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Prof. Alexander Karaulov
Sechenov First Moscow State Medical University

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0 antigen presenting cells
0 immumotherapy
0 Immune Cell Therapy
0 Antibody response to infection
0 Immunology & immunopathogenesis

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Journal article
Published: 24 August 2021 in Nanomaterials
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Designing nanoprobes in which quantum dots (QDs) are used as photoluminescent labels is an especially promising line of research due to their possible medical applications ranging from disease diagnosis to drug delivery. In spite of the significant progress made in designing such nanoprobes, the properties of their individual components, i.e., photoluminescent QDs, vectorization moieties, and pharmacological agents, still require further optimization to enhance the efficiency of diagnostic or therapeutic procedures. Here, we have developed a method of engineering compact multifunctional nanoprobes based on functional components with optimized properties: bright photoluminescence of CdSe/ZnS (core/shell) QDs, a compact and effective antitumor agent (an acridine derivative), and direct conjugation of the components via electrostatic interaction, which provides a final hydrodynamic diameter of nanoprobes smaller than 15 nm. Due to the possibility of conjugating various biomolecules with hydroxyl and carboxyl moieties to QDs, the method represents a versatile approach to the biomarker-recognizing molecule imaging of the delivery of the active substance as part of compact nanoprobes.

ACS Style

Pavel Linkov; Pavel Samokhvalov; Maria Baryshnikova; Marie Laronze-Cochard; Janos Sapi; Alexander Karaulov; Igor Nabiev. Conjugates of Ultrasmall Quantum Dots and Acridine Derivatives as Prospective Nanoprobes for Intracellular Investigations. Nanomaterials 2021, 11, 2160 .

AMA Style

Pavel Linkov, Pavel Samokhvalov, Maria Baryshnikova, Marie Laronze-Cochard, Janos Sapi, Alexander Karaulov, Igor Nabiev. Conjugates of Ultrasmall Quantum Dots and Acridine Derivatives as Prospective Nanoprobes for Intracellular Investigations. Nanomaterials. 2021; 11 (9):2160.

Chicago/Turabian Style

Pavel Linkov; Pavel Samokhvalov; Maria Baryshnikova; Marie Laronze-Cochard; Janos Sapi; Alexander Karaulov; Igor Nabiev. 2021. "Conjugates of Ultrasmall Quantum Dots and Acridine Derivatives as Prospective Nanoprobes for Intracellular Investigations." Nanomaterials 11, no. 9: 2160.

Journal article
Published: 16 July 2021 in Russian Clinical Laboratory Diagnostics
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The investigation aims - a quantitative assessment of cervical surface changes with digital analysis and computer technologies in dysplasia. Colposcopy was made in 90 women from 21 to 52 years (avr. age 33,9±8,13 y.o.) with mild epithelial dysplasia (CIN1), moderate dysplasia (CIN2), severe dysplasia (CIN3). The algorithm detected indicators which provide the cervical dysplasia classification on pre cytological and pre molecular-genetic patients investigations. The outcome of an algorithm was the identification of the cervix surface condition severity by an objective quantification. The cervical dysplasia type (CIN) was classified as IndGV values. The mild dysplasia (CIN1) had IndGV=8,5, moderate dysplasia (CIN2) - IndGV=13, severe dysplasia (CIN3) - IndGV=15,6. The cervical affected surface area (IndInt) equalled 0,17 in CIN1, 0,19 in CIN2, 0,22 in CIN3. A change severity has a direct relation with a grey color value. It demonstrates quantify classification in digital analysis. The algorithm is used in real-time mode and no requires considerable material outlays. This makes it possible to use an algorithm after clinical examination and predict patient management.

ACS Style

A. D. Dushkin; M. S. Afanasiev; A. M. Zatevalov; V. A. Aleshkin; A. Yu. Mironov; Yu. V. Nesvizhsky; O. Y. Borisova; T. G. Grishacheva; A. V. Karaulov. Digital analysis and quantitative assessment of the cervical surface with dysplasia. Russian Clinical Laboratory Diagnostics 2021, 66, 1 .

AMA Style

A. D. Dushkin, M. S. Afanasiev, A. M. Zatevalov, V. A. Aleshkin, A. Yu. Mironov, Yu. V. Nesvizhsky, O. Y. Borisova, T. G. Grishacheva, A. V. Karaulov. Digital analysis and quantitative assessment of the cervical surface with dysplasia. Russian Clinical Laboratory Diagnostics. 2021; 66 (7):1.

Chicago/Turabian Style

A. D. Dushkin; M. S. Afanasiev; A. M. Zatevalov; V. A. Aleshkin; A. Yu. Mironov; Yu. V. Nesvizhsky; O. Y. Borisova; T. G. Grishacheva; A. V. Karaulov. 2021. "Digital analysis and quantitative assessment of the cervical surface with dysplasia." Russian Clinical Laboratory Diagnostics 66, no. 7: 1.

Review
Published: 30 June 2021 in International Journal of Molecular Sciences
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Eosinophils are specialized white blood cells, which are involved in the pathology of diverse allergic and nonallergic inflammatory diseases. Eosinophils are traditionally known as cytotoxic effector cells but have been suggested to additionally play a role in immunomodulation and maintenance of homeostasis. The exact role of these granule-containing leukocytes in health and diseases is still a matter of debate. Degranulation is one of the key effector functions of eosinophils in response to diverse stimuli. The different degranulation patterns occurring in eosinophils (piecemeal degranulation, exocytosis and cytolysis) have been extensively studied in the last few years. However, the exact mechanism of the diverse degranulation types remains unknown and is still under investigation. In this review, we focus on recent findings and highlight the diversity of stimulation and methods used to evaluate eosinophil degranulation.

ACS Style

Timothée Fettrelet; Lea Gigon; Alexander Karaulov; Shida Yousefi; Hans-Uwe Simon. The Enigma of Eosinophil Degranulation. International Journal of Molecular Sciences 2021, 22, 7091 .

AMA Style

Timothée Fettrelet, Lea Gigon, Alexander Karaulov, Shida Yousefi, Hans-Uwe Simon. The Enigma of Eosinophil Degranulation. International Journal of Molecular Sciences. 2021; 22 (13):7091.

Chicago/Turabian Style

Timothée Fettrelet; Lea Gigon; Alexander Karaulov; Shida Yousefi; Hans-Uwe Simon. 2021. "The Enigma of Eosinophil Degranulation." International Journal of Molecular Sciences 22, no. 13: 7091.

Journal article
Published: 01 June 2021 in International Archives of Allergy and Immunology
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Introduction: Modulating specific biological effects through the changes in cytokine receptors’ expression level remains poorly understood. This study aimed to investigate the influence of the dose-dependent effect of TNF on the balance between proapoptotic and proliferation response depending on the parameters of TNFR1/2 expression density. Methods: Tumor cell lines (HEp-2, K-562, MCF-7, ZR-75/1, MOLT-4, IM-9, and Raji) were characterized for TNFR1/2 co-expression using flow cytometry and were studied to reveal the dose-dependent effect of rhTNF on cell cycle and apoptosis parameters. The associations among the studied parameters were estimated by correlation and regression analysis. Results: It was found for ZR-75/1 cells (the cell line characterized by high expression of both types) that a dose-dependent increase in expression of both types of TNF-α receptors on cells reduces the proliferative activity of cells. For MOLT-4 cells (which are characterized by lower expression), an increase in proliferative response of cells was positively associated with the percentage of both TNFR1+ and TNFR2+ cells. However, opposite effects on the cells were shown for the K-562 and MCF-7 lines having a similar expression profile. A similarity (a large percentage of double-positive cells) was revealed for the lines having similar effects (K-562 and ZR-75/1). Conclusions: High expression of TNF receptor type 1 is not always associated with predominant activation of proapoptotic pathways. However, in the case of simultaneous high expression of both types of receptors, the proportion of double-positive cells is crucial for the activation of either the proapoptotic or proliferation pathways.

