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Prof. Gabriele Brecchia
Department of Veterinary Medicine, University of Milan, Via dell'Università 6-26900 Lodi, Italy

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0 Nutraceuticals
0 Rabbit
0 Physiology of reproduction
0 Physiology of nutrition and digestive system
0 Animal models of inflammation

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Journal article
Published: 05 August 2021 in Applied Sciences
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In the last three decades, we assisted in a shift in the dairy product preferences in developed countries, with an increase in goat-derived products consumption. As already seen in the bovine sector, the diffusion of goat milk consumption has led to an abandonment of the local breeds in favor of the more productive cosmopolitan breeds, with an intense reduction in the livestock biodiversity. However, in several studies, it has been shown that local breeds present unique features such as a robust behavior towards the local climate and a high quality of their dairy products. This study aims to assess the differences between the basic lactation variables (milk yield, fat %, protein %, lactose % and somatic cell count) in the Alpine goat and the local breed Verzasca goat from a Bayesian point of observation. Results indicate that the Nera di Verzasca goat has overall lactation characteristics similar toa cosmopolite breed such as the Alpine goat, except for the milk daily yield reduced with respect to Alpine goats (1.68 ± 0.84 and 2.14 ± 1.03, respectively). Moreover, the Verzasca goat showed a tendency to maintain a lower level of somatic cell count along with lactation (798 ± 1734 and 1216 ± 2828, respectively). These findings help to increase the knowledge about the Italian local goat breeds and are important in the optic of biodiversity conservation.

ACS Style

Stella Agradi; Alessia Gazzonis; Giulio Curone; Massimo Faustini; Susanna Draghi; Gabriele Brecchia; Daniele Vigo; Maria Manfredi; Sergio Zanzani; Luisa Pulinas; Majlind Sulce; Albana Munga; Marta Castrica; Laura Menchetti. Lactation Characteristics in Alpine and Nera di Verzasca Goats in Northern Italy: A Statistical Bayesian Approach. Applied Sciences 2021, 11, 7235 .

AMA Style

Stella Agradi, Alessia Gazzonis, Giulio Curone, Massimo Faustini, Susanna Draghi, Gabriele Brecchia, Daniele Vigo, Maria Manfredi, Sergio Zanzani, Luisa Pulinas, Majlind Sulce, Albana Munga, Marta Castrica, Laura Menchetti. Lactation Characteristics in Alpine and Nera di Verzasca Goats in Northern Italy: A Statistical Bayesian Approach. Applied Sciences. 2021; 11 (16):7235.

Chicago/Turabian Style

Stella Agradi; Alessia Gazzonis; Giulio Curone; Massimo Faustini; Susanna Draghi; Gabriele Brecchia; Daniele Vigo; Maria Manfredi; Sergio Zanzani; Luisa Pulinas; Majlind Sulce; Albana Munga; Marta Castrica; Laura Menchetti. 2021. "Lactation Characteristics in Alpine and Nera di Verzasca Goats in Northern Italy: A Statistical Bayesian Approach." Applied Sciences 11, no. 16: 7235.

Journal article
Published: 30 July 2021 in Foods
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High-pressure (HP) treatment could lead to several advantages when applied to fish and seafood since it would affect the extension of the shelf life of this highly perishable food. In this regard, this study aimed to evaluate the effect of high-pressure treatment (500 MPa for 2 min at a temperature of 4 °C) on changes in quality on two different kinds of fresh fish fillets (Salmo salar and Pleuronectes platessa). Specifically, physico-chemical (VOCs, untargeted metabolomics spectra, pH and color), microbiological (Enterobacteriaceae, Pseudomonas spp., mesophilic and psychrotrophic bacteria) and sensory traits were evaluated at different days of refrigerated storage. From the results obtained, it is possible to state that the high pressure significantly (p ≤ 0.05) reduced microbial growth for each investigated microorganism. Regarding the colorimetric coordinates, no remarkable effects on a* and b* indices were found, while a significant effect (p = 0.01) was observed on the colorimetric index L*, making the HP-treated samples lighter than their respective controls. The sensory analysis showed that for the odor attribute, the HP treatment seems to have had a stabilizing action during shelf-life. Moreover, the treated samples obtained a better score than the respective controls (p ≤ 0.05). With regards to texture and appearance attributes, the treatment seems to have had a significant (p ≤ 0.05) effect, making the treated samples more compact and opaque than controls, therefore resulting in the loss of the characteristics of raw fish for the treated samples. Moreover, from a chemical point of view, HP treatment prevents the development of volatile sulfides and delays the formation of histamine (p ≤ 0.05). Very interestingly, the metabolomic approach revealed novel dipeptide markers for the HP procedure.

