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Dr. Mohamed Abdel-Daim
Suez Canal University, Ismailia, Egypt

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0 Alternative Medicine
0 antioxidant
0 medicinal plants
0 environmental pollutants
0 pharmacology and toxicology

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medicinal plants
environmental pollutants

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Review
Published: 26 August 2021 in Antioxidants
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Oral cancer continues to be a leading cause of death worldwide, and its prevalence is particularly high in developing countries, where people chew tobacco and betel nut on a regular basis. Radiation-, chemo-, targeted-, immuno-, and hormone-based therapies along with surgery are commonly used as part of a treatment plan. However, these treatments frequently result in various unwanted short- to long-term side effects. As a result, there is an urgent need to develop treatment options for oral cancer that have little or no adverse effects. Numerous bioactive compounds derived from various plants have recently attracted attention as therapeutic options for cancer treatment. Antioxidants found in medicinal plants, such as vitamins E, C, and A, reduce damage to the mucosa by neutralizing free radicals found in various oral mucosal lesions. Phytochemicals found in medicinal plants have the potential to modulate cellular signalling pathways that alter the cellular defence mechanisms to protect normal cells from reactive oxygen species (ROS) and induce apoptosis in cancer cells. This review aims to provide a comprehensive overview of various medicinal plants and phytoconstituents that have shown the potential to be used as oral cancer therapeutics.

ACS Style

Suraj Prakash; Radha; Manoj Kumar; Neeraj Kumari; Mamta Thakur; Sonia Rathour; Ashok Pundir; Abhishek Kumar Sharma; Sneh Punia Bangar; Sangram Dhumal; Surinder Singh; Anitha Thiyagarajan; Anshu Sharma; Munisha Sharma; Sushil Changan; Minnu Sasi; Marisennayya Senapathy; Prakash Chandra Pradhan; Nitin Kumar Garg; Tamilselvan Ilakiya; Mukesh Nitin; Mohamed M. Abdel-Daim; Sunil Puri; Suman Natta; Abhijit Dey; Ryszard Amarowicz; Mohamed Mekhemar. Plant-Based Antioxidant Extracts and Compounds in the Management of Oral Cancer. Antioxidants 2021, 10, 1358 .

AMA Style

Suraj Prakash, Radha, Manoj Kumar, Neeraj Kumari, Mamta Thakur, Sonia Rathour, Ashok Pundir, Abhishek Kumar Sharma, Sneh Punia Bangar, Sangram Dhumal, Surinder Singh, Anitha Thiyagarajan, Anshu Sharma, Munisha Sharma, Sushil Changan, Minnu Sasi, Marisennayya Senapathy, Prakash Chandra Pradhan, Nitin Kumar Garg, Tamilselvan Ilakiya, Mukesh Nitin, Mohamed M. Abdel-Daim, Sunil Puri, Suman Natta, Abhijit Dey, Ryszard Amarowicz, Mohamed Mekhemar. Plant-Based Antioxidant Extracts and Compounds in the Management of Oral Cancer. Antioxidants. 2021; 10 (9):1358.

Chicago/Turabian Style

Suraj Prakash; Radha; Manoj Kumar; Neeraj Kumari; Mamta Thakur; Sonia Rathour; Ashok Pundir; Abhishek Kumar Sharma; Sneh Punia Bangar; Sangram Dhumal; Surinder Singh; Anitha Thiyagarajan; Anshu Sharma; Munisha Sharma; Sushil Changan; Minnu Sasi; Marisennayya Senapathy; Prakash Chandra Pradhan; Nitin Kumar Garg; Tamilselvan Ilakiya; Mukesh Nitin; Mohamed M. Abdel-Daim; Sunil Puri; Suman Natta; Abhijit Dey; Ryszard Amarowicz; Mohamed Mekhemar. 2021. "Plant-Based Antioxidant Extracts and Compounds in the Management of Oral Cancer." Antioxidants 10, no. 9: 1358.

Journal article
Published: 17 August 2021 in Archives of Physiology and Biochemistry
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The current research was aimed to evaluate the antidiabetic activity of Terminalia citrina methanolic extract (TCME) by streptozotocin-induced diabetes in male Wistar rats. TCME exhibited better in-vitro antioxidant and alpha-amylase inhibitory activity as compared to other tested extracts. TCME at 250, 500, and 750 mg/kg showed notable (p < .05) antidiabetic potential by lowering fasting blood glucose level, restoring lipid level, serum amylase, HbA1c, kidney, and liver function tests as coevidenced from histological findings of the liver, pancreas, and kidney. TCME remarkably reinstated the antioxidant enzymatic activities (CAT: 0.181 ± 0.011 IU/mg protein, SOD: 21.45 ± 1.53 IU/mg protein) and reduced lipid peroxidation level (40.60 ± 2.41 µM/mg protein) in the liver and kidney tissue of diabetic rats at 750 mg/kg dose. The acute and subacute oral toxicity study of TCME exhibited no clinical toxicity signs and mortality. Its GC-MS spectrum unveiled the existence of 10-octadecenoic acid and other compounds which might have contributed to antidiabetic potential.

ACS Style

Ammara Saleem; Muhammad Furqan Akhtar; Ayesha Latif; Mohamed M. Abdel-Daim; Mirza Muhammad Faran Ashraf Baig; Mohammad Saleem; Malik Hassan Mehmood. Chemical characterisation and appraisal of antidiabetic potential of Terminalia citrina extract in streptozotocin induced hyperglycaemia in Wistar rats. Archives of Physiology and Biochemistry 2021, 1 -14.

AMA Style

Ammara Saleem, Muhammad Furqan Akhtar, Ayesha Latif, Mohamed M. Abdel-Daim, Mirza Muhammad Faran Ashraf Baig, Mohammad Saleem, Malik Hassan Mehmood. Chemical characterisation and appraisal of antidiabetic potential of Terminalia citrina extract in streptozotocin induced hyperglycaemia in Wistar rats. Archives of Physiology and Biochemistry. 2021; ():1-14.

Chicago/Turabian Style

Ammara Saleem; Muhammad Furqan Akhtar; Ayesha Latif; Mohamed M. Abdel-Daim; Mirza Muhammad Faran Ashraf Baig; Mohammad Saleem; Malik Hassan Mehmood. 2021. "Chemical characterisation and appraisal of antidiabetic potential of Terminalia citrina extract in streptozotocin induced hyperglycaemia in Wistar rats." Archives of Physiology and Biochemistry , no. : 1-14.

Journal article
Published: 12 August 2021 in Pharmaceutics
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The present study was conducted to evaluate the analgesic potential of the new triamilide macrolide antibiotic, tulathromycin, at 20 and 40 mg/kg of body weight (BW), subcutaneously against acute pain in mice. Acute pain was induced either chemically (using acetic acid-induced writhing and formalin-induced pain tests) or thermally (using hot-plate, and tail-flick tests). In the acetic acid-induced writhing test, tulathromycin induced a dose-dependent and significant decrease in the number of writhes compared with the control group. In the late phase of the formalin test, a significant decline in hind paw licking time compared with the control group was observed. In the hot-plate and tail-flick tests, tulathromycin caused a dose-dependent and significant prolongation of latency of nociceptive response to heat stimuli, compared with the control group. These findings may indicate that tulathromycin possesses significant peripheral and central analgesic potentials that may be valuable in symptomatic relief of pain, in addition to its well-established antibacterial effect.

