This page has only limited features, please log in for full access.

Dr. Weixiang Xu
Shenyang Agricultural University

Basic Info

Basic Info is private.

Research Keywords & Expertise

0 Inflammation
0 Lung
0 Toxicology
0 ochratoxin
0 Astaxanthin

Honors and Awards

The user has no records in this section


Career Timeline

The user has no records in this section.


Short Biography

The user biography is not available.
Following
Followers
Co Authors
The list of users this user is following is empty.
Following: 0 users

Feed

Journal article
Published: 23 January 2020 in Food and Chemical Toxicology
Reads 0
Downloads 0

We investigated the protective effect and mechanism of selenium-enriched yeast (SY) on caecal injury induced by ochratoxin A (OTA) in broilers. Eighty broiler chickens of 1-day-old with similar weight were randomly assigned to Control group, OTA group, SY group and OTA + SY group, and were intragastricaly administered with OTA and SY for 21 consecutive days. The results showed that SY could reduce the caecal pathological injuries and could inhibit oxidative stress caused by OTA exposure. The OTA + SY group showed a statistically significant (p < 0.01) reduction in the level of MDA, IL-1β, IL-6 and IFN-γ, whereas the levels of GSH, SOD activity and IL-10 were significantly increased (p < 0.01). By regulating TLR4/MYD88 signaling pathway, SY inhibited the expression of NF-κB, increased the expression of tight junction-related genes Claudin-1, Occludin and ZO-1, and antagonized the intestinal barrier injury caused by OTA exposure. Moreover, the microbial diversity analyses indicated that SY could intervene changes in the diversity of gut microbiota and the imbalance of gut microbiota caused by OTA. SY could relieve caecal pathological injuries, alleviate OTA-induced caecal oxidative stress and inflammatory response, increase the gut microbial diversity and protect broiler's intestinal barrier from injury.

ACS Style

Shuhua Yang; Lin Li; Lihui Yu; Lin Sun; Kang Li; Cui Tong; Weixiang Xu; Gengyuan Cui; Miao Long; Peng Li. Selenium-enriched yeast reduces caecal pathological injuries and intervenes changes of the diversity of caecal microbiota caused by Ochratoxin-A in broilers. Food and Chemical Toxicology 2020, 137, 111139 .

AMA Style

Shuhua Yang, Lin Li, Lihui Yu, Lin Sun, Kang Li, Cui Tong, Weixiang Xu, Gengyuan Cui, Miao Long, Peng Li. Selenium-enriched yeast reduces caecal pathological injuries and intervenes changes of the diversity of caecal microbiota caused by Ochratoxin-A in broilers. Food and Chemical Toxicology. 2020; 137 ():111139.

Chicago/Turabian Style

Shuhua Yang; Lin Li; Lihui Yu; Lin Sun; Kang Li; Cui Tong; Weixiang Xu; Gengyuan Cui; Miao Long; Peng Li. 2020. "Selenium-enriched yeast reduces caecal pathological injuries and intervenes changes of the diversity of caecal microbiota caused by Ochratoxin-A in broilers." Food and Chemical Toxicology 137, no. : 111139.

Journal article
Published: 17 September 2019 in Toxins
Reads 0
Downloads 0

The aim of this research was to evaluate the potential protective mechanism of astaxanthin (ASTA) against oxidative damage and inflammation caused by ochratoxin (OTA) in mouse lung. We divided mice into a control group (CG), an OTA group (PG), an astaxanthin group (AG), and an OTA+ASTA group (JG). Oxidative indices (malondialdehyde (MDA), total superoxide dismutase (T-SOD), and reduced glutathione (GSH)) and inflammatory markers (interleukin 1β (IL-1β), interleukin 6 (IL-6), and tumor necrosis factor α (TNF-α)) were assayed in the lung, and the lung-weight-to-body-weight ratio was calculated. Apoptosis was detected in pathological sections by the TdT-mediated dUTP nick-end labeling (TUNEL) assay. Oxidative damage and inflammation were detected in the lung of mice after exposure to OTA. Besides, Nrf2- and NF-κB-pathway-associated proteins were detected by Western blot. In contrast with OTA, ASTA significantly raised the expression of Nrf2, HO-1, and MnSOD, while the expression of other proteins (Keap1, TLR4, and NF-κB) was significantly decreased. These results indicate that ASTA exerted protective effects against OTA-induced oxidative damage and inflammation in the lung by regulating the Nrf2 and NF-κB pathways.

ACS Style

Weixiang Xu; Mingyang Wang; Gengyuan Cui; Lin Li; Danyang Jiao; Beibei Yao; Ketao Xu; Yueli Chen; Miao Long; Shuhua Yang; Jianbin He. Astaxanthin Protects OTA-Induced Lung Injury in Mice through the Nrf2/NF-κB Pathway. Toxins 2019, 11, 540 .

AMA Style

Weixiang Xu, Mingyang Wang, Gengyuan Cui, Lin Li, Danyang Jiao, Beibei Yao, Ketao Xu, Yueli Chen, Miao Long, Shuhua Yang, Jianbin He. Astaxanthin Protects OTA-Induced Lung Injury in Mice through the Nrf2/NF-κB Pathway. Toxins. 2019; 11 (9):540.

Chicago/Turabian Style

Weixiang Xu; Mingyang Wang; Gengyuan Cui; Lin Li; Danyang Jiao; Beibei Yao; Ketao Xu; Yueli Chen; Miao Long; Shuhua Yang; Jianbin He. 2019. "Astaxanthin Protects OTA-Induced Lung Injury in Mice through the Nrf2/NF-κB Pathway." Toxins 11, no. 9: 540.