ACS Style

Alina Alshevskaya; Olga Koneva; Irina Belomestnova; Julia Lopatnikova; Irina Evsegneeva; Julia Zhukova; Fedor Kireev; Aleksander Karaulov; Sergey Sennikov. Ligand-Regulated Expression of TNF Receptors 1 and 2 Determines Receptor-Mediated Functional Responses. International Archives of Allergy and Immunology 2021, 1 -12.

AMA Style

Alina Alshevskaya, Olga Koneva, Irina Belomestnova, Julia Lopatnikova, Irina Evsegneeva, Julia Zhukova, Fedor Kireev, Aleksander Karaulov, Sergey Sennikov. Ligand-Regulated Expression of TNF Receptors 1 and 2 Determines Receptor-Mediated Functional Responses. International Archives of Allergy and Immunology. 2021; ():1-12.

Chicago/Turabian Style

Alina Alshevskaya; Olga Koneva; Irina Belomestnova; Julia Lopatnikova; Irina Evsegneeva; Julia Zhukova; Fedor Kireev; Aleksander Karaulov; Sergey Sennikov. 2021. "Ligand-Regulated Expression of TNF Receptors 1 and 2 Determines Receptor-Mediated Functional Responses." International Archives of Allergy and Immunology , no. : 1-12.

Case report
Published: 22 March 2021 in Case Reports in Oncology
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Cervical cancer is an important problem in women’s health and a worldwide oncological disease. In 2018, the WHO registered 569,847 new cases in the world, and 3.4% were in the Russian Federation. We describe here a case of invasive cervical cancer stage IB2 associated with human papilloma virus in a woman who was treated by multicourse photodynamic therapy (PDT). A 38-year-old woman presented with abdominal pain and genital tract spotting in October 2015. Colposcopy revealed a neoplasm in cauliflower form. PAP smear result was cancer in situ (Tis). The biopsy result from the cervical canal and neoplasm was invasive squamous cell carcinoma. The patient underwent full preoperative examination (blood test, biochemical blood test, coagulation test, urinalysis, X-ray of chest organs, ECG, ultrasound investigation of pelvic organs, and PAP smear). Magnetic resonance imaging investigation showed a heterogeneous tumor, uneven contours, and intensity accumulating contrast. The patient was not pregnant, and a fertility-preserving treatment method was used. Three PDT sessions allowed to avoid vaginal radical trachelectomy. Pregnancy occurred 3 years and 8 months after the first PDT session. The patient had testing after treatment 4 times (3rd, 12th, 24th, and 60th months). She had a pregnancy without complications and had operative delivery by Cesarean section in April 2020. There was a 5-year remission period without episodes of relapse. The patient has an 8-month-old baby.

ACS Style

Maxim Afanasiev; Alexander Dushkin; Tatyana Grishacheva; Stanislav Afanasiev; Yuri Nesvizhsky; Alexander V. Karaulov; Andrey Pylev. The Multi-Course Approach of Photodynamic Therapy to Treat Invasive Cervical Cancer IB2: A Case Report. Case Reports in Oncology 2021, 14, 506 -519.

AMA Style

Maxim Afanasiev, Alexander Dushkin, Tatyana Grishacheva, Stanislav Afanasiev, Yuri Nesvizhsky, Alexander V. Karaulov, Andrey Pylev. The Multi-Course Approach of Photodynamic Therapy to Treat Invasive Cervical Cancer IB2: A Case Report. Case Reports in Oncology. 2021; 14 (1):506-519.

Chicago/Turabian Style

Maxim Afanasiev; Alexander Dushkin; Tatyana Grishacheva; Stanislav Afanasiev; Yuri Nesvizhsky; Alexander V. Karaulov; Andrey Pylev. 2021. "The Multi-Course Approach of Photodynamic Therapy to Treat Invasive Cervical Cancer IB2: A Case Report." Case Reports in Oncology 14, no. 1: 506-519.

Journal article
Published: 03 February 2021 in Cells
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Eosinophils are a subset of granulocytes characterized by a high abundance of specific granules in their cytoplasm. To act as effector cells, eosinophils degranulate and form eosinophil extracellular traps (EETs), which contain double-stranded DNA (dsDNA) co-localized with granule proteins. The exact molecular mechanism of EET formation remains unknown. Although the term “EET release” has been used in scientific reports, it is unclear whether EETs are pre-formed in eosinophils and subsequently released. Moreover, although eosinophil degranulation has been extensively studied, a precise time-course of granule protein release has not been reported until now. In this study, we investigated the time-dependent release of eosinophil peroxidase (EPX) and mitochondrial DNA (mtDNA) following activation of both human and mouse eosinophils. Unexpectedly, maximal degranulation was already observed within 1 min with no further change upon complement factor 5 (C5a) stimulation of interleukin-5 (IL-5) or granulocyte/macrophage colony-stimulating factor (GM-CSF)-primed eosinophils. In contrast, bulk mtDNA release in the same eosinophil populations occurred much slower and reached maximal levels between 30 and 60 min. Although no single-cell analyses have been performed, these data suggest that the molecular pathways leading to degranulation and mtDNA release are at least partially different. Moreover, based on these data, it is likely that the association between the mtDNA scaffold and granule proteins in the process of EET formation occurs in the extracellular space.

ACS Style

Nina Germic; Timothée Fettrelet; Darko Stojkov; Aref Hosseini; Michael Horn; Alexander Karaulov; Dagmar Simon; Shida Yousefi; Hans-Uwe Simon. The Release Kinetics of Eosinophil Peroxidase and Mitochondrial DNA Is Different in Association with Eosinophil Extracellular Trap Formation. Cells 2021, 10, 306 .

AMA Style

Nina Germic, Timothée Fettrelet, Darko Stojkov, Aref Hosseini, Michael Horn, Alexander Karaulov, Dagmar Simon, Shida Yousefi, Hans-Uwe Simon. The Release Kinetics of Eosinophil Peroxidase and Mitochondrial DNA Is Different in Association with Eosinophil Extracellular Trap Formation. Cells. 2021; 10 (2):306.

Chicago/Turabian Style

Nina Germic; Timothée Fettrelet; Darko Stojkov; Aref Hosseini; Michael Horn; Alexander Karaulov; Dagmar Simon; Shida Yousefi; Hans-Uwe Simon. 2021. "The Release Kinetics of Eosinophil Peroxidase and Mitochondrial DNA Is Different in Association with Eosinophil Extracellular Trap Formation." Cells 10, no. 2: 306.

