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Dr. Devesh Tewari
Lovely Professional University

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Journal article
Published: 16 August 2021 in Plants
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Analgesic drugs like morphine and non-steroidal anti-inflammatory drugs exhibit several harmful effects. Here, we show for the first time the analgesic activity of Ficus palmata L. fruit extract (FPFE) on different analgesic rat models along with the in silico studies of some of the main phytochemicals of this plant. We performed in vivo pain models, along with in silico docking studies against the active site of COX-2 protein and mu-opioid receptors. A significant (p< 0.05) analgesic effect of FPFE was observed, and it was found that rutin has good pose and score as compared to diclofenac and morphinan antagonist (X-ligand), and psoralen has binding affinity almost equal to diclofenac, but a lower binding affinity as compared to rutin. The results proved that F. palmata fruits have the potential to ameliorate painful conditions.

ACS Style

Devesh Tewari; Pawan Gupta; Sweta Bawari; Archana N. Sah; Davide Barreca; Maryam Khayatkashani; Hamid Reza Khayat Kashani. Himalayan Ficus palmata L. Fruit Extract Showed In Vivo Central and Peripheral Analgesic Activity Involving COX-2 and Mu Opioid Receptors. Plants 2021, 10, 1685 .

AMA Style

Devesh Tewari, Pawan Gupta, Sweta Bawari, Archana N. Sah, Davide Barreca, Maryam Khayatkashani, Hamid Reza Khayat Kashani. Himalayan Ficus palmata L. Fruit Extract Showed In Vivo Central and Peripheral Analgesic Activity Involving COX-2 and Mu Opioid Receptors. Plants. 2021; 10 (8):1685.

Chicago/Turabian Style

Devesh Tewari; Pawan Gupta; Sweta Bawari; Archana N. Sah; Davide Barreca; Maryam Khayatkashani; Hamid Reza Khayat Kashani. 2021. "Himalayan Ficus palmata L. Fruit Extract Showed In Vivo Central and Peripheral Analgesic Activity Involving COX-2 and Mu Opioid Receptors." Plants 10, no. 8: 1685.

Review
Published: 01 July 2021 in Molecules
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Curcumin, a natural polyphenolic compound present in Curcuma longa L. rhizomes, shows potent antioxidant, anti-inflammatory, anti-cancer, and anti-atherosclerotic properties. Atherosclerosis is a comprehensive term for a series of degenerative and hyperplasic lesions such as thickening or sclerosis in large- and medium-sized arteries, causing decreased vascular-wall elasticity and lumen diameter. Atherosclerotic cerebro-cardiovascular disease has become a major concern for human health in recent years due to its clinical sequalae of strokes and heart attacks. Curcumin concoction treatment modulates several important signaling pathways related to cellular migration, proliferation, cholesterol homeostasis, inflammation, and gene transcription, among other relevant actions. Here, we provide an overview of curcumin in atherosclerosis prevention and disclose the underlying mechanisms of action of its anti-atherosclerotic effects.

ACS Style

Laxman Singh; Shikha Sharma; Suowen Xu; Devesh Tewari; Jian Fang. Curcumin as a Natural Remedy for Atherosclerosis: A Pharmacological Review. Molecules 2021, 26, 4036 .

AMA Style

Laxman Singh, Shikha Sharma, Suowen Xu, Devesh Tewari, Jian Fang. Curcumin as a Natural Remedy for Atherosclerosis: A Pharmacological Review. Molecules. 2021; 26 (13):4036.

Chicago/Turabian Style

Laxman Singh; Shikha Sharma; Suowen Xu; Devesh Tewari; Jian Fang. 2021. "Curcumin as a Natural Remedy for Atherosclerosis: A Pharmacological Review." Molecules 26, no. 13: 4036.

Preprint
Published: 31 May 2021
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Curcumin, a hydrophobic bioactive constituent from Curcuma longa, has several health promoting properties including anti-atherosclerotic properties. Further, curcumin has blood glucose- and lipid-lowering properties, prophylactic, and therapeutic effects in other cardiometabolic diseases. Atherosclerosis is an umbrella term for a series of degenerative and hyperplasic lesions such as thickening or sclerosis in large and medium -sized artery walls that decrease vascular-wall elasticity and lumen diameter. The atherosclerotic cerebro-cardiovascular disease has become a major concern to human health in recent years. Considering the notable cardiovascular actions of curcumin, the present review summarizes the current status and future perspective of research on curcumin and its ability to prevent or treat atherosclerosis

ACS Style

Laxman Singh; Shikha Sharma; Suowen Xu; Devesh Tewari; Jian Fang. Curcumin as a Natural Remedy for Atherosclerosis: A Pharmacological Review. 2021, 1 .

AMA Style

Laxman Singh, Shikha Sharma, Suowen Xu, Devesh Tewari, Jian Fang. Curcumin as a Natural Remedy for Atherosclerosis: A Pharmacological Review. . 2021; ():1.

Chicago/Turabian Style

Laxman Singh; Shikha Sharma; Suowen Xu; Devesh Tewari; Jian Fang. 2021. "Curcumin as a Natural Remedy for Atherosclerosis: A Pharmacological Review." , no. : 1.