ACS Style

Marta Castrica; Radmila Pavlovic; Claudia Balzaretti; Giulio Curone; Gabriele Brecchia; Emma Copelotti; Sara Panseri; Davide Pessina; Claudio Arnoldi; Luca Chiesa. Effect of High-Pressure Processing on Physico-Chemical, Microbiological and Sensory Traits in Fresh Fish Fillets (Salmo salar and Pleuronectes platessa). Foods 2021, 10, 1775 .

AMA Style

Marta Castrica, Radmila Pavlovic, Claudia Balzaretti, Giulio Curone, Gabriele Brecchia, Emma Copelotti, Sara Panseri, Davide Pessina, Claudio Arnoldi, Luca Chiesa. Effect of High-Pressure Processing on Physico-Chemical, Microbiological and Sensory Traits in Fresh Fish Fillets (Salmo salar and Pleuronectes platessa). Foods. 2021; 10 (8):1775.

Chicago/Turabian Style

Marta Castrica; Radmila Pavlovic; Claudia Balzaretti; Giulio Curone; Gabriele Brecchia; Emma Copelotti; Sara Panseri; Davide Pessina; Claudio Arnoldi; Luca Chiesa. 2021. "Effect of High-Pressure Processing on Physico-Chemical, Microbiological and Sensory Traits in Fresh Fish Fillets (Salmo salar and Pleuronectes platessa)." Foods 10, no. 8: 1775.

Journal article
Published: 03 June 2021 in Animals
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Goji berry shows a wide range of beneficial properties in human health, but only a few studies evaluated its effects in livestock animals. The objective of this research was to assess the effects of goji berry supplementation on the hormonal profile, productive, and reproductive performance of does. Two months before artificial insemination, 105 nulliparous does were randomly divided into three groups (n = 35) based on the dietary treatment: commercial diet (C), or a diet supplemented with either 1% (G1), or 3% (G3) of goji berry, respectively. The results showed that receptivity was higher in G1 than in the C group (p< 0.05). Trends toward significance for differences between the G1 and G3 groups in marginal means of LH concentrations (p = 0.059), and between G1 and C in LH AUC values (p = 0.078), were evidenced. Estrogen concentrations showed a more fluctuating trend but a significant interaction effect (p< 0.001). The G1 group showed higher litter weight than C at birth (p = 0.008) and weaning (p< 0.001), as well as higher litter size at weaning (p = 0.020). The G1 group also exhibited the highest mean milk production (p< 0.01). In conclusion, goji berry influenced reproductive and productive performance, probably via modulating hormonal patterns and milk production in rabbits. However, further studies are needed to validate these preliminary results.

ACS Style

Egon Andoni; Giulio Curone; Stella Agradi; Olimpia Barbato; Laura Menchetti; Daniele Vigo; Riccardo Zelli; Elisa Cotozzolo; Maria Ceccarini; Massimo Faustini; Alda Quattrone; Marta Castrica; Gabriele Brecchia. Effect of Goji Berry (Lycium barbarum) Supplementation on Reproductive Performance of Rabbit Does. Animals 2021, 11, 1672 .

AMA Style

Egon Andoni, Giulio Curone, Stella Agradi, Olimpia Barbato, Laura Menchetti, Daniele Vigo, Riccardo Zelli, Elisa Cotozzolo, Maria Ceccarini, Massimo Faustini, Alda Quattrone, Marta Castrica, Gabriele Brecchia. Effect of Goji Berry (Lycium barbarum) Supplementation on Reproductive Performance of Rabbit Does. Animals. 2021; 11 (6):1672.

Chicago/Turabian Style

Egon Andoni; Giulio Curone; Stella Agradi; Olimpia Barbato; Laura Menchetti; Daniele Vigo; Riccardo Zelli; Elisa Cotozzolo; Maria Ceccarini; Massimo Faustini; Alda Quattrone; Marta Castrica; Gabriele Brecchia. 2021. "Effect of Goji Berry (Lycium barbarum) Supplementation on Reproductive Performance of Rabbit Does." Animals 11, no. 6: 1672.