ACS Style

Mohamed Elbadawy; Amira Abugomaa; Hussein M. El-Husseiny; Ahmed S. Mandour; Mohamed M. Abdel-Daim; Salama Mostafa Aboelenin; Mohamed Mohamed Soliman; Amany El-Mleeh. The Anti-Nociceptive Potential of Tulathromycin against Chemically and Thermally Induced Pain in Mice. Pharmaceutics 2021, 13, 1247 .

AMA Style

Mohamed Elbadawy, Amira Abugomaa, Hussein M. El-Husseiny, Ahmed S. Mandour, Mohamed M. Abdel-Daim, Salama Mostafa Aboelenin, Mohamed Mohamed Soliman, Amany El-Mleeh. The Anti-Nociceptive Potential of Tulathromycin against Chemically and Thermally Induced Pain in Mice. Pharmaceutics. 2021; 13 (8):1247.

Chicago/Turabian Style

Mohamed Elbadawy; Amira Abugomaa; Hussein M. El-Husseiny; Ahmed S. Mandour; Mohamed M. Abdel-Daim; Salama Mostafa Aboelenin; Mohamed Mohamed Soliman; Amany El-Mleeh. 2021. "The Anti-Nociceptive Potential of Tulathromycin against Chemically and Thermally Induced Pain in Mice." Pharmaceutics 13, no. 8: 1247.

Journal article
Published: 09 August 2021 in Antioxidants
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Aflatoxin B1 (AFB1), a threatening mycotoxin, usually provokes oxidative stress and causes hepatotoxicity in animals and humans. Luteolin (LUTN), well-known as an active phytochemical agent, acts as a strong antioxidant. This research was designed to investigate whether LUTN exerts protective effects against AFB1-induced hepatotoxicity and explore the possible molecular mechanism in mice. A total of forty-eight mice were randomly allocated following four treatment groups (n = 12): Group 1, physiological saline (CON). Group 2, treated with 0.75 mg/kg BW aflatoxin B1 (AFB1). Group 3, treated with 50 mg/kg BW luteolin (LUTN), and Group 4, treated with 0.75 mg/kg BW aflatoxin B1 + 50 mg/kg BW luteolin (AFB1 + LUTN). Our findings revealed that LUTN treatment significantly alleviated growth retardation and rescued liver injury by relieving the pathological and serum biochemical alterations (ALT, AST, ALP, and GGT) under AFB1 exposure. LUTN ameliorated AFB1-induced oxidative stress by scavenging ROS and MDA accumulation and boosting the capacity of the antioxidant enzyme (CAT, T-SOD, GSH-Px and T-AOC). Moreover, LUTN treatment considerably attenuates the AFB1-induced apoptosis in mouse liver, as demonstrated by declined apoptotic cells percentage, decreased Bax, Cyt-c, caspase-3 and caspase-9 transcription and protein with increased Bcl-2 expression. Notably, administration of LUTN up-regulated the Nrf2 and its associated downstream molecules (HO-1, NQO1, GCLC, SOD1) at mRNA and protein levels under AFB1 exposure. Our results indicated that LUTN effectively alleviated AFB1-induced liver injury, and the underlying mechanisms were associated with the activation of the Nrf2 signaling pathway. Taken together, LUTN may serve as a potential mitigator against AFB1-induced liver injury and could be helpful for the development of novel treatment to combat liver diseases in humans and/or animals.

ACS Style

Shahid Rajput; Aftab Shaukat; Kuntan Wu; Imran Rajput; Dost Baloch; Rana Akhtar; Muhammad Raza; Agnieszka Najda; Papliński Rafał; Ashraf Albrakati; Attalla El-Kott; Mohamed Abdel-Daim. Luteolin Alleviates AflatoxinB1-Induced Apoptosis and Oxidative Stress in the Liver of Mice through Activation of Nrf2 Signaling Pathway. Antioxidants 2021, 10, 1268 .

AMA Style

Shahid Rajput, Aftab Shaukat, Kuntan Wu, Imran Rajput, Dost Baloch, Rana Akhtar, Muhammad Raza, Agnieszka Najda, Papliński Rafał, Ashraf Albrakati, Attalla El-Kott, Mohamed Abdel-Daim. Luteolin Alleviates AflatoxinB1-Induced Apoptosis and Oxidative Stress in the Liver of Mice through Activation of Nrf2 Signaling Pathway. Antioxidants. 2021; 10 (8):1268.

Chicago/Turabian Style

Shahid Rajput; Aftab Shaukat; Kuntan Wu; Imran Rajput; Dost Baloch; Rana Akhtar; Muhammad Raza; Agnieszka Najda; Papliński Rafał; Ashraf Albrakati; Attalla El-Kott; Mohamed Abdel-Daim. 2021. "Luteolin Alleviates AflatoxinB1-Induced Apoptosis and Oxidative Stress in the Liver of Mice through Activation of Nrf2 Signaling Pathway." Antioxidants 10, no. 8: 1268.

Journal article
Published: 04 August 2021 in Animals
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Quercetin was fed to groups of broiler chickens at concentrations of 200, 400, and 800 ppm, and a control group was supplemented with a basal diet. Results revealed that quercetin dietary supplementation numerically improved the growth performance traits and significantly increased (p< 0.05) the European production efficiency factor (EPEF) in the 200 ppm group. The total coliforms and Clostridium perfringens were decreased (p< 0.05) in quercetin-supplemented groups. Conversely, Lactobacillus counts were increased (p< 0.05), due to improvement of the gut microbiota environment in quercetin-supplemented groups. Moreover, the mRNA expression of intestinal Cu/Zn-superoxide dismutase (SOD1), glutathione peroxidase (GSH-Px) and nutritional transporters, including glucose transporter 2 (GLUT2), peptide transporter 1 (PEPT1), and fatty acid synthase (FAS) genes, were significantly upregulated in quercetin-supplemented groups. Quercetin enhanced intestinal morphometry. We can suggest quercetin supplementation in broiler chickens by levels between 200 and 400 ppm to enhance their development and gut environment.

ACS Style

Mervat Abdel-Latif; Ahmed Elbestawy; Ali El-Far; Ahmed Noreldin; Mohamed Emam; Roua Baty; Ghadeer Albadrani; Mohamed Abdel-Daim; Hatem Abd El-Hamid. Quercetin Dietary Supplementation Advances Growth Performance, Gut Microbiota, and Intestinal mRNA Expression Genes in Broiler Chickens. Animals 2021, 11, 2302 .