Journal article
Published: 02 March 2021 in South African Journal of Botany
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Prunus cerasoides D. Don is a plant of great venerative value in the Himalayan region. The fruits and seed kernels of this plant are traditionally used for the treatment of urinary stones. Present study was aimed to demonstrate the in vitro and preclinical antilithic potential of the hydroethanolic extract of Prunus cerasoides fruits against calcium oxalate urolithiasis. In vitro antiurolithiatic screening was done by nucleation, and aggregation assay, while preclinical evaluation was carried out on ethylene glycol (0.75% v/v) and ammonium chloride (1% w/v) rendered urolithiasic male Wistar rats. P. cerasoides fruit extract induced nucleation of multiple small sized calcium oxalate crystals and inhibited their aggregation in the metastable solutions. P. cerasoides fruit extract to a large extent prevented lithogenic treatment induced anorexia, weight loss, polydipsia, polyuria, crystalluria, hypercalciuria, hyperoxaluria, hyperuricosuria, hyperphosphaturia, hypocitraturia and hypomagnesuria. It also showed preventive effect on the deposition of calcium, oxalate and phosphate in kidney tissues and exhibited ameliorative effect on serum urea, creatinine and uric acid. Moreover, inhibitory effect on oxidative stress induced degeneration of renal tissue was also recorded from histopathological analysis of the kidneys. PCFE showed promising outcomes as an antiurolithiatic both prophylactically and curatively. The effects can be attributed to its ability to restore the equilibrium between the urinary promoters and inhibitors of CaOx crystallization, its anticrystallization activity and its ameliorating effects on renal cellularity, urine and serum chemistry.

ACS Style

Sweta Bawari; Archana N. Sah; Devesh Tewari. Excavating the antiurolithiatic potential of wild himalayan cherry through in vitro and preclinical investigations. South African Journal of Botany 2021, 1 .

AMA Style

Sweta Bawari, Archana N. Sah, Devesh Tewari. Excavating the antiurolithiatic potential of wild himalayan cherry through in vitro and preclinical investigations. South African Journal of Botany. 2021; ():1.

Chicago/Turabian Style

Sweta Bawari; Archana N. Sah; Devesh Tewari. 2021. "Excavating the antiurolithiatic potential of wild himalayan cherry through in vitro and preclinical investigations." South African Journal of Botany , no. : 1.

Journal article
Published: 28 November 2020 in Current Pharmaceutical Biotechnology
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An increase in the prevalence of Inflammatory Bowel Diseases (IBD) as a multifactorial intestinal chronic inflammation as well as the absence of a certain cure, has created an innovative era in the management of IBD by molecule/pathway-based anti-inflammatory approaches. There are credible documentations that demonstrate Mitogen-Activated Protein Kinases (MAPK) acts as IBD regulator. Upon the activation of MAPK signalling pathway, the transcription and expression of various encoding inflammatory molecules implicated in IBD are altered, thereby exacerbating the inflammation development. The current pharmacological management of IBD, including drug and biological therapies are expensive, possess temporary relief and some adverse effects. In this context, a variety of dietary fruits or medicinal herbs have received worldwide attention versus the development of IBD. Infact, natural ingredients, such as Flavaglines, Fisetin, Myricitrin, Cardamonin, Curcumin, Octacosanol and Mangiferin possess protective and therapeutic effects against IBD via modulation of different segments of MAPK signaling pathway. This review paper calls attention to the role of MAPK signaling triggered by natural products in the prevention and treatment of IBD.

ACS Style

Mehdi Zobeiri; Saeideh Momtaz; Fatemeh Parvizi; Devesh Tewari; Mohammad Hosein Farzaei; Seyed Mohammad Nabavi. Targeting Mitogen-Activated Protein Kinases by Natural Products: A Novel Therapeutic Approach for Inflammatory Bowel Diseases. Current Pharmaceutical Biotechnology 2020, 21, 1342 -1353.

AMA Style

Mehdi Zobeiri, Saeideh Momtaz, Fatemeh Parvizi, Devesh Tewari, Mohammad Hosein Farzaei, Seyed Mohammad Nabavi. Targeting Mitogen-Activated Protein Kinases by Natural Products: A Novel Therapeutic Approach for Inflammatory Bowel Diseases. Current Pharmaceutical Biotechnology. 2020; 21 (13):1342-1353.

Chicago/Turabian Style

Mehdi Zobeiri; Saeideh Momtaz; Fatemeh Parvizi; Devesh Tewari; Mohammad Hosein Farzaei; Seyed Mohammad Nabavi. 2020. "Targeting Mitogen-Activated Protein Kinases by Natural Products: A Novel Therapeutic Approach for Inflammatory Bowel Diseases." Current Pharmaceutical Biotechnology 21, no. 13: 1342-1353.

Review article
Published: 29 September 2020 in Current Opinion in Environmental Science & Health
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Emerging research in the field of behavioral neuroscience has demonstrated the fundamental role of the cerebral organization. For brain development, various important functions are required for instance synaptic plasticity and neurogenesis. This property is described in terms of neuroplasticity. Neuroplasticity denotes the extraordinary ability of the brain for the recognition of its structure and function after an experience with some external stimuli and involves in the various behavioral process of the brain such as cognitive functions. It has multiple factors that can range from gene alteration to environmental factors. Environmental factors exert both negative and positive impact on cognitive functions of brain. Here we elaborate about the neuroplasticity, their mechanism and relation between environment and brain cells which includes remarkable effects on brain development after alteration in maternal care, under stressful conditions, sleep deprivation and enriched environment.

ACS Style

Ashish Mishra; Pooja Patni; Satisha Hegde; Lotfi Aleya; Devesh Tewari. Neuroplasticity and environment: A pharmacotherapeutic approach toward preclinical and clinical understanding. Current Opinion in Environmental Science & Health 2020, 19, 100210 .

AMA Style

Ashish Mishra, Pooja Patni, Satisha Hegde, Lotfi Aleya, Devesh Tewari. Neuroplasticity and environment: A pharmacotherapeutic approach toward preclinical and clinical understanding. Current Opinion in Environmental Science & Health. 2020; 19 ():100210.

Chicago/Turabian Style

Ashish Mishra; Pooja Patni; Satisha Hegde; Lotfi Aleya; Devesh Tewari. 2020. "Neuroplasticity and environment: A pharmacotherapeutic approach toward preclinical and clinical understanding." Current Opinion in Environmental Science & Health 19, no. : 100210.