Journal article
Published: 27 April 2021 in Antioxidants
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Polyunsaturated fatty acid (PUFA) metabolism and tissue distribution is modulated by the oxidation of these molecules. This research aimed to investigate the implication of dietary n-3 PUFA supplementation (precursor and long-chain PUFA) on the PUFA profile and oxidative status of the liver, testis, and brain of adult rabbit bucks. Twenty New Zealand White rabbit bucks were divided into four experimental groups (n = 5 per group) and were fed different diets for 110 days: control (CNT), standard diet containing 50 mg/kg alpha-tocopheryl acetate (vitamin E); CNT+, standard diet + 200 mg/kg vitamin E; FLAX, standard diet + 10% flaxseed + 200 mg/kg vitamin E; or FISH, standard diet + 3.5% fish oil + 200 mg/kg vitamin E. Antioxidants (enzymatic and non-enzymatic), oxidative status (malondialdehyde and isoprostanoids), and n-3 and n-6 PUFAs of tissues were analysed. A chain mechanism of oxidant/antioxidant molecules, which largely depended on the particular PUFA composition, was delineated in the different organs. The liver showed an oxidant/antioxidant profile and lipid pathways widely modulated by PUFA and vitamin E administration; on the other hand, the testis’ oxidative profile rather than its lipid profile seemed to be particularly affected, an outcome opposite to that of the brain (modulation operated by dietary PUFA).

ACS Style

Simona Mattioli; Giulia Collodel; Cinzia Signorini; Elisa Cotozzolo; Daria Noto; Daniela Cerretani; Lucia Micheli; Anna Fiaschi; Gabriele Brecchia; Laura Menchetti; Elena Moretti; Camille Oger; Claudio De Felice; Cesare Castellini. Tissue Antioxidant Status and Lipid Peroxidation Are Related to Dietary Intake of n-3 Polyunsaturated Acids: A Rabbit Model. Antioxidants 2021, 10, 681 .

AMA Style

Simona Mattioli, Giulia Collodel, Cinzia Signorini, Elisa Cotozzolo, Daria Noto, Daniela Cerretani, Lucia Micheli, Anna Fiaschi, Gabriele Brecchia, Laura Menchetti, Elena Moretti, Camille Oger, Claudio De Felice, Cesare Castellini. Tissue Antioxidant Status and Lipid Peroxidation Are Related to Dietary Intake of n-3 Polyunsaturated Acids: A Rabbit Model. Antioxidants. 2021; 10 (5):681.

Chicago/Turabian Style

Simona Mattioli; Giulia Collodel; Cinzia Signorini; Elisa Cotozzolo; Daria Noto; Daniela Cerretani; Lucia Micheli; Anna Fiaschi; Gabriele Brecchia; Laura Menchetti; Elena Moretti; Camille Oger; Claudio De Felice; Cesare Castellini. 2021. "Tissue Antioxidant Status and Lipid Peroxidation Are Related to Dietary Intake of n-3 Polyunsaturated Acids: A Rabbit Model." Antioxidants 10, no. 5: 681.

Journal article
Published: 12 February 2021 in Animals
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The aim of this work was to find the best strategy to diagnose pregnancy failures in buffalo. A total of 109 animals belonging to a buffalo herd subjected to a synchronization and artificial insemination (AI) program were enrolled in this study. Blood samples were collected at days 0, 14, 25, 28 and 40 after AI for the determination of progesterone (P4) and pregnancy-associated glycoproteins (PAGs) by the radioimmunoassay (RIA) method. Transrectal ultrasonography was performed on day 25, 28 and 40 after AI to monitor pregnancy. The animals included in the data analysis were assigned ex post in pregnant (n = 50) and mortality (n = 12) groups. By ultrasonography, the predictive sign of mortality was the heartbeat. At day 25, the PAGs concentration was significant in predicting embryonic mortality with respect to ultrasonography and P4, at the cut-off of 1.1 ng/mL. At day 28, either PAGs, at a cut-off of 2.2 ng/mL, or ultrasonography, with no detection of heartbeat, were highly predictive of embryonic mortality. PAGs were the best marker (p < 0.05) for predicting embryonic mortality between 25 and 40 days of gestation in buffalo. Its utilization as a diagnostic tool can influence management decisions in order to improve farm reproductive management.

ACS Style

Vittoria Barile; Laura Menchetti; Anna Casano; Gabriele Brecchia; Noelita Melo de Sousa; Riccardo Zelli; Claudio Canali; Jean Beckers; Olimpia Barbato. Approaches to Identify Pregnancy Failure in Buffalo Cows. Animals 2021, 11, 487 .

