This page has only limited features, please log in for full access.

Dr. Željko Petrovski
LAQV-REQUIMTE, Departamento de Química, Faculdade de Ciências e Tecnologia da Universidade Nova de Lisboa, 2829-516 Caparica, Portugal

Basic Info


Research Keywords & Expertise

0 Catalysis
0 Drug Delivery
0 Ionic Liquids
0 Plastic Degradation
0 Ionic liquids application

Fingerprints

Ionic Liquids
Drug Delivery

Honors and Awards

The user has no records in this section


Career Timeline

The user has no records in this section.


Short Biography

The user biography is not available.
Following
Followers
Co Authors
The list of users this user is following is empty.
Following: 0 users

Feed

Review
Published: 07 June 2021 in Surfaces
Reads 0
Downloads 0

Antiseptics and disinfectants are extensively used for a variety of topical and hard-surface applications. A wide variety of biocides as active chemical agents is found in these products, including alcohols, phenols, iodine, and chlorine. Many of these active agents demonstrate broad-spectrum antimicrobial activity; however, the mode of action of these agents is not well-documented. This review is focused on several examples of ionic systems based on ionic surfactants and ionic liquids as well as nanomaterials and nanoparticles acting as antiseptics and disinfectants for surfaces. It is important to note that many of these biocides may be used singly or in combination in a variety of products, which vary considerably in activity against microorganisms. Antimicrobial activity can be influenced by several factors such as formulation effects, presence of an organic load, synergy, temperature, dilution, and test method. The most promissory compounds based on ionic systems and nanomaterials published in mainly the last decade is chronologically reported in this review.

ACS Style

Francisco Faísca; Luis Filipe; Zeljko Petrovski; Miguel Santos; Sandra Gago; Luís Branco. Ionic Systems and Nanomaterials as Antiseptic and Disinfectant Agents for Surface Applications: A Review. Surfaces 2021, 4, 169 -190.

AMA Style

Francisco Faísca, Luis Filipe, Zeljko Petrovski, Miguel Santos, Sandra Gago, Luís Branco. Ionic Systems and Nanomaterials as Antiseptic and Disinfectant Agents for Surface Applications: A Review. Surfaces. 2021; 4 (2):169-190.

Chicago/Turabian Style

Francisco Faísca; Luis Filipe; Zeljko Petrovski; Miguel Santos; Sandra Gago; Luís Branco. 2021. "Ionic Systems and Nanomaterials as Antiseptic and Disinfectant Agents for Surface Applications: A Review." Surfaces 4, no. 2: 169-190.

Paper
Published: 16 April 2021 in RSC Advances
Reads 0
Downloads 0

Antifungal susceptibility assays and molecular dynamics simulation studies reveal a novel cetylpyridinium amphotericin B ionic liquid formulation with dual functionality: antifungal and antibacterial activities.

ACS Style

Diego O. Hartmann; Karina Shimizu; Maika Rothkegel; Marija Petkovic; Ricardo Ferraz; Željko Petrovski; Luís C. Branco; José N. Canongia Lopes; Cristina Silva Pereira. Tailoring amphotericin B as an ionic liquid: an upfront strategy to potentiate the biological activity of antifungal drugs. RSC Advances 2021, 11, 14441 -14452.

AMA Style

Diego O. Hartmann, Karina Shimizu, Maika Rothkegel, Marija Petkovic, Ricardo Ferraz, Željko Petrovski, Luís C. Branco, José N. Canongia Lopes, Cristina Silva Pereira. Tailoring amphotericin B as an ionic liquid: an upfront strategy to potentiate the biological activity of antifungal drugs. RSC Advances. 2021; 11 (24):14441-14452.

Chicago/Turabian Style

Diego O. Hartmann; Karina Shimizu; Maika Rothkegel; Marija Petkovic; Ricardo Ferraz; Željko Petrovski; Luís C. Branco; José N. Canongia Lopes; Cristina Silva Pereira. 2021. "Tailoring amphotericin B as an ionic liquid: an upfront strategy to potentiate the biological activity of antifungal drugs." RSC Advances 11, no. 24: 14441-14452.

Journal article
Published: 28 February 2021 in Marine Drugs
Reads 0
Downloads 0

The ever-increasing interest in keeping a young appearance and healthy skin has leveraged the skincare industry. This, coupled together with the increased concern regarding the safety of synthetic products, has boosted the demand for new and safer natural ingredients. Accordingly, the aim of this study was to evaluate the dermatological potential of the brown seaweed Carpomitra costata. The antioxidant, anti-enzymatic, antimicrobial, photoprotective and anti-inflammatory properties of five C. costata fractions (F1–F5) were evaluated. The ethyl acetate fraction (F3) demonstrated the most promising results, with the best ability to scavenge 2,2-diphenyl-1-picrylhydrazyl (DPPH) radicals (EC50 of 140.1 µg/mL) and the capacity to reduce reactive oxygen species (ROS) production promoted by UVA and UVB radiation in 3T3 cells, revealing its antioxidant and photoprotective potential. This fraction also exhibited the highest anti-enzymatic capacity, inhibiting the activities of collagenase, elastase and tyrosinase (IC50 of 7.2, 4.8 and 85.9 µg/mL, respectively). Moreover, F3 showed anti-inflammatory potential, reducing TNF-α and IL-6 release induced by LPS treatment in RAW 264.7 cells. These bioactivities may be related to the presence of phenolic compounds, such as phlorotannins, as demonstrated by NMR analysis. The results highlight the potential of C. costata as a source of bioactive ingredients for further dermatological applications.

