Alzheimer’s disease (AD) may cause damage to the memory cells permanently, which results in the form of dementia. The diagnosis of Alzheimer’s disease at an early stage is a problematic task for researchers. For this, machine learning and deep convolutional neural network (CNN) based approaches are readily available to solve various problems related to brain image data analysis. In clinical research, magnetic resonance imaging (MRI) is used to diagnose AD. For accurate classification of dementia stages, we need highly discriminative features obtained from MRI images. Recently advanced deep CNN-based models successfully proved their accuracy. However, due to a smaller number of image samples available in the datasets, there exist problems of over-fitting hindering the performance of deep learning approaches. In this research, we developed a Siamese convolutional neural network (SCNN) model inspired by VGG-16 (also called Oxford Net) to classify dementia stages. In our approach, we extend the insufficient and imbalanced data by using augmentation approaches. Experiments are performed on a publicly available dataset open access series of imaging studies (OASIS), by using the proposed approach, an excellent test accuracy of 99.05% is achieved for the classification of dementia stages. We compared our model with the state-of-the-art models and discovered that the proposed model outperformed the state-of-the-art models in terms of performance, efficiency, and accuracy.

Brain tumors have become a leading cause of death around the globe. The main reason for this epidemic is the difficulty conducting a timely diagnosis of the tumor. Fortunately, magnetic resonance images (MRI) are utilized to diagnose tumors in most cases. The performance of a Convolutional Neural Network (CNN) depends on many factors (i.e., weight initialization, optimization, batches and epochs, learning rate, activation function, loss function, and network topology), data quality, and specific combinations of these model attributes. When we deal with a segmentation or classification problem, utilizing a single optimizer is considered weak testing or validity unless the decision of the selection of an optimizer is backed up by a strong argument. Therefore, optimizer selection processes are considered important to validate the usage of a single optimizer in order to attain these decision problems. In this paper, we provides a comprehensive comparative analysis of popular optimizers of CNN to benchmark the segmentation for improvement. In detail, we perform a comparative analysis of 10 different state-of-the-art gradient descent-based optimizers, namely Adaptive Gradient (Adagrad), Adaptive Delta (AdaDelta), Stochastic Gradient Descent (SGD), Adaptive Momentum (Adam), Cyclic Learning Rate (CLR), Adaptive Max Pooling (Adamax), Root Mean Square Propagation (RMS Prop), Nesterov Adaptive Momentum (Nadam), and Nesterov accelerated gradient (NAG) for CNN. The experiments were performed on the BraTS2015 data set. The Adam optimizer had the best accuracy of 99.2% in enhancing the CNN ability in classification and segmentation.

The rapid growth of electronic documents are causing problems like unstructured data that need more time and effort to search a relevant document. Text Document Classification (TDC) has a great significance in information processing and retrieval where unstructured documents are organized into pre-defined classes. Urdu is the most favorite research language in South Asian languages because of its complex morphology, unique features, and lack of linguistic resources like standard datasets. As compared to short text, like sentiment analysis, long text classification needs more time and effort because of large vocabulary, more noise, and redundant information. Machine Learning (ML) and Deep Learning (DL) models have been widely used in text processing. Despite the major limitations of ML models, like learn directed features, these are the favorite methods for Urdu TDC. To the best of our knowledge, it is the first study of Urdu TDC using DL model. In this paper, we design a large multi-purpose and multi-format dataset that contain more than ten thousand documents organize into six classes. We use Single-layer Multisize Filters Convolutional Neural Network (SMFCNN) for classification and compare its performance with sixteen ML baseline models on three imbalanced datasets of various sizes. Further, we analyze the effects of preprocessing methods on SMFCNN performance. SMFCNN outperformed the baseline classifiers and achieved 95.4%, 91.8%, and 93.3% scores of accuracy on medium, large and small size dataset respectively. The designed dataset would be publically and freely available in different formats for future research in Urdu text processing.

Large volume of Genomics data is produced on daily basis due to the advancement in sequencing technology. This data is of no value if it is not properly analysed. Different kinds of analytics are required to extract useful information from this raw data. Classification, Prediction, Clustering and Pattern Extraction are useful techniques of data mining. These techniques require appropriate selection of attributes of data for getting accurate results. However, Bioinformatics data is high dimensional, usually having hundreds of attributes. Such large a number of attributes affect the performance of machine learning algorithms used for classification/prediction. So, dimensionality reduction techniques are required to reduce the number of attributes that can be further used for analysis. In this paper, Principal Component Analysis and Factor Analysis are used for dimensionality reduction of Bioinformatics data. These techniques were applied on Leukaemia data set and the number of attributes was reduced from to.

Next Generation Sequencing (NGS) technology has resulted in massive amounts of proteomics and genomics data. This data is of no use if it is not properly analyzed. ETL (Extraction, Transformation, Loading) is an important step in designing data analytics applications. ETL requires proper understanding of features of data. Data format plays a key role in understanding of data, representation of data, space required to store data, data I/O during processing of data, intermediate results of processing, in-memory analysis of data and overall time required to process data. Different data mining and machine learning algorithms require input data in specific types and formats. This paper explores the data formats used by different tools and algorithms and also presents modern data formats that are used on Big Data Platform. It will help researchers and developers in choosing appropriate data format to be used for a particular tool or algorithm.