AMA Style

Mervat Abdel-Latif, Ahmed Elbestawy, Ali El-Far, Ahmed Noreldin, Mohamed Emam, Roua Baty, Ghadeer Albadrani, Mohamed Abdel-Daim, Hatem Abd El-Hamid. Quercetin Dietary Supplementation Advances Growth Performance, Gut Microbiota, and Intestinal mRNA Expression Genes in Broiler Chickens. Animals. 2021; 11 (8):2302.

Chicago/Turabian Style

Mervat Abdel-Latif; Ahmed Elbestawy; Ali El-Far; Ahmed Noreldin; Mohamed Emam; Roua Baty; Ghadeer Albadrani; Mohamed Abdel-Daim; Hatem Abd El-Hamid. 2021. "Quercetin Dietary Supplementation Advances Growth Performance, Gut Microbiota, and Intestinal mRNA Expression Genes in Broiler Chickens." Animals 11, no. 8: 2302.

Review
Published: 31 July 2021 in Insects
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Pollination plays a significant role in the agriculture sector and serves as a basic pillar for crop production. Plants depend on vectors to move pollen, which can include water, wind, and animal pollinators like bats, moths, hoverflies, birds, bees, butterflies, wasps, thrips, and beetles. Cultivated plants are typically pollinated by animals. Animal-based pollination contributes to 30% of global food production, and bee-pollinated crops contribute to approximately one-third of the total human dietary supply. Bees are considered significant pollinators due to their effectiveness and wide availability. Bee pollination provides excellent value to crop quality and quantity, improving global economic and dietary outcomes. This review highlights the role played by bee pollination, which influences the economy, and enlists the different types of bees and other insects associated with pollination.

ACS Style

Shaden A. M. Khalifa; Esraa H. Elshafiey; Aya A. Shetaia; Aida A. Abd El-Wahed; Ahmed F. Algethami; Syed G. Musharraf; Mohamed F. AlAjmi; Chao Zhao; Saad H. D. Masry; Mohamed M. Abdel-Daim; Mohammed F. Halabi; Guoyin Kai; Yahya Al Naggar; Mokhtar Bishr; Mohamed A. M. Diab; Hesham R. El-Seedi. Overview of Bee Pollination and Its Economic Value for Crop Production. Insects 2021, 12, 688 .

AMA Style

Shaden A. M. Khalifa, Esraa H. Elshafiey, Aya A. Shetaia, Aida A. Abd El-Wahed, Ahmed F. Algethami, Syed G. Musharraf, Mohamed F. AlAjmi, Chao Zhao, Saad H. D. Masry, Mohamed M. Abdel-Daim, Mohammed F. Halabi, Guoyin Kai, Yahya Al Naggar, Mokhtar Bishr, Mohamed A. M. Diab, Hesham R. El-Seedi. Overview of Bee Pollination and Its Economic Value for Crop Production. Insects. 2021; 12 (8):688.

Chicago/Turabian Style

Shaden A. M. Khalifa; Esraa H. Elshafiey; Aya A. Shetaia; Aida A. Abd El-Wahed; Ahmed F. Algethami; Syed G. Musharraf; Mohamed F. AlAjmi; Chao Zhao; Saad H. D. Masry; Mohamed M. Abdel-Daim; Mohammed F. Halabi; Guoyin Kai; Yahya Al Naggar; Mokhtar Bishr; Mohamed A. M. Diab; Hesham R. El-Seedi. 2021. "Overview of Bee Pollination and Its Economic Value for Crop Production." Insects 12, no. 8: 688.

Journal article
Published: 21 July 2021 in BMC Veterinary Research
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Broilers are continuously stressed because of the rapid growth rate and the environmental issues associated with industrialized poultry production systems, which lead to higher susceptibility for infection with pathogens. It is well known that vitamin E (Vit. E) and selenium (Se) supplementation have protective functions in such stressful conditions. This protocol was to investigate the impact of Vit. E and/or Se on the production performance, some serum biochemistry, and expression of some growth-related gene in the liver tissue of the broilers. The day-old chicks were allotted into four groups according to the supplement; Control group and groups supplemented with Vit. E and/or Se into Vit. E group (100 mg Vit. E/kg diet), Se group (0.3 mg sodium selenite/kg diet), and Vit E + Se group that supplemented with both Vit. E and Se. The data of the present experiment showed that dietary inclusion of Vit. E and/or Se significantly (P ≤ 0.05) improved the production parameters without any side effect on the general health status of the broilers, which indicated by normal serum biochemical parameters. Moreover, the treatments positively affected the expression of some genes related to growth performance including growth hormone receptor (GHR) and insulin-like growth factor 1 (IGF1) in the liver tissue of broilers. Dietary supplementation of Vit. E and/or Se improved the production parameters and upregulate the growth-related genes without effect on the general health status of the broilers.

ACS Style

Olla A. Khalifa; Rasha A. Al Wakeel; Shabaan A. Hemeda; Mohamed M. Abdel-Daim; Ghadeer M. Albadrani; Ahmad El Askary; Sabreen E. Fadl; Fatma Elgendey. The impact of vitamin E and/or selenium dietary supplementation on growth parameters and expression levels of the growth-related genes in broilers. BMC Veterinary Research 2021, 17, 1 .

AMA Style

Olla A. Khalifa, Rasha A. Al Wakeel, Shabaan A. Hemeda, Mohamed M. Abdel-Daim, Ghadeer M. Albadrani, Ahmad El Askary, Sabreen E. Fadl, Fatma Elgendey. The impact of vitamin E and/or selenium dietary supplementation on growth parameters and expression levels of the growth-related genes in broilers. BMC Veterinary Research. 2021; 17 ():1.

Chicago/Turabian Style

Olla A. Khalifa; Rasha A. Al Wakeel; Shabaan A. Hemeda; Mohamed M. Abdel-Daim; Ghadeer M. Albadrani; Ahmad El Askary; Sabreen E. Fadl; Fatma Elgendey. 2021. "The impact of vitamin E and/or selenium dietary supplementation on growth parameters and expression levels of the growth-related genes in broilers." BMC Veterinary Research 17, no. : 1.

Review article
Published: 19 July 2021 in Biomedicine & Pharmacotherapy
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Glioblastoma multiforme is one of the most deadly malignant tumors, with more than 10,000 cases recorded annually in the United States. Various clinical analyses and studies show that certain chronic diseases, including cancer, interact between cell-reactive radicals rise and pathogenesis. Reactive oxygen and nitrogenous sources include endogenous (physiological processes), and exogenous sources contain reactive oxygen and nitrogen (xenobiotic interaction). The cellular oxidation/reduction shifts to oxidative stress when the regulation mechanisms of antioxidants are surpassed, and this raises the ability to damage cellular lipids, proteins, and nucleic acids. This review is focused on how phytochemicals play crucial role against glioblastoma multiforme and to combat these, bioactive molecules and their derivatives are either used alone, in combination with anticancer drugs or as nanomedicine formulations for better cancer theranostics over the conventional approach. Bioactive molecules found in seeds, vegetables, and fruits have antioxidant, anti-inflammatory, and anticancer properties that may help cancer survivors feel better throughout chemotherapy or treatment. However, incorporating them into the nanocarrier-based drug delivery for the treatment of GBMs, which could be a promising therapeutic strategy for this tumor entity, increasing targeting effectiveness, increasing bioavailability, and reducing side effects with this target-specificity, drug internalization into cells is significantly improved, and off-target organ aggregation is reduced.