ACS Style

Patrícia Susano; Joana Silva; Celso Alves; Alice Martins; Helena Gaspar; Susete Pinteus; Teresa Mouga; Márcia Goettert; Željko Petrovski; Luís Branco; Rui Pedrosa. Unravelling the Dermatological Potential of the Brown Seaweed Carpomitra costata. Marine Drugs 2021, 19, 135 .

AMA Style

Patrícia Susano, Joana Silva, Celso Alves, Alice Martins, Helena Gaspar, Susete Pinteus, Teresa Mouga, Márcia Goettert, Željko Petrovski, Luís Branco, Rui Pedrosa. Unravelling the Dermatological Potential of the Brown Seaweed Carpomitra costata. Marine Drugs. 2021; 19 (3):135.

Chicago/Turabian Style

Patrícia Susano; Joana Silva; Celso Alves; Alice Martins; Helena Gaspar; Susete Pinteus; Teresa Mouga; Márcia Goettert; Željko Petrovski; Luís Branco; Rui Pedrosa. 2021. "Unravelling the Dermatological Potential of the Brown Seaweed Carpomitra costata." Marine Drugs 19, no. 3: 135.

Journal article
Published: 02 December 2020 in Reactions
Reads 0
Downloads 0

Ionic oxidoperoxido-molybdenum(VI) complexes of the type [Cat][MoO(O2)2(pic)], with pic = N,O-chelated picolinate ligand and Cat = monocation, were prepared in high yields (82–95%) from the precursor complex [H3O][MoO(O2)2(pic)] via [H]+ cation exchange for 1-ethyl-3-methylimidazolium [EMIM]+, 1-butyl-3-methylimidazolium [BMIM]+, 1-octyl-3-methylimidazolium [OMIM]+, N-cetylpyridinium [C16Py]+, and N-methyl-N,N,N-trioctylammonium [Aliquat]+. The structure and purity of the ionic compounds were assessed by 1H and 13C NMR, FT-IR, and elemental analysis (C, H, N), and the electrochemical properties were studied by differential pulse voltammetry (DPV) and cyclic voltammetry (CV). The [Cat][MoO(O2)2(pic)] compounds showed promising catalytic epoxidation activity based on the model reaction of cis-cyclooctene with tert-butyl hydroperoxide as oxidant. The type of cation influenced the physical state of the compound and the catalytic performance.

ACS Style

Željko Petrovski; Margarida M. Antunes; Ana Soraia Mendo; Luís Cabrita; Isabel S. Gonçalves; Anabela A. Valente; Luís C. Branco. Ionic Liquids Based on Oxidoperoxido-Molybdenum(VI) Complexes with a Chelating Picolinate Ligand for Catalytic Epoxidation. Reactions 2020, 1, 147 -161.

AMA Style

Željko Petrovski, Margarida M. Antunes, Ana Soraia Mendo, Luís Cabrita, Isabel S. Gonçalves, Anabela A. Valente, Luís C. Branco. Ionic Liquids Based on Oxidoperoxido-Molybdenum(VI) Complexes with a Chelating Picolinate Ligand for Catalytic Epoxidation. Reactions. 2020; 1 (2):147-161.

Chicago/Turabian Style

Željko Petrovski; Margarida M. Antunes; Ana Soraia Mendo; Luís Cabrita; Isabel S. Gonçalves; Anabela A. Valente; Luís C. Branco. 2020. "Ionic Liquids Based on Oxidoperoxido-Molybdenum(VI) Complexes with a Chelating Picolinate Ligand for Catalytic Epoxidation." Reactions 1, no. 2: 147-161.

Proceedings
Published: 01 December 2020 in Proceedings
Reads 0
Downloads 0

The majority of antibiotics display low oral bioavailability due to reduced solubility in water and/or inefficient permeability across biological membranes. Their efficiency is further limited by the frequent presence of polymorphic structures with different pharmaceutical activities. In this communication, we present our latest results on the development of organic salts and ionic liquids from fluoroquinolones (FQ-OSILs) as highly efficient ionic formulations of this family of antimicrobials. Ciprofloxacin and norfloxacin were used as anions and as cations, by combination with biocompatible organic counter-ions. In vitro bioavailability studies showed that all prepared FQ-OSILs presented higher solubility in water than the original drugs. All compounds were found to be isomorphic and with tailorable antimicrobial activity according to the cation–anion combination against Staphylococcus aureus, Bacillus subtilis and Klebsiella pneumoniae strains.

ACS Style

Diogo Madeira; Celso Alves; Joana Silva; Catarina Florindo; Alexandra Costa; Željko Petrovski; Isabel Marrucho; Rui Pedrosa; Miguel Santos; Luís Branco. Fluoroquinolone-Based Organic Salts and Ionic Liquids as Highly Bioavailable Broad-Spectrum Antimicrobials. Proceedings 2020, 78, 3 .