Journal article
Published: 24 August 2020 in Nutrients
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Fenugreek seeds are widely used in Asia and other places of the world for their nutritive and medicinal properties. In Asia, fenugreek seeds are also recommended for geriatric populations. Here, we evaluated for the first time the effect of fenugreek seed feed supplementation on the liver antioxidant defense systems in aging mice. The study was conducted on 12-months aged mice which were given fenugreek seed dietary supplement. We evaluated the activities of various antioxidant defense enzymes such as superoxide dismutase (SOD), glutathione reductase (GR), and glutathione peroxidase (GPx), and also estimated the phenolics and free radical scavenging properties in mice liver upon fenugreek supplementation. The estimation of SOD, GPx, and GR activities in aged mice liver revealed a significant (p < 0.01) difference among all the liver enzymes. Overall, this study reveals that fenugreek seed dietary supplementation has a positive effect on the activities of the hepatic antioxidant defense enzymes in the aged mice.

ACS Style

Devesh Tewari; Artur Jóźwik; Małgorzata Łysek-Gładysińska; Weronika Grzybek; Wioletta Adamus-Białek; Jacek Bicki; Nina Strzałkowska; Agnieszka Kamińska; Olaf K. Horbańczuk; Atanas G. Atanasov. Fenugreek (Trigonella foenum-graecum L.) Seeds Dietary Supplementation Regulates Liver Antioxidant Defense Systems in Aging Mice. Nutrients 2020, 12, 2552 .

AMA Style

Devesh Tewari, Artur Jóźwik, Małgorzata Łysek-Gładysińska, Weronika Grzybek, Wioletta Adamus-Białek, Jacek Bicki, Nina Strzałkowska, Agnieszka Kamińska, Olaf K. Horbańczuk, Atanas G. Atanasov. Fenugreek (Trigonella foenum-graecum L.) Seeds Dietary Supplementation Regulates Liver Antioxidant Defense Systems in Aging Mice. Nutrients. 2020; 12 (9):2552.

Chicago/Turabian Style

Devesh Tewari; Artur Jóźwik; Małgorzata Łysek-Gładysińska; Weronika Grzybek; Wioletta Adamus-Białek; Jacek Bicki; Nina Strzałkowska; Agnieszka Kamińska; Olaf K. Horbańczuk; Atanas G. Atanasov. 2020. "Fenugreek (Trigonella foenum-graecum L.) Seeds Dietary Supplementation Regulates Liver Antioxidant Defense Systems in Aging Mice." Nutrients 12, no. 9: 2552.

Bioanalytical
Published: 11 August 2020 in Analytical Letters
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Wild Himalayan fig (F. palmata Forssk.) is of remarkable medicinal and cultural importance in the Himalayan region. Its fruits are consumed widely, and various components of the species are used in folk medicine. Very limited knowledge is available about the phytochemistry and biological activities of this species. Therefore, here we investigate the fruit of the F. palmata using different extraction methods for their comparative phytochemical and biological activities. Antioxidant and enzyme inhibitory activities using various in vitro assays along with detailed chemical profiling using ultra-high-performance liquid chromatography – electrospray ionization – mass spectrometry. In addition to aliphatic and aromatic carboxylic acids, several flavonoids are present in the extracts. These include C-and O-substituted derivatives of sugar and their aglycones. The results of biological activities showed potential antioxidant and enzyme inhibitory effect by F. palmata fruit. In conclusion, the fruit contains a substantial number of bioactive compounds and may be recommended for the designing novel nutraceutical and related products.

ACS Style

Devesh Tewari; Gokhan Zengin; Gunes Ak; Kouadio Ibrahime Sinan; Zoltán Cziáky; Saurabh Tarun Mishra; József Jekő. Phenolic Profiling, Antioxidants, Multivariate, and Enzyme Inhibitory Properties of Wild Himalayan Fig (Ficus palmata Forssk.): A Potential Candidate for Designing Innovative Nutraceuticals and Related Products. Analytical Letters 2020, 54, 1439 -1456.

AMA Style

Devesh Tewari, Gokhan Zengin, Gunes Ak, Kouadio Ibrahime Sinan, Zoltán Cziáky, Saurabh Tarun Mishra, József Jekő. Phenolic Profiling, Antioxidants, Multivariate, and Enzyme Inhibitory Properties of Wild Himalayan Fig (Ficus palmata Forssk.): A Potential Candidate for Designing Innovative Nutraceuticals and Related Products. Analytical Letters. 2020; 54 (9):1439-1456.

Chicago/Turabian Style

Devesh Tewari; Gokhan Zengin; Gunes Ak; Kouadio Ibrahime Sinan; Zoltán Cziáky; Saurabh Tarun Mishra; József Jekő. 2020. "Phenolic Profiling, Antioxidants, Multivariate, and Enzyme Inhibitory Properties of Wild Himalayan Fig (Ficus palmata Forssk.): A Potential Candidate for Designing Innovative Nutraceuticals and Related Products." Analytical Letters 54, no. 9: 1439-1456.

Journal article
Published: 27 July 2020 in Science of The Total Environment
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Salt is an essential component of daily life that balances the physiological functions of the human body as well as other living systems. Different varieties of salts are available in the global market. Out of many salt varieties, Himalayan rock salts have gained tremendous importance among consumers due to its diverse nutritional and medicinal properties. There are two types of Himalayan rock salts. One is the Himalayan pink salt and the other one is Himalayan black salt. Out of the two, the Himalayan pink salt is studied extensively but the black salt is underexplored. In the present study, the Himalayan black rock salt was explored to generate more scientific evidence in terms of its geochemical characterization using FE-SEM, X-ray diffractometry (XRD), elemental content using atomic absorption spectrophotometry (AAS) and in vitro antioxidant activity by different methods for the first time. The study revealed that Himalayan black salt was irregular in shape with a quadrilateral, cubic, irregular crystalline structure. The Himalayan black salt exhibited antioxidant effect and interestingly showed low Na levels than common sea salt and Himalayan pink salt. The Himalayan black salt also contained important minerals like iron, calcium and magnesium which are beneficial to human health thus exhibiting superior characteristics over other conventional table salts.

