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Prof. Igor Nabiev
Université de Reims Champagne-Ardenne

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0 Quantum Dots
0 Energy transfer
0 light-matter interaction
0 nanobiotechnologies

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Journal article
Published: 24 August 2021 in Nanomaterials
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Designing nanoprobes in which quantum dots (QDs) are used as photoluminescent labels is an especially promising line of research due to their possible medical applications ranging from disease diagnosis to drug delivery. In spite of the significant progress made in designing such nanoprobes, the properties of their individual components, i.e., photoluminescent QDs, vectorization moieties, and pharmacological agents, still require further optimization to enhance the efficiency of diagnostic or therapeutic procedures. Here, we have developed a method of engineering compact multifunctional nanoprobes based on functional components with optimized properties: bright photoluminescence of CdSe/ZnS (core/shell) QDs, a compact and effective antitumor agent (an acridine derivative), and direct conjugation of the components via electrostatic interaction, which provides a final hydrodynamic diameter of nanoprobes smaller than 15 nm. Due to the possibility of conjugating various biomolecules with hydroxyl and carboxyl moieties to QDs, the method represents a versatile approach to the biomarker-recognizing molecule imaging of the delivery of the active substance as part of compact nanoprobes.

ACS Style

Pavel Linkov; Pavel Samokhvalov; Maria Baryshnikova; Marie Laronze-Cochard; Janos Sapi; Alexander Karaulov; Igor Nabiev. Conjugates of Ultrasmall Quantum Dots and Acridine Derivatives as Prospective Nanoprobes for Intracellular Investigations. Nanomaterials 2021, 11, 2160 .

AMA Style

Pavel Linkov, Pavel Samokhvalov, Maria Baryshnikova, Marie Laronze-Cochard, Janos Sapi, Alexander Karaulov, Igor Nabiev. Conjugates of Ultrasmall Quantum Dots and Acridine Derivatives as Prospective Nanoprobes for Intracellular Investigations. Nanomaterials. 2021; 11 (9):2160.

Chicago/Turabian Style

Pavel Linkov; Pavel Samokhvalov; Maria Baryshnikova; Marie Laronze-Cochard; Janos Sapi; Alexander Karaulov; Igor Nabiev. 2021. "Conjugates of Ultrasmall Quantum Dots and Acridine Derivatives as Prospective Nanoprobes for Intracellular Investigations." Nanomaterials 11, no. 9: 2160.

Journal article
Published: 06 August 2021 in Nanomaterials
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Quantum dots (QDs) are promising candidates for producing bright, color-pure, cost-efficient, and long-lasting QD-based light-emitting diodes (QDLEDs). However, one of the significant problems in achieving high efficiency of QDLEDs is the imbalance between the rates of charge-carrier injection into the emissive QD layer and their transport through the device components. Here we investigated the effect of the parameters of the deposition of a poly (methyl methacrylate) (PMMA) electron-blocking layer (EBL), such as PMMA solution concentration, on the characteristics of EBL-enhanced QDLEDs. A series of devices was fabricated with the PMMA layer formed from acetone solutions with concentrations ranging from 0.05 to 1.2 mg/mL. The addition of the PMMA layer allowed for an increase of the maximum luminance of QDLED by a factor of four compared to the control device without EBL, that is, to 18,671 cd/m2, with the current efficiency increased by an order of magnitude and the turn-on voltage decreased by ~1 V. At the same time, we have demonstrated that each particular QDLED characteristic has a maximum at a specific PMMA layer thickness; therefore, variation of the EBL deposition conditions could serve as an additional parameter space when other QDLED optimization approaches are being developed or implied in future solid-state lighting and display devices.

ACS Style

Mariya Zvaigzne; Alexei Alexandrov; Anastasia Tkach; Dmitriy Lypenko; Igor Nabiev; Pavel Samokhvalov. Optimizing the PMMA Electron-Blocking Layer of Quantum Dot Light-Emitting Diodes. Nanomaterials 2021, 11, 2014 .

AMA Style

Mariya Zvaigzne, Alexei Alexandrov, Anastasia Tkach, Dmitriy Lypenko, Igor Nabiev, Pavel Samokhvalov. Optimizing the PMMA Electron-Blocking Layer of Quantum Dot Light-Emitting Diodes. Nanomaterials. 2021; 11 (8):2014.

Chicago/Turabian Style

Mariya Zvaigzne; Alexei Alexandrov; Anastasia Tkach; Dmitriy Lypenko; Igor Nabiev; Pavel Samokhvalov. 2021. "Optimizing the PMMA Electron-Blocking Layer of Quantum Dot Light-Emitting Diodes." Nanomaterials 11, no. 8: 2014.

Protocol
Published: 31 July 2021 in Methods in Molecular Biology
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Early detection of malignant tumors, micrometastases, and disseminated tumor cells is one of the effective way of fighting cancer. Among the many existing imaging methods like computed tomography (CT), ultrasound (US), magnetic resonance imaging (MRI), positron emission tomography (PET), and single-photon emission computed tomography (SPECT), optical imaging with fluorescent probes is one of the most promising alternatives because it is fast, inexpensive, safe, sensitive, and specific. However, traditional fluorescent probes, based on organic fluorescent dyes, suffer from the low signal-to-noise ratio. Furthermore, conventional organic fluorescent dyes are unsuitable for deep tissue imaging because of the strong visible light absorption by biological tissues. The use of fluorescent semiconductor nanocrystals, or quantum dots (QDs), may overcome this limitation due to their large multiphoton cross section, which ensures efficient imaging of thick tissue sections inaccessible with conventional fluorescent probes. Moreover, the lower photobleaching and higher brightness of fluorescence signals from QDs ensures a much better discrimination of positive signals from the background. The use of fluorescent nanoprobes based on QDs conjugated to uniformly oriented high-affinity single-domain antibodies (sdAbs) may significantly increase the sensitivity and specificity due to better recognition of analytes and deeper penetration into tissues due to small size of such nanoprobes. Here, we describe a protocol for the fabrication of nanoprobes based on sdAbs and QDs, preparation of experimental xenograft mouse models for quality control, and multiphoton imaging of deep-tissue solid tumors, micrometastases, and disseminated tumor cells.