AMA Style

Diogo Madeira, Celso Alves, Joana Silva, Catarina Florindo, Alexandra Costa, Željko Petrovski, Isabel Marrucho, Rui Pedrosa, Miguel Santos, Luís Branco. Fluoroquinolone-Based Organic Salts and Ionic Liquids as Highly Bioavailable Broad-Spectrum Antimicrobials. Proceedings. 2020; 78 (1):3.

Chicago/Turabian Style

Diogo Madeira; Celso Alves; Joana Silva; Catarina Florindo; Alexandra Costa; Željko Petrovski; Isabel Marrucho; Rui Pedrosa; Miguel Santos; Luís Branco. 2020. "Fluoroquinolone-Based Organic Salts and Ionic Liquids as Highly Bioavailable Broad-Spectrum Antimicrobials." Proceedings 78, no. 1: 3.

Journal article
Published: 23 July 2020 in Pharmaceutics
Reads 0
Downloads 0

As the development of novel antibiotics has been at a halt for several decades, chemically enhancing existing drugs is a very promising approach to drug development. Herein, we report the preparation of twelve organic salts and ionic liquids (OSILs) from ciprofloxacin and norfloxacin as anions with enhanced antimicrobial activity. Each one of the fluoroquinolones (FQs) was combined with six different organic hydroxide cations in 93–100% yield through a buffer-assisted neutralization methodology. Six of those were isomorphous salts while the remaining six were ionic liquids, with four of them being room temperature ionic liquids. The prepared compounds were not toxic to healthy cell lines and displayed between 47- and 1416-fold more solubility in water at 25 and 37 °C than the original drugs, with the exception of the ones containing the cetylpyridinium cation. In general, the antimicrobial activity against Klebsiella pneumoniae was particularly enhanced for the ciprofloxacin-based OSILs, with up to ca. 20-fold decreases of the inhibitory concentrations in relation to the parent drug, while activity against Staphylococcus aureus and the commensal Bacillus subtilis strain was often reduced. Depending on the cation–drug combination, broad-spectrum or strain-specific antibiotic salts were achieved, potentially leading to the future development of highly bioavailable and safe antimicrobial ionic formulations.

ACS Style

Miguel Santos; Celso Alves; Joana Silva; Catarina Florindo; Alexandra Costa; Željko Petrovski; Isabel Marrucho; Rui Pedrosa; Luís Branco. Antimicrobial Activities of Highly Bioavailable Organic Salts and Ionic Liquids from Fluoroquinolones. Pharmaceutics 2020, 12, 694 .

AMA Style

Miguel Santos, Celso Alves, Joana Silva, Catarina Florindo, Alexandra Costa, Željko Petrovski, Isabel Marrucho, Rui Pedrosa, Luís Branco. Antimicrobial Activities of Highly Bioavailable Organic Salts and Ionic Liquids from Fluoroquinolones. Pharmaceutics. 2020; 12 (8):694.

Chicago/Turabian Style

Miguel Santos; Celso Alves; Joana Silva; Catarina Florindo; Alexandra Costa; Željko Petrovski; Isabel Marrucho; Rui Pedrosa; Luís Branco. 2020. "Antimicrobial Activities of Highly Bioavailable Organic Salts and Ionic Liquids from Fluoroquinolones." Pharmaceutics 12, no. 8: 694.

Journal article
Published: 11 July 2020 in Antioxidants
Reads 0
Downloads 0

Skin aging is a biological process influenced by intrinsic and extrinsic factors. The last ones, mainly exposure to UV radiation, increases reactive oxygen species (ROS) production leading to a loss of extracellular matrix, also enhanced by enzymatic degradation of matrix supporting molecules. Thus, and with the growing demand for eco-friendly skin products, natural compounds extracted from brown seaweeds revealed to be good candidates due to their broad range of bioactivities, especially as antioxidants. The aim of this study was to assess the dermo-cosmetic potential of different fractions obtained from the brown seaweed Fucus spiralis. For this purpose, in vitro antioxidant (Total Phenolic Content (TPC), 1,1-Diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity, Ferric Reducing Antioxidant Power (FRAP), Oxygen Radical Absorbance Capacity (ORAC)), anti-enzymatic (collagenase, elastase and hyaluronidase), antimicrobial, anti-inflammatory (NO production) and photoprotective (ROS production) capacities were evaluated. Although nearly all fractions evidenced antioxidant effects, fraction F10 demonstrated the highest antioxidant ability (EC50 of 38.5 µg/mL, DPPH assay), and exhibited a strong effect as an inhibitor of collagenase (0.037 µg/mL) and elastase (3.0 µg/mL). Moreover, this fraction was also the most potent on reducing ROS production promoted by H2O2 (IC50 of 41.3 µg/mL) and by UVB (IC50 of 31.3 µg/mL). These bioactivities can be attributed to its high content of phlorotannins, as evaluated by LC-MS analysis, reinforcing the potential of F. spiralis for further dermatological applications.

ACS Style

Rafaela Freitas; Alice Martins; Joana Silva; Celso Alves; Susete Pinteus; Joana Alves; Fernando Teodoro; Helena Ribeiro; Lídia Gonçalves; Željko Petrovski; Luís Branco; Rui Pedrosa. Highlighting the Biological Potential of the Brown Seaweed Fucus spiralis for Skin Applications. Antioxidants 2020, 9, 611 .

