The main focus of this article is to mathematically formulate the microfluidics-based mechanical system for nanofluids. A 50:50 mixture of propylene glycol (PG) and water is used as a heat transfer fluid because of its tremendous anti-freezing properties, and nontoxicity and it is safe to be utilized at the domestic level. Titanium dioxide (titania) nanoparticles are suspended in the working fluid to enhance its heat transfer ability. The fluid flow is induced by electroosmosis in a microtube, which is further assisted by cilia beating. The impacts of Joule heating and non-linear thermal radiation are also considered. The simplification of the dimensionless system is done under lubrication theory and the Debye-Hückel linearization principle. The nonlinear system of equations is executed for a numerical solution by adopting the symbolic mathematical software Maple 17 using the command “dsolve” along with the additional command “numeric” to get the numerical solution. This command utilizes a low-ordered method along with accuracy-enhancing schemes such as the deferred correction technique and Richardson extrapolation to get a numerical answer of desired accuracy, where we can choose the accuracy level and mesh points according to our requirements. The detailed analysis of results obtained from the numerical treatment of the considered problem indicates that the efficiency of the PG + water enhances due to the suspension of the nanoparticles and heat is rapidly removed from the system. Further, the velocity of the fluid is augmented by decreasing the thickness of the electric double layer and raising the strength of the electric field in the forwarding direction.