José Alcami

Prof. José Alcami

orcid

Research Focus & Metrics

Academic Career Length

41Years (1986-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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1 August 2000 in EMBO Reports
Verified
Journal Article
Open access
PDF file
SMSantos Mañes
Santos Mañes
GRGustavo del Real
Gustavo del Real
RLRosa Ana Lacalle
Rosa Ana Lacalle
PLPilar Lucas
Pilar Lucas
CGConcepción Gómez‐Moutón
Concepción Gómez‐Moutón
CMCarlos Martínez‐A
Carlos Martínez‐A
HIV‐1 infection triggers lateral membrane diffusion following interaction of the viral envelope with cell surface receptors. We show that these membrane changes are necessary for infection, as initial gp120–CD4 engagement leads to redistribution and clustering of membrane microdomains, enabling subsequent interaction of this complex with HIV‐1 co‐receptors. Disruption of cell membrane rafts by cholesterol depletion before viral exposure inhibits entry by both X4 and R5 strains of HIV‐1, although viral replication in infected cells is unaffected by this treatment. This inhibitory effect is fully reversed by cholesterol replenishment of the cell membrane. These results indicate a general mechanism for HIV‐1 envelope glycoprotein‐mediated fusion by reorganization of membrane microdomains in the target cell, and offer new strategies for preventing HIV‐1 infection.

1 November 2009 in Nature Reviews Microbiology
Verified
Journal Article
Closed access
PDF file
MCMayte Coiras
Mayte Coiras
MHMaría Rosa López Huertas
María Rosa López Huertas
Mayte Perez-OlmedaMayte Perez-Olmeda
Mayte Perez-Olmeda
JAJosé Alcami
José Alcami

1 January 2001 in Kidney International
Verified
Journal Article
Closed access
MCM. Carmen Iglesias-de la Cruz
M. Carmen Iglesias-de la Cruz
MRMaría P Ruiz
María P Ruiz
JAJosé Alcami
José Alcami
LDLuisa Díez-Marqués
Luisa Díez-Marqués
RORocío Ortega-Velázquez
Rocío Ortega-Velázquez
DRDiego Rodríguez-Puyol
Diego Rodríguez-Puyol

25 April 1991 in Nature
Verified
Journal Article
Closed access
PDF file
FBFrançoise Bachelerie
Françoise Bachelerie
JAJosé Alcami
José Alcami
FAF. Arenzana-Seisdedos
F. Arenzana-Seisdedos
JVJ-L. Virelizier
J-L. Virelizier

1 May 2010 in Bioorganic & Medicinal Chemistry Letters
Verified
Journal Article
Closed access
PGPaolo Di Gianvincenzo
Paolo Di Gianvincenzo
MMMarco Marradi
Marco Marradi
OMOlga María Martínez-Ávila
Olga María Martínez-Ávila
LBLuis Miguel Bedoya
Luis Miguel Bedoya
JAJosé Alcami
José Alcami
SPSoledad Penadés
Soledad Penadés

7 September 2020 in Nature Medicine
Verified
Journal Article
Closed access
PDF file
MAMohamed Abdel-Mohsen
Mohamed Abdel-Mohsen
DRDouglas D. Richman
Douglas D. Richman
RSRobert F. Siliciano
Robert F. Siliciano
MNMichel C. Nussenzweig
Michel C. Nussenzweig
BHBonnie J Howell
Bonnie J Howell
LMLuis J. Montaner
Luis J. Montaner