ACS Style

Priti Tagde; Pooja Tagde; Sandeep Tagde; Tanima Bhattacharya; Vishal Garg; Rokeya Akter; Habibur Rahman; Agnieszka Najda; Ghadeer M. Albadrani; Amany A. Sayed; Muhammad Furqan Akhtar; Ammara Saleem; Ahmed E. Altyar; Deepak Kaushik; Mohamed M. Abdel-Daim. Natural bioactive molecules: An alternative approach to the treatment and control of glioblastoma multiforme. Biomedicine & Pharmacotherapy 2021, 141, 111928 .

AMA Style

Priti Tagde, Pooja Tagde, Sandeep Tagde, Tanima Bhattacharya, Vishal Garg, Rokeya Akter, Habibur Rahman, Agnieszka Najda, Ghadeer M. Albadrani, Amany A. Sayed, Muhammad Furqan Akhtar, Ammara Saleem, Ahmed E. Altyar, Deepak Kaushik, Mohamed M. Abdel-Daim. Natural bioactive molecules: An alternative approach to the treatment and control of glioblastoma multiforme. Biomedicine & Pharmacotherapy. 2021; 141 ():111928.

Chicago/Turabian Style

Priti Tagde; Pooja Tagde; Sandeep Tagde; Tanima Bhattacharya; Vishal Garg; Rokeya Akter; Habibur Rahman; Agnieszka Najda; Ghadeer M. Albadrani; Amany A. Sayed; Muhammad Furqan Akhtar; Ammara Saleem; Ahmed E. Altyar; Deepak Kaushik; Mohamed M. Abdel-Daim. 2021. "Natural bioactive molecules: An alternative approach to the treatment and control of glioblastoma multiforme." Biomedicine & Pharmacotherapy 141, no. : 111928.

Journal article
Published: 19 July 2021 in Biology
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The ameliorative effect of L-arginine (LA) and L-carnitine (LC) against fipronil (FPN)-induced neurotoxicity was explored. In this case, 36 adult male rats were randomly divided into six groups: group I received distilled water, group II received 500 mg/kg LA, group III received 100 mg/kg LC, group IV received 4.85 mg/kg FPN, group V received 4.85 mg/kg FPN and 500 mg/kg LA and group VI received 4.85 mg/kg FPN and 100 mg/kg LC for 6 weeks. Cognitive performance was assessed using Barnes maze (BM). Serum corticosterone, brain total antioxidant capacity (TAC), malondialdehyde (MDA) and dopamine were measured. Histopathology and immunohistochemistry of ionized calcium-binding adaptor (Iba-1), doublecortin (DCX) and serotonin (S-2A) receptors were performed. Fipronil induced noticeable deterioration in spatial learning and memory performance. In addition, FPN significantly (p< 0.05) diminished brain antioxidant defense system and dopamine coincide with elevated serum corticosterone level. Histopathological examination revealed degenerative and necrotic changes. Furthermore, Iba-1 and DCX were significantly expressed in cortex and hippocampus whereas S-2A receptors were significantly lowered in FPN group. However, administration of LA or LC alleviated FPN-induced deteriorations. In conclusion, LA and LC could be prospective candidates for mitigation of FPN-induced neurotoxicity via their antioxidant, anti-inflammatory and neuropotentiating effects.

ACS Style

Yasmina Mahmoud; Ahmed Ali; Heba Abdelrazek; Tahany Aldayel; Mohamed Abdel-Daim; Menna El-Menyawy. Neurotoxic Effect of Fipronil in Male Wistar Rats: Ameliorative Effect of L-Arginine and L-Carnitine. Biology 2021, 10, 682 .

AMA Style

Yasmina Mahmoud, Ahmed Ali, Heba Abdelrazek, Tahany Aldayel, Mohamed Abdel-Daim, Menna El-Menyawy. Neurotoxic Effect of Fipronil in Male Wistar Rats: Ameliorative Effect of L-Arginine and L-Carnitine. Biology. 2021; 10 (7):682.

Chicago/Turabian Style

Yasmina Mahmoud; Ahmed Ali; Heba Abdelrazek; Tahany Aldayel; Mohamed Abdel-Daim; Menna El-Menyawy. 2021. "Neurotoxic Effect of Fipronil in Male Wistar Rats: Ameliorative Effect of L-Arginine and L-Carnitine." Biology 10, no. 7: 682.

Journal article
Published: 12 July 2021 in Animals
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Ammonia is a critical hazardous nitrogen metabolic product in aquaculture. Despite trials for its control, ammonia intoxication remains one of the most critical issues to overcome. In this study, we explored the modulatory effect and potential mechanism by which Yucca schidigera extract (YSE) can ameliorate ammonia intoxication-induced adverse effects on tilapia health and metabolism. A total number of 120 Nile tilapia were evenly assigned into four groups with three replicates each. The first group served as normal control group; the second group was exposed to ammonia alone from the beginning of the experiment and for four weeks. The third group was supplied with YSE in water at a dose of 8 mg/L and exposed to ammonia. The fourth group was supplied with YSE only in water at a dose of 8 mg/L. YSE supplementation succeeded in improving water quality by reducing pH and ammonia levels. Moreover, YSE supplementation markedly alleviated chronic ammonia-induced adverse impacts on fish growth by increasing the final body weight (FBW), specific growth rate (SGR), feed intake and protein efficiency ratio (PER) while reducing the feed conversion ratio (FCR) via improvements in food intake, elevation of hepatic insulin-like growth factor (ILGF-1) and suppression of myostatin (MSTN) expression levels with the restoration of lipid reserves and the activation of lipogenic potential in adipose tissue as demonstrated by changes in the circulating metabolite levels. In addition, the levels of hepato-renal injury biomarkers were restored, hepatic lipid peroxidation was inhibited and the levels of hepatic antioxidant biomarkers were enhanced. Therefore, the current study suggests that YSE supplementation exerted an ameliorative role against chronic ammonia-induced oxidative stress and toxic effects due to its free radical-scavenging potential, potent antioxidant activities and anti-inflammatory effects.

ACS Style

Zizy Elbialy; Abdallah Salah; Ahmed Elsheshtawy; Merna Rizk; Muyassar Abualreesh; Mohamed Abdel-Daim; Shimaa Salem; Ahmad Askary; Doaa Assar. Exploring the Multimodal Role of Yucca schidigera Extract in Protection against Chronic Ammonia Exposure Targeting: Growth, Metabolic, Stress and Inflammatory Responses in Nile Tilapia (Oreochromis niloticus L.). Animals 2021, 11, 2072 .