AMA Style

Vittoria Barile, Laura Menchetti, Anna Casano, Gabriele Brecchia, Noelita Melo de Sousa, Riccardo Zelli, Claudio Canali, Jean Beckers, Olimpia Barbato. Approaches to Identify Pregnancy Failure in Buffalo Cows. Animals. 2021; 11 (2):487.

Chicago/Turabian Style

Vittoria Barile; Laura Menchetti; Anna Casano; Gabriele Brecchia; Noelita Melo de Sousa; Riccardo Zelli; Claudio Canali; Jean Beckers; Olimpia Barbato. 2021. "Approaches to Identify Pregnancy Failure in Buffalo Cows." Animals 11, no. 2: 487.

Research article
Published: 26 December 2020 in Mediators of Inflammation
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The aim of this research was to evaluate the inflammatory and/or oxidative damage related to silver nanoparticles (AgNPs), which are responsible for negative effects on sperm physiology and metabolism. Thirty New Zealand White rabbit bucks were divided into 5 experimental groups (6 animals/group): Control, treated with 0.9% NaCl; AgNP, treated with a 5 mM AgNP solution; LPS, treated with 50 g/kg b.w. E. coli LPS; AgNPs + NSAID, treated with an anti-inflammatory drug at 0.2 mg/kg b.w. and 5 mM AgNPs; and AgNPs + Vit E, treated with 0.18 mg/kg b.w. vitamin E and 5 mM AgNPs. Sperm quality and oxidative and inflammatory status were assessed at different times (0-60 days). Two statistical models were built: the first evaluated the effects of AgNPs and LPS (vs. Control), whereas the second evaluated the protective effect of an NSAID and vitamin E against AgNP-induced damage. Three principal component analyses were performed: sperm traits (motility, volume), oxidative status (antioxidants, oxidative metabolites, and redox reactions), and cytokines (TNF-α, IL-8, and IL-6). A negative effect on reproductive traits resulted after NP administration. In particular, an inflammatory/oxidative response took place in the reproductive tract during the first 2-3 wks of AgNP administration (cytokine and oxidative metabolite generation); the inflammatory/oxidative thrust impaired the status of rabbit tissues (seminal plasma, sperm, and blood), inducing a response (increased antioxidant enzymes and redox reactions) at 4-7 wks; oxidative stress, if not totally counteracted, likely induced toxicity in the late phases of AgNP administration (8-9 wks). In conclusion, exposure to silver nanoparticles produced a similar but more persistent effect than that of LPS on rabbit reproductive tissues: AgNP administration triggered a proinflammatory response linked to oxidative thrust, worsening many sperm parameters. However, only anti-inflammatory treatment counteracted the negative effects of AgNPs, whereas vitamin E seemed to act as an adjuvant, attenuating the oxidative cascade.

ACS Style

Collodel Giulia; Mattioli Simona; Moretti Elena; Cerretani Daniela; Micheli Lucia; Fiaschi Anna Ida; Menchetti Laura; Brecchia Gabriele; Castellini Cesare. Oxidative and/or Inflammatory Thrust Induced by Silver Nanoparticles in Rabbits: Effect of Vitamin E or NSAID Administration on Semen Parameters. Mediators of Inflammation 2020, 2020, 1 -15.

AMA Style

Collodel Giulia, Mattioli Simona, Moretti Elena, Cerretani Daniela, Micheli Lucia, Fiaschi Anna Ida, Menchetti Laura, Brecchia Gabriele, Castellini Cesare. Oxidative and/or Inflammatory Thrust Induced by Silver Nanoparticles in Rabbits: Effect of Vitamin E or NSAID Administration on Semen Parameters. Mediators of Inflammation. 2020; 2020 ():1-15.

Chicago/Turabian Style

Collodel Giulia; Mattioli Simona; Moretti Elena; Cerretani Daniela; Micheli Lucia; Fiaschi Anna Ida; Menchetti Laura; Brecchia Gabriele; Castellini Cesare. 2020. "Oxidative and/or Inflammatory Thrust Induced by Silver Nanoparticles in Rabbits: Effect of Vitamin E or NSAID Administration on Semen Parameters." Mediators of Inflammation 2020, no. : 1-15.

