A novel mathematical analysis is established that summits the key features of peristaltic propulsion for a non-Newtonian micropolar fluid with the electroosmosis and heat transfer enhancement using nanoparticles. In such physiological models, the channel have a symmetric configuration in accordance with the biological problem. Being mindful of this fact, we have disclosed an integrated analysis on symmetric channel that incorporates major physiological applications. The creeping flow inference is reviewed to model this realistic problem. Flow equations are model using cartesian coordinates and simplified using long wave length and low Reynolds number approximation. Nonlinear linear couple equations are solving numerically. We have studied the variation in the properties of nanofluid developed by two different types of nanoparticles (i.e. Cu and Ag nanoparticles). Graphical illustrations are unveiled to highlight the physical aspects of nanoparticles and flow parameters. The exploration demonstrates that the micro-rotation of the nano-liquid elements enhances the thermal conductivity of the fluid movement. The effect of micropolar fluid parameters on mean flow and pressure variables is also presented.