ACS Style

Vikas Chander; Devesh Tewari; Vipul Negi; Rakesh Singh; Kumud Upadhyaya; Lotfi Aleya. Structural characterization of Himalayan black rock salt by SEM, XRD and in-vitro antioxidant activity. Science of The Total Environment 2020, 748, 141269 .

AMA Style

Vikas Chander, Devesh Tewari, Vipul Negi, Rakesh Singh, Kumud Upadhyaya, Lotfi Aleya. Structural characterization of Himalayan black rock salt by SEM, XRD and in-vitro antioxidant activity. Science of The Total Environment. 2020; 748 ():141269.

Chicago/Turabian Style

Vikas Chander; Devesh Tewari; Vipul Negi; Rakesh Singh; Kumud Upadhyaya; Lotfi Aleya. 2020. "Structural characterization of Himalayan black rock salt by SEM, XRD and in-vitro antioxidant activity." Science of The Total Environment 748, no. : 141269.

Preprint
Published: 08 July 2020
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Fenugreek seeds are widely used in Asia and other places of the world for their nutritive and medicinal properties. In Asia, Fenugreek seeds are also widely recommended for the geriatric populations. Here, we evaluated for the first time the effect of fenugreek seed feed supplementation on the liver antioxidant defense systems in aging mice. The study was conducted on 12 months aged mice which were given fenugreek seed dietary supplement. We have evaluated the activities of various antioxidant defense enzymes like superoxide dismutase (SOD), glutathione reductase (GR), and glutathione peroxidase (GPx), and estimated the phenolics and free radical scavenging properties in mice liver upon fenugreek supplementation. The estimation of SOD, GPx and GR activities in aged mice liver revealed a significant (P<0.01) difference among all the liver enzymes. Overall, this study reveals that fenugreek seed dietary supplementation has a positive effect in on the activities of the hepatic antioxidant defense enzymes in the aged mice.

ACS Style

Devesh Tewari; Artur Jóźwik; Małgorzata Łysek-Gładysińska; Weronika Grzybek; Wioletta Adamus-Białek; Jacek Bicki; Nina Strzałkowska; Agnieszka Kamińska; Olaf K. Horbańczuk; Atanas G. Atanasov. Fenugreek (Trigonellafoenum-graecum L.) Seeds Dietary Supplementation Regulates Liver Antioxidant Defense Systems in Aging Mice. 2020, 1 .

AMA Style

Devesh Tewari, Artur Jóźwik, Małgorzata Łysek-Gładysińska, Weronika Grzybek, Wioletta Adamus-Białek, Jacek Bicki, Nina Strzałkowska, Agnieszka Kamińska, Olaf K. Horbańczuk, Atanas G. Atanasov. Fenugreek (Trigonellafoenum-graecum L.) Seeds Dietary Supplementation Regulates Liver Antioxidant Defense Systems in Aging Mice. . 2020; ():1.

Chicago/Turabian Style

Devesh Tewari; Artur Jóźwik; Małgorzata Łysek-Gładysińska; Weronika Grzybek; Wioletta Adamus-Białek; Jacek Bicki; Nina Strzałkowska; Agnieszka Kamińska; Olaf K. Horbańczuk; Atanas G. Atanasov. 2020. "Fenugreek (Trigonellafoenum-graecum L.) Seeds Dietary Supplementation Regulates Liver Antioxidant Defense Systems in Aging Mice." , no. : 1.

Review article
Published: 06 June 2020 in Journal of the Neurological Sciences
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Amyloid beta (Aβ) is an intricate molecule that interacts with several biomolecules and/or produces insoluble assemblies and eventually the nonphysiological depositions of its alternate with normal neuronal conditions leading to Alzheimer's disease (AD). Aβ is formed through the proteolytic cleavage of an integral type I membrane protein amyloid precursor protein (APP). Significant efforts are being made to explore the exact role of Aβ in AD pathogenesis. It is believed that the deposition of Aβ in the brain takes place from Aβ components which are derived from the brain itself. However, recent evidence suggests that Aβ derived also from the periphery and hence the Aβ circulating in the blood is capable of penetrating the blood-brain barrier (BBB) and the role of Aβ derived from the periphery is largely unknown so far. Therefore, Aβ origin determination and the underlying mechanisms of its pathological effects are of considerable interest in exploring effective therapeutic strategies. The purpose of this review is to provide a novel insight into AD pathogenesis based on Aβ in both the brain and periphery and highlight new therapeutic avenues to combat AD pathogenesis.

ACS Style

Sahab Uddin; Tanvir Kabir; Devesh Tewari; Abdullah Al Mamun; Bijo Mathew; Lotfi Aleya; George E. Barreto; May N. Bin-Jumah; Mohamed Abdel-Daim; Ghulam Md Ashraf. Revisiting the role of brain and peripheral Aβ in the pathogenesis of Alzheimer's disease. Journal of the Neurological Sciences 2020, 416, 116974 .

AMA Style

Sahab Uddin, Tanvir Kabir, Devesh Tewari, Abdullah Al Mamun, Bijo Mathew, Lotfi Aleya, George E. Barreto, May N. Bin-Jumah, Mohamed Abdel-Daim, Ghulam Md Ashraf. Revisiting the role of brain and peripheral Aβ in the pathogenesis of Alzheimer's disease. Journal of the Neurological Sciences. 2020; 416 ():116974.

