeng Zhou, Qiyong Liu, Hongyan Ren, Baofa Jiang. A Mixed Method to Evaluate Burden of Malaria Due to Flooding and Waterlogging in Mengcheng County, China: A Case Study. PLOS ONE. 2014; 9 (5):e97520.
Chicago/Turabian StyleGuoyong Ding; Lu Gao; Xuewen Li; Maigeng Zhou; Qiyong Liu; Hongyan Ren; Baofa Jiang. 2014. "A Mixed Method to Evaluate Burden of Malaria Due to Flooding and Waterlogging in Mengcheng County, China: A Case Study." PLOS ONE 9, no. 5: e97520.
One of the largest vegetable cultivation field sites in Northeast China was selected to investigate the occurrence and distribution pattern of fluoroquinolones (FQs) in the soil–vegetable system. A total of 100 surface soil samples and 68 vegetable samples were collected from this study area. The antibiotic concentration was analyzed using high-performance liquid chromatography tandem mass spectrometry. Results indicated the presence of FQs in all soil samples. Ciprofloxacin (CIP) had the highest mean concentration, at 104.4 μg·kg− 1 in the soil, a level that represents a relatively high risk to the environment and to human health. However, in the vegetable samples, norfloxacin (NOR) was significantly higher than CIP and enrofloxacin (ENR), ranging from 18.2 to 658.3 μg·kg− 1. The transfer ability of NOR in soil–vegetables is greater than that of CIP and ENR. Moreover, we found that the solanaceous fruits had a higher antibiotic accumulation ability than the leafy vegetables. Taken together, these data indicate that greater attention should be paid to the region in which vegetables with higher accumulation ability are grown.
Xuewen Li; Yun-Feng Xie; Cang-Lin Li; Hui-Nan Zhao; Ning Wang; Jin-Feng Wang. Investigation of residual fluoroquinolones in a soil–vegetable system in an intensive vegetable cultivation area in Northern China. Science of The Total Environment 2013, 468-469, 258 -264.
AMA StyleXuewen Li, Yun-Feng Xie, Cang-Lin Li, Hui-Nan Zhao, Ning Wang, Jin-Feng Wang. Investigation of residual fluoroquinolones in a soil–vegetable system in an intensive vegetable cultivation area in Northern China. Science of The Total Environment. 2013; 468-469 ():258-264.
Chicago/Turabian StyleXuewen Li; Yun-Feng Xie; Cang-Lin Li; Hui-Nan Zhao; Ning Wang; Jin-Feng Wang. 2013. "Investigation of residual fluoroquinolones in a soil–vegetable system in an intensive vegetable cultivation area in Northern China." Science of The Total Environment 468-469, no. : 258-264.
Exposure to endocrine disruptors (EDs) during early development might lead to adverse health outcomes later in life. Tributyltin (TBT), a proven ED, is widely used in consumer goods and industrial products. Herein we demonstrate the effects of low doses of tributyltin chloride (TBTCl) on reproduction of male KM mice. Pregnant mice were administered by gavage with 0, 1, 10, or 100 μg TBTCl/kg body weight/day from day 6 of pregnancy through the period of lactation. TBTCl dramatically decreased sperm counts and motility on postnatal days (PNDs) 49 and 152. Meanwhile, a significant increase in sperm abnormality was observed in exposed mice on PND 49, but comparable to that in the control on PND 152. The histopathological analysis of testes of treated animals showed a dose-dependent increase in sloughing of germ cells in seminiferous tubules. Mice treated with 10 μg TBTCl/kg exhibited decreased intratesticular 17β-estradiol (E2) levels on PND 49, and then followed by an obvious recovery on PND 152. While, no significant differences in serum E2, testosterone (T) levels and intratesticular T levels were detectable between control and TBTCl-exposed offspring at the sacrifice. These results suggest that perinatal TBTCl exposure is implicated in causing long lasting alterations in male reproductive system and these changes may persist far into adulthood.
Jiliang Si; Peng Li; Quanbing Xin; Xuewen Li; Lihong An; Jie Li. Perinatal exposure to low doses of tributyltin chloride reduces sperm count and quality in mice. Environmental Toxicology 2013, 30, 44 -52.
AMA StyleJiliang Si, Peng Li, Quanbing Xin, Xuewen Li, Lihong An, Jie Li. Perinatal exposure to low doses of tributyltin chloride reduces sperm count and quality in mice. Environmental Toxicology. 2013; 30 (1):44-52.
Chicago/Turabian StyleJiliang Si; Peng Li; Quanbing Xin; Xuewen Li; Lihong An; Jie Li. 2013. "Perinatal exposure to low doses of tributyltin chloride reduces sperm count and quality in mice." Environmental Toxicology 30, no. 1: 44-52.
Recent studies have demonstrated the persistence of antibiotics in soil, especially in areas of vegetable cultivation. However, there are very few studies of the influence of planting regimes on the levels of antibiotic pollution. This work introduces geographical-detector models to investigate the relationship between planting patterns (vegetable planting model, manure type and quantity, planting age, greenhouse area, and topographic elevation) and residual fluoroquinolones (FQs) in soil in a pilot project in Shouguang County, Shandong Province (the largest vegetable-producing area in China). The results led to the following findings. 1. The vegetable planting model is the major determinant of the spatial stratification of FQ in the soil. For example, the “cucumber–cucumber” model (growing cucumbers after cucumbers) has a three-fold power of determinant compared to the “pepper–melon” model (growing melons after peppers). 2. Planting age (years with continuous vegetable cultivation) does not necessarily affect the spatial distribution of FQ owing to their relatively short degradation period. 3. Interactions between risk factors were more significant than the individual factors for FQ pollution. In particular, the interaction between the vegetable planting model and amount of manure resulted in the highest pollution level. The findings of the present study make it possible to introduce effective and practical measures to alleviate pollution of soils by FQ in the study area. Adjustment of the vegetable cultivation models and application of chicken manure (less than 6 kg/m2 manure annually with a more dry than fresh manure) could be an effective and flexible approach to alleviate FQ pollution.
Xuewen Li; Yunfeng Xie; Jinfeng Wang; George Christakos; Jiliang Si; Huinan Zhao; Yanqiang Ding; Jie Li. Influence of planting patterns on fluoroquinolone residues in the soil of an intensive vegetable cultivation area in northern China. Science of The Total Environment 2013, 458-460, 63 -69.
AMA StyleXuewen Li, Yunfeng Xie, Jinfeng Wang, George Christakos, Jiliang Si, Huinan Zhao, Yanqiang Ding, Jie Li. Influence of planting patterns on fluoroquinolone residues in the soil of an intensive vegetable cultivation area in northern China. Science of The Total Environment. 2013; 458-460 ():63-69.
Chicago/Turabian StyleXuewen Li; Yunfeng Xie; Jinfeng Wang; George Christakos; Jiliang Si; Huinan Zhao; Yanqiang Ding; Jie Li. 2013. "Influence of planting patterns on fluoroquinolone residues in the soil of an intensive vegetable cultivation area in northern China." Science of The Total Environment 458-460, no. : 63-69.