Review
Published: 20 January 2021 in Viruses
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The paper covers the history of the discovery and description of phiKZ, the first known giant bacteriophage active on Pseudomonas aeruginosa. It also describes its unique features, especially the characteristic manner of DNA packing in the head around a cylinder-shaped structure (“inner body”), which probably governs an ordered and tight packaging of the phage genome. Important properties of phiKZ-like phages include a wide range of lytic activity and the blue opalescence of their negative colonies, and provide a background for the search and discovery of new P. aeruginosa giant phages. The importance of the phiKZ species and of other giant phage species in practical phage therapy is noted given their broad use in commercial phage preparations.

ACS Style

Victor Krylov; Maria Bourkaltseva; Elena Pleteneva; Olga Shaburova; Sergey Krylov; Alexander Karaulov; Sergey Zhavoronok; Oxana Svitich; Vitaly Zverev. Phage phiKZ—The First of Giants. Viruses 2021, 13, 149 .

AMA Style

Victor Krylov, Maria Bourkaltseva, Elena Pleteneva, Olga Shaburova, Sergey Krylov, Alexander Karaulov, Sergey Zhavoronok, Oxana Svitich, Vitaly Zverev. Phage phiKZ—The First of Giants. Viruses. 2021; 13 (2):149.

Chicago/Turabian Style

Victor Krylov; Maria Bourkaltseva; Elena Pleteneva; Olga Shaburova; Sergey Krylov; Alexander Karaulov; Sergey Zhavoronok; Oxana Svitich; Vitaly Zverev. 2021. "Phage phiKZ—The First of Giants." Viruses 13, no. 2: 149.

Journal article
Published: 10 January 2021 in Terapevticheskii arkhiv
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During a pandemic, nonspecific immunoprophylaxis of SARS-CoV-2 infection and other acute respiratory infections (ARI), which can worsen the course of COVID-19, is increasingly in demand in addition to specific immunization. BCG vaccine appears to be one of the candidate immunostimulants in this regard. At the same time, other microbe-derived preparations capable of inducing a state of trained immunity deserve attention. BCG and other bacterial immunostimulatory agents containing a large number of biologically active subunits have long been considered as objects of search for promising pharmacological substances. The review analyzes the linkages between BCG, mycobacterial adjuvants, bacterial lysates, trained immunity, muramylpeptides (MPs) and NOD2 receptors in light of the choice of a low molecular weight alternative to multicomponent bacterial immunostimulants for ARI prevention during the COVID-19 pandemic. The search for key molecules by which bacteria stimulate innate and adaptive immune responses proceeds in a spiral. On different loops of this spiral, MPs have repeatedly reproduced the nonspecific effects of multicomponent bacterial adjuvants, vaccines and immunostimulants. MPs and peptidoglycans containing MPs determine the adjuvant properties of the cell walls of mycobacteria and their peptide-glycolipid fraction (wax D). MPs were able to replace Mycobacterium tuberculosis in complete Freunds adjuvant. MPs determine the NOD2-dependent ability of BCG to induce trained immunity. Probably, MPs provide NOD2-mediated long-term prophylactic action of bacterial lysates. All of the above has prompted revisiting the previously obtained evidence of the efficacy of glucosaminylmuramyl dipeptide (GMDP) as a NOD2 agonist in treatment/prevention of respiratory infections. We speculate here that MPs, in particular GMDP, at rational dosing regimens will be able to reproduce many aspects of the nonspecific effects of BCG and multicomponent bacterial immunostimulants in preventing ARI during the COVID-19 pandemic and in the post-pandemic period.

ACS Style

Oleg V. Kalyuzhin; Tatiana M. Andronova; Alexander V. Karaulov. BCG, muramylpeptides, trained immunity (part II): a low molecular weight alternative to multicomponent bacterial immunostimulants for prevention of respiratory infections during a pandemic. Terapevticheskii arkhiv 2021, 93, 108 -113.

AMA Style

Oleg V. Kalyuzhin, Tatiana M. Andronova, Alexander V. Karaulov. BCG, muramylpeptides, trained immunity (part II): a low molecular weight alternative to multicomponent bacterial immunostimulants for prevention of respiratory infections during a pandemic. Terapevticheskii arkhiv. 2021; 93 (1):108-113.

Chicago/Turabian Style

Oleg V. Kalyuzhin; Tatiana M. Andronova; Alexander V. Karaulov. 2021. "BCG, muramylpeptides, trained immunity (part II): a low molecular weight alternative to multicomponent bacterial immunostimulants for prevention of respiratory infections during a pandemic." Terapevticheskii arkhiv 93, no. 1: 108-113.

Journal article
Published: 01 January 2021 in Allergy, Asthma & Immunology Research
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ACS Style

Antonina V. Karsonova; Ksenja A. Riabova; Musa R. Khaitov; Olga G. Elisyutina; Nataliya Ilina; Elena S. Fedenko; Daria S. Fomina; Evgeny Beltyukov; Natalya L. Bondarenko; Irina V. Evsegneeva; Polina A. Glazkova; Dmitry Yu. Semenov; Marianne van Hage; Hans Grönlund; Alexander V. Karaulov; Rudolf Valenta; Mirela Curin. Milk-Specific IgE Reactivity Without Symptoms in Albumin-Sensitized Cat Allergic Patients. Allergy, Asthma & Immunology Research 2021, 13, 668 -670.

AMA Style

Antonina V. Karsonova, Ksenja A. Riabova, Musa R. Khaitov, Olga G. Elisyutina, Nataliya Ilina, Elena S. Fedenko, Daria S. Fomina, Evgeny Beltyukov, Natalya L. Bondarenko, Irina V. Evsegneeva, Polina A. Glazkova, Dmitry Yu. Semenov, Marianne van Hage, Hans Grönlund, Alexander V. Karaulov, Rudolf Valenta, Mirela Curin. Milk-Specific IgE Reactivity Without Symptoms in Albumin-Sensitized Cat Allergic Patients. Allergy, Asthma & Immunology Research. 2021; 13 (4):668-670.

Chicago/Turabian Style

Antonina V. Karsonova; Ksenja A. Riabova; Musa R. Khaitov; Olga G. Elisyutina; Nataliya Ilina; Elena S. Fedenko; Daria S. Fomina; Evgeny Beltyukov; Natalya L. Bondarenko; Irina V. Evsegneeva; Polina A. Glazkova; Dmitry Yu. Semenov; Marianne van Hage; Hans Grönlund; Alexander V. Karaulov; Rudolf Valenta; Mirela Curin. 2021. "Milk-Specific IgE Reactivity Without Symptoms in Albumin-Sensitized Cat Allergic Patients." Allergy, Asthma & Immunology Research 13, no. 4: 668-670.