ACS Style

Alyona Sukhanova; Fernanda Ramos-Gomes; Patrick Chames; Pavel Sokolov; Daniel Baty; Frauke Alves; Igor Nabiev. Multiphoton Deep-Tissue Imaging of Micrometastases and Disseminated Cancer Cells Using Conjugates of Quantum Dots and Single-Domain Antibodies. Methods in Molecular Biology 2021, 105 -123.

AMA Style

Alyona Sukhanova, Fernanda Ramos-Gomes, Patrick Chames, Pavel Sokolov, Daniel Baty, Frauke Alves, Igor Nabiev. Multiphoton Deep-Tissue Imaging of Micrometastases and Disseminated Cancer Cells Using Conjugates of Quantum Dots and Single-Domain Antibodies. Methods in Molecular Biology. 2021; ():105-123.

Chicago/Turabian Style

Alyona Sukhanova; Fernanda Ramos-Gomes; Patrick Chames; Pavel Sokolov; Daniel Baty; Frauke Alves; Igor Nabiev. 2021. "Multiphoton Deep-Tissue Imaging of Micrometastases and Disseminated Cancer Cells Using Conjugates of Quantum Dots and Single-Domain Antibodies." Methods in Molecular Biology , no. : 105-123.

Journal article
Published: 05 July 2021 in Applied Physics Letters
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Polariton emission from optical cavities integrated with various luminophores has been extensively studied recently due to the wide variety of possible applications in photonics, particularly promising in terms of the fabrication of low-threshold sources of coherent emission. Tunable microcavities allow extensive investigation of the photophysical properties of matter placed inside the cavity by deterministically changing the coupling strength and controllable switching from weak to strong and ultra-strong coupling regimes. Here, we demonstrate room-temperature strong coupling of exciton transitions in CdSe/ZnS/CdS/ZnS colloidal quantum dots with the optical modes of a tunable low-mode-volume microcavity. Strong coupling is evidenced by a large Rabi splitting of the photoluminescence spectra depending on the detuning of the microcavity. A coupling strength of 154 meV has been achieved. High quantum yields, excellent photostability, and scalability of fabrication of quantum dots (QDs) pave the way to practical applications of coupled systems based on colloidal QDs in photonics, optoelectronics, and sensing.

ACS Style

Dmitriy Dovzhenko; Maksim Lednev; Konstantin Mochalov; Ivan Vaskan; Pavel Samokhvalov; Yury Rakovich; Igor Nabiev. Strong exciton−photon coupling with colloidal quantum dots in a tunable microcavity. Applied Physics Letters 2021, 119, 011102 .

AMA Style

Dmitriy Dovzhenko, Maksim Lednev, Konstantin Mochalov, Ivan Vaskan, Pavel Samokhvalov, Yury Rakovich, Igor Nabiev. Strong exciton−photon coupling with colloidal quantum dots in a tunable microcavity. Applied Physics Letters. 2021; 119 (1):011102.

Chicago/Turabian Style

Dmitriy Dovzhenko; Maksim Lednev; Konstantin Mochalov; Ivan Vaskan; Pavel Samokhvalov; Yury Rakovich; Igor Nabiev. 2021. "Strong exciton−photon coupling with colloidal quantum dots in a tunable microcavity." Applied Physics Letters 119, no. 1: 011102.

Paper
Published: 01 February 2021 in Nanoscale
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The effective two-photon absorption in the hybrid material comprising quantum dots (QDs) in a poly(methyl methacrylate) (PMMA) matrix and gold nanorods (GNRs) was increased 12-fold due to nonlinear energy transfer from GNR plasmons to QD excitons.

ACS Style

Victor Krivenkov; Pavel Samokhvalov; Ana Sánchez-Iglesias; Marek Grzelczak; Igor Nabiev; Yury Rakovich. Strong increase in the effective two-photon absorption cross-section of excitons in quantum dots due to the nonlinear interaction with localized plasmons in gold nanorods. Nanoscale 2021, 13, 4614 -4623.

AMA Style

Victor Krivenkov, Pavel Samokhvalov, Ana Sánchez-Iglesias, Marek Grzelczak, Igor Nabiev, Yury Rakovich. Strong increase in the effective two-photon absorption cross-section of excitons in quantum dots due to the nonlinear interaction with localized plasmons in gold nanorods. Nanoscale. 2021; 13 (8):4614-4623.

Chicago/Turabian Style

Victor Krivenkov; Pavel Samokhvalov; Ana Sánchez-Iglesias; Marek Grzelczak; Igor Nabiev; Yury Rakovich. 2021. "Strong increase in the effective two-photon absorption cross-section of excitons in quantum dots due to the nonlinear interaction with localized plasmons in gold nanorods." Nanoscale 13, no. 8: 4614-4623.

