Recent research indicates that Photoplethysmography (PPG) signals carry more information than oxygen saturation level (SpO2) and can be utilized for affordable, fast, and noninvasive healthcare applications. All these encourage the researchers to estimate its feasibility as an alternative to many expansive, time-wasting, and invasive methods. This systematic review discusses the current literature on diagnostic features of PPG signal and their applications that might present a potential venue to be adapted into many health and fitness aspects of human life. The research methodology is based on the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines 2020. To this aim, papers from 1981 to date are reviewed and categorized in terms of the healthcare application domain. Along with consolidated research areas, recent topics that are growing in popularity are also discovered. We also highlight the potential impact of using PPG signals on an individual’s quality of life and public health. The state-of-the-art studies suggest that in the years to come PPG wearables will become pervasive in many fields of medical practices, and the main domains include cardiology, respiratory, neurology, and fitness. Main operation challenges, including performance and robustness obstacles, are identified.

Kidney-type glutaminase (GLS) and liver-type glutaminase (GLS2) are dysregulated in many cancers, making them appealing targets for cancer therapy. However, their use as prognostic biomarkers is controversial and remains an active area of cancer research. Here, we performed a systematic multiomic analysis to determine whether glutaminases function as prognostic biomarkers in human cancers. Glutaminase expression and methylation status were assessed and their prominent functional protein partners and correlated genes were identified using various web-based bioinformatics tools. The cross-cancer relationship of glutaminases with mutations and copy number alterations was also investigated. Gene ontology (GO) and pathway analysis were performed to assess the integrated effect of glutaminases and their correlated genes on various cancers. Subsequently, the prognostic roles of GLS and GLS2 in human cancers were mined using univariate and multivariate survival analyses. GLS was frequently over-expressed in breast, esophagus, head-and-neck, and blood cancers, and was associated with a poor prognosis, whereas GLS2 overexpression implied poor overall survival in colon, blood, ovarian, and thymoma cancers. Both GLS and GLS2 play oncogenic and anti-oncogenic roles depending on the type of cancer. The varying prognostic characteristics of glutaminases suggest that GLS and GLS2 expression differentially modulate the clinical outcomes of cancers.

The electrocardiogram (ECG) signal has become a popular biometric modality due to characteristics that make it suitable for developing reliable authentication systems. However, the long segment of signal required for recognition is still one of the limitations of existing ECG biometric recognition methods and affects its acceptability as a biometric modality. This paper investigates how a short segment of an ECG signal can be effectively used for biometric recognition, using deep-learning techniques. A small convolutional neural network (CNN) is designed to achieve better generalization capability by entropy enhancement of a short segment of a heartbeat signal. Additionally, it investigates how various blind and feature-dependent segments with different lengths affect the performance of the recognition system. Experiments were carried out on two databases for performance evaluation that included single and multisession records. In addition, a comparison was made between the performance of the proposed classifier and four well-known CNN models: GoogLeNet, ResNet, MobileNet and EfficientNet. Using a time–frequency domain representation of a short segment of an ECG signal around the R-peak, the proposed model achieved an accuracy of 99.90% for PTB, 98.20% for the ECG-ID mixed-session, and 94.18% for ECG-ID multisession datasets. Using the preprinted ResNet, we obtained 97.28% accuracy for 0.5-second segments around the R-peaks for ECG-ID multisession datasets, outperforming existing methods. It was found that the time–frequency domain representation of a short segment of an ECG signal can be feasible for biometric recognition by achieving better accuracy and acceptability of this modality.

A healthcare monitoring system needs the support of recent technologies such as artificial intelligence (AI), machine learning (ML), and big data, especially during the COVID-19 pandemic. This global pandemic has already taken millions of lives. Both infected and uninfected people have generated big data where AI and ML can use to combat and detect COVID-19 at an early stage. Motivated by this, an improved ML framework for the early detection of this disease is proposed in this paper. The state-of-the-art Harris hawks optimization (HHO) algorithm with an improved objective function is proposed and applied to optimize the hyperparameters of the ML algorithms, namely HHO-based eXtreme gradient boosting (HHOXGB), light gradient boosting (HHOLGB), categorical boosting (HHOCAT), random forest (HHORF) and support vector classifier (HHOSVC). An ensemble technique was applied to these optimized ML models to improve the prediction performance. Our proposed method was applied to publicly available big COVID-19 data and yielded a prediction accuracy of 92.38% using the ensemble model. In contrast, HHOXGB provided the highest accuracy of 92.23% as a single optimized model. The performance of the proposed method was compared with the traditional algorithms and other ML-based methods. In both cases, our proposed method performed better. Furthermore, not only the classification improvement, but also the features are analyzed in terms of feature importance calculated by SHapely adaptive exPlanations (SHAP) values. A graphical user interface is also discussed as a potential tool for nonspecialist users such as clinical staff and nurses. The processed data, trained model, and codes related to this study are available at GitHub.

This paper proposes an encryption-based image watermarking scheme using a combination of second-level discrete wavelet transform (2DWT) and discrete cosine transform (DCT) with an auto extraction feature. The 2DWT has been selected based on the analysis of the trade-off between imperceptibility of the watermark and embedding capacity at various levels of decomposition. DCT operation is applied to the selected area to gather the image coefficients into a single vector using a zig-zig operation. We have utilized the same random bit sequence as the watermark and seed for the embedding zone coefficient. The quality of the reconstructed image was measured according to bit correction rate, peak signal-to-noise ratio (PSNR), and similarity index. Experimental results demonstrated that the proposed scheme is highly robust under different types of image-processing attacks. Several image attacks, e.g., JPEG compression, filtering, noise addition, cropping, sharpening, and bit-plane removal, were examined on watermarked images, and the results of our proposed method outstripped existing methods, especially in terms of the bit correction ratio (100%), which is a measure of bit restoration. The results were also highly satisfactory in terms of the quality of the reconstructed image, which demonstrated high imperceptibility in terms of peak signal-to-noise ratio (PSNR ≥ 40 dB) and structural similarity (SSIM ≥ 0.9) under different image attacks.

Although fingerprint-based systems are the commonly used biometric systems, they suffer from a critical vulnerability to a presentation attack (PA). Therefore, several approaches based on a fingerprint biometrics have been developed to increase the robustness against a PA. We propose an alternative approach based on the combination of fingerprint and electrocardiogram (ECG) signals. An ECG signal has advantageous characteristics that prevent the replication. Combining a fingerprint with an ECG signal is a potentially interesting solution to reduce the impact of PAs in biometric systems. We also propose a novel end-to-end deep learning-based fusion neural architecture between a fingerprint and an ECG signal to improve PA detection in fingerprint biometrics. Our model uses state-of-the-art EfficientNets for generating a fingerprint feature representation. For the ECG, we investigate three different architectures based on fully-connected layers (FC), a 1D-convolutional neural network (1D-CNN), and a 2D-convolutional neural network (2D-CNN). The 2D-CNN converts the ECG signals into an image and uses inverted Mobilenet-v2 layers for feature generation. We evaluated the method on a multimodal dataset, that is, a customized fusion of the LivDet 2015 fingerprint dataset and ECG data from real subjects. Experimental results reveal that this architecture yields a better average classification accuracy compared to a single fingerprint modality.