Due to the structure of acylhydrazones both by the pharmacophore –CO–NH–N= group and by the different substituents present in the molecules of compounds of this class, various pharmacological activities were reported, including antitumor, antimicrobial, antiviral, antiparasitic, anti-inflammatory, immunomodulatory, antiedematous, antiglaucomatous, antidiabetic, antioxidant, and actions on the central nervous system and on the cardiovascular system. This fragment is found in the structure of several drugs used in the therapy of some diseases that are at the top of public health problems, like microbial infections and cardiovascular diseases. Moreover, the acylhydrazone moiety is present in the structure of some compounds with possible applications in the treatment of other different pathologies, such as schizophrenia, Parkinson’s disease, Alzheimer’s disease, and Huntington’s disease. Considering these aspects, we consider that a study of the literature data regarding the structural and biological properties of these compounds is useful.

Prosthetic mesh implants in hernia repair are frequently used based on the fact that lower recurrence rates are detected compared to anatomic repair. In latest years, researchers tried to answer weather there is an ideal mesh material for abdominal hernia repair. The studies tried to compare resistance, bio-tolerance, rates of recurrence and infection of several materials used in alloplasty. The results are far from pointing an unique ideal chemical structure of mesh. In our study, we compared the results of a cohort of 265 patients operated in 2010 and 2011 in our clinic for complicated abdominal incisional hernias. We compared the results of polypropylene mesh vs. polyester. Polypropylene mesh proved significantly better for preventing hernia recurrence and showed a lower shrinkage rate.

To improve the management of psoriasis, we have started from the hypothesis that normalization of vitamin D serum reduces the severity of psoriasis and positively influences the diagnostic criteria of metabolic syndrome. Experimental part. The objective of the prospective study was to evaluate the impact of oral vitamin D on psoriazis and metabolic syndrome in a group of 184 patients diagnosed with psoriazis and metabolic syndrome, between 2010-2017. In all patients included in the study, we evaluated family history, personal medical history, the living and working conditions, the history of psoriatic disease (control group only), clinical data (waist circumference), height (cm), body mass index, blood pressure (mmHg)) and laboratory examinations. Regarding the severity of psoriasis, in all 141 patients treated with vitamin D, a significant improvement was seen after 12 months of treatment. We bring a new approach to the treatment of psoriasis with vitamin D.

In this paper, we report on the antimicrobial activity assessment of 49 compounds previously synthesized as derivatives of alanine or phenylalanine that incorporate a 4-(4-X-phenylsulfonyl)phenyl fragment (X = H, Cl, or Br), namely 21 acyclic compounds (6 × N-acyl-α-amino acids, 1 × N-acyl-α-amino acid ester, and 14 × N-acyl-α-amino ketones) and 28 pentatomic heterocycles from the oxazole-based compound class (6 × 4H-1,3-oxazol-5-ones, 16 × 5-aryl-1,3-oxazoles, and 6 × ethyl 1,3-oxazol-5-yl carbonates). Both in silico and in vitro qualitative and quantitative assays were used to investigate the antimicrobial potential of these derivatives against planktonic and biofilm-embedded microbial strains. Some of the tested compounds showed promising antimicrobial and antibiofilm activity depending on their chemical scaffold and lipophilic character.

Searching new antioxidants compounds to prevent or reduce the impact of oxidative stress on cells, we designed and synthesized several N-acylhydrazone derivatives with dibenzo[a,d][7]annulene moiety. In this work, a series of previously synthesized N-acylhydrazone derivatives bearing 5H-dibenzo[a,d][7]annulene moiety 7a-g were evaluated for antioxidant activity effect, using the DPPH method. The highest antioxidant activity was exhibited by the compound 7f containing in his molecule 4-hydroxy-3-methoxyphenyl fragment.

Bogdan Socea, Alexandru Carap, Ovidiu Gabriel Bratu, Camelia Cristina Diaconu, Mihai Dimitriu, Laura Ileana Socea, Simona Bobic, Vlad Denis Constantin - The Role of the Composite and Biologic Meshes in the Trocar Site Hernia Repair Following Laparoscopic Surgery