Research article
Published: 17 January 2021 in The Journal of Physical Chemistry C
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Remote control of the pH of the medium is an important task for many applications in chemistry, medicine, and biology. Remote control of the pH using light is an intelligent and cost-effective approach. The nanoscale plasmon–exciton (plexciton) light–matter coupling is a physical phenomenon that provokes strong changes in the optical properties of the original plasmon and exciton bands, resulting in a transparency dip in the initial plasmon spectrum and formation of two hybrid plexciton side bands separated by the Rabi splitting energy. The plexciton coupling strength is unaffected by the temperature and light irradiation stressors but strongly depends on the transition dipole moment of the exciton material. Here, we show that the optical parameters of the plexciton coupling can be controlled by varying the pH of the medium. To demonstrate this, we obtained resonant light–matter coupling between the plasmon band of silver nanoplates and the J-band of J-aggregates with a Rabi splitting energy of up to 450 meV and found that both the extinction dip and the splitting energy are strongly affected by variation of pH from 2.5 to 11. We explain this effect by a change in the structure of the J-aggregates and reduction of the J-band intensity, which is confirmed by numerical simulation.

ACS Style

Victor Krivenkov; Pavel Samokhvalov; Igor Nabiev; Yury P. Rakovich. pH-Sensing Platform Based on Light–Matter Coupling in Colloidal Complexes of Silver Nanoplates and J-Aggregates. The Journal of Physical Chemistry C 2021, 125, 1972 -1979.

AMA Style

Victor Krivenkov, Pavel Samokhvalov, Igor Nabiev, Yury P. Rakovich. pH-Sensing Platform Based on Light–Matter Coupling in Colloidal Complexes of Silver Nanoplates and J-Aggregates. The Journal of Physical Chemistry C. 2021; 125 (3):1972-1979.

Chicago/Turabian Style

Victor Krivenkov; Pavel Samokhvalov; Igor Nabiev; Yury P. Rakovich. 2021. "pH-Sensing Platform Based on Light–Matter Coupling in Colloidal Complexes of Silver Nanoplates and J-Aggregates." The Journal of Physical Chemistry C 125, no. 3: 1972-1979.

Journal article
Published: 11 December 2020 in Nanomaterials
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Colloidal quantum dots (QDs) are a promising luminescent material for the development of next generation hybrid light-emitting diodes (QDLEDs). In particular, QDs are of great interest in terms of the development of solid-state light sources with an emission spectrum that mimics daylight. In this study, we used CdSe(core)/ZnS/CdS/ZnS(shell) QDs with organic ligands mimicking polyfluorene and its modified derivatives to obtain QD–polymer composites emitting white light. We found that the emission of the composites obtained by spin-coating, being strongly dependent on the chemical structure of the polymer matrix and the QD-to-polymer mass ratio, can be accurately controlled and adjusted to bring its emission spectrum close to the spectrum of daylight (CIE coordinates: 1931 0.307; 0.376). Moreover, the light emission of these composites has been found to be temporally stable, which is due to the minimal structural instability and volume-uniform charge and energy transfer properties. Thus, the use of the synthesized polyfluorene-based organic ligands with controllable chemical structures adaptable to the structure of the polymer matrix can significantly increase the stability of white light emission from QD composites, which can be considered promising electroluminescent materials for fabrication of white QDLEDs.

ACS Style

Mariya Zvaigzne; Irina Domanina; Dmitriy Il’Gach; Alexander Yakimansky; Igor Nabiev; Pavel Samokhvalov. Quantum Dot–Polyfluorene Composites for White-Light-Emitting Quantum Dot-Based LEDs. Nanomaterials 2020, 10, 2487 .

AMA Style

Mariya Zvaigzne, Irina Domanina, Dmitriy Il’Gach, Alexander Yakimansky, Igor Nabiev, Pavel Samokhvalov. Quantum Dot–Polyfluorene Composites for White-Light-Emitting Quantum Dot-Based LEDs. Nanomaterials. 2020; 10 (12):2487.

Chicago/Turabian Style

Mariya Zvaigzne; Irina Domanina; Dmitriy Il’Gach; Alexander Yakimansky; Igor Nabiev; Pavel Samokhvalov. 2020. "Quantum Dot–Polyfluorene Composites for White-Light-Emitting Quantum Dot-Based LEDs." Nanomaterials 10, no. 12: 2487.

Originalpaper
Published: 01 November 2020 in JETP Letters
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The development of optical and, in particular, photoluminescent sensors is currently becoming more and more significant because of their universality, selectivity, and high sensitivity ensuring their wide applications in practice. The efficiency of existing photoluminescent sensors can be increased by using photoluminescent nanomaterials and hybrid nanostructures. For biological applications of photoluminescent sensors, it is extremely relevant to excite photoluminescence in the near infrared spectral range, which allows excluding the effect of autofluorescence of biomolecules and ensuring a deeper penetration of radiation into biological tissues. In this work, it has been studied how the spectral and kinetic parameters of photoluminescence change under two-photon excitation of semiconductor quantum dots incorporated into a one-dimensional photonic crystal, a porous silicon microcavity. It has been shown that the formation of a weak coupling between an exciton transition in quantum dots and an eigenmode of the microcavity enhances the photoluminescence of quantum dots. It is important that quantum dots placed in the porous silicon matrix hold a sufficiently large cross section for two-photon absorption, which makes it possible to efficiently excite their exciton states up to saturation without reaching powers leading to the photothermic destruction of the structure of porous silicon and to the disappearance of the weak coupling effect. It has been demonstrated that the radiative recombination rate under the two-photon excitation of the system consisting of quantum dots and the microcavity increases by a factor of 4.3; it has been shown that this increase is due to the Purcell effect. Thus, fabricated microcavities based on 1D porous silicon crystals allow controlling the quantum yield of photoluminescence of quantum dots under two-photon excitation, which opens prospects for the development of new photoluminescent sensors based on quantum dots operating in the near infrared spectral range.