Chicago/Turabian Style

Sahab Uddin; Tanvir Kabir; Devesh Tewari; Abdullah Al Mamun; Bijo Mathew; Lotfi Aleya; George E. Barreto; May N. Bin-Jumah; Mohamed Abdel-Daim; Ghulam Md Ashraf. 2020. "Revisiting the role of brain and peripheral Aβ in the pathogenesis of Alzheimer's disease." Journal of the Neurological Sciences 416, no. : 116974.

Review
Published: 19 May 2020 in Molecular Neurobiology
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Alzheimer’s disease (AD) is a progressive neurodegenerative disease involving aggregation of misfolded proteins inside the neuron causing prolonged cellular stress. The neuropathological hallmarks of AD include the formation of senile plaques and neurofibrillary tangles in specific brain regions that lead to synaptic loss and neuronal death. The exact mechanism of neuron dysfunction in AD remains obscure. In recent years, endoplasmic reticulum (ER) dysfunction has been implicated in neuronal degeneration seen in AD. Apart from AD, many other diseases also involve misfolded proteins aggregations in the ER, a condition referred to as ER stress. The response of the cell to ER stress is to activate a group of signaling pathways called unfolded protein response (UPR) that stimulates a particular transcriptional program to restore ER function and ensure cell survival. ER stress also involves the generation of reactive oxygen species (ROS) that, together with mitochondrial ROS and decreased effectiveness of antioxidant mechanisms, producing a condition of chronic oxidative stress. The unfolded proteins may not always produce a response that leads to the restoration of cellular functions, but they may also lead to inflammation by a set of different pathways with deleterious consequences. In this review, we extensively discuss the role of ER stress and how to target it using different pharmacological approaches in AD development and onset.

ACS Style

Sahab Uddin; Devesh Tewari; Gaurav Sharma; Tanvir Kabir; George E. Barreto; May N. Bin-Jumah; Asma Perveen; Mohamed Abdel-Daim; Ghulam Md Ashraf. Molecular Mechanisms of ER Stress and UPR in the Pathogenesis of Alzheimer’s Disease. Molecular Neurobiology 2020, 57, 2902 -2919.

AMA Style

Sahab Uddin, Devesh Tewari, Gaurav Sharma, Tanvir Kabir, George E. Barreto, May N. Bin-Jumah, Asma Perveen, Mohamed Abdel-Daim, Ghulam Md Ashraf. Molecular Mechanisms of ER Stress and UPR in the Pathogenesis of Alzheimer’s Disease. Molecular Neurobiology. 2020; 57 (7):2902-2919.

Chicago/Turabian Style

Sahab Uddin; Devesh Tewari; Gaurav Sharma; Tanvir Kabir; George E. Barreto; May N. Bin-Jumah; Asma Perveen; Mohamed Abdel-Daim; Ghulam Md Ashraf. 2020. "Molecular Mechanisms of ER Stress and UPR in the Pathogenesis of Alzheimer’s Disease." Molecular Neurobiology 57, no. 7: 2902-2919.

Journal article
Published: 10 May 2020 in Ethnobotany Research and Applications
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Background: The genus Saussurea of Asteraceae comprises approximately 490 species. Plants belonging to this genus are being used in different countries as traditional medicines. Brahma Kamal (Saussurea obvallata (DC.) Edgew.), is one of the most important and endangered species of this genus and is being used in traditional, ornamental and religious purposes. The aim of this work is to review and understand the scientific work conducted so far on S. obvallata, which includes its ethnomedicinal uses, pharmacognostic description, phytochemistry, pharmacology, micro-propagation and important conservation aspect.Methods: Systematic literature searches were performed on S. obvallata through various scientific search engines including Google Scholar, Scopus, PubMed, USPTO, Agricola, Science Direct, Mendely, Springer, JSTOR, Research Gate, Google patents, published books and conference proceedings using different keywords for screening of relevant information.Results & Conclusion: The literature analysis revealed diverse traditional uses of S. obvallata, against wounds, paralysis, cerebral-ischemia, cardiac and mental disorders. Various extracts of S. obvallata were also evaluated for their chemical composition and pharmacological activities including but not limited to anti-hypoxia, anticancer, radio-protective, antioxidant and antimicrobial activities using different in-vitro and in-vivo models. S. obvallata is being used widely in traditional medicine and socio-economic applications but scientifically, it is not fully assessed regarding its complete therapeutic effects, toxicity and safety in human body. Further studies are essential and also should focus on the conservation, cultivation and sustainable utilization of the species.

ACS Style

Prabhakar Semwal; Sakshi Painuli; Devesh Tewari; Rainer W Bussmann; Lok Man S Palni; Ashish Thapliyal. Assesment of non-timber Brahma Kamal (Saussurea obvallata (DC.) Edgew.), an important Himalayan medicinal plant: Ethnomedicinal, phytochemical and pharmacological overview. Ethnobotany Research and Applications 2020, 19, 1 -15.

AMA Style

Prabhakar Semwal, Sakshi Painuli, Devesh Tewari, Rainer W Bussmann, Lok Man S Palni, Ashish Thapliyal. Assesment of non-timber Brahma Kamal (Saussurea obvallata (DC.) Edgew.), an important Himalayan medicinal plant: Ethnomedicinal, phytochemical and pharmacological overview. Ethnobotany Research and Applications. 2020; 19 ():1-15.

Chicago/Turabian Style

Prabhakar Semwal; Sakshi Painuli; Devesh Tewari; Rainer W Bussmann; Lok Man S Palni; Ashish Thapliyal. 2020. "Assesment of non-timber Brahma Kamal (Saussurea obvallata (DC.) Edgew.), an important Himalayan medicinal plant: Ethnomedicinal, phytochemical and pharmacological overview." Ethnobotany Research and Applications 19, no. : 1-15.