AMA Style

Zizy Elbialy, Abdallah Salah, Ahmed Elsheshtawy, Merna Rizk, Muyassar Abualreesh, Mohamed Abdel-Daim, Shimaa Salem, Ahmad Askary, Doaa Assar. Exploring the Multimodal Role of Yucca schidigera Extract in Protection against Chronic Ammonia Exposure Targeting: Growth, Metabolic, Stress and Inflammatory Responses in Nile Tilapia (Oreochromis niloticus L.). Animals. 2021; 11 (7):2072.

Chicago/Turabian Style

Zizy Elbialy; Abdallah Salah; Ahmed Elsheshtawy; Merna Rizk; Muyassar Abualreesh; Mohamed Abdel-Daim; Shimaa Salem; Ahmad Askary; Doaa Assar. 2021. "Exploring the Multimodal Role of Yucca schidigera Extract in Protection against Chronic Ammonia Exposure Targeting: Growth, Metabolic, Stress and Inflammatory Responses in Nile Tilapia (Oreochromis niloticus L.)." Animals 11, no. 7: 2072.

Review article
Published: 10 July 2021 in Oxidative Medicine and Cellular Longevity
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The biological and therapeutic properties of seaweeds have already been well known. Several studies showed that among the various natural marine sources of antioxidants, seaweeds have become a potential source of antioxidants because of their bioactive compounds. Most of the metabolic diseases are caused by oxidative stress. It is very well known that antioxidants have a pivotal role in the treatment of those diseases. Recent researches have revealed the potential activity of seaweeds as complementary medicine, which have therapeutic properties for health and disease management. Among the seaweeds, brown seaweeds (Phaeophyta) and their derived bioactive substances showed excellent antioxidant properties than other seaweeds. This review focuses on brown seaweeds and their derived major bioactive compounds such as sulfated polysaccharide, polyphenol, carotenoid, and sterol antioxidant effects and molecular mechanisms in the case of the oxidative stress-originated disease. Antioxidants have a potential role in the modification of stress-induced signaling pathways along with the activation of the oxidative defensive pathways. This review would help to provide the basis for further studies to researchers on the potential antioxidant role in the field of medical health care and future drug development.

ACS Style

Rahima Begum; Saurav Howlader; A. N. M. Mamun-Or-Rashid; S. M. Rafiquzzaman; Ghulam Md Ashraf; Ghadeer M. Albadrani; Amany A. Sayed; Ilaria Peluso; Mohamed M. Abdel-Daim; Sahab Uddin. Antioxidant and Signal-Modulating Effects of Brown Seaweed-Derived Compounds against Oxidative Stress-Associated Pathology. Oxidative Medicine and Cellular Longevity 2021, 2021, 1 -22.

AMA Style

Rahima Begum, Saurav Howlader, A. N. M. Mamun-Or-Rashid, S. M. Rafiquzzaman, Ghulam Md Ashraf, Ghadeer M. Albadrani, Amany A. Sayed, Ilaria Peluso, Mohamed M. Abdel-Daim, Sahab Uddin. Antioxidant and Signal-Modulating Effects of Brown Seaweed-Derived Compounds against Oxidative Stress-Associated Pathology. Oxidative Medicine and Cellular Longevity. 2021; 2021 ():1-22.

Chicago/Turabian Style

Rahima Begum; Saurav Howlader; A. N. M. Mamun-Or-Rashid; S. M. Rafiquzzaman; Ghulam Md Ashraf; Ghadeer M. Albadrani; Amany A. Sayed; Ilaria Peluso; Mohamed M. Abdel-Daim; Sahab Uddin. 2021. "Antioxidant and Signal-Modulating Effects of Brown Seaweed-Derived Compounds against Oxidative Stress-Associated Pathology." Oxidative Medicine and Cellular Longevity 2021, no. : 1-22.

Review article
Published: 09 July 2021 in Environmental Science and Pollution Research
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The infectiousness of COVID-19 is high among the susceptible population, making the calculation of the reproduction number (R) an essential step to implement preventive measures. We aim to estimate COVID-19 transmission to determine if the disease is successfully controlled or extra measured should be adopted to attain this goal. The daily incidence data of COVID-19 in Saudi Arabia from March 2nd, 2020, to April 4th, 2021, were obtained from the continuously updated Saudi Ministry of Health COVID-19 repository. To get accurate estimation of the situation over the last 4 months (from December 1st, 2020, to April 4th, 2021), we calculated the weekly (every 7 days) R starting from March 2nd, 2020, and till the last week of the available data. The calculated values of R were represented as median, first quantile (Q1), and third quantile (Q3). As early as the first week of December 2020, the median R was 0.81 (0.80–0.83) which means that each existing infected case would transmit infection to only one person. This was followed by fluctuations over the next few weeks around R value of 1, reaching its highest level of 1.45 (1.42–1.47) between December 31st, 2020, and January 6th, 2021. This was followed by a relatively steady decline over the following weeks, with some till mid-March where the R values started to slightly rise again. Social distancing, protective precautions, avoiding abuse of the partial lifting, expanding the screening process, and other Saudi measures sound to be successful and should be replicated in similar communities. This measure should be continued till the vaccination process is completed, to reduce the number of contacts and to avoid uncontrolled transmission of the disease.

ACS Style

Theeb Ayedh Alkahtani; Abdullah Alakeel; Reem Abdullah Alakeel; Faten Abdulrahman Khorshid; Hisham Hamoud Alshammari; Abdullah M. Alguwaihes; Mohammad Almohideb; Eman Merghani Ali; May Bin-Jumah; Mohamed M. Abdel-Daim; Anwar Ali Jammah. The current reproduction number of COVID-19 in Saudi Arabia: is the disease controlled? Environmental Science and Pollution Research 2021, 1 -6.

AMA Style

Theeb Ayedh Alkahtani, Abdullah Alakeel, Reem Abdullah Alakeel, Faten Abdulrahman Khorshid, Hisham Hamoud Alshammari, Abdullah M. Alguwaihes, Mohammad Almohideb, Eman Merghani Ali, May Bin-Jumah, Mohamed M. Abdel-Daim, Anwar Ali Jammah. The current reproduction number of COVID-19 in Saudi Arabia: is the disease controlled? Environmental Science and Pollution Research. 2021; ():1-6.

Chicago/Turabian Style

Theeb Ayedh Alkahtani; Abdullah Alakeel; Reem Abdullah Alakeel; Faten Abdulrahman Khorshid; Hisham Hamoud Alshammari; Abdullah M. Alguwaihes; Mohammad Almohideb; Eman Merghani Ali; May Bin-Jumah; Mohamed M. Abdel-Daim; Anwar Ali Jammah. 2021. "The current reproduction number of COVID-19 in Saudi Arabia: is the disease controlled?" Environmental Science and Pollution Research , no. : 1-6.