Journal article
Published: 15 December 2020 in Terapevticheskii arkhiv
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It has long been known that Bacillus CalmetteGurin (BCG) vaccine provides nonspecific protection against many non-mycobacterial infections, which has been discussed in the last decade through the prism of the concept of trained immunity. Within the framework of this concept, a persistent increase in resistance to various pathogens, which occurs after an infectious disease or exposure to certain microbial agents, is associated with epigenetic reprogramming of innate immune cells and their bone marrow progenitors. The COVID-19 pandemic has drawn attention of scientists and practitioners to BCG as an inducer of trained immunity. A number of epidemiological studies have suggested a negative association between the coverage of the population with BCG vaccination and the burden of SARS-CoV-2 infection. A series of independent clinical studies of the effectiveness of this vaccine in non-specific prevention of COVID-19 has been initiated in different countries. Recently, the key role of cytosolic NOD2 receptors in BCG-induced trained immunity has been proven. This actualizes the search for effective immunoactive preparations for prevention of respiratory infections in the pandemic among low molecular weight peptidoglycan fragments of the bacterial cell wall, muramylpeptides (MPs), which are known to be NOD2 agonists. The review highlights the proven and proposed linkages between BCG, MPs, NOD2 and trained immunity in the light of the COVID-19 pandemic. Analysis of the data presented indicates the prospects for preclinical and clinical studies of MPs as potential drugs for nonspecific prevention of SARS-CoV-2 infection and/or other respiratory infections in risk groups during the pandemic. First of all, attention should be paid to glucosaminylmuramyl dipeptide, approved for clinical use in Russia and a number of post-Soviet countries for the complex treatment and prevention of acute and recurrent respiratory infections.

ACS Style

O. V. Kalyuzhin; T. M. Andronova; A. V. Karaulov. BCG, muramylpeptides, trained immunity (part I): linkages in the light of the COVID-19 pandemic. Terapevticheskii arkhiv 2020, 92, 195 -200.

AMA Style

O. V. Kalyuzhin, T. M. Andronova, A. V. Karaulov. BCG, muramylpeptides, trained immunity (part I): linkages in the light of the COVID-19 pandemic. Terapevticheskii arkhiv. 2020; 92 (12):195-200.

Chicago/Turabian Style

O. V. Kalyuzhin; T. M. Andronova; A. V. Karaulov. 2020. "BCG, muramylpeptides, trained immunity (part I): linkages in the light of the COVID-19 pandemic." Terapevticheskii arkhiv 92, no. 12: 195-200.

Journal article
Published: 08 July 2020 in International Archives of Allergy and Immunology
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Background: Interrelation between thyrocytes and immunocytes has been established. However, the roles of mast cells and thyroid hormones in the triggering mechanism of thyroid autoimmune processes have been insufficiently investigated. This study evaluated the role of thyroid hormones and mast cells in the mechanisms of losing tolerance to thyroid autoantigens. Materials and Methods: Two groups of patients were studied: patients with Graves’ disease and patients with nodular euthyroid goiter. Wistar rats with induced exogenous hypothyroidism, thyrotoxicosis, and thyrotoxicosis in parallel with administration of interleukin-2 were used. The levels of hormones, autoantibodies, and cytokines in the serum and thyroid tissue were analyzed through the enzyme-linked immunosorbent assay. Morphological verification was performed through the immune-histochemical method with antibodies against tryptase and CD86. Transmission electron microscopy and laser confocal microscopy were used. Results: In both Graves’ disease and induced thyrotoxicosis, we detected a significant increase in the levels of interferon-γ, active interfollicular infiltration and degranulation of mast cells, and the intrathyroid overexpression of CD86. Complex analysis of the rat’s thyroid morphofunctional state and systemic and local levels of cytokines in induced thyrotoxicosis and hypothyroidism demonstrated an increase of intrathyroid degranulation of mast cells and a drastic disruption of IFNγ/IL10 balance. Conclusions: When exposed to excessive amounts of thyroid hormones, an inflammatory response is triggered in the thyroid gland, and mast cells overexpress costimulating CD86 in the thyroid. This finding confirms their possible involvement in auto­antigen presentation. Significant increase in the levels of interferon-γ shows a determining influence of cytokine on the progression of the pathological process.

ACS Style

Victoria Vladimirovna Zdor; Boris Izraelivich Geltser; Marina Gennadiyevna Eliseikina; Elena Vladimirovna Markelova; Yaakov Nikolayevich Tikhonov; Natalia Gennadiyevna Plekhova; Alexander V. Karaulov. Roles of Thyroid Hormones, Mast Cells, and Inflammatory Mediators in the Initiation and Progression of Autoimmune Thyroid Diseases. International Archives of Allergy and Immunology 2020, 181, 715 -726.

AMA Style

Victoria Vladimirovna Zdor, Boris Izraelivich Geltser, Marina Gennadiyevna Eliseikina, Elena Vladimirovna Markelova, Yaakov Nikolayevich Tikhonov, Natalia Gennadiyevna Plekhova, Alexander V. Karaulov. Roles of Thyroid Hormones, Mast Cells, and Inflammatory Mediators in the Initiation and Progression of Autoimmune Thyroid Diseases. International Archives of Allergy and Immunology. 2020; 181 (9):715-726.

Chicago/Turabian Style

Victoria Vladimirovna Zdor; Boris Izraelivich Geltser; Marina Gennadiyevna Eliseikina; Elena Vladimirovna Markelova; Yaakov Nikolayevich Tikhonov; Natalia Gennadiyevna Plekhova; Alexander V. Karaulov. 2020. "Roles of Thyroid Hormones, Mast Cells, and Inflammatory Mediators in the Initiation and Progression of Autoimmune Thyroid Diseases." International Archives of Allergy and Immunology 181, no. 9: 715-726.

Review
Published: 16 June 2020 in International Archives of Allergy and Immunology
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A vaccine to protect against COVID-19 is urgently needed. Such a vaccine should efficiently induce high-affinity neutralizing antibodies which neutralize SARS-CoV-2, the cause of COVID-19. However, there is a concern regarding both vaccine-induced eosinophilic lung disease and eosinophil-associated Th2 immunopotentiation following infection after vaccination. Here, we review the anticipated characteristics of a COVID-19 vaccine to avoid vaccine-associated eosinophil immunopathology.

ACS Style

Hans-Uwe Simon; Alexander V. Karaulov; Martin F. Bachmann. Strategies to Prevent SARS-CoV-2-Mediated Eosinophilic Disease in Association with COVID-19 Vaccination and Infection. International Archives of Allergy and Immunology 2020, 181, 624 -628.

AMA Style

Hans-Uwe Simon, Alexander V. Karaulov, Martin F. Bachmann. Strategies to Prevent SARS-CoV-2-Mediated Eosinophilic Disease in Association with COVID-19 Vaccination and Infection. International Archives of Allergy and Immunology. 2020; 181 (8):624-628.

Chicago/Turabian Style

Hans-Uwe Simon; Alexander V. Karaulov; Martin F. Bachmann. 2020. "Strategies to Prevent SARS-CoV-2-Mediated Eosinophilic Disease in Association with COVID-19 Vaccination and Infection." International Archives of Allergy and Immunology 181, no. 8: 624-628.