AMA Style

Rafaela Freitas, Alice Martins, Joana Silva, Celso Alves, Susete Pinteus, Joana Alves, Fernando Teodoro, Helena Ribeiro, Lídia Gonçalves, Željko Petrovski, Luís Branco, Rui Pedrosa. Highlighting the Biological Potential of the Brown Seaweed Fucus spiralis for Skin Applications. Antioxidants. 2020; 9 (7):611.

Chicago/Turabian Style

Rafaela Freitas; Alice Martins; Joana Silva; Celso Alves; Susete Pinteus; Joana Alves; Fernando Teodoro; Helena Ribeiro; Lídia Gonçalves; Željko Petrovski; Luís Branco; Rui Pedrosa. 2020. "Highlighting the Biological Potential of the Brown Seaweed Fucus spiralis for Skin Applications." Antioxidants 9, no. 7: 611.

Journal article
Published: 02 March 2020 in Pharmaceutics
Reads 0
Downloads 0

The preparation and characterization of ionic liquids and organic salts (OSILs) that contain anionic penicillin G [secoPen] and amoxicillin [seco-Amx] hydrolysate derivatives and their in vitro antibacterial activity against sensitive and resistant Escherichia coli and Staphylococcus aureus strains is reported. Eleven hydrolyzed β-lactam-OSILs were obtained after precipitation in moderate-to-high yields via the neutralization of the basic ammonia buffer of antibiotics with different cation hydroxide salts. The obtained minimum inhibitory concentration (MIC) data of the prepared compounds showed a relative decrease of the inhibitory concentrations (RDIC) in the order of 100 in the case of [C2OHMIM][seco-Pen] against sensitive S. aureus ATCC25923 and, most strikingly, higher than 1000 with [C16Pyr][seco-Amx] against methicillin-resistant Staphylococcus aureus (MRSA) ATCC 43300. These outstanding in vitro results showcase that a straightforward transformation of standard antibiotics into hydrolyzed organic salts can dramatically change the pharmaceutical activity of a drug, including giving rise to potent formulations of antibiotics against deadly bacteria strains.

ACS Style

Ricardo Ferraz; Dário Silva; Ana Rita Dias; Vitorino Dias; Miguel M. Santos; Luís Pinheiro; Cristina Prudêncio; João Paulo Noronha; Željko Petrovski; Luís C. Branco. Synthesis and Antibacterial Activity of Ionic Liquids and Organic Salts Based on Penicillin G and Amoxicillin hydrolysate Derivatives against Resistant Bacteria. Pharmaceutics 2020, 12, 221 .

AMA Style

Ricardo Ferraz, Dário Silva, Ana Rita Dias, Vitorino Dias, Miguel M. Santos, Luís Pinheiro, Cristina Prudêncio, João Paulo Noronha, Željko Petrovski, Luís C. Branco. Synthesis and Antibacterial Activity of Ionic Liquids and Organic Salts Based on Penicillin G and Amoxicillin hydrolysate Derivatives against Resistant Bacteria. Pharmaceutics. 2020; 12 (3):221.

Chicago/Turabian Style

Ricardo Ferraz; Dário Silva; Ana Rita Dias; Vitorino Dias; Miguel M. Santos; Luís Pinheiro; Cristina Prudêncio; João Paulo Noronha; Željko Petrovski; Luís C. Branco. 2020. "Synthesis and Antibacterial Activity of Ionic Liquids and Organic Salts Based on Penicillin G and Amoxicillin hydrolysate Derivatives against Resistant Bacteria." Pharmaceutics 12, no. 3: 221.

Conference paper
Published: 12 November 2019 in Proceedings of 5th International Electronic Conference on Medicinal Chemistry
Reads 0
Downloads 0

Bacterial resistance to current antibiotics has a major impact on worldwide human health, leading to 700K deaths every year. The development of novel antibiotics did not present significant progress, namely regarding clinical trials, over the last years due to low returns. Thus, innovative alternatives must be devised to tackle the continuous rise of antimicrobial resistance. Ionic Liquids and Organic Salts from Active Pharmaceutical Ingredients (API-OSILs) have risen in academia for over 10 years as an efficient formulation for drugs with low bioavailability and permeability, as well as reduction or elimination of polymorphism, thereby potentially enhancing their pharmaceutical efficiency. To the best of our knowledge, our group is the first to perform research on the development of API-OSILs from antibiotics as a way to improve their efficiency. More specifically, we have successfully combined ampicillin, penicillin and amoxicillinas anions with biocompatible organic cations such as choline, alkylpyridiniums and alkylimidazoliums. Furthermore, we have also combined fluoroquinolones (ciprofloxacin and norfloxacin) as cations with biocompatible carboxylic and sulfonic acids. In this communication, we present our latest developments in the synthesis and spectroscopic (NMR, FTIR) and physicochemical (DSC) characterization of ionic liquids and organic salts from these antibiotics, in addition to in vitro antimicrobial activity data, in particular towards Methicillin Resistant Staphylococcus aureus and multi-resistant Escherichia coli, as well as sensitive strains of gram-positive and gram-negative bacteria.