Short communication
Published: 25 April 2020 in Current Research in Biotechnology
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Nanopharmaceuticals and nanonutraceuticals research has been lately receiving a lot of scientific attention. We aimed to identify the top 100 most cited original articles of the scientific area, analyze their research themes, major contributors regarding authors, institutions, countries and journals. The bibliometric data was extracted from the Web of Science electronic database. Data was further processed by a bibliometric software, VOSviewer, to generate bubble maps to visualize the results. Inter-institutional and international collaboration networks were constructed to further understand the cooperation between different study centers. Results revealed that over 60% of the articles were published in the 2000s. As of November 2019, the articles were cited 576–3665 times, with 20.1–261.8 citations per year. The majority of the most prolific institutions were based in the United States. Besides the United States, China, South Korea, Canada and Germany contributed heavily to the 100 articles. Some popular themes included drug delivery, tumor, toxicity/biocompatibility and biodistribution. Regarding composition materials, gold, silver and polymeric nanoparticles were the most commonly used.

ACS Style

Andy Wai Kan Yeung; Eliana B. Souto; Alessandra Durazzo; Massimo Lucarini; Ettore Novellino; Devesh Tewari; Dongdong Wang; Atanas G. Atanasov; Antonello Santini. Big impact of nanoparticles: analysis of the most cited nanopharmaceuticals and nanonutraceuticals research. Current Research in Biotechnology 2020, 2, 53 -63.

AMA Style

Andy Wai Kan Yeung, Eliana B. Souto, Alessandra Durazzo, Massimo Lucarini, Ettore Novellino, Devesh Tewari, Dongdong Wang, Atanas G. Atanasov, Antonello Santini. Big impact of nanoparticles: analysis of the most cited nanopharmaceuticals and nanonutraceuticals research. Current Research in Biotechnology. 2020; 2 ():53-63.

Chicago/Turabian Style

Andy Wai Kan Yeung; Eliana B. Souto; Alessandra Durazzo; Massimo Lucarini; Ettore Novellino; Devesh Tewari; Dongdong Wang; Atanas G. Atanasov; Antonello Santini. 2020. "Big impact of nanoparticles: analysis of the most cited nanopharmaceuticals and nanonutraceuticals research." Current Research in Biotechnology 2, no. : 53-63.

Research paper
Published: 21 April 2020 in Iranian Journal of Science and Technology, Transactions A: Science
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Saussurea obvallata (DC.) Edgew. of Asteraceae family is an endangered plant species used for traditional, cultural and religious purposes. The species is not systematically explored till date at global level. Here, we show the genetic variation and gene flow evaluation within and among the population of S. obvallata from different sites of Uttarakhand region of India by utilizing ten ISSR primers. The result showed 59 polymorphic loci in 30 studied individuals and 100% polymorphism in all the fragments. Number of alleles for each locus (Na), Shannon’s index (I), number of effective alleles per locus (Ne) and Nei’s gene diversity (H) were calculated to be 1.59, 1.52, 0.38 and 0.27, respectively. The mean polymorphic loci percentage (Pp%) was found 60%, whereas genetic differentiation level (Gst) amid population were 39.37% and 60.63% genetic variation found among and within populations, respectively. The molecular variance partitioning by AMOVA demonstrated a noteworthy genetic differentiation within (66%) and among (44%) populations. The study revealed the lowest gene flow level among all studied populations of S. obvallata; therefore, the use of modern biotechnological interventions is recommended for conservation and sustainable utilization of this valuable species.

ACS Style

Prabhakar Semwal; Sakshi Painuli; Arun Jugran; L. M. S. Palni; Susheel Verma; Ashish Thapliyal; Devesh Tewari. Genetic Diversity of Scanty Available Himalayan Saussurea obvallata (DC.) Edgew. Iranian Journal of Science and Technology, Transactions A: Science 2020, 44, 587 -594.

AMA Style

Prabhakar Semwal, Sakshi Painuli, Arun Jugran, L. M. S. Palni, Susheel Verma, Ashish Thapliyal, Devesh Tewari. Genetic Diversity of Scanty Available Himalayan Saussurea obvallata (DC.) Edgew. Iranian Journal of Science and Technology, Transactions A: Science. 2020; 44 (3):587-594.

Chicago/Turabian Style

Prabhakar Semwal; Sakshi Painuli; Arun Jugran; L. M. S. Palni; Susheel Verma; Ashish Thapliyal; Devesh Tewari. 2020. "Genetic Diversity of Scanty Available Himalayan Saussurea obvallata (DC.) Edgew." Iranian Journal of Science and Technology, Transactions A: Science 44, no. 3: 587-594.

Review article
Published: 16 April 2020 in Ageing Research Reviews
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Alzheimer's disease (AD) is a devastating and irreversible cognitive impairment and the most common type of dementia. Along with progressive cognitive impairment, dysfunction of the circadian rhythms also plays a pivotal role in the progression of AD. A mutual relationship among circadian rhythms, sleep, and AD has been well-recommended. The etiopathogenesis of the disturbances of the circadian system and AD share some general features that also unlock the outlook of observing them as a mutually dependent pathway. Indeed, the burden of amyloid β (Aβ), neurofibrillary tangles (NFTs), neuroinflammation, oxidative stress, and dysfunction of circadian rhythms may lead to AD. Aging can alter both sleep timings and quality that can be strongly disrupted in AD. Increased production of Aβ and reduced Aβ clearance are caused by a close interplay of Aβ, sleep disturbance and raised wakefulness. Besides Aβ, the impact of tau pathology is possibly noteworthy to the sleep deprivation found in AD. Hence, this review is focused on the primary mechanistic complexities linked to disruption of circadian rhythms, sleep deprivation, and AD. Furthermore, this review also highlights the potential therapeutic strategies to abate AD pathogenesis.

ACS Style

Sahab Uddin; Devesh Tewari; Abdullah Al Mamun; Tanvir Kabir; Kamal Niaz; Mir Imam Ibne Wahed; George E. Barreto; Ghulam Md. Ashraf. Circadian and sleep dysfunction in Alzheimer’s disease. Ageing Research Reviews 2020, 60, 101046 .