Other
Published: 12 June 2020
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Background Emerging evidence links morbidity and mortality of pandemic COVID-19 pneumonia to an inflammatory cytokine storm. Methods Eighty nine patients with COVID-19 pneumonia and heightened systemic inflammation (elevated serum C reactive protein and interleukin-6 levels) were treated with Tocilizumab (TCZ), a human monoclonal IgG1 antibody to the interleukin-6 receptor. Results Clinical and laboratory improvement was seen comparing baseline and 1-2 day post-infusion indices. Among 72 patients not receiving mechanical ventilation, NEWS2 scores fell from 5 to 2 (p < 0.001) C reactive protein levels fell from 95 to 14 mg/L (p < 0.001) and lymphocyte counts rose from 900 to 1000/uL (p = 0.036). Sixty three of 72 patients were discharged from hospital, one patient died, and 8 remained in hospital at time of writing. Among 17 patients receiving mechanical ventilation, despite a rapid decrease in CRP levels from 89 to 35 mg/L (p = 0.014) and early improvements in NEWS2 scores in 10 of 17, ten patients died and seven remain in hospital at time of writing. Overall, mortality was only seen in patients who had markedly elevated CRP levels (>30 mg/L) and low lymphocyte counts (< 1000/uL) before TCZ administration. Conclusions Inflammation and lymphocytopenia are linked to mortality in COVID-19. Inhibition of IL-6 activity by administration of Tocilizumab, an anti IL-6 receptor antibody is associated with rapid improvement in both CRP and lymphocyte counts and in clinical indices. Controlled clinical trials are needed to confirm the utility of IL-6 blockade in this setting. Additional interventions will be needed for patients requiring mechanical ventilation.

ACS Style

Daria S. Fomina; Mar’Yana A. Lysenko; Irina P. Beloglazova; Zinaida Yu. Mutovina; Nataliya G. Poteshkina; Inna V. Samsonova; Tat’Yana S. Kruglova; Anton A. Chernov; Alexander V. Karaulov; Michael M. Lederman. Temporal clinical and laboratory response to interleukin-6 receptor blockade with Tocilizumab in 89 hospitalized patients with COVID-19 pneumonia. 2020, 1 .

AMA Style

Daria S. Fomina, Mar’Yana A. Lysenko, Irina P. Beloglazova, Zinaida Yu. Mutovina, Nataliya G. Poteshkina, Inna V. Samsonova, Tat’Yana S. Kruglova, Anton A. Chernov, Alexander V. Karaulov, Michael M. Lederman. Temporal clinical and laboratory response to interleukin-6 receptor blockade with Tocilizumab in 89 hospitalized patients with COVID-19 pneumonia. . 2020; ():1.

Chicago/Turabian Style

Daria S. Fomina; Mar’Yana A. Lysenko; Irina P. Beloglazova; Zinaida Yu. Mutovina; Nataliya G. Poteshkina; Inna V. Samsonova; Tat’Yana S. Kruglova; Anton A. Chernov; Alexander V. Karaulov; Michael M. Lederman. 2020. "Temporal clinical and laboratory response to interleukin-6 receptor blockade with Tocilizumab in 89 hospitalized patients with COVID-19 pneumonia." , no. : 1.

Journal article
Published: 04 June 2020 in Russian Clinical Laboratory Diagnostics
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The aim of the work - to establish the interconnection and interdependence of toll-like mediated pathogenetic mechanisms of urogenital infection in pregnant women from the position of epigenomics. Using discriminant analysis in 89 patients with urogenital infection in pregnant women for the first time was established a reliable evidence-based relationship and interdependence between mucosal immunity, the severity of the infectious process, clinical manifestations, symptoms of miscarriage in the background of simultaneous development of the infectious process and pregnancy. For urgent delivery (infection), urgent childbirth (infection and clinical manifestation) and premature birth, mucosal immunity determines the severity of anti-infective resistance (with increasing mucosal immunity oppression of infectious process and clinical manifestations is logged , and its decrease increases the severity of infection process and clinical manifestations); the inhibition of mucosal immunity prevails over its hyperreaction (inhibition of mucosal immunity is determined by the physiological immunodepression in response to the development of pregnancy, as well as in response to herpes virus infection when activated); the severity of the infectious process depends on the severity of clinical manifestations and symptoms of miscarriage. During miscarriage mucosal immunity provides the pathophysiological course of infectious process and the clinical manifestations and development of symptoms of misacrriage; increasing levels of mucosal immunity to hyperreaction contributes to the development of symptoms of abortion and miscarriage; not registered mutual influence of oppression, mucosal immunity and its hyperreaction; the severity of the infectious process does not depend on the severity of clinical signs and symptoms of miscarriage. In urgent childbirth (infection), the oppression of mucosal immunity does not affect the severity of clinical manifestations, symptoms of abortion and the infectious process. In urgent or premature birth, and termination of pregnancy, the oppression of mucosal immunity affects the severity of clinical manifestations, the severity of the infectious process and the symptoms of abortion; the severity of clinical manifestations and the severity of the symptoms of abortion are interrelated. In urgent birth (infection) mucosal immunity overreaction affects the severity of clinical manifestations, symptoms of miscarriage and infection; in case of term and preterm labour overreaction mucosal immunity on the severity of infection and symptoms of abortion and does not affect the severity of clinical manifestations and at the termination of a pregnancy mucosal immunity on the severity of the infectious process and does not affect the severity of clinical signs and symptoms of abortion. The levels of mucosal immunity inhibition, its hyperreaction, clinical manifestations, symptoms of pregnancy termination and the severity of the infectious process do not depend on the type of herpes simplex virus. In the absence of infection with herpes simplex virus in patients with urogenital infections of pregnant women, there is no mutual influence and the relationship between the oppression of mucosal immunity and hyperreaction of mucosal immunity, the oppression of mucosal immunity prevails over its hyperreaction. With increasing mucosal immunity oppression, increased anti-infectious resistance of the body (the decreased activity of the infectious process), and with its decrease decreased (increased activity of the infectious process). Hyperreaction of mucosal immunity influenced the severity of pregnancy termination symptoms, clinical manifestations and infectious process, and also determined the severity of pregnancy termination symptoms. The severity of the infectious process and clinical manifestations influenced the symptoms of abortion. The severity of the infectious process did not affect the clinical manifestations. During infection with herpes simplex virus type I or type I and II on the background prevalence of oppression mucosal immunity over hyperreaction mucosal immunity, the presence of relationships between them, and the impact of mucosal immunity on the severity of the infectious process and the clinical manifestations increase mucosal immunity has been shown to decrease the severity of infection and clinical manifestations (reduction of anti-infective resistance), while reducing mucosal immunity the severity of infection and clinical manifestations increased. Hyperreaction of mucosal immunity influenced the severity of pregnancy termination symptoms and determined the severity of pregnancy termination symptoms. The severity of the infectious process and clinical manifestations influenced the symptoms of abortion. The severity of clinical manifestations reflects the severity of the infectious process. In type I and type II of pregnancy, the level of mucosal immunity determines the anti-infectious resistance of the body in urogenital infection of pregnant women. Inhibition of mucosal immunity and its hyperreactions are interrelated, have an impact on each other, as a result of their integral interaction, increasing the levels of mucosal immunity leads to a decrease in the severity of clinical manifestations and the infectious process, reducing the levels of mucosal immunity contributes to the manifestation of clinical manifestations, as well as increasing the severity of the infectious process. Hyperreaction of mucosal immunity affects the severity of symptoms of abortion, infection and clinical manifestations. The infectious process and clinical manifestations determine the severity of the symptoms of abortion. In type III and type IV of pregnancy course, there is no mutual influence of mucosal immunity oppression and its hyperreaction. The levels of indicators of mucosal immunity oppression and its hyperreaction are interrelated; the increase in the severity of mucosal immunity...