ACS Style

Miguel Santos; Inês Grilo; Ricardo Ferraz; Diogo Madeira; Bárbara Soares; Núria Inácio; Luís Pinheiro; Zeljko Petrovski; Cristina Prudêncio; Rita Sobral; Luís Branco. Tackling bacterial resistance using antibiotics as ionic liquids and organic salts. Proceedings of 5th International Electronic Conference on Medicinal Chemistry 2019, 1 .

AMA Style

Miguel Santos, Inês Grilo, Ricardo Ferraz, Diogo Madeira, Bárbara Soares, Núria Inácio, Luís Pinheiro, Zeljko Petrovski, Cristina Prudêncio, Rita Sobral, Luís Branco. Tackling bacterial resistance using antibiotics as ionic liquids and organic salts. Proceedings of 5th International Electronic Conference on Medicinal Chemistry. 2019; ():1.

Chicago/Turabian Style

Miguel Santos; Inês Grilo; Ricardo Ferraz; Diogo Madeira; Bárbara Soares; Núria Inácio; Luís Pinheiro; Zeljko Petrovski; Cristina Prudêncio; Rita Sobral; Luís Branco. 2019. "Tackling bacterial resistance using antibiotics as ionic liquids and organic salts." Proceedings of 5th International Electronic Conference on Medicinal Chemistry , no. : 1.

Journal article
Published: 05 April 2018 in Journal of Molecular Liquids
Reads 0
Downloads 0

Ethyl lactate is a hydrophilic green solvent which is bio-renewable and biodegradable with low toxicity towards humans and animals. For the first time, we report that aqueous solutions of ethyl lactate separate into two aqueous phases upon addition of salts. The performance of trisodium citrate, disodium tartrate and disodium succinate as salting-out media for the separation of natural organic compounds, such as caffeine and catechin, from their aqueous solutions was examined. In this respect, cloud points for the ternary solutions composed of ethyl lactate, water and salt were determined at ambient pressure (0.1 MPa) at 298.2 K. Partition coefficients of caffeine and catechin between two phases were determined by chemical analysis of phases in equilibrium for different initial compositions at 298.2 K. The obtained results clearly demonstrate the ability of the ternary mixture to phase separate, providing good salting-out media for the efficient and sustainable separation from aqueous solution. 1H NMR spectroscopy was employed to elucidate the mechanisms of phase splitting in the ternary (ethyl lactate + water + salt) systems at molecular level. The discovery of aqueous biphasic system (ABS) containing ethyl lactate as hydrophilic solvent opens a new and green platform for extraction of various compounds from aqueous solutions.

ACS Style

Ishara Kamalanathan; Zeljko Petrovski; Luis Branco; Vesna Najdanovic-Visak. Novel aqueous biphasic system based on ethyl lactate for sustainable separations: Phase splitting mechanism. Journal of Molecular Liquids 2018, 262, 37 -45.

AMA Style

Ishara Kamalanathan, Zeljko Petrovski, Luis Branco, Vesna Najdanovic-Visak. Novel aqueous biphasic system based on ethyl lactate for sustainable separations: Phase splitting mechanism. Journal of Molecular Liquids. 2018; 262 ():37-45.

Chicago/Turabian Style

Ishara Kamalanathan; Zeljko Petrovski; Luis Branco; Vesna Najdanovic-Visak. 2018. "Novel aqueous biphasic system based on ethyl lactate for sustainable separations: Phase splitting mechanism." Journal of Molecular Liquids 262, no. : 37-45.

Journal article
Published: 01 January 2018 in Frontiers in Marine Science
Reads 0
Downloads 0
ACS Style

Rita Lourenço; Inês Ferreira; Miriam Presas; Ana Nunes; Luís Branco; Manuel Nunes Da Ponte; João Carlos Lima; Mário Diniz; Susana Gaudêncio; Zeljko Petrovski. Marine-derived Actinomycetes Cultured in Carbon Dioxide Atmosphere and Buffered Media. Frontiers in Marine Science 2018, 5, 1 .

AMA Style

Rita Lourenço, Inês Ferreira, Miriam Presas, Ana Nunes, Luís Branco, Manuel Nunes Da Ponte, João Carlos Lima, Mário Diniz, Susana Gaudêncio, Zeljko Petrovski. Marine-derived Actinomycetes Cultured in Carbon Dioxide Atmosphere and Buffered Media. Frontiers in Marine Science. 2018; 5 ():1.

Chicago/Turabian Style

Rita Lourenço; Inês Ferreira; Miriam Presas; Ana Nunes; Luís Branco; Manuel Nunes Da Ponte; João Carlos Lima; Mário Diniz; Susana Gaudêncio; Zeljko Petrovski. 2018. "Marine-derived Actinomycetes Cultured in Carbon Dioxide Atmosphere and Buffered Media." Frontiers in Marine Science 5, no. : 1.

Article
Published: 03 September 2015 in ChemInform
Reads 0
Downloads 0
ACS Style

Ricardo Ferraz; Cristina Prudêncio; Mónica Vieira; Rúben Fernandes; Joao Paulo Noronha; Željko Petrovski. ChemInform Abstract: Ionic Liquids Synthesis - Methodologies. ChemInform 2015, 46, 1 .

AMA Style

Ricardo Ferraz, Cristina Prudêncio, Mónica Vieira, Rúben Fernandes, Joao Paulo Noronha, Željko Petrovski. ChemInform Abstract: Ionic Liquids Synthesis - Methodologies. ChemInform. 2015; 46 (38):1.