AMA Style

Sahab Uddin, Devesh Tewari, Abdullah Al Mamun, Tanvir Kabir, Kamal Niaz, Mir Imam Ibne Wahed, George E. Barreto, Ghulam Md. Ashraf. Circadian and sleep dysfunction in Alzheimer’s disease. Ageing Research Reviews. 2020; 60 ():101046.

Chicago/Turabian Style

Sahab Uddin; Devesh Tewari; Abdullah Al Mamun; Tanvir Kabir; Kamal Niaz; Mir Imam Ibne Wahed; George E. Barreto; Ghulam Md. Ashraf. 2020. "Circadian and sleep dysfunction in Alzheimer’s disease." Ageing Research Reviews 60, no. : 101046.

Review article
Published: 14 February 2020 in Frontiers in Pharmacology
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Excessive alcohol consumption is the cause of several diseases and thus is of a major concern for society. Worldwide alcohol consumption has increased by many folds over the past decades. This urgently calls for intervention and relapse counteract measures. Modern pharmacological solutions induce complete alcohol self-restraint and prevent relapse, but they have many side effects. Natural products are most promising as they cause fewer adverse effects. Here we discuss in detail the medicinal plants used in various traditional/folklore medicine systems for targeting alcohol abuse. We also comprehensively describe preclinical and clinical studies done on some of these plants along with the possible mechanisms of action.

ACS Style

Laxman Singh; Tanuj Joshi; Devesh Tewari; Javier Echeverría; Andrei Mocan; Archana N. Sah; Emil Parvanov; Nikolay T. Tzvetkov; Zheng Feei Ma; Yeong Yeh Lee; Piotr Poznański; Lukasz Huminiecki; Mariusz Sacharczuk; Artur Jóźwik; Jarosław O. Horbańczuk; Joanna Feder-Kubis; Atanas G. Atanasov. Ethnopharmacological Applications Targeting Alcohol Abuse: Overview and Outlook. Frontiers in Pharmacology 2020, 10, 1 .

AMA Style

Laxman Singh, Tanuj Joshi, Devesh Tewari, Javier Echeverría, Andrei Mocan, Archana N. Sah, Emil Parvanov, Nikolay T. Tzvetkov, Zheng Feei Ma, Yeong Yeh Lee, Piotr Poznański, Lukasz Huminiecki, Mariusz Sacharczuk, Artur Jóźwik, Jarosław O. Horbańczuk, Joanna Feder-Kubis, Atanas G. Atanasov. Ethnopharmacological Applications Targeting Alcohol Abuse: Overview and Outlook. Frontiers in Pharmacology. 2020; 10 ():1.

Chicago/Turabian Style

Laxman Singh; Tanuj Joshi; Devesh Tewari; Javier Echeverría; Andrei Mocan; Archana N. Sah; Emil Parvanov; Nikolay T. Tzvetkov; Zheng Feei Ma; Yeong Yeh Lee; Piotr Poznański; Lukasz Huminiecki; Mariusz Sacharczuk; Artur Jóźwik; Jarosław O. Horbańczuk; Joanna Feder-Kubis; Atanas G. Atanasov. 2020. "Ethnopharmacological Applications Targeting Alcohol Abuse: Overview and Outlook." Frontiers in Pharmacology 10, no. : 1.

Journal article
Published: 01 February 2020 in International Journal of Biological Macromolecules
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The study entailed formulation of gold nanoparticles (AuNPs) upon reduction of chloroauric acid by modified apple polysaccharide (MAP). AuNPs were conjugated with insulin (INS) for its oral delivery to treat type 1 diabetes mellitus (DM). The size of MAP conjugated AuNPs loaded with INS was 124 ± 8.55 nm with zeta potential −10.5 ± 0.54 mV. The animal study carried out in streptozotocin induced rat model revealed that AuNPs conjugated insulin (AuNPs-INS) in high dose caused 3.36 folds decrease in blood glucose level in 240 min, whereas, orally administered INS failed to decrease the blood glucose level. The 28-day study also revealed better improvement in body weight, lipid profile, urea, creatinine and liver parameters in AuNPs-INS (high dose) for which the observed value was close with respect to intraperitoneally administrated insulin followed by medium dose of AuNPs-INS, low dose of AuNPS-INS, AuNPs alone and modified apple polysaccharide.

ACS Style

Yogita Kumari; Sachin Kumar Singh; Rajesh Kumar; Bimlesh Kumar; Gurmandeep Kaur; Monica Gulati; Devesh Tewari; K. Gowthamarajan; V.V.S. Narayana Reddy Karri; Clarisse Ayinkamiye; Rubiya Khursheed; Ankit Awasthi; Narendra Kumar Pandey; Souvik Mohanta; Saurabh Gupta; Leander Corrie; Pooja Patni; Rajan Kumar. Modified apple polysaccharide capped gold nanoparticles for oral delivery of insulin. International Journal of Biological Macromolecules 2020, 149, 976 -988.

AMA Style

Yogita Kumari, Sachin Kumar Singh, Rajesh Kumar, Bimlesh Kumar, Gurmandeep Kaur, Monica Gulati, Devesh Tewari, K. Gowthamarajan, V.V.S. Narayana Reddy Karri, Clarisse Ayinkamiye, Rubiya Khursheed, Ankit Awasthi, Narendra Kumar Pandey, Souvik Mohanta, Saurabh Gupta, Leander Corrie, Pooja Patni, Rajan Kumar. Modified apple polysaccharide capped gold nanoparticles for oral delivery of insulin. International Journal of Biological Macromolecules. 2020; 149 ():976-988.