Journal article
Published: 29 June 2021 in Medical Hypotheses
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Huntington disease (HD) is a type of neurodegenerative disease that is characterized by presence of multiple repeats (more than 36) of cytosine-adenine-guanine (CAG) trinucleotides and mutated huntingtin (mHtt). This can further lead to oxidative stress, enhancement in level of ROS/RNS, mitochondrial dysfunction and neuroinflammations. Many clinical and preclinical trials have been conducted so far for the effective treatment of HD however, none of the drugs has shown complete relief. The regeneration of neurons is a very complicated process and associated with multiple pathological pathways. Hence, finding a unique solution using single drug that could act on multiple pathological pathways is really cumbersome. In the proposed hypothesis the use of demethyleneberberine (DMB) as a potential anti-HD agent has been explained. It is a metabolite of berberine and reported to act on multiple mechanistic pathways that are responsible for HD. Present article highlights new mechanistic insights through which DMB inhibits ROS/RNS, oxidative stress, mitochondrial dysfunctions and neuroinflammation such as NFκB, TNF-α, IL-6 and IL-8, cytokinin. Further its action on cellular apoptosis and neuronal cell death are also reported.

ACS Style

Saurabh Gupta; Arzoo Khan; Sukriti Vishwas; Monica Gulati; Thakur Gurjeet Singh; Kamal Dua; Sachin Kumar Singh; Agnieszka Najda; Amany A. Sayed; Rafa Almeer; Mohamed M. Abdel-Daim. Demethyleneberberine: A possible treatment for Huntington’s disease. Medical Hypotheses 2021, 153, 110639 .

AMA Style

Saurabh Gupta, Arzoo Khan, Sukriti Vishwas, Monica Gulati, Thakur Gurjeet Singh, Kamal Dua, Sachin Kumar Singh, Agnieszka Najda, Amany A. Sayed, Rafa Almeer, Mohamed M. Abdel-Daim. Demethyleneberberine: A possible treatment for Huntington’s disease. Medical Hypotheses. 2021; 153 ():110639.

Chicago/Turabian Style

Saurabh Gupta; Arzoo Khan; Sukriti Vishwas; Monica Gulati; Thakur Gurjeet Singh; Kamal Dua; Sachin Kumar Singh; Agnieszka Najda; Amany A. Sayed; Rafa Almeer; Mohamed M. Abdel-Daim. 2021. "Demethyleneberberine: A possible treatment for Huntington’s disease." Medical Hypotheses 153, no. : 110639.

Research article
Published: 29 June 2021 in Environmental Science and Pollution Research International
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We conducted the current analysis to determine the potential role of measles vaccination in the context of the spread of COVID-19. Data were extracted from the World Health Organization’s (WHO) Global Health Observatory data repository about the measles immunization coverage estimates and correlated to overall morbidity and mortality for COVID-19 among different countries. Data were statistically analyzed to calculate the Spearman rank correlation coefficient (rho). There was a significant positive correlation between the vaccine coverage (%) and new cases per one million populations (rho = 0.24; p-value = 0.025); however, this correlation was absent in deaths per one million populations (rho = 0.17; p-value = 0.124). On further analysis of the effect of first reported year of vaccination policy, there was no significant correlation with both of total cases per one million populations (rho = 0.11; p-value = 0.327) and deaths per one million populations (rho = −0.02; p-value = 0.829). Claims regarding the possible protective effect of measles vaccination seem to be doubtful.

ACS Style

Raed Ibrahim Altulayhi; Rakan M. Alqahtani; Reem Abdullah Alakeel; Faten Abdulrahman Khorshid; Rehab Hamoud Alshammari; Sana Ghazi Alattas; Fahad Abdullah M. Alshammari; May Bin-Jumah; Mohamed M. Abdel-Daim; Mohammad Almohideb. Correlation between measles immunization coverage and overall morbidity and mortality for COVID-19: an epidemiological study. Environmental Science and Pollution Research International 2021, 1 -8.

AMA Style

Raed Ibrahim Altulayhi, Rakan M. Alqahtani, Reem Abdullah Alakeel, Faten Abdulrahman Khorshid, Rehab Hamoud Alshammari, Sana Ghazi Alattas, Fahad Abdullah M. Alshammari, May Bin-Jumah, Mohamed M. Abdel-Daim, Mohammad Almohideb. Correlation between measles immunization coverage and overall morbidity and mortality for COVID-19: an epidemiological study. Environmental Science and Pollution Research International. 2021; ():1-8.

Chicago/Turabian Style

Raed Ibrahim Altulayhi; Rakan M. Alqahtani; Reem Abdullah Alakeel; Faten Abdulrahman Khorshid; Rehab Hamoud Alshammari; Sana Ghazi Alattas; Fahad Abdullah M. Alshammari; May Bin-Jumah; Mohamed M. Abdel-Daim; Mohammad Almohideb. 2021. "Correlation between measles immunization coverage and overall morbidity and mortality for COVID-19: an epidemiological study." Environmental Science and Pollution Research International , no. : 1-8.

Review article
Published: 21 June 2021 in Oxidative Medicine and Cellular Longevity
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Neurodegenerative disorders (NDs) are heterogeneous groups of ailments typically characterized by progressive damage of the nervous system. Several drugs are used to treat NDs but they have only symptomatic benefits with various side effects. Numerous researches have been performed to prove the advantages of phytochemicals for the treatment of NDs. Furthermore, phytochemicals such as polyphenols might play a pivotal role in rescue from neurodegeneration due to their various effects as anti-inflammatory, antioxidative, and antiamyloidogenic agents by controlling apoptotic factors, neurotrophic factors (NTFs), free radical scavenging system, and mitochondrial stress. On the other hand, neurotrophins (NTs) including nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), NT4/5, and NT3 might have a crucial neuroprotective role, and their diminution triggers the development of the NDs. Polyphenols can interfere directly with intracellular signaling molecules to alter brain activity. Several natural products also improve the biosynthesis of endogenous genes encoding antiapoptotic Bcl-2 as well as NTFs such as glial cell and brain-derived NTFs. Various epidemiological studies have demonstrated that the initiation of these genes could play an essential role in the neuroprotective function of dietary compounds. Hence, targeting NTs might represent a promising approach for the management of NDs. In this review, we focus on the natural product-mediated neurotrophic signal-modulating cascades, which are involved in the neuroprotective effects.

ACS Style

Sahab Uddin; Abdullah Al Mamun; Motiar Rahman; Philippe Jeandet; Athanasios Alexiou; Tapan Behl; Shahid Sarwar; Eduardo Sobarzo-Sánchez; Ghulam Md Ashraf; Amany A. Sayed; Ghadeer M. Albadrani; Ilaria Peluso; Mohamed M. Abdel-Daim. Natural Products for Neurodegeneration: Regulating Neurotrophic Signals. Oxidative Medicine and Cellular Longevity 2021, 2021, 1 -17.

AMA Style

Sahab Uddin, Abdullah Al Mamun, Motiar Rahman, Philippe Jeandet, Athanasios Alexiou, Tapan Behl, Shahid Sarwar, Eduardo Sobarzo-Sánchez, Ghulam Md Ashraf, Amany A. Sayed, Ghadeer M. Albadrani, Ilaria Peluso, Mohamed M. Abdel-Daim. Natural Products for Neurodegeneration: Regulating Neurotrophic Signals. Oxidative Medicine and Cellular Longevity. 2021; 2021 ():1-17.