Chicago/Turabian Style

Ricardo Ferraz; Cristina Prudêncio; Mónica Vieira; Rúben Fernandes; Joao Paulo Noronha; Željko Petrovski. 2015. "ChemInform Abstract: Ionic Liquids Synthesis - Methodologies." ChemInform 46, no. 38: 1.

Communication
Published: 16 July 2015 in ChemMedChem
Reads 0
Downloads 0

Significant antiproliferative effects against various tumor cell lines were observed with novel ampicillin salts as ionic liquids. The combination of anionic ampicillin with appropriate ammonium, imidazolium, phosphonium, and pyridinium cations yielded active pharmaceutical ingredient ionic liquids (API‐ILs) that show potent antiproliferative activities against five different human cancer cell lines: T47D (breast), PC3 (prostate), HepG2 (liver), MG63 (osteosarcoma), and RKO (colon). Some API‐ILs showed IC50 values between 5 and 42 nM, activities that stand in dramatic contrast to the negligible cytotoxic activity level shown by the ampicillin sodium salt. Moreover, very low cytotoxicity against two primary cell lines—skin (SF) and gingival fibroblasts (GF)—indicates that the majority of these API‐ILs are nontoxic to normal human cell lines. The most promising combination of antitumor activity and low toxicity toward healthy cells was observed for the 1‐hydroxyethyl‐3‐methylimidazolium–ampicillin pair ([C2OHMIM][Amp]), making this the most suitable lead API‐IL for future studies.

ACS Style

Ricardo Ferraz; João Costa-Rodrigues; Maria Helena Fernandes; Miguel Santos; Isabel Marrucho; Luis Paulo Rebelo; Cristina Prudêncio; João Paulo Noronha; Željko Petrovski; Luís C. Branco. Antitumor Activity of Ionic Liquids Based on Ampicillin. ChemMedChem 2015, 10, 1480 -1483.

AMA Style

Ricardo Ferraz, João Costa-Rodrigues, Maria Helena Fernandes, Miguel Santos, Isabel Marrucho, Luis Paulo Rebelo, Cristina Prudêncio, João Paulo Noronha, Željko Petrovski, Luís C. Branco. Antitumor Activity of Ionic Liquids Based on Ampicillin. ChemMedChem. 2015; 10 (9):1480-1483.

Chicago/Turabian Style

Ricardo Ferraz; João Costa-Rodrigues; Maria Helena Fernandes; Miguel Santos; Isabel Marrucho; Luis Paulo Rebelo; Cristina Prudêncio; João Paulo Noronha; Željko Petrovski; Luís C. Branco. 2015. "Antitumor Activity of Ionic Liquids Based on Ampicillin." ChemMedChem 10, no. 9: 1480-1483.

Research letter
Published: 06 November 2014 in Green Chemistry Letters and Reviews
Reads 0
Downloads 0

A sustainable organic synthetic methodology for the preparation of novel biocompatible ionic liquids (ILs) based on gluconate anion has been developed. Four functionalized methylimidazolium cations were efficiently combined with gluconic acid by acid-base neutralization reactions. All salts were obtained as RTILs in high yields (92–98%) and in high purity levels. Proton Nuclear Magnetic Resonance (1H NMR) studies had proved the correct cation/anion proportion (1:1) and their chemical stability. These novel gluconate ILs can be applied for chemistry, material science, and medicine areas.

ACS Style

Alexandra Costa; Andreia Forte; Karolina Zalewska; Gonçalo Tiago; Zeljko Petrovski; Luis C. Branco. Novel biocompatible ionic liquids based on gluconate anion. Green Chemistry Letters and Reviews 2014, 8, 8 -12.

AMA Style

Alexandra Costa, Andreia Forte, Karolina Zalewska, Gonçalo Tiago, Zeljko Petrovski, Luis C. Branco. Novel biocompatible ionic liquids based on gluconate anion. Green Chemistry Letters and Reviews. 2014; 8 (1):8-12.

Chicago/Turabian Style

Alexandra Costa; Andreia Forte; Karolina Zalewska; Gonçalo Tiago; Zeljko Petrovski; Luis C. Branco. 2014. "Novel biocompatible ionic liquids based on gluconate anion." Green Chemistry Letters and Reviews 8, no. 1: 8-12.

Journals
Published: 01 January 2014 in RSC Advances
Reads 0
Downloads 0

Antibacterial activities of novel Active Pharmaceutical Ingredient Ionic Liquids (API–ILs) based on ampicillin anion [Amp] have been evaluated. They showed growth inhibition and bactericidal properties on some sensitive bacteria and especially some Gram-negative resistant bacteria when compared to the [Na][Amp] and the initial bromide and chloride salts. For these studies were analysed the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBIC) against sensitive Gram-negative bacteria Escherichia coli ATCC 25922 and Klebsiella pneumoniae (clinically isolated), as well as sensitive Gram positive Staphylococcus Aureus ATCC 25923, Staphylococcus epidermidis and Enterococcus faecalis and completed using clinically isolated resistent strains such as E. coli TEM CTX M9, E. coli CTX M2 and E. coli AmpC MOX. From the obtained MIC values of studied API–ILs and standard [Na][Amp] were derived RDIC values (relative decrease of inhibitory concentration). High RDIC values of [C16Pyr][Amp] especially against two resistant Gram-negative strains E. coli TEM CTX M9 (RDIC >1000) and E. coli CTX M2 (RDIC >100) point clearly to a potential promising role of API–ILs as antimicrobial drugs in particular against resistant bacterial strains.