ACS Style

I. S. Kriukova; V. A. Krivenkov; P. S. Samokhvalov; I. R. Nabiev. Weak Coupling between Light and Matter in Photonic Crystals Based on Porous Silicon Responsible for the Enhancement of Fluorescence of Quantum Dots under Two-Photon Excitation. JETP Letters 2020, 112, 537 -542.

AMA Style

I. S. Kriukova, V. A. Krivenkov, P. S. Samokhvalov, I. R. Nabiev. Weak Coupling between Light and Matter in Photonic Crystals Based on Porous Silicon Responsible for the Enhancement of Fluorescence of Quantum Dots under Two-Photon Excitation. JETP Letters. 2020; 112 (9):537-542.

Chicago/Turabian Style

I. S. Kriukova; V. A. Krivenkov; P. S. Samokhvalov; I. R. Nabiev. 2020. "Weak Coupling between Light and Matter in Photonic Crystals Based on Porous Silicon Responsible for the Enhancement of Fluorescence of Quantum Dots under Two-Photon Excitation." JETP Letters 112, no. 9: 537-542.

Journal article
Published: 23 October 2020 in Chemistry of Materials
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ACS Style

Pavel Linkov; Pavel Samokhvalov; Sergei Grokhovsky; Marie Laronze-Cochard; Janos Sapi; Igor Nabiev. Selection of the Optimal Chromatography Medium for Purification of Quantum Dots and Their Bioconjugates. Chemistry of Materials 2020, 32, 1 .

AMA Style

Pavel Linkov, Pavel Samokhvalov, Sergei Grokhovsky, Marie Laronze-Cochard, Janos Sapi, Igor Nabiev. Selection of the Optimal Chromatography Medium for Purification of Quantum Dots and Their Bioconjugates. Chemistry of Materials. 2020; 32 (21):1.

Chicago/Turabian Style

Pavel Linkov; Pavel Samokhvalov; Sergei Grokhovsky; Marie Laronze-Cochard; Janos Sapi; Igor Nabiev. 2020. "Selection of the Optimal Chromatography Medium for Purification of Quantum Dots and Their Bioconjugates." Chemistry of Materials 32, no. 21: 1.

Journal article
Published: 21 September 2020 in Optics Letters
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Photoluminescence (PL)-based sensing techniques have been significantly developed in practice due to their key advantages in terms of sensitivity and versatility of the approach. Recently, various nanostructured and hybrid materials have been used to improve the PL quantum yield and the spectral resolution. The near-infrared (NIR) fluorescence excitation has attracted much attention because it offers deep tissue penetration and it avoids the autofluorescence of the biological samples. In our study, we have shown both spectral and temporal PL modifications under two-photon excitation of quantum dots (QDs) placed in one-dimensional porous silicon photonic crystal (PhC) microcavities. We have demonstrated an up-to-4.3-fold Purcell enhancement of the radiative relaxation rate under two-photon excitation. The data show that the use of porous silicon PhC microcavities operating in the weak coupling regime permits the enhancement of the PL quantum yield of QDs under two-photon excitation, thus extending the limits of their biosensing applications in the NIR region of the optical spectrum.

ACS Style

Dmitriy Dovzhenko; Victor Krivenkov; Irina Kriukova; Pavel Samokhvalov; Alexander Karaulov; Igor Nabiev. Enhanced spontaneous emission from two-photon-pumped quantum dots in a porous silicon microcavity. Optics Letters 2020, 45, 5364 -5367.

AMA Style

Dmitriy Dovzhenko, Victor Krivenkov, Irina Kriukova, Pavel Samokhvalov, Alexander Karaulov, Igor Nabiev. Enhanced spontaneous emission from two-photon-pumped quantum dots in a porous silicon microcavity. Optics Letters. 2020; 45 (19):5364-5367.

Chicago/Turabian Style

Dmitriy Dovzhenko; Victor Krivenkov; Irina Kriukova; Pavel Samokhvalov; Alexander Karaulov; Igor Nabiev. 2020. "Enhanced spontaneous emission from two-photon-pumped quantum dots in a porous silicon microcavity." Optics Letters 45, no. 19: 5364-5367.

Research article
Published: 04 September 2020 in The Journal of Physical Chemistry Letters
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Reliable control of spontaneous radiation from quantum emitters, such as quantum dots (QDs), is an extremely important problem in quantum science, nanophotonics, and engineering. The QD photoluminescence (PL) may be enhanced near plasmon nanoparticles due to excitation field enhancement or the Purcell effect. However, both of these effects have their specific limitations. The excitation enhancement is usually accompanied by a decrease in the PL quantum yield (QY) due to the plasmon-induced energy transfer, and the Purcell effect cannot significantly enhance the PL of QDs with an initially high QY because of the obvious limitation of the QY by the value of 100%. Here, we have shown that the synergistic combination of excitation enhancement caused by silver nanospheres and the Purcell effect caused by silver nanoplates in the same QD-in-polymer hybrid thin-film nanostructure permits simultaneous increases in the radiative and excitation rates to be obtained. This overcomes the limitations of each individual effect and yields a synergistic PL increase (+1320%) higher than the sum of the PL enhancements determined by each effect alone (+70% and +360%).

ACS Style

Victor Krivenkov; Pavel Samokhvalov; Igor Nabiev; Yury Rakovich. Synergy of Excitation Enhancement and the Purcell Effect for Strong Photoluminescence Enhancement in a Thin-Film Hybrid Structure based on Quantum Dots and Plasmon Nanoparticles. The Journal of Physical Chemistry Letters 2020, 11, 1 .