ACS Style

A. V. Karaulov; S. S. Afanasiev; A. M. Zatevalov; Yu. V. Nesvizhsky; E. A. Voropaeva; N. L. Bondarenko; A. Y. Mironov; O. Yu. Borisova; Yu. N. Urban; A. D. Voropaev; A. B. Borisova. DISCRIMINANT ANALYSIS IN ESTABLISHING THE RELATIONSHIP OF PATHOGENETIC MECHANISMS OF GESTATIONAL COMPLICATIONS IN UROGENITAL INFECTION IN PREGNANT WOMEN. Russian Clinical Laboratory Diagnostics 2020, 65, 1 .

AMA Style

A. V. Karaulov, S. S. Afanasiev, A. M. Zatevalov, Yu. V. Nesvizhsky, E. A. Voropaeva, N. L. Bondarenko, A. Y. Mironov, O. Yu. Borisova, Yu. N. Urban, A. D. Voropaev, A. B. Borisova. DISCRIMINANT ANALYSIS IN ESTABLISHING THE RELATIONSHIP OF PATHOGENETIC MECHANISMS OF GESTATIONAL COMPLICATIONS IN UROGENITAL INFECTION IN PREGNANT WOMEN. Russian Clinical Laboratory Diagnostics. 2020; 65 (7):1.

Chicago/Turabian Style

A. V. Karaulov; S. S. Afanasiev; A. M. Zatevalov; Yu. V. Nesvizhsky; E. A. Voropaeva; N. L. Bondarenko; A. Y. Mironov; O. Yu. Borisova; Yu. N. Urban; A. D. Voropaev; A. B. Borisova. 2020. "DISCRIMINANT ANALYSIS IN ESTABLISHING THE RELATIONSHIP OF PATHOGENETIC MECHANISMS OF GESTATIONAL COMPLICATIONS IN UROGENITAL INFECTION IN PREGNANT WOMEN." Russian Clinical Laboratory Diagnostics 65, no. 7: 1.

Journal article
Published: 01 June 2020 in Journal of Allergy and Clinical Immunology
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Asthma is a severe and chronic disabling disease affecting more than 300 million people worldwide. Although in the past few drugs for the treatment of asthma were available, new treatment options are currently emerging, which appear to be highly effective in certain subgroups of patients. Accordingly, there is a need for biomarkers that allow selection of patients for refined and personalized treatment strategies. Recently, serological chip tests based on microarrayed allergen molecules and peptides derived from the most common rhinovirus strains have been developed, which may discriminate 2 of the most common forms of asthma, that is, allergen- and virus-triggered asthma. In this perspective, we argue that classification of patients with asthma according to these common trigger factors may open new possibilities for personalized management of asthma.

ACS Style

Katarzyna Niespodziana; Kristina Borochova; Petra Pazderova; Thomas Schlederer; Natalia Astafyeva; Tatiana Baranovskaya; Mohamed-Ridha Barbouche; Evgeny Beltyukov; Angelika Berger; Elena Borzova; Jean Bousquet; Roxana S. Bumbacea; Snezhana Bychkovskaya; Luis Caraballo; Kian Fan Chung; Adnan Custovic; Guillermo Docena; Thomas Eiwegger; Irina Evsegneeva; Alexander Emelyanov; Peter Errhalt; Rustem Fassakhov; Rezeda Fayzullina; Elena Fedenko; Daria Fomina; Zhongshan Gao; Pedro Giavina-Bianchi; Maia Gotua; Susanne Greber-Platzer; Gunilla Hedlin; Natalia Ilina; Zhanat Ispayeva; Marco Idzko; Sebastian L. Johnston; Ömer Kalayci; Alexander Karaulov; Antonina Karsonova; Musa Khaitov; Elena Kovzel; Marek L. Kowalski; Dmitry Kudlay; Michael Levin; Svetlana Makarova; Paolo Maria Matricardi; Kari C. Nadeau; Leyla Namazova-Baranova; Olga Naumova; Oleksandr Nazarenko; Paul M. O’Byrne; Faith Osier; Alexander N. Pampura; Carmen Panaitescu; Nikolaos G. Papadopoulos; Hae-Sim Park; Ruby Pawankar; Wolfgang Pohl; Harald Renz; Ksenja Riabova; Vanitha Sampath; Bülent E. Sekerel; Elopy Sibanda; Valérie Siroux; Ludmila P. Sizyakina; Jin-Lyu Sun; Zsolt Szepfalusi; Tetiana Umanets; Hugo P.S. Van Bever; Marianne van Hage; Margarita Vasileva; Erika von Mutius; Jiu-Yao Wang; Gary Wong; Sergii Zaikov; Mihaela Zidarn; Rudolf Valenta. Toward personalization of asthma treatment according to trigger factors. Journal of Allergy and Clinical Immunology 2020, 145, 1529 -1534.

AMA Style

Katarzyna Niespodziana, Kristina Borochova, Petra Pazderova, Thomas Schlederer, Natalia Astafyeva, Tatiana Baranovskaya, Mohamed-Ridha Barbouche, Evgeny Beltyukov, Angelika Berger, Elena Borzova, Jean Bousquet, Roxana S. Bumbacea, Snezhana Bychkovskaya, Luis Caraballo, Kian Fan Chung, Adnan Custovic, Guillermo Docena, Thomas Eiwegger, Irina Evsegneeva, Alexander Emelyanov, Peter Errhalt, Rustem Fassakhov, Rezeda Fayzullina, Elena Fedenko, Daria Fomina, Zhongshan Gao, Pedro Giavina-Bianchi, Maia Gotua, Susanne Greber-Platzer, Gunilla Hedlin, Natalia Ilina, Zhanat Ispayeva, Marco Idzko, Sebastian L. Johnston, Ömer Kalayci, Alexander Karaulov, Antonina Karsonova, Musa Khaitov, Elena Kovzel, Marek L. Kowalski, Dmitry Kudlay, Michael Levin, Svetlana Makarova, Paolo Maria Matricardi, Kari C. Nadeau, Leyla Namazova-Baranova, Olga Naumova, Oleksandr Nazarenko, Paul M. O’Byrne, Faith Osier, Alexander N. Pampura, Carmen Panaitescu, Nikolaos G. Papadopoulos, Hae-Sim Park, Ruby Pawankar, Wolfgang Pohl, Harald Renz, Ksenja Riabova, Vanitha Sampath, Bülent E. Sekerel, Elopy Sibanda, Valérie Siroux, Ludmila P. Sizyakina, Jin-Lyu Sun, Zsolt Szepfalusi, Tetiana Umanets, Hugo P.S. Van Bever, Marianne van Hage, Margarita Vasileva, Erika von Mutius, Jiu-Yao Wang, Gary Wong, Sergii Zaikov, Mihaela Zidarn, Rudolf Valenta. Toward personalization of asthma treatment according to trigger factors. Journal of Allergy and Clinical Immunology. 2020; 145 (6):1529-1534.