ACS Style

Ricardo Ferraz; Vânia Teixeira; Débora Rodrigues; Rúben Fernandes; Cristina Prudêncio; João Paulo Noronha; Željko Petrovski; Luis Branco. Antibacterial activity of Ionic Liquids based on ampicillin against resistant bacteria. RSC Advances 2014, 4, 4301 -4307.

AMA Style

Ricardo Ferraz, Vânia Teixeira, Débora Rodrigues, Rúben Fernandes, Cristina Prudêncio, João Paulo Noronha, Željko Petrovski, Luis Branco. Antibacterial activity of Ionic Liquids based on ampicillin against resistant bacteria. RSC Advances. 2014; 4 (9):4301-4307.

Chicago/Turabian Style

Ricardo Ferraz; Vânia Teixeira; Débora Rodrigues; Rúben Fernandes; Cristina Prudêncio; João Paulo Noronha; Željko Petrovski; Luis Branco. 2014. "Antibacterial activity of Ionic Liquids based on ampicillin against resistant bacteria." RSC Advances 4, no. 9: 4301-4307.

Journal article
Published: 01 November 2013 in International Journal of Pharmaceutics
Reads 0
Downloads 0

In order to overcome the problems associated with low water solubility, and consequently low bioavailability of active pharmaceutical ingredients (APIs), herein we explore a modular ionic liquid synthetic strategy for improved APIs. Ionic liquids containing l-ampicillin as active pharmaceutical ingredient anion were prepared using the methodology developed in our previous work, using organic cations selected from substituted ammonium, phosphonium, pyridinium and methylimidazolium salts, with the intent of enhancing the solubility and bioavailability of l-ampicillin forms. In order to evaluate important properties of the synthesized API-ILs, the water solubility at 25 °C and 37 °C (body temperature) as well as octanol–water partition coefficients (Kow's) and HDPC micelles partition at 25 °C were measured. Critical micelle concentrations (CMC's) in water at 25 °C and 37 °C of the pharmaceutical ionic liquids bearing cations with surfactant properties were also determined from ionic conductivity measurements

ACS Style

Catarina Florindo; João Mendes de Araújo; Filipa Alves; Carla Matos; Ricardo Ferraz; Cristina Prudêncio; João Paulo Noronha; Željko Petrovski; Luis Branco; Luis Paulo Rebelo; Isabel Marrucho. Evaluation of solubility and partition properties of ampicillin-based ionic liquids. International Journal of Pharmaceutics 2013, 456, 553 -559.

AMA Style

Catarina Florindo, João Mendes de Araújo, Filipa Alves, Carla Matos, Ricardo Ferraz, Cristina Prudêncio, João Paulo Noronha, Željko Petrovski, Luis Branco, Luis Paulo Rebelo, Isabel Marrucho. Evaluation of solubility and partition properties of ampicillin-based ionic liquids. International Journal of Pharmaceutics. 2013; 456 (2):553-559.

Chicago/Turabian Style

Catarina Florindo; João Mendes de Araújo; Filipa Alves; Carla Matos; Ricardo Ferraz; Cristina Prudêncio; João Paulo Noronha; Željko Petrovski; Luis Branco; Luis Paulo Rebelo; Isabel Marrucho. 2013. "Evaluation of solubility and partition properties of ampicillin-based ionic liquids." International Journal of Pharmaceutics 456, no. 2: 553-559.

Journal article
Published: 15 January 2013 in Fluid Phase Equilibria
Reads 0
Downloads 0

Liquid–liquid equilibria (LLE) of the solutions of imidazolium ionic liquids having bistriflamide [NTf2]− and triflate [OTf]− anions with non-polar (benzene, toluene and p-xylene) and polar aromatic compounds (nicotine and aniline) were investigated. The respective temperature-composition phase diagrams were obtained at 0.1 MPa and in a temperature range 273.15 K–423.15 K. The diagrams posses the features already established for the systems of this type: (i) for the same anion, the mutual solubility continuously increases as the cation alkyl chain extends; (ii) the mutual solubility of the imidazolium ionic liquids having bistriflamide [NTf2]− anion is higher compared to that when the triflate [OTf]− anion is present; (iii) the solubility is reduced as the alkylation of the benzene ring increases. However, the LLE results for the solutions [Cnmim][OTf] + nicotine/or aniline) demonstrate a very sudden effect of the cation chain length on the liquid phase behavior. In particular, the addition of only two CH2 groups to the chain drastically increases the mutual solubility making the respective solutions always homogeneous. The experimental liquid–liquid equilibria (LLE) data for the [C2mim][OTf] + aniline, [C4mim][OTf] + aniline, and [C2mim][OTf] + nicotine systems were modeled using the UNIQUAC equation. The agreement of calculated compositions with experimental data is very satisfactory.

ACS Style

M.S. Calado; Z. Petrovski; M.S. Manic; V. Najdanovic-Visak; E.A. Macedo; Z.P. Visak. Liquid–liquid equilibria of imidazolium ionic liquids having bistriflamide or triflate anions with aromatic non-polar and polar compounds. Fluid Phase Equilibria 2013, 337, 67 -72.