Chicago/Turabian Style

Sahab Uddin; Abdullah Al Mamun; Motiar Rahman; Philippe Jeandet; Athanasios Alexiou; Tapan Behl; Shahid Sarwar; Eduardo Sobarzo-Sánchez; Ghulam Md Ashraf; Amany A. Sayed; Ghadeer M. Albadrani; Ilaria Peluso; Mohamed M. Abdel-Daim. 2021. "Natural Products for Neurodegeneration: Regulating Neurotrophic Signals." Oxidative Medicine and Cellular Longevity 2021, no. : 1-17.

Journal article
Published: 21 June 2021 in Animals
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Haemonchosis is a parasitic disease of small ruminants that adversely affects livestock production. Haemonchus contortus is one of the most prevalent nematode parasites that infect the abomasum of small ruminants. This parasite reduces milk production, overall growth and sometimes causes the death of the infected animals. The evaluation of the biocontrol potential of some abomasum bacterial isolates against H. contortus is investigated in this study. Out of which, three isolates—Comamonas testosteroni, Comamonas jiangduensis, Pseudomonas weihenstephanesis—show significant effect against the nematode L3, adult, and egg hatch inhibition assays. Various concentrations of metabolites from these bacteria are prepared and applied in different treatments compared with control. In the case of adult mortality assay, 50% metabolites of C. testosteroni and P. weihenstephanesis show 46% adult mortality, whereas C. jiangduensis shows 40% mortality. It is observed that decreasing the concentration of bacterial metabolite, lowers nematode mortality. The minimum nematode mortality rate is recorded at the lowest filtrates concentration of all the bacterial isolates. The same trend is observed in egg hatch inhibition assay, where the higher concentration of bacterial culture filtrates shows 100% inhibition of H. contortus egg. It is concluded that the effect of bacterial culture filtrates against H. contortus is dose-dependent for their activity against nematode L3, adult, and inhibition of egg hatchment.

ACS Style

Asfa Nazish; Fozia; Baharullah Khattak; Taj Ali Khan; Ijaz Ahmad; Riaz Ullah; Ahmed Bari; Majid Asmari; Hafiz Mahmood; Muhammad Sohaib; Ahmad El Askary; Attalla El-Kott; Mohamed Abdel-Daim. Antinematode Activity of Abomasum Bacterial Culture Filtrates against Haemonchus contortus in Small Ruminants. Animals 2021, 11, 1843 .

AMA Style

Asfa Nazish, Fozia, Baharullah Khattak, Taj Ali Khan, Ijaz Ahmad, Riaz Ullah, Ahmed Bari, Majid Asmari, Hafiz Mahmood, Muhammad Sohaib, Ahmad El Askary, Attalla El-Kott, Mohamed Abdel-Daim. Antinematode Activity of Abomasum Bacterial Culture Filtrates against Haemonchus contortus in Small Ruminants. Animals. 2021; 11 (6):1843.

Chicago/Turabian Style

Asfa Nazish; Fozia; Baharullah Khattak; Taj Ali Khan; Ijaz Ahmad; Riaz Ullah; Ahmed Bari; Majid Asmari; Hafiz Mahmood; Muhammad Sohaib; Ahmad El Askary; Attalla El-Kott; Mohamed Abdel-Daim. 2021. "Antinematode Activity of Abomasum Bacterial Culture Filtrates against Haemonchus contortus in Small Ruminants." Animals 11, no. 6: 1843.

Review article
Published: 15 June 2021 in Biomedicine & Pharmacotherapy
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Oral mucocutaneous cancers (OMCs) are cancers that affect both the oral mucosa and perioral cutaneous structures. Common OMCs are squamous cell carcinoma (SCC), basal cell carcinoma (BCC) and malignant melanoma (MM). Anatomical similarities and conventions which categorizes these lesions blur the magnitude of OMCs in diverse populations. The burden of OMC is high in the sub-Saharan Africa and Indian subcontinents, and the cost of management is prohibitive in the resource-limited, developing world. Hence, there is a pressing demand for the use of cost-effective in silico approaches to identify diagnostic tools and treatment targets for diseases with high burdens in these regions. Due to their ubiquitousness and accessibility, the use of therapeutic efficacy of plant bioactive compounds in the management of OMC is both appropriate and plausible. Furthermore, screening known mechanistic disease targets with well annotated plant bioactive compound libraries is poised to improve the routine management of OMCs provided that the requisite access to database resources are available and accessible. Using natural products minimizes the side effects and morbidities associated with conventional therapies. The development of innovative treatments approaches would tremendously benefit the African and Indian populace and reduce the mortalities associated with OMCs in the developing world. Hence, we discuss herein, the potential benefits, opportunities and challenges of using bioactive compound libraries in the management of OMCs.

ACS Style

Henry A. Adeola; Afsareen Bano; Ravina Vats; Amit Vashishtha; Deepika Verma; Deepak Kaushik; Vineet Mittal; Habibur Rahman; Agnieszka Najda; Ghadeer M. Albadrani; Amany A. Sayed; Sameh M. Farouk; Emad H.M. Hassanein; Muhammad Furqan Akhtar; Ammara Saleem; Mohamed M. Abdel-Daim; Rashmi Bhardwaj. Bioactive compounds and their libraries: An insight into prospective phytotherapeutics approach for oral mucocutaneous cancers. Biomedicine & Pharmacotherapy 2021, 141, 111809 .

AMA Style

Henry A. Adeola, Afsareen Bano, Ravina Vats, Amit Vashishtha, Deepika Verma, Deepak Kaushik, Vineet Mittal, Habibur Rahman, Agnieszka Najda, Ghadeer M. Albadrani, Amany A. Sayed, Sameh M. Farouk, Emad H.M. Hassanein, Muhammad Furqan Akhtar, Ammara Saleem, Mohamed M. Abdel-Daim, Rashmi Bhardwaj. Bioactive compounds and their libraries: An insight into prospective phytotherapeutics approach for oral mucocutaneous cancers. Biomedicine & Pharmacotherapy. 2021; 141 ():111809.

Chicago/Turabian Style

Henry A. Adeola; Afsareen Bano; Ravina Vats; Amit Vashishtha; Deepika Verma; Deepak Kaushik; Vineet Mittal; Habibur Rahman; Agnieszka Najda; Ghadeer M. Albadrani; Amany A. Sayed; Sameh M. Farouk; Emad H.M. Hassanein; Muhammad Furqan Akhtar; Ammara Saleem; Mohamed M. Abdel-Daim; Rashmi Bhardwaj. 2021. "Bioactive compounds and their libraries: An insight into prospective phytotherapeutics approach for oral mucocutaneous cancers." Biomedicine & Pharmacotherapy 141, no. : 111809.

