In this paper, a microwave fluidic glucose sensor based on dual complementary split ring resonators (CSRRs) with a switching circuit is proposed for non-invasive and continuous glucose concentration detection. A CSRR has been designed to detect subtle changes in the dielectric constant of glucose solutions, and the electric field distribution is utilized to determine the effective sensing region. In a well-controlled environment, the glucose concentration can be detected by tracking the transmission coefficient of the designed CSRR. However, because the variations in dielectric constant with the glucose concentration are very small, the environmental factors (i.e., ambient temperature and relative humidity) can be dominant compared to the glucose concentration. To qualify the effect of the environmental factors, the variation in the transmission coefficient of the CSRR has been measured when the ambient temperature condition is varied from 293 K to 313 K and the relative humidity is varied from 30% to 90% inside temperature- and humidity-controlled chamber. Moreover, the environmental effects are calibrated out using two identical CSRRs with the switching circuit: one detects changes in the glucose concentration, while the other operates as a reference for environmental factors. After the elimination of the environmental effects, glucose concentrations in the range of 0 mg/dL to 400 mg/dL have been measured, and the sensitivity is 0.008dB/(100mg/dL). In addition, the reproducibility of the proposed sensor is verified by repeated measurements. It is demonstrated that the proposed sensor can detect glucose concentrations under practical environmental conditions

In this paper, a fluidic glucose sensor that is based on a complementary split-ring resonator (CSRR) is proposed for the microwave frequency region. The detection of glucose with different concentrations from 0 mg/dL to 400 mg/dL in a non-invasive manner is possible by introducing a fluidic system. The glucose concentration can be continuously monitored by tracking the transmission coefficient $S_{21}$ as a sensing parameter. The variation tendency in $S_{21}$ by the glucose concentration is analyzed with equivalent circuit model. In addition, to eradicate the systematic error due to temperature variation, the sensor is tested in two temperature conditions: the constant temperature condition and the time-dependent varying temperature condition. For the varying temperature condition, the temperature correction function was derived between the temperature and the variation in $S_{21}$ for DI water. By applying the fitting function to glucose solution, the subsidiary results due to temperature can be completely eliminated. As a result, the $S_{21}$ varies by 0.03 dB as the glucose concentration increases from 0 mg/dL to 400 mg/dL.

This review paper focuses on radio-frequency (RF) biosensors for real-time and continuous glucose sensing reported in the literature, including our recent research. Diverse versions of glucose biosensors based on RF devices and circuits are briefly introduced, and their performances are compared. In addition, the limitations of the developed RF glucose biosensors are discussed. Finally, we present perspectives on state-of-art RF biosensing chips for point-of-care diagnosis and describe their future challenges.

In this paper, a radio frequency vital sign sensor based on double voltage-controlled oscillators (VCOs) combined with a switchable phase-locked loop (PLL) is proposed for a noncontact remote vital sign sensing system. Our sensing system primarily detects the periodic movements of the human lungs and the hearts via the impedance variation of the resonator. With a change in impedance, both the VCO oscillation frequency and the PLL feedback voltage also change. Thus, by tracking the feedback voltage of the PLL, breath and heart rate signals can be acquired simultaneously. However, as the distance between the body and the sensor varies, there are certain points with minimal sensitivity, making it is quite difficult to detect vital signs. These points, called impedance null points, periodically occur at distances proportional to the wavelength. To overcome the impedance null point problem, two resonators operating at different frequencies, 2.40 and 2.76 GHz, are employed as receiving components. In an experiment to investigate the sensing performance as a function of distance, the measurement distance was accurately controlled by a linear actuator. Furthermore, to evaluate the sensing performance in a real environment, experiments were carried out with a male and a female subject in a static vehicle. To demonstrate the real-time vital sign monitoring capability, spectrograms were utilized, and the accuracy was assessed relative to reference sensors. Based on the results, it is demonstrated that the proposed remote sensor can reliably detect vital signs in a real vehicle environment.

In this paper, a microwave fluidic glucose sensor based on a microwave resonator coupled with an interferometric system is proposed for sensitivity enhancement. The proposed glucose sensor consists of two parts: a sensing part and a sensitivity enhancement part. The former is composed of a rectangular complementary split ring resonator (CSRR), and the latter is composed of a variable attenuator, a variable phase shifter, two hybrid couplers, and an RF power detector. Because the variation in the electrical properties, which is utilized in the microwave detection scheme, with glucose concentration over the possible concentration range in the human body is very small, improvement of the sensitivity is critical for practical use. Thus, the effective sensing area of the rectangular CSRR is determined by considering the electric field distribution. In addition, magnitude and phase conditions for the effective sensitivity enhancement are derived from a mathematical analysis of the proposed interferometric system. In the present experiment, aimed at demonstrating the detection performance as a function of the glucose concentration in the range of 0 mg/dL to 400 mg/dL, the sensitivity is significantly improved by 48 times by applying the derived conditions for effective sensitivity enhancement. Furthermore, the accuracy of the proposed glucose sensor for glucose concentrations at a step of 100 mg/dL is verified by the Clarke error grid. Based on the measurement results, the proposed glucose sensor is demonstrated to be applicable to noninvasive and continuous monitoring in practical environments.