Journal article
Published: 26 December 2020 in Animals
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The microbiota is extremely important for the animal’s health, but, to date, knowledge on the intestinal microbiota of the rabbit is very limited. This study aimed to describe bacterial populations that inhabit the different gastrointestinal compartments of the rabbit: stomach, duodenum, jejunum, ileum, caecum, and colon. Samples of the luminal content from all compartments of 14 healthy New White Zealand rabbits were collected at slaughter and analyzed using next generation 16S rRNA Gene Sequencing. The findings uncovered considerable differences in the taxonomic levels among the regions of the digestive tract. Firmicutes were the most abundant phylum in all of the sections (45.9%), followed by Bacteroidetes in the large intestine (38.9%) and Euryarchaeota in the foregut (25.9%). Four clusters of bacterial populations were observed along the digestive system: (i) stomach, (ii) duodenum and jejunum, (iii) ileum, and (iv) large intestine. Caecum and colon showed the highest richness and diversity in bacterial species, while the highest variability was found in the upper digestive tract. Knowledge of the physiological microbiota of healthy rabbits could be important for preserving the health and welfare of the host as well as for finding strategies to manipulate the gut microbiota in order to also promote productive performance.

ACS Style

Elisa Cotozzolo; Paola Cremonesi; Giulio Curone; Laura Menchetti; Federica Riva; Filippo Biscarini; Maria Laura Marongiu; Marta Castrica; Bianca Castiglioni; Dino Miraglia; Sebastiano Luridiana; Gabriele Brecchia. Characterization of Bacterial Microbiota Composition along the Gastrointestinal Tract in Rabbits. Animals 2020, 11, 31 .

AMA Style

Elisa Cotozzolo, Paola Cremonesi, Giulio Curone, Laura Menchetti, Federica Riva, Filippo Biscarini, Maria Laura Marongiu, Marta Castrica, Bianca Castiglioni, Dino Miraglia, Sebastiano Luridiana, Gabriele Brecchia. Characterization of Bacterial Microbiota Composition along the Gastrointestinal Tract in Rabbits. Animals. 2020; 11 (1):31.

Chicago/Turabian Style

Elisa Cotozzolo; Paola Cremonesi; Giulio Curone; Laura Menchetti; Federica Riva; Filippo Biscarini; Maria Laura Marongiu; Marta Castrica; Bianca Castiglioni; Dino Miraglia; Sebastiano Luridiana; Gabriele Brecchia. 2020. "Characterization of Bacterial Microbiota Composition along the Gastrointestinal Tract in Rabbits." Animals 11, no. 1: 31.

Journal article
Published: 30 October 2020 in Animals
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This study examined the effects of goji berries dietary supplementation on the energetic metabolism of doe. Thirty days before artificial insemination, 75 New Zealand White does were assigned to three different diets: commercial standard diet (C) and supplemented with 1% (LG) and 3% (HG) of goji berries, respectively. Body conditions, hormones and metabolites were monitored until weaning. Body weight and BCS were higher in HG than C (p < 0.05). LG showed lower T3/T4 ratio and cortisol concentrations (p < 0.05) and tended to have lower indices of insulin resistances (p < 0.1) than HG. Compared to control, leptin was higher in HG at AI (p < 0.01) and in LG during lactation (p < 0.05). Two principal components were extracted by multivariate analysis describing the relationships between (1) non-esterified fatty acids, insulin and glucose levels, and (2) body conditions and leptin metabolism. The first component highlighted the energy deficit and the insulin resistance of the does during pregnancy and lactation. The second one showed that leptin, body weight and Body Condition Score (BCS) enhance as levels of goji berries in the diet increase. Thus, the effects of goji supplementation are dose-dependent: an improvement on energy metabolism was achieved with a low-dose while the highest dose could determine excessive fattening and insulin resistance in does.

ACS Style

Laura Menchetti; Giulio Curone; Egon Andoni; Olimpia Barbato; Alessandro Troisi; Bernard Fioretti; Angela Polisca; Michela Codini; Claudio Canali; Daniele Vigo; Gabriele Brecchia. Impact of Goji Berries (Lycium barbarum) Supplementation on the Energy Homeostasis of Rabbit Does: Uni- and Multivariate Approach. Animals 2020, 10, 2000 .

