A strategy for biocatalyst immobilization in flow directly from the crude cell extract is described.

No oxidant needed – just electric current! Continuous synthesis of benzyl amides directly from aromatic hydrocarbons.

Here we explore further the use of oxadiazolines, non-stabilised diazo precursors which are bench stable, in direct, non-catalytic, aldehyde C–H functionalisation reactions under UV photolysis in flow and free from additives.