Dr. Ashutosh Sharma
Department of Chemistry, University of Illinois at Chicago, Chicago, IL 60607, USA
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Academic Career Length
33Years (1994-Present)
(Calculated once Scilit publication data is synced: current year − year of first publication + 1)
Representative Publications
View All Publications1 November 2018 in Cell
Journal Article
YZYunxiao Zhang
Yunxiao ZhangDBDavid P. Bulkley
David P. BulkleyYXYao Xin
Yao Xin
KRKelsey J. Roberts
Kelsey J. Roberts
DADaniel E. Asarnow
Daniel E. Asarnow
PBPhilip A. Beachy
Philip A. Beachy +4
21 May 2012 in Journal of Materials Chemistry
Journal Article
AGAtul Goel
Atul GoelVKVijay Kumar
Vijay Kumar
SSSalil P. Singh
Salil P. Singh
Ashutosh SharmaSPSattey Prakash
Sattey Prakash
RAR. S. Anand
R. S. Anand
+1
A novel series of light emitting and thermally stable non-aggregating benzannulated quinolines and acridines were designed and prepared from ketene-S,S-acetal under mild conditions through C–C bond formation. Photophysical and electrochemical analyses of these bipolar N-heterocyclic compounds revealed intense solvatochromism due to the intramolecular charge-transfer character, exemplary for 9b, which covered PL ranging from blue (480 nm) to green (501 nm) to yellow (562 nm) to orange (589 nm) using aprotic solvents of varying polarity. Organic light emitting devices with a device configuration of ITO/PEDOT:PSS (40 nm)/NPB (20 nm)/(N-heterocyclic compound) (50 nm)/BCP (7 nm)/LiF (0.7 nm)/Al (200 nm) were successfully prepared. The optoelectronic properties of these compounds were altered by controlled tuning of donor–acceptor and aromatic π-conjugation in benzo[f]quinolines and benzo[a]acridines, which exhibited a low turn-on voltage with electroluminescence ranging from blue (6c: λEL 455 nm) to green (8a: λEL 496 nm) to yellow (11: λEL 545 nm) to red (9b: λEL 630 nm).
10 January 2014 in Organic Letters
Journal Article
AGAtul Goel
Atul Goel
Ashutosh SharmaMKManoj Kathuria
Manoj KathuriaABArindam Bhattacharjee
Arindam BhattacharjeeAVAshwni Verma
Ashwni VermaKMKalyan Mitra
Kalyan Mitra
+2
10 January 2025 in Biochemistry
Journal Article
Kyli BerkleyJZJulian Zalejski
Julian ZalejskiNSNidhi Sharma
Nidhi Sharma
Ashutosh Sharma21 January 2015 in Chemical Communications
Journal Article
AGAtul Goel
Atul GoelSUShahida Umar
Shahida Umar
PNPankaj Nag
Pankaj Nag
Ashutosh SharmaLKLalit Kumar
Lalit Kumar
ANAAMIR NAZIR
AAMIR NAZIR +3
The discovery of an iron(III)-selective ratiometric fluorescent probe to detect and visualize endogenous labile iron pools in living organisms at the molecular level has been long awaited. Herein we report the first dual colorimetric and ratiometric fluorescent probe naphtho[2,1-b][1,10]phenanthroline NAP-3 for selective and ‘direct’ visualization of labile iron(III) pools in a multicellular organism, Caenorhabditis elegans.
21 October 2015 in The Analyst
Journal Article
Ashutosh SharmaSUShahida Umar
Shahida Umar
PKParmita Kar
Parmita Kar
KSKavita Singh
Kavita Singh
MSMonika Sachdev
Monika Sachdev
AGAtul Goel
Atul GoelWe discovered a new type of nontoxic, highly fluorogenic and biocompatible probe AFN for selective staining of intracellular Lipid Droplets (LDs) in both fixed and live human cervical cancer cells (HeLa) and 3T3-L1 pre-adipocytes without any background artifacts.
About Me
Dr. Ashutosh Sharma is a
visiting research assistant professor at the Department
of Chemistry, University of Illinois, Chicago. He completed his PhD studies in Chemistry from Central Drug Research Institute (CDRI) Luckow, India. One of his projects concerns
the design and development of novel ratiometric fluorescent sensors and their
application to quantitative imaging of diverse cellular signaling molecules. He
describes an overview of the design principles for ratiometric fluorescent
sensors and their application to simultaneous in situ quantitative imaging of
two membrane lipids. He has published more than 15 papers in various journals
and serves as an editorial member for Journal of Imaging, Journal of
Chemistry, and ARKIVOC. His research interests inscribe
the design and development of novel molecular fluorescent probes for imaging
and analysis of cellular systems for targeting dysregulation in the signaling
(downstream/upstream) pathways. Currently ongoing research work is based on
the development of the novel drug candidate for the inhibition of membrane
lipid-protein interaction. This inhibition of membrane lipid-protein leads to
the development of novel drug candidate with exceptional efficacy with no
off-target effect and no drug resistance.