Chicago/Turabian Style

Katarzyna Niespodziana; Kristina Borochova; Petra Pazderova; Thomas Schlederer; Natalia Astafyeva; Tatiana Baranovskaya; Mohamed-Ridha Barbouche; Evgeny Beltyukov; Angelika Berger; Elena Borzova; Jean Bousquet; Roxana S. Bumbacea; Snezhana Bychkovskaya; Luis Caraballo; Kian Fan Chung; Adnan Custovic; Guillermo Docena; Thomas Eiwegger; Irina Evsegneeva; Alexander Emelyanov; Peter Errhalt; Rustem Fassakhov; Rezeda Fayzullina; Elena Fedenko; Daria Fomina; Zhongshan Gao; Pedro Giavina-Bianchi; Maia Gotua; Susanne Greber-Platzer; Gunilla Hedlin; Natalia Ilina; Zhanat Ispayeva; Marco Idzko; Sebastian L. Johnston; Ömer Kalayci; Alexander Karaulov; Antonina Karsonova; Musa Khaitov; Elena Kovzel; Marek L. Kowalski; Dmitry Kudlay; Michael Levin; Svetlana Makarova; Paolo Maria Matricardi; Kari C. Nadeau; Leyla Namazova-Baranova; Olga Naumova; Oleksandr Nazarenko; Paul M. O’Byrne; Faith Osier; Alexander N. Pampura; Carmen Panaitescu; Nikolaos G. Papadopoulos; Hae-Sim Park; Ruby Pawankar; Wolfgang Pohl; Harald Renz; Ksenja Riabova; Vanitha Sampath; Bülent E. Sekerel; Elopy Sibanda; Valérie Siroux; Ludmila P. Sizyakina; Jin-Lyu Sun; Zsolt Szepfalusi; Tetiana Umanets; Hugo P.S. Van Bever; Marianne van Hage; Margarita Vasileva; Erika von Mutius; Jiu-Yao Wang; Gary Wong; Sergii Zaikov; Mihaela Zidarn; Rudolf Valenta. 2020. "Toward personalization of asthma treatment according to trigger factors." Journal of Allergy and Clinical Immunology 145, no. 6: 1529-1534.

Journal article
Published: 22 May 2020 in Russian Journal of Infection and Immunity
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The neuropeptides comprise an important part in the nervous system interacting with endocrine and immune systems. Peptide regulators are responsible for the continuity of communicating elements, which support homeostasis, however, despite abundant research examining neuropeptides, not all specific mechanisms and features of interacting proteins with cells and immune components have been uncovered. Objective: to perform a comprehensive assessment of neuropeptide system in patients with herpes zoster. Materials and methods: 106 in-hospital patients were examined diagnosed with herpes zoster within 2016–2019 period. Control group consisted of 30 healthy age- and sex-matched volunteers. Blood serum was collected after verifying diagnosis on day 1. After discharge, patients were monitored for signs of pain syndrome and overall state within 3 months. It allowed to divide patients into 3 groups retrospectively. Group 1 — patients with herpes zoster, accompanied by mild or moderate pain syndrome; group 2 — patients with herpes zoster, accompanied by severe pain; group 3 — patients with herpes zoster, complicated by postherpetic neuralgia. Level of serum protein s100B, myelin basic protein, nerve growth factor, brain-derived neurotrophic factor, neuron specific enolase was measured by using specific reagents purchased from “R&D Diagnostics Inc.” (США). Results. it was found that level of serum protein S100B in all groups was significantly increased compared to control group, showing no inter-group differences. Amount of myelin basic protein in all study groups vs. control was significantly higher. Moreover, level of these parameters in group 2 vs. group 1 and 3 was significantly elevated. In addition, level of nerve growth factor was significantly increased in group 1 vs. groups 2 and 3, whereas in group 3 it was significantly lower than in control and group 2. Brain-derived neurotrophic factor was significantly decreased in all the study groups compared to control, showing no significant intergroup differences. Level of neuron-specific enolase was significantly increased in group 3 vs. control as well as group 1 and 2. The data obtained allowed to identify two parameters for assessing a risk of postherpetic neuralgia in acute herpes zoster, as well as provided deeper insights into the pathogenesis of neuroimmune disorders accompanying herpes zoster.

ACS Style

S. V. Knysh; E. V. Markelova; A. I. Simakova; Alexander Karaulov. Neuropeptide system parameters in acute herpes zoster. Russian Journal of Infection and Immunity 2020, 10, 329 -337.

AMA Style

S. V. Knysh, E. V. Markelova, A. I. Simakova, Alexander Karaulov. Neuropeptide system parameters in acute herpes zoster. Russian Journal of Infection and Immunity. 2020; 10 (2):329-337.

Chicago/Turabian Style

S. V. Knysh; E. V. Markelova; A. I. Simakova; Alexander Karaulov. 2020. "Neuropeptide system parameters in acute herpes zoster." Russian Journal of Infection and Immunity 10, no. 2: 329-337.

Article
Published: 01 May 2020 in Bulletin of Experimental Biology and Medicine
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We studied changes in the transcription of genes encoding cytokines (TNF, IL-6, IL-10, and IL-32), cell activation markers (ICAM1, CD38, Fas, and FCGRIII), ROS production catalyst (NOX2), autophagy (Beclin 1, LC3B, and p62) and apoptosis (BAX, BCL2) regulators in peripheral blood mononuclear cells upon contact with quantum dots CdSe/ZnS-MPA and CdSe/CdSeZnS/ZnS-PTVP. Up-regulation of TNF, ICAM1, Fas, p62 mRNA and down-regulation of the FCGRIII and NOX2 mRNA in response to the presence of quantum dots were revealed. The formation of serum protein corona on the surface of quantum dots abolished this effect.

ACS Style

D. V. Novikov; S. G. Selivanova; N. V. Krasnogorova; Ekaterina Gorshkova; S. N. Pleskova; V V Novikov; Alexander Karaulov. Serum Protein Corona Abolishes Changes in the Expression of Proinflammatory Genes Induced by Quantum Dots in Human Blood Mononuclear Cell. Bulletin of Experimental Biology and Medicine 2020, 169, 95 -99.

AMA Style

D. V. Novikov, S. G. Selivanova, N. V. Krasnogorova, Ekaterina Gorshkova, S. N. Pleskova, V V Novikov, Alexander Karaulov. Serum Protein Corona Abolishes Changes in the Expression of Proinflammatory Genes Induced by Quantum Dots in Human Blood Mononuclear Cell. Bulletin of Experimental Biology and Medicine. 2020; 169 (1):95-99.

Chicago/Turabian Style

D. V. Novikov; S. G. Selivanova; N. V. Krasnogorova; Ekaterina Gorshkova; S. N. Pleskova; V V Novikov; Alexander Karaulov. 2020. "Serum Protein Corona Abolishes Changes in the Expression of Proinflammatory Genes Induced by Quantum Dots in Human Blood Mononuclear Cell." Bulletin of Experimental Biology and Medicine 169, no. 1: 95-99.