AMA Style

M.S. Calado, Z. Petrovski, M.S. Manic, V. Najdanovic-Visak, E.A. Macedo, Z.P. Visak. Liquid–liquid equilibria of imidazolium ionic liquids having bistriflamide or triflate anions with aromatic non-polar and polar compounds. Fluid Phase Equilibria. 2013; 337 ():67-72.

Chicago/Turabian Style

M.S. Calado; Z. Petrovski; M.S. Manic; V. Najdanovic-Visak; E.A. Macedo; Z.P. Visak. 2013. "Liquid–liquid equilibria of imidazolium ionic liquids having bistriflamide or triflate anions with aromatic non-polar and polar compounds." Fluid Phase Equilibria 337, no. : 67-72.

Journals
Published: 15 February 2012 in MedChemComm
Reads 0
Downloads 0

Novel ionic liquids containing ampicillin as an active pharmaceutical ingredient anion were prepared with good yields by using a new, efficient synthetic procedure based on the neutralization of a moderately basic ammonia solution of ampicillin with different organic cation hydroxides. The relevant physical and thermal properties of these novel ionic liquids based on ampicillin were also evaluated.

ACS Style

Ricardo Ferraz; Luis Branco; Isabel Marrucho; João Mendes de Araújo; Luis Paulo Rebelo; Manuel Nunes da Ponte; Cristina Prudêncio; João Paulo Noronha; Željko Petrovski. Development of novel ionic liquids based on ampicillin. MedChemComm 2012, 3, 494 -497.

AMA Style

Ricardo Ferraz, Luis Branco, Isabel Marrucho, João Mendes de Araújo, Luis Paulo Rebelo, Manuel Nunes da Ponte, Cristina Prudêncio, João Paulo Noronha, Željko Petrovski. Development of novel ionic liquids based on ampicillin. MedChemComm. 2012; 3 (4):494-497.

Chicago/Turabian Style

Ricardo Ferraz; Luis Branco; Isabel Marrucho; João Mendes de Araújo; Luis Paulo Rebelo; Manuel Nunes da Ponte; Cristina Prudêncio; João Paulo Noronha; Željko Petrovski. 2012. "Development of novel ionic liquids based on ampicillin." MedChemComm 3, no. 4: 494-497.

Journal article
Published: 08 September 2011 in ChemInform
Reads 0
Downloads 0
ACS Style

Ricardo Ferraz; Luis C. Branco; Cristina Prudencio; Joao Paulo Noronha; Zeljko Petrovski. ChemInform Abstract: Ionic Liquids as Active Pharmaceutical Ingredients. ChemInform 2011, 42, 1 .

AMA Style

Ricardo Ferraz, Luis C. Branco, Cristina Prudencio, Joao Paulo Noronha, Zeljko Petrovski. ChemInform Abstract: Ionic Liquids as Active Pharmaceutical Ingredients. ChemInform. 2011; 42 (40):1.

Chicago/Turabian Style

Ricardo Ferraz; Luis C. Branco; Cristina Prudencio; Joao Paulo Noronha; Zeljko Petrovski. 2011. "ChemInform Abstract: Ionic Liquids as Active Pharmaceutical Ingredients." ChemInform 42, no. 40: 1.

Review
Published: 09 May 2011 in ChemMedChem
Reads 0
Downloads 0

Ionic liquids (ILs) are ionic compounds that possess a melting temperature below 100 °C. Their physical and chemical properties are attractive for various applications. Several organic materials that are now classified as ionic liquids were described as far back as the mid‐19th century. The search for new and different ILs has led to the progressive development and application of three generations of ILs: 1) The focus of the first generation was mainly on their unique intrinsic physical and chemical properties, such as density, viscosity, conductivity, solubility, and high thermal and chemical stability. 2) The second generation of ILs offered the potential to tune some of these physical and chemical properties, allowing the formation of “task‐specific ionic liquids” which can have application as lubricants, energetic materials (in the case of selective separation and extraction processes), and as more environmentally friendly (greener) reaction solvents, among others. 3) The third and most recent generation of ILs involve active pharmaceutical ingredients (API), which are being used to produce ILs with biological activity. Herein we summarize recent developments in the area of third‐generation ionic liquids that are being used as APIs, with a particular focus on efforts to overcome current hurdles encountered by APIs. We also offer some innovative solutions in new medical treatment and delivery options.

ACS Style

Ricardo Ferraz; Luis Branco; Cristina Prudêncio; João Paulo Noronha; Željko Petrovski. Ionic Liquids as Active Pharmaceutical Ingredients. ChemMedChem 2011, 6, 975 -985.

AMA Style

Ricardo Ferraz, Luis Branco, Cristina Prudêncio, João Paulo Noronha, Željko Petrovski. Ionic Liquids as Active Pharmaceutical Ingredients. ChemMedChem. 2011; 6 (6):975-985.

Chicago/Turabian Style

Ricardo Ferraz; Luis Branco; Cristina Prudêncio; João Paulo Noronha; Željko Petrovski. 2011. "Ionic Liquids as Active Pharmaceutical Ingredients." ChemMedChem 6, no. 6: 975-985.