Chicago/Turabian Style

Yogita Kumari; Sachin Kumar Singh; Rajesh Kumar; Bimlesh Kumar; Gurmandeep Kaur; Monica Gulati; Devesh Tewari; K. Gowthamarajan; V.V.S. Narayana Reddy Karri; Clarisse Ayinkamiye; Rubiya Khursheed; Ankit Awasthi; Narendra Kumar Pandey; Souvik Mohanta; Saurabh Gupta; Leander Corrie; Pooja Patni; Rajan Kumar. 2020. "Modified apple polysaccharide capped gold nanoparticles for oral delivery of insulin." International Journal of Biological Macromolecules 149, no. : 976-988.

Review article
Published: 08 January 2020 in Acta Pharmaceutica Sinica B
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Peroxisome proliferator-activated receptor γ (PPARγ) is a transcriptional coactivator that binds to a diverse range of transcription factors. PPARγ coactivator 1 (PGC-1) coactivators possess an extensive range of biological effects in different tissues, and play a key part in the regulation of the oxidative metabolism, consequently modulating the production of reactive oxygen species, autophagy, and mitochondrial biogenesis. Owing to these findings, a large body of studies, aiming to establish the role of PGC-1 in the neuromuscular system, has shown that PGC-1 could be a promising target for therapies targeting neuromuscular diseases. Among these, some evidence has shown that various signaling pathways linked to PGC-1α are deregulated in muscular dystrophy, leading to a reduced capacity for mitochondrial oxidative phosphorylation and increased reactive oxygen species (ROS) production. In the light of these results, any intervention aimed at activating PGC-1 could contribute towards ameliorating the progression of muscular dystrophies. PGC-1α is influenced by different patho-physiological/pharmacological stimuli. Natural products have been reported to display modulatory effects on PPARγ activation with fewer side effects in comparison to synthetic drugs. Taken together, this review summarizes the current knowledge on Duchenne muscular dystrophy, focusing on the potential effects of natural compounds, acting as regulators of PGC-1α.

ACS Style

Ipek Suntar; Antoni Sureda; Tarun Belwal; Ana Sanches Silva; Rosa Anna Vacca; Devesh Tewari; Eduardo Sobarzo-Sánchez; Seyed Fazel Nabavi; Samira Shirooie; Ahmad Reza Dehpour; Suowen Xu; Bahman Yousefi; Maryam Majidinia; Maria Daglia; Giuseppe D'Antona. Natural products, PGC-1 , and Duchenne muscular dystrophy. Acta Pharmaceutica Sinica B 2020, 10, 734 -745.

AMA Style

Ipek Suntar, Antoni Sureda, Tarun Belwal, Ana Sanches Silva, Rosa Anna Vacca, Devesh Tewari, Eduardo Sobarzo-Sánchez, Seyed Fazel Nabavi, Samira Shirooie, Ahmad Reza Dehpour, Suowen Xu, Bahman Yousefi, Maryam Majidinia, Maria Daglia, Giuseppe D'Antona. Natural products, PGC-1 , and Duchenne muscular dystrophy. Acta Pharmaceutica Sinica B. 2020; 10 (5):734-745.

Chicago/Turabian Style

Ipek Suntar; Antoni Sureda; Tarun Belwal; Ana Sanches Silva; Rosa Anna Vacca; Devesh Tewari; Eduardo Sobarzo-Sánchez; Seyed Fazel Nabavi; Samira Shirooie; Ahmad Reza Dehpour; Suowen Xu; Bahman Yousefi; Maryam Majidinia; Maria Daglia; Giuseppe D'Antona. 2020. "Natural products, PGC-1 , and Duchenne muscular dystrophy." Acta Pharmaceutica Sinica B 10, no. 5: 734-745.

Review
Published: 01 January 2020 in Biotechnology Advances
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Cardiovascular diseases (CVDs) cause the largest mortality worldwide, and much attention has been focused to unravel the mechanisms and optimize the treatment regimens. Curcumin is an important bioactive component of turmeric that has been widely applied as traditional medicine to prevent and treat various diseases in some countries. Recent studies have demonstrated its potent activities in modulating multiple signaling pathways associated with cellular growth, proliferation, survival, inflammation and oxidative stress. The cardiovascular protective properties of curcumin in CVDs have been fully illustrated in numerous studies. In this review, we first briefly introduce the medicinal history of curcumin. Secondly, we systematically analyze the preclinical studies of curcumin in CVDs such as cardiac hypertrophy, heart failure, drug-induced cardiotoxicity, myocardial infarction, atherosclerosis, abdominal aortic aneurysm, stroke and diabetic cardiovascular complications. The potential molecular targets of curcumin are also summarized. Thirdly, the clinical trials of curcumin in CVDs are overviewed and discussed. Finally, we discuss the therapeutic utility of derivatives of curcumin, and highlight existing problems of curcumin as an effective drug lead in treating CVDs.

ACS Style

Hong Li; Antoni Sureda; Hari Prasad Devkota; Valeria Pittalà; Davide Barreca; Ana Sanches Silva; Devesh Tewari; Suowen Xu; Seyed Mohammad Nabavi. Curcumin, the golden spice in treating cardiovascular diseases. Biotechnology Advances 2020, 38, 107343 .

AMA Style

Hong Li, Antoni Sureda, Hari Prasad Devkota, Valeria Pittalà, Davide Barreca, Ana Sanches Silva, Devesh Tewari, Suowen Xu, Seyed Mohammad Nabavi. Curcumin, the golden spice in treating cardiovascular diseases. Biotechnology Advances. 2020; 38 ():107343.

Chicago/Turabian Style

Hong Li; Antoni Sureda; Hari Prasad Devkota; Valeria Pittalà; Davide Barreca; Ana Sanches Silva; Devesh Tewari; Suowen Xu; Seyed Mohammad Nabavi. 2020. "Curcumin, the golden spice in treating cardiovascular diseases." Biotechnology Advances 38, no. : 107343.