Review
Published: 01 May 2020 in World Allergy Organization Journal
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A large number of allergens have been discovered but we know little about their potential to induce inflammation (allergenic activity) and symptoms. Nowadays, the clinical importance of allergens is determined by the frequency and intensity of their IgE antibody binding (allergenicity). This is a rather limited parameter considering the development of experimental allergology in the last 20 years and the criteria that support personalized medicine. Now it is known that some allergens, in addition to their IgE antibody binding properties, can induce inflammation through non IgE mediated pathways, which can increase their allergenic activity. There are several ways to evaluate the allergenic activity, among them the provocation tests, the demonstration of non-IgE mediated pathways of inflammation, case control studies of IgE-binding frequencies, and animal models of respiratory allergy. In this review we have explored the current status of basic and clinical research on allergenic activity of indoor allergens and confirm that, for most of them, this important property has not been investigated. However, during recent years important advances have been made in the field, and we conclude that for at least the following, allergenic activity has been demonstrated: Der p 1, Der p 2, Der p 5 and Blo t 5 from HDMs; Per a 10 from P. americana; Asp f 1, Asp f 2, Asp f 3, Asp f 4 and Asp f 6 from A. fumigatus; Mala s 8 and Mala s 13 from M. sympodialis; Alt a 1 from A. alternata; Pen c 13 from P. chrysogenum; Fel d 1 from cats; Can f 1, Can f 2, Can f 3, Can f 4 and Can f 5 from dogs; Mus m 1 from mice and Bos d 2 from cows. Defining the allergenic activity of other indoor IgE antibody binding molecules is necessary for a precision-medicine-oriented management of allergic diseases.

ACS Style

Luis Caraballo; Rudolf Valenta; Leonardo Puerta; Anna Pomés; Josefina Zakzuk; Enrique Fernandez-Caldas; Nathalie Acevedo; Mario Sanchez-Borges; Ignacio Ansotegui; Luo Zhang; Marianne van Hage; Eva Abel-Fernández; L. Karla Arruda; Susanne Vrtala; Mirela Curin; Hans Gronlund; Antonina Karsonova; Jonathan Kilimajer; Ksenja Riabova; Daria Trifonova; Alexander Karaulov. The allergenic activity and clinical impact of individual IgE-antibody binding molecules from indoor allergen sources. World Allergy Organization Journal 2020, 13, 100118 .

AMA Style

Luis Caraballo, Rudolf Valenta, Leonardo Puerta, Anna Pomés, Josefina Zakzuk, Enrique Fernandez-Caldas, Nathalie Acevedo, Mario Sanchez-Borges, Ignacio Ansotegui, Luo Zhang, Marianne van Hage, Eva Abel-Fernández, L. Karla Arruda, Susanne Vrtala, Mirela Curin, Hans Gronlund, Antonina Karsonova, Jonathan Kilimajer, Ksenja Riabova, Daria Trifonova, Alexander Karaulov. The allergenic activity and clinical impact of individual IgE-antibody binding molecules from indoor allergen sources. World Allergy Organization Journal. 2020; 13 (5):100118.

Chicago/Turabian Style

Luis Caraballo; Rudolf Valenta; Leonardo Puerta; Anna Pomés; Josefina Zakzuk; Enrique Fernandez-Caldas; Nathalie Acevedo; Mario Sanchez-Borges; Ignacio Ansotegui; Luo Zhang; Marianne van Hage; Eva Abel-Fernández; L. Karla Arruda; Susanne Vrtala; Mirela Curin; Hans Gronlund; Antonina Karsonova; Jonathan Kilimajer; Ksenja Riabova; Daria Trifonova; Alexander Karaulov. 2020. "The allergenic activity and clinical impact of individual IgE-antibody binding molecules from indoor allergen sources." World Allergy Organization Journal 13, no. 5: 100118.

Review article
Published: 30 April 2020 in Cell Death & Disease
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Extracellular DNA trap formation is a cellular function of neutrophils, eosinophils, and basophils that facilitates the immobilization and killing of invading microorganisms in the extracellular milieu. To form extracellular traps, granulocytes release a scaffold consisting of mitochondrial DNA in association with granule proteins. As we understand more about the molecular mechanism for the formation of extracellular DNA traps, the in vivo function of this phenomenon under pathological conditions remains an enigma. In this article, we critically review the literature to summarize the evidence for extracellular DNA trap formation under in vivo conditions. Extracellular DNA traps have not only been detected in infectious diseases but also in chronic inflammatory diseases, as well as in cancer. While on the one hand, extracellular DNA traps clearly exhibit an important function in host defense, it appears that they can also contribute to the maintenance of inflammation and metastasis, suggesting that they may represent an interesting drug target for such pathological conditions.

ACS Style

Shida Yousefi; Dagmar Simon; Darko Stojkov; Antonina Karsonova; Alexander Karaulov; Hans-Uwe Simon. In vivo evidence for extracellular DNA trap formation. Cell Death & Disease 2020, 11, 1 -15.

AMA Style

Shida Yousefi, Dagmar Simon, Darko Stojkov, Antonina Karsonova, Alexander Karaulov, Hans-Uwe Simon. In vivo evidence for extracellular DNA trap formation. Cell Death & Disease. 2020; 11 (4):1-15.

Chicago/Turabian Style

Shida Yousefi; Dagmar Simon; Darko Stojkov; Antonina Karsonova; Alexander Karaulov; Hans-Uwe Simon. 2020. "In vivo evidence for extracellular DNA trap formation." Cell Death & Disease 11, no. 4: 1-15.

Article
Published: 23 April 2020 in Bulletin of Experimental Biology and Medicine
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Pharmacokinetics of suppository forms of bacteriophages was studied on male Chinchilla rabbits. Suppositories with various composition of bacteriophages were administered once per rectum to rabbits, and the presence of phage particles was estimated in the blood, urine, and feces over 24 h. Pharmacokinetic study showed that the phages were detected in the blood, urine, and feces at various terms of the experiment irrespective of the size of viral particles, which confirmed the possibility of their systemic effects after rectal administration. Thus, the use of suppository form of bacteriophages can ensure the presence of phage particles even in infection foci that cannot directly contact with the preparation.

ACS Style

S. S. Bochkareva; Alexander Karaulov; A. V. Aleshkin; L. I. Novikova; I. A. Kiseleva; E. O. Rubal’Skii; E. R. Mekhtiev; A. O. Styshnev; E. R. Zul’Karneev; M. N. Anurova; E. O. Bakhrushina; A. V. Letarov. Analysis of the Pharmacokinetics of Suppository Forms of Bacteriophages. Bulletin of Experimental Biology and Medicine 2020, 168, 748 -752.

AMA Style

S. S. Bochkareva, Alexander Karaulov, A. V. Aleshkin, L. I. Novikova, I. A. Kiseleva, E. O. Rubal’Skii, E. R. Mekhtiev, A. O. Styshnev, E. R. Zul’Karneev, M. N. Anurova, E. O. Bakhrushina, A. V. Letarov. Analysis of the Pharmacokinetics of Suppository Forms of Bacteriophages. Bulletin of Experimental Biology and Medicine. 2020; 168 (6):748-752.

Chicago/Turabian Style

S. S. Bochkareva; Alexander Karaulov; A. V. Aleshkin; L. I. Novikova; I. A. Kiseleva; E. O. Rubal’Skii; E. R. Mekhtiev; A. O. Styshnev; E. R. Zul’Karneev; M. N. Anurova; E. O. Bakhrushina; A. V. Letarov. 2020. "Analysis of the Pharmacokinetics of Suppository Forms of Bacteriophages." Bulletin of Experimental Biology and Medicine 168, no. 6: 748-752.