Tuberculous meningitis (TBM) caused by Mycobacterium tuberculosis resistant to antituberculosis drugs is an increasingly common clinical problem. This study aimed to evaluate drug resistance profiles of TBM isolates in adult patients in nine European countries involving 32 centers to provide insight into the empiric treatment of TBM. Mycobacterium tuberculosis was cultured from the cerebrospinal fluid (CSF) of 142 patients and was tested for susceptibility to first-line antituberculosis drugs, streptomycin (SM), isoniazid (INH), rifampicin (RIF) and ethambutol (EMB). Twenty of 142 isolates (14.1 %) were resistant to at least one antituberculosis drug, and five (3.5 %) were resistant to at least INH and RIF, [multidrug resistant (MDR)]. The resistance rate was 12, 4.9, 4.2 and 3.5 % for INH, SM, EMB and RIF, respectively. The monoresistance rate was 6.3, 1.4 and 0.7 % for INH, SM and EMB respectively. There was no monoresistance to RIF. The mortality rate was 23.8 % in fully susceptible cases while it was 33.3 % for those exhibiting monoresistance to INH, and 40 % in cases with MDR-TBM. In compared to patients without resistance to any first-line drug, the relative risk of death for INH-monoresistance and MDR-TBM was 1.60 (95 % CI, 0.38–6.82) and 2.14 (95 % CI, 0:34–13:42), respectively. INH-resistance and MDR rates seemed not to be worrisome in our study. However, considering their adverse effects on treatment, rapid detection of resistance to at least INH and RIF would be most beneficial for designing anti-TB therapy. Still, empiric TBM treatment should be started immediately without waiting the drug susceptibility testing.

Hydatid cyst is a zoonotic disease that can affect multiple organs and is difficult to diagnose and treat. Spinal hydatid cyst (SHC) is a rare hydatid cyst involvement observed in 1% of all cases. It can induce various neurological symptoms depending on the region of the involvement. Paraplegia is one of the most prevalent neurological symptoms. In this case report, a 63-year-old male patient with bilateral lower extremity paraplegia was operated on by neurosurgery and diagnosed with SHC at the level of Th 11 vertebra in the pathological examination of surgically removed materials. Thus, we aimed to emphasize the significance of pathological and microbiological examination in the differential diagnosis of spinal disorders.

Korona virüs aralık 2019’un sonu itibari ile tüm dünyada yaygınlaşmış ve Mart 2020’den sonra ülkemizde de yaygın görülmeye başlamıştır. Tedavide uygulanan antiviral ilaçlardan sitokin reseptör antagonistlerine kadar çok geniş bir yelpazededir. Burada ayaktan hasta bakımındaki tedavi önerileri ile birlikte yoğun bakımdaki kritik hasta bakımı önerileri de yer almaktadır.

Streptococcus pneumoniae,community-acquired pneumonia,adult

Objective: Tularemia is a zoonotic disease. Sporadic cases and outbreaks occur in humans. Here, we report a waterborne outbreak, its clinical presentation, and the results of treatment. Material and Methods: An increase in the frequency of patients presenting with lymphadenopathy from the same region was detected. Patients with serological diagnosis of tularemia were included in the study between December 2018 and April 2019. This case series were evaluated as an outbreak, clinical and laboratory parameters, demographic characteristics, clinical forms of tularemia and laboratory findings such as immunoglobulin M antibody titer for F. tularemia, inflammatory markers (C-reactive protein, leukocytosis, erythrocyte sedimentation rate), choice of first antibiotic treatment, total duration of treatment, initial clinical/laboratory response day, relapse and reinfection ratios have been investigated. The bacteria was investigated from drinking water fountains by polymerase chain reaction (PCR) (16sRNA Nanobiz® F. tularemia). Results: Tularemia was diagnosed serologically in 35 patients. Distribution of clinical forms was glandular (21 cases-60%); ulceroglandular (11 cases-31.4%); oropharyngeal (2 cases-5.7%) and oculoglandular (1 case-2.8%), respectively. First serologic test positivity was 80%. Inflammatory markers such as C-reactive protein, leukocytes, erythrocyte sedimentation rate were high. Antibiotic choice for treatment was streptomycin in 19 cases (54.3%), ciprofloxacin in nine cases (25.7%), gentamicin in four cases (11.4%); doxycycline in three cases (8.6%) respectively. The common suspicious contact was the use of drinking water from street fountains. F.tularemia PCR (16sRNA) was positive in 35 of these fountains (35/80, 43.75%). Conclusion: Tularemia should always be considered in head and neck lymphandenopathies that do not heal or show late recovery. We should keep in mind tularemia in a water-borne outbreak, were high it is rare.