AMA Style

Victor Krivenkov, Pavel Samokhvalov, Igor Nabiev, Yury Rakovich. Synergy of Excitation Enhancement and the Purcell Effect for Strong Photoluminescence Enhancement in a Thin-Film Hybrid Structure based on Quantum Dots and Plasmon Nanoparticles. The Journal of Physical Chemistry Letters. 2020; 11 (19):1.

Chicago/Turabian Style

Victor Krivenkov; Pavel Samokhvalov; Igor Nabiev; Yury Rakovich. 2020. "Synergy of Excitation Enhancement and the Purcell Effect for Strong Photoluminescence Enhancement in a Thin-Film Hybrid Structure based on Quantum Dots and Plasmon Nanoparticles." The Journal of Physical Chemistry Letters 11, no. 19: 1.

Journal article
Published: 15 July 2020 in Optics Express
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Controlling spontaneous emission by modifying the local electromagnetic environment is of great interest for applications in optoelectronics, biosensing and energy harvesting. Although the development of devices based on one-dimensional porous silicon photonic crystals with embedded luminophores is a promising approach for applications, the efficiency of the embedded luminophores remains a key challenge because of the strong quenching of the emission due to the contact of the luminophores with the surface of porous silicon preventing the observation of interesting light–matter coupling effects. Here, we experimentally demonstrate an increase in the quantum dot (QD) spontaneous emission rate inside a porous silicon microcavity and almost an order of magnitude enhancement of QD photoluminescence intensity in the weak light–matter coupling regime. Furthermore, we have demonstrated drastic alteration of the QD spontaneous emission at the edge of the photonic band gap in porous silicon distributed Bragg reflectors and proved its dependence on the change in the density of photonic states.

ACS Style

Dmitriy Dovzhenko; Igor Martynov; Pavel Samokhvalov; Evgeniy Osipov; Maxim Lednev; Alexander Chistyakov; Alexander Karaulov; Igor Nabiev. Enhancement of spontaneous emission of semiconductor quantum dots inside one-dimensional porous silicon photonic crystals. Optics Express 2020, 28, 22705 -22717.

AMA Style

Dmitriy Dovzhenko, Igor Martynov, Pavel Samokhvalov, Evgeniy Osipov, Maxim Lednev, Alexander Chistyakov, Alexander Karaulov, Igor Nabiev. Enhancement of spontaneous emission of semiconductor quantum dots inside one-dimensional porous silicon photonic crystals. Optics Express. 2020; 28 (15):22705-22717.

Chicago/Turabian Style

Dmitriy Dovzhenko; Igor Martynov; Pavel Samokhvalov; Evgeniy Osipov; Maxim Lednev; Alexander Chistyakov; Alexander Karaulov; Igor Nabiev. 2020. "Enhancement of spontaneous emission of semiconductor quantum dots inside one-dimensional porous silicon photonic crystals." Optics Express 28, no. 15: 22705-22717.

Research article
Published: 14 July 2020 in ACS Applied Materials & Interfaces
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The layer-by-layer (LbL) deposition approach allows combined incorporation of fluorescent, magnetic, and plasmonic nanoparticles into the shell of polyelectrolyte microcapsules to obtain stimulus-responsive systems whose imaging and drug release functions can be triggered by external stimuli. The combined use of fluorescent quantum dots (QDs) and magnetic nanoparticles (MNPs) yields magnetic-field-driven imaging tools that can be tracked and imaged even deep in tissue when the appropriate type of QDs and wavelength of their excitation are used. QDs are excellent photonic labels for microcapsule encoding due to their close-to-unity photoluminescence (PL) quantum yields, narrow PL emission bands, and tremendous one- and two-photon extinction coefficients. However, the presence of MNPs and electrically charged polyelectrolyte molecules used for the LbL fabrication of magneto-optical microcapsules provokes alterations of the QD optical properties because of the photoinduced charge and energy transfer resulting in QD photodarkening or photobrightening. These lead to variation of the microcapsule PL signal under illumination, which hampers their tracking and quantitative analysis in cells and tissues. Here, we have studied the effects of the structure and spatial arrangement of the nanoparticles within the microcapsule polyelectrolyte shell, the total shell thickness, and the shell surface charge on their PL properties under continuous illumination. The roles of the charge transfer and its main driving forces in the stability of the microcapsules PL signal have been established, and the design of the microcapsules dually encoded with QDs and MNPs providing the strongest and most stable PL has been determined. Controlling the energy transfer from the QDs and MNPs and the charge transfer from QDs to polyelectrolyte layers in the engineering of magneto-optical microcapsules with a bright and stable PL signal extends their applications to long-lasting quantitative fluorescence imaging.

ACS Style

Galina Nifontova; Victor Krivenkov; Maria Zvaigzne; Pavel S. Samokhvalov; Anton E. Efimov; Olga I. Agapova; Igor I. Agapov; Evgeny Korostylev; Sergei Zarubin; Alexander Karaulov; Igor R. Nabiev; Alyona Sukhanova. Controlling Charge Transfer from Quantum Dots to Polyelectrolyte Layers Extends Prospective Applications of Magneto-Optical Microcapsules. ACS Applied Materials & Interfaces 2020, 12, 35882 -35894.