Research article
Published: 11 June 2021 in Environmental Science and Pollution Research
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This study was aimed at elucidating the protective effects of 18β-glycyrrhetinic acid (18βGA) against acrylamide (Acr)-induced cellular damage in diabetic rats. Rats were randomly assigned into eight groups (n = 8) following 12 h of fasting: control group, a single dose of 50 mg/kg streptozotocin (STZ) intraperitoneally (diabetic group), 50 mg/kg 18βGA orally after 2 weeks from STZ injection (18βGA group), 20 mg/kg Acr after 1month from STZ injection (Acr group), STZ plus Acr (STZ-Acr group), STZ plus 18βGA (STZ-18βGA group), Acr plus 18βGA (Acr-18βGA group), or STZ plus Acr plus 18βGA (STZ-Acr-18βGA group). Administration of 18βGA alone increased GSH, GSH-PX, SOD, and CAT in both liver and kidneys. While STZ injection was associated with diabetic and oxidative stress changes as indicated by the higher serum glucose, cholesterol, creatinine, IL-1β, IL-6, TNF-α, and antioxidant enzyme activities, together with increased lipid peroxides and decreased antioxidant biomarkers in the liver and kidneys. Similarly, the co-administration of STZ and Acr was associated with similar, more augmented effects, compared to STZ alone. The administration of 18βGA normalized STZ and Acr-induced elevations in oxidative defense variables in the liver and kidney tissues and blood biomarkers. Thus, our study demonstrated that the damaging effects of Acr were more exaggerated in diabetic rats. Furthermore, it showed the ability of 18βGA to inhibit reactive oxygen species generation and restore the antioxidant defenses in diabetic rats with Acr-induced liver and kidney cytotoxicity.

ACS Style

Ibtesam S. Alanazi; Mohamed Emam; Mabrouk Elsabagh; Saad Alkahtani; Mohamed M. Abdel-Daim. The protective effects of 18β-glycyrrhetinic acid against acrylamide-induced cellular damage in diabetic rats. Environmental Science and Pollution Research 2021, 1 -9.

AMA Style

Ibtesam S. Alanazi, Mohamed Emam, Mabrouk Elsabagh, Saad Alkahtani, Mohamed M. Abdel-Daim. The protective effects of 18β-glycyrrhetinic acid against acrylamide-induced cellular damage in diabetic rats. Environmental Science and Pollution Research. 2021; ():1-9.

Chicago/Turabian Style

Ibtesam S. Alanazi; Mohamed Emam; Mabrouk Elsabagh; Saad Alkahtani; Mohamed M. Abdel-Daim. 2021. "The protective effects of 18β-glycyrrhetinic acid against acrylamide-induced cellular damage in diabetic rats." Environmental Science and Pollution Research , no. : 1-9.

Correction
Published: 05 June 2021 in Environmental Science and Pollution Research
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ACS Style

Marwa Adel Afify; Rakan M. Alqahtani; Mohammed Abdulrahman Mohammed Alzamil; Faten Abdulrahman Khorshid; Sumayyah Mohammad Almarshedy; Sana Ghazi Alattas; Talal Nabeel Alrawaf; May Bin-Jumah; Mohamed M. Abdel-Daim; Mohammad Almohideb. Correction to: Correlation between polio immunization coverage and overall morbidity and mortality for COVID-19: an epidemiological study. Environmental Science and Pollution Research 2021, 1 -2.

AMA Style

Marwa Adel Afify, Rakan M. Alqahtani, Mohammed Abdulrahman Mohammed Alzamil, Faten Abdulrahman Khorshid, Sumayyah Mohammad Almarshedy, Sana Ghazi Alattas, Talal Nabeel Alrawaf, May Bin-Jumah, Mohamed M. Abdel-Daim, Mohammad Almohideb. Correction to: Correlation between polio immunization coverage and overall morbidity and mortality for COVID-19: an epidemiological study. Environmental Science and Pollution Research. 2021; ():1-2.

Chicago/Turabian Style

Marwa Adel Afify; Rakan M. Alqahtani; Mohammed Abdulrahman Mohammed Alzamil; Faten Abdulrahman Khorshid; Sumayyah Mohammad Almarshedy; Sana Ghazi Alattas; Talal Nabeel Alrawaf; May Bin-Jumah; Mohamed M. Abdel-Daim; Mohammad Almohideb. 2021. "Correction to: Correlation between polio immunization coverage and overall morbidity and mortality for COVID-19: an epidemiological study." Environmental Science and Pollution Research , no. : 1-2.

Review article
Published: 31 May 2021 in Biomedicine & Pharmacotherapy
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Cancer treatment is improving widely over time, but finding a proper defender to beat them seems like a distant dream. The quest for identification and discovery of drugs with an effective action is still a vital work. The role of a membrane protein called P-glycoprotein, which functions as garbage chute that efflux the waste, xenobiotics, and toxins out of the cancer cells acts as a major reason behind the therapeutic failure of most chemotherapeutic drugs. In this review, we mainly focused on a multiple strategies by employing 5-Fluorouracil, curcumin, and lipids in Nano formulation for the possible treatment of colorectal cancer and its metastasis. Eventually, multidrug resistance and angiogenesis can be altered and it would be helpful in colorectal cancer targeting.We have depicted the possible way for the depletion of colorectal cancer cells without disturbing the normal cells. The concept of focusing on multiple pathways for marking the colorectal cancer cells could help in activating one among the pathways if the other one fails. The activity of the 5-Fluorouracil can be enhanced with the help of curcumin which acts as a chemosensitizer, chemotherapeutic agent, and even for altering the resistance. As we eat to survive, so do the cancer cells. The cancer cells utilize the energy source to stay alive and survive. Fatty acids can be used as the energy source and this concept can be employed for targeting the colorectal cancer cells and also for altering the resistant part.

ACS Style

Chenmala Karthika; Balaji Hari; Habibur Rahman; Rokeya Akter; Agnieszka Najda; Ghadeer M. Albadrani; Amany A. Sayed; Muhammad Furqan Akhtar; Mohamed M. Abdel-Daim. Multiple strategies with the synergistic approach for addressing colorectal cancer. Biomedicine & Pharmacotherapy 2021, 140, 111704 .

AMA Style

Chenmala Karthika, Balaji Hari, Habibur Rahman, Rokeya Akter, Agnieszka Najda, Ghadeer M. Albadrani, Amany A. Sayed, Muhammad Furqan Akhtar, Mohamed M. Abdel-Daim. Multiple strategies with the synergistic approach for addressing colorectal cancer. Biomedicine & Pharmacotherapy. 2021; 140 ():111704.

Chicago/Turabian Style

Chenmala Karthika; Balaji Hari; Habibur Rahman; Rokeya Akter; Agnieszka Najda; Ghadeer M. Albadrani; Amany A. Sayed; Muhammad Furqan Akhtar; Mohamed M. Abdel-Daim. 2021. "Multiple strategies with the synergistic approach for addressing colorectal cancer." Biomedicine & Pharmacotherapy 140, no. : 111704.