AMA Style

Laura Menchetti, Giulio Curone, Egon Andoni, Olimpia Barbato, Alessandro Troisi, Bernard Fioretti, Angela Polisca, Michela Codini, Claudio Canali, Daniele Vigo, Gabriele Brecchia. Impact of Goji Berries (Lycium barbarum) Supplementation on the Energy Homeostasis of Rabbit Does: Uni- and Multivariate Approach. Animals. 2020; 10 (11):2000.

Chicago/Turabian Style

Laura Menchetti; Giulio Curone; Egon Andoni; Olimpia Barbato; Alessandro Troisi; Bernard Fioretti; Angela Polisca; Michela Codini; Claudio Canali; Daniele Vigo; Gabriele Brecchia. 2020. "Impact of Goji Berries (Lycium barbarum) Supplementation on the Energy Homeostasis of Rabbit Does: Uni- and Multivariate Approach." Animals 10, no. 11: 2000.

Journal article
Published: 16 October 2020 in Foods
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Forty-two New Zealand White rabbits (n = 21/group) were fed with two different diets: a commercial diet (control group) and a diet supplemented with goji berries (3% w/w). After slaughtering, the effect of dietary supplementation on microbiological, physico-chemical, and sensory characteristics of the rabbit loins, packed in an oxygen-permeable package, was evaluated at 6 h post mortem (day 0), after 4 and 10 days of refrigerated storage. No relevant results were obtained for pH and total volatile basic Nitrogen (TVBN) values but with regards to the color, some significant differences were observed between the groups. The goji berries (GBs) dietary supplementation had positive effects by reducing thiobarbituric acid reactive substances (TBARS) values in all the observations (p < 0.001). Moreover, microbiological results showed that the supplementation had a significant impact on Lactobacillus spp. (p < 0.001) prevalence, indeed the goji group had higher means on day 0 (p < 0.05) and on day 4 (p < 0.001) than the control group. Lastly, with regards to the consumer’s test, the tasters assigned a higher score to GBs rabbit meatballs and the purchase interest increased when the rabbit diet was known. Overall, these results indicate that the goji berries inclusion in the rabbit diet could represent a valuable strategy to improve quality and sensory traits of meat.

ACS Style

Marta Castrica; Laura Menchetti; Claudia M. Balzaretti; Raffaella Branciari; David Ranucci; Elisa Cotozzolo; Daniele Vigo; Giulio Curone; Gabriele Brecchia; Dino Miraglia. Impact of Dietary Supplementation with Goji Berries (Lycium barbarum) on Microbiological Quality, Physico-Chemical, and Sensory Characteristics of Rabbit Meat. Foods 2020, 9, 1480 .

AMA Style

Marta Castrica, Laura Menchetti, Claudia M. Balzaretti, Raffaella Branciari, David Ranucci, Elisa Cotozzolo, Daniele Vigo, Giulio Curone, Gabriele Brecchia, Dino Miraglia. Impact of Dietary Supplementation with Goji Berries (Lycium barbarum) on Microbiological Quality, Physico-Chemical, and Sensory Characteristics of Rabbit Meat. Foods. 2020; 9 (10):1480.

Chicago/Turabian Style

Marta Castrica; Laura Menchetti; Claudia M. Balzaretti; Raffaella Branciari; David Ranucci; Elisa Cotozzolo; Daniele Vigo; Giulio Curone; Gabriele Brecchia; Dino Miraglia. 2020. "Impact of Dietary Supplementation with Goji Berries (Lycium barbarum) on Microbiological Quality, Physico-Chemical, and Sensory Characteristics of Rabbit Meat." Foods 9, no. 10: 1480.

Journal article
Published: 20 July 2020 in Animals
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This study aimed to evaluate the relationships between fatty acids and the pattern that most contributes to discriminate between two farming systems, in which the main difference was the practice, or not, of alpine summer-grazing. Milk and cheese were sampled every month in two farms of Original Brown cows identical under geographical location and management during no grazing season point of view in the 2018 season. Fatty acids concentrations were determined by gas chromatography. The principal component analysis extracted three components (PCs). Mammary gland de novo synthetized fatty acids (C14:0, C14:1 n9, and C16:0) and saturated and monosaturated C18 fatty acids (C18:0, C18:1 n9c) were inversely associated in the PC1; PC2 included polyunsaturated C18 fatty acids (C18:2 n6c, C18:3 n3) and C15:0 while conjugated linoleic acid (CLA n9c, n11t) and fatty acids containing 20 or more carbon atoms (C21:0, C20:5 n3) were associated in the PC3. The processes of rumen fermentation and