AMA Style

Galina Nifontova, Victor Krivenkov, Maria Zvaigzne, Pavel S. Samokhvalov, Anton E. Efimov, Olga I. Agapova, Igor I. Agapov, Evgeny Korostylev, Sergei Zarubin, Alexander Karaulov, Igor R. Nabiev, Alyona Sukhanova. Controlling Charge Transfer from Quantum Dots to Polyelectrolyte Layers Extends Prospective Applications of Magneto-Optical Microcapsules. ACS Applied Materials & Interfaces. 2020; 12 (32):35882-35894.

Chicago/Turabian Style

Galina Nifontova; Victor Krivenkov; Maria Zvaigzne; Pavel S. Samokhvalov; Anton E. Efimov; Olga I. Agapova; Igor I. Agapov; Evgeny Korostylev; Sergei Zarubin; Alexander Karaulov; Igor R. Nabiev; Alyona Sukhanova. 2020. "Controlling Charge Transfer from Quantum Dots to Polyelectrolyte Layers Extends Prospective Applications of Magneto-Optical Microcapsules." ACS Applied Materials & Interfaces 12, no. 32: 35882-35894.

Original paper
Published: 09 July 2020 in Annalen der Physik
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Efficient biexciton (BX) photoluminescence (PL) from quantum dots (QDs) paves the way to the generation of entangled photons and related applications. However, the quantum yield (QY) of BX PL is much lower than that for single excitons (EX) due to efficient Auger‐like recombination. In the vicinity of plasmon nanoparticles, the recombination rates of EX and BX may be affected by the Purcell effect, fluorescence quenching, and the excitation rate enhancement. Here, the effect of the plasmon resonance spectral position on the EX and BX PL is experimentally studied in two cases: when the plasmon band overlaps with the excitation wavelength and when it coincides with the QDs PL band. In the first case, the EX and BX excitation efficiencies are significantly increased but the EX QY reduced. As a result, the BX‐to‐EX QY ratio is higher than 1 at plasmon–exciton systems separations shorter than 40 nm. In the second case, the radiative recombination rates are enhanced by several orders of magnitude, which led to an increase in BX QY over distances of up to 90 nm. Finally, these two effects are obtained in the same hybrid structure, with the resultant increase in both excitation efficiency and QY of BX PL.

ACS Style

Victor Krivenkov; Daria Dyagileva; Pavel Samokhvalov; Igor Nabiev; Yury Rakovich. Effect of Spectral Overlap and Separation Distance on Exciton and Biexciton Quantum Yields and Radiative and Nonradiative Recombination Rates in Quantum Dots Near Plasmon Nanoparticles. Annalen der Physik 2020, 532, 1 .

AMA Style

Victor Krivenkov, Daria Dyagileva, Pavel Samokhvalov, Igor Nabiev, Yury Rakovich. Effect of Spectral Overlap and Separation Distance on Exciton and Biexciton Quantum Yields and Radiative and Nonradiative Recombination Rates in Quantum Dots Near Plasmon Nanoparticles. Annalen der Physik. 2020; 532 (8):1.

Chicago/Turabian Style

Victor Krivenkov; Daria Dyagileva; Pavel Samokhvalov; Igor Nabiev; Yury Rakovich. 2020. "Effect of Spectral Overlap and Separation Distance on Exciton and Biexciton Quantum Yields and Radiative and Nonradiative Recombination Rates in Quantum Dots Near Plasmon Nanoparticles." Annalen der Physik 532, no. 8: 1.

Journal article
Published: 04 May 2020 in Scientific Reports
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Colloidal quantum dots and other semiconductor nanocrystals are essential components of next-generation lighting and display devices. Due to their easily tunable and narrow emission band and near-unity fluorescence quantum yield, they allow cost-efficient fabrication of bright, pure-color and wide-gamut light emitting diodes (LEDs) and displays. A critical improvement in the quantum dot LED (QLED) technology was achieved when zinc oxide nanoparticles (NPs) were first introduced as an electron transport layer (ETL) material, which tremendously enhanced the device brightness and current efficiency due to the high mobility of electrons in ZnO and favorable alignment of its energy bands. During the next decade, the strategy of ZnO NP doping allowed the fabrication of QLEDs with a brightness of about 200 000 cd/m2 and current efficiency over 60 cd/A. On the other hand, the known ZnO doping approaches rely on a very fine tuning of the energy levels of the ZnO NP conduction band minimum; hence, selection of the appropriate dopant that would ensure the best device characteristics is often ambiguous. Here we address this problem via detailed comparison of QLEDs whose ETLs are formed by a set of ZnO NPs doped with Al, Ga, Mg, or Li. Although magnesium-doped ZnO NPs are the most common ETL material used in recently designed QLEDs, our experiments have shown that their aluminum-doped counterparts ensure better device performance in terms of brightness, current efficiency and turn-on voltage. These findings allow us to suggest ZnO NPs doped with Al as the best ETL material to be used in future QLEDs.

ACS Style

Alexei Alexandrov; Mariya Zvaigzne; Dmitri Lypenko; Igor Nabiev; Pavel Samokhvalov. Al-, Ga-, Mg-, or Li-doped zinc oxide nanoparticles as electron transport layers for quantum dot light-emitting diodes. Scientific Reports 2020, 10, 1 -11.

AMA Style

Alexei Alexandrov, Mariya Zvaigzne, Dmitri Lypenko, Igor Nabiev, Pavel Samokhvalov. Al-, Ga-, Mg-, or Li-doped zinc oxide nanoparticles as electron transport layers for quantum dot light-emitting diodes. Scientific Reports. 2020; 10 (1):1-11.

Chicago/Turabian Style

Alexei Alexandrov; Mariya Zvaigzne; Dmitri Lypenko; Igor Nabiev; Pavel Samokhvalov. 2020. "Al-, Ga-, Mg-, or Li-doped zinc oxide nanoparticles as electron transport layers for quantum dot light-emitting diodes." Scientific Reports 10, no. 1: 1-11.

Protocol
Published: 04 April 2020 in Cardiovascular Development
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A quantum dot (QD)-based lab-on-bead system is a unique tool for multiple analysis of cancer markers in human serum samples by using a flow cytometer. In terms of specificity and sensitivity, this method is comparable with ELISA, the “gold standard” of serological in-clinic detection of single analytes. Fluorescent microspheres encoded with QDs have been used for the quantitative detection of free and total prostate-specific antigen in human serum samples. Developed multiplex assay demonstrates a clear discrimination between serum samples from control subjects and cancer patients. The proposed QD-based method is adaptable and makes it possible to develop numerous clinical tests with decreased duration and cost for early diagnosis of various diseases.

ACS Style

Tatiana Tsoy; Alexander Karaulov; Igor Nabiev; Alyona Sukhanova. Multiplexed Detection of Cancer Serum Antigens with a Quantum Dot-Based Lab-on-Bead System. Cardiovascular Development 2020, 2135, 225 -236.

AMA Style

Tatiana Tsoy, Alexander Karaulov, Igor Nabiev, Alyona Sukhanova. Multiplexed Detection of Cancer Serum Antigens with a Quantum Dot-Based Lab-on-Bead System. Cardiovascular Development. 2020; 2135 ():225-236.

Chicago/Turabian Style

Tatiana Tsoy; Alexander Karaulov; Igor Nabiev; Alyona Sukhanova. 2020. "Multiplexed Detection of Cancer Serum Antigens with a Quantum Dot-Based Lab-on-Bead System." Cardiovascular Development 2135, no. : 225-236.

Protocol
Published: 04 April 2020 in Cardiovascular Development
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Fluorescent semiconductor nanocrystals, known as quantum dots (QDs), and magnetic nanoparticles (MNPs) are extensively studied perspective tools for optical (fluorescence) and magnetic resonance imaging techniques. The unique optical properties, high photostability, and bright luminescence of QDs make them more promising fluorophores than the classical organic dyes. Encoding polyelectrolyte microcapsules with QDs and MNPs ensures their sensitivity to both photoexcitation and magnetic field. This chapter presents the protocol for obtaining a stimulus-sensitive delivery system based on QD- and MNP-encoded polyelectrolyte microcapsules by means of layer-by-layer self-assembly. The resultant fluorescent magnetic polyelectrolyte microcapsules are 3.4–5.5 μm in size, have a hollow structure, and are brightly fluorescent to be detected with the standard imaging equipment. Polyelectrolyte microcapsule surface bears functional groups for subsequent functionalization with vector capture molecules. The polyelectrolyte microcapsules containing combination of QDs and MNPs are advanced visualization tools, since they can be sorted in a magnetic field and at the same time are suitable for fluorescent imaging what can be applied within a wide range of diagnostic and therapeutic protocols.

ACS Style

Galina Nifontova; Fernanda Ramos-Gomes; Frauke Alves; Igor Nabiev; Alyona Sukhanova. Stimulus-Sensitive Theranostic Delivery Systems Based on Microcapsules Encoded with Quantum Dots and Magnetic Nanoparticles. Cardiovascular Development 2020, 2135, 199 -212.

AMA Style

Galina Nifontova, Fernanda Ramos-Gomes, Frauke Alves, Igor Nabiev, Alyona Sukhanova. Stimulus-Sensitive Theranostic Delivery Systems Based on Microcapsules Encoded with Quantum Dots and Magnetic Nanoparticles. Cardiovascular Development. 2020; 2135 ():199-212.

Chicago/Turabian Style

Galina Nifontova; Fernanda Ramos-Gomes; Frauke Alves; Igor Nabiev; Alyona Sukhanova. 2020. "Stimulus-Sensitive Theranostic Delivery Systems Based on Microcapsules Encoded with Quantum Dots and Magnetic Nanoparticles." Cardiovascular Development 2135, no. : 199-212.

Research article
Published: 12 February 2020 in ACS Photonics
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Conventional approaches to the determination of the two-photon absorption cross-section (TPACS) of fluorescent semiconductor nanocrystals, including quantum dots (QDs) and nanoplatelets (NPLs), cannot be applied to samples with unknown concentrations and low optical densities and may be inaccurate in the case of multi-exciton nanocrystal excitation. Here, we have studied the two-photon-excited photoluminescence saturation in QD and NPL samples and propose a novel technique for determining of their TPACS from the parameters of this process. The technique allows the measurement of the TPACSs of single exciton states in the samples of unknown concentration, as well as in thin films with ultralow optical densities. The calculated values agreed with the results obtained by conventional methods. The new technique paves new ways to studying small amounts of fluorescence nanocrystals of unknown quantity under two-photon excitation.

ACS Style

Victor Krivenkov; Pavel S. Samokhvalov; Daria Dyagileva; Alexander Karaulov; Igor R. Nabiev. Determination of the Single-Exciton Two-Photon Absorption Cross Sections of Semiconductor Nanocrystals through the Measurement of Saturation of Their Two-Photon-Excited Photoluminescence. ACS Photonics 2020, 7, 831 -836.

AMA Style

Victor Krivenkov, Pavel S. Samokhvalov, Daria Dyagileva, Alexander Karaulov, Igor R. Nabiev. Determination of the Single-Exciton Two-Photon Absorption Cross Sections of Semiconductor Nanocrystals through the Measurement of Saturation of Their Two-Photon-Excited Photoluminescence. ACS Photonics. 2020; 7 (3):831-836.

Chicago/Turabian Style

Victor Krivenkov; Pavel S. Samokhvalov; Daria Dyagileva; Alexander Karaulov; Igor R. Nabiev. 2020. "Determination of the Single-Exciton Two-Photon Absorption Cross Sections of Semiconductor Nanocrystals through the Measurement of Saturation of Their Two-Photon-Excited Photoluminescence." ACS Photonics 7, no. 3: 831-836.

Journal article
Published: 20 January 2020 in Scientific Reports
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Semiconductor quantum dots (QDs) embedded into polymer microbeads are known to be very attractive emitters for spectral multiplexing and colour encoding. Their luminescence lifetimes or decay kinetics have been, however, rarely exploited as encoding parameter, although they cover time ranges which are not easily accessible with other luminophores. We demonstrate here the potential of QDs made from II/VI semiconductors with luminescence lifetimes of several 10 ns to expand the lifetime range of organic encoding luminophores in multiplexing applications using time-resolved flow cytometry (LT-FCM). For this purpose, two different types of QD-loaded beads were prepared and characterized by photoluminescence measurements on the ensemble level and by single-particle confocal laser scanning microscopy. Subsequently, these lifetime-encoded microbeads were combined with dye-encoded microparticles in systematic studies to demonstrate the potential of these QDs to increase the number of lifetime codes for lifetime multiplexing and combined multiplexing in the time and colour domain (tempo-spectral multiplexing). These studies were done with a recently developed novel luminescence lifetime flow cytometer (LT-FCM setup) operating in the time-domain, that presents an alternative to reports on phase-sensitive lifetime detection in flow cytometry.

ACS Style

Daniel Kage; Katrin Hoffmann; Galina Nifontova; Victor Krivenkov; Alyona Sukhanova; Igor Nabiev; Ute Resch-Genger. Tempo-spectral multiplexing in flow cytometry with lifetime detection using QD-encoded polymer beads. Scientific Reports 2020, 10, 1 -11.

AMA Style

Daniel Kage, Katrin Hoffmann, Galina Nifontova, Victor Krivenkov, Alyona Sukhanova, Igor Nabiev, Ute Resch-Genger. Tempo-spectral multiplexing in flow cytometry with lifetime detection using QD-encoded polymer beads. Scientific Reports. 2020; 10 (1):1-11.

Chicago/Turabian Style

Daniel Kage; Katrin Hoffmann; Galina Nifontova; Victor Krivenkov; Alyona Sukhanova; Igor Nabiev; Ute Resch-Genger. 2020. "Tempo-spectral multiplexing in flow cytometry with lifetime detection using QD-encoded polymer beads." Scientific Reports 10, no. 1: 1-11.

Journal article
Published: 08 November 2019 in Photonics
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Fluorescent semiconductor nanocrystals or quantum dots (QDs) are characterized by unique optical properties, including a high photostability, wide absorption spectrum, and narrow, symmetric fluorescence spectrum. This makes them attractive fluorescent nanolabels for the optical encoding of microcarriers intended for targeted drug delivery, diagnosis, and imaging of transport processes on the body, cellular, and subcellular levels. Incorporation of QDs into carriers in the form of polyelectrolyte microcapsules through layer-by-layer adsorption of oppositely charged polyelectrolyte polymers yields microcapsules with a bright fluorescence signal and adaptable size, structure, and surface characteristics without using organic solvents. The easily modifiable surface of the microcapsules allows for its subsequent functionalization with capture molecules, such as antibodies, which ensures specific and selective interaction with cells, including tumor cells, with the use of the bioconjugation technique developed here. We obtained stable water-soluble nanolabels based on QDs whose surface was modified with polyethylene glycol (PEG) derivatives and determined their colloidal and optical characteristics. The obtained nanocrystals were used to encode polyelectrolyte microcapsules optically. The microcapsule surface was modified with humanized monoclonal antibodies (Abs) recognizing a cancer marker, epidermal growth factor receptor (EGFR). The possibility of effective, specific, and selective delivery of the microcapsules to tumor cells expressing EGFR has been demonstrated. The results show that the QD-encoded polyelectrolyte microcapsules functionalized with monoclonal Abs against EGFR can be used for targeted imaging and diagnosis.

ACS Style

Galina Nifontova; Daria Kalenichenko; Maria Baryshnikova; Fernanda Ramos Gomes; Frauke Alves; Alexander Karaulov; Igor Nabiev; Alyona Sukhanova. Biofunctionalized Polyelectrolyte Microcapsules Encoded with Fluorescent Semiconductor Nanocrystals for Highly Specific Targeting and Imaging of Cancer Cells. Photonics 2019, 6, 117 .

AMA Style

Galina Nifontova, Daria Kalenichenko, Maria Baryshnikova, Fernanda Ramos Gomes, Frauke Alves, Alexander Karaulov, Igor Nabiev, Alyona Sukhanova. Biofunctionalized Polyelectrolyte Microcapsules Encoded with Fluorescent Semiconductor Nanocrystals for Highly Specific Targeting and Imaging of Cancer Cells. Photonics. 2019; 6 (4):117.

Chicago/Turabian Style

Galina Nifontova; Daria Kalenichenko; Maria Baryshnikova; Fernanda Ramos Gomes; Frauke Alves; Alexander Karaulov; Igor Nabiev; Alyona Sukhanova. 2019. "Biofunctionalized Polyelectrolyte Microcapsules Encoded with Fluorescent Semiconductor Nanocrystals for Highly Specific Targeting and Imaging of Cancer Cells." Photonics 6, no. 4: 117.