Prof. Dr. Leonardo Degennaro
Università degli studi di Bari Aldo Moro, Bari, Italy
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Academic Career Length
26Years (2001-Present)
(Calculated once Scilit publication data is synced: current year − year of first publication + 1)
Representative Publications
View All Publications13 May 2014 in Chemical Reviews
Journal Article
29 April 2016 in Angewandte Chemie International Edition
Journal Article
MZMarina Zenzola
Marina Zenzola
RDRobert Doran
Robert Doran
Leonardo Degennaro
Renzo LuisiJBJames A Bull
James A BullA new system for NH transfer is developed for the preparation of sulfoximines, which are emerging as valuable motifs for drug discovery. The protocol employs readily available sources of nitrogen without the requirement for either preactivation or for metal catalysts. Mixing ammonium salts with diacetoxyiodobenzene directly converts sulfoxides into sulfoximines. This report describes the first example of using of ammonia sources with diacetoxyiodobenzene to generate an electrophilic nitrogen center. Control and mechanistic studies suggest a short‐lived electrophilic intermediate, which is likely to be PhINH or PhIN+.
14 March 2017 in Beilstein Journal of Organic Chemistry
Journal Article
FFFlavio Fanelli
Flavio Fanelli
GPGiovanna Parisi
Giovanna Parisi
Leonardo DegennaroRenzo LuisiMicroreactor technology and flow chemistry could play an important role in the development of green and sustainable synthetic processes. In this review, some recent relevant examples in the field of flash chemistry, catalysis, hazardous chemistry and continuous flow processing are described. Selected examples highlight the role that flow chemistry could play in the near future for a sustainable development.
1 December 2016 in Chemical Communications
Journal Article
ATArianna Tota
Arianna Tota
MZMarina Zenzola
Marina Zenzola
SCStephen J. Chawner
Stephen J. Chawner
SJSahra St John-Campbell
Sahra St John-Campbell
Claudia CarlucciRenzo Luisi +3
Direct synthesis of NH-sulfoximines from sulfides has been achieved through O and NH transfer in the same reaction, occurring with complete selectivity. The reaction is mediated by bisacetoxyiodobenzene under simple conditions and employs inexpensive N-sources. Preliminary studies indicate that NH-transfer is likely to be first, followed by oxidation, but the reaction proceeds successfully in either order. A wide range of functional groups and biologically relevant compounds are tolerated. The use of AcO15NH4 affords 15N-labeled compounds.
15 September 2017 in Journal of the American Chemical Society
Journal Article
GPGiovanna Parisi
Giovanna Parisi
Marco ColellaSMSerena Monticelli
Serena Monticelli
GRGiuseppe Romanazzi
Giuseppe RomanazziWHWolfgang Holzer
Wolfgang HolzerRenzo Luisi +3
13 October 2016 in Organic & Biomolecular Chemistry
Journal Article
The almost unexplored four-membered azetidines represent a particularly interesting class of molecules, among the family of saturated nitrogen heterocycles. This review reports recent developments in direct metal-based functionalization of the azetidine ring, focusing on the regio- and stereoselectivity of these reactions.
About Me
Leonardo Degennaro obtained the master degree in Chemistry and Pharmaceutical Technology in 1999 and the PhD in Applied Chemical and Enzymatic Synthesis in 2003. In 2002, he was "visiting scholar" at the University of Groningen under the supervision of Prof. B. L. Feringa. In 2006, he was appointed assistant professor in Organic Chemistry at the Department of Pharmacy of University of Bari. In 2011, he has been a "visiting assistant professor" at the University of Kyoto working in the group of Prof. J.-i. Yoshida. Their research activity is aimed at developing new stereocontrolled synthesis by using small heterocycles and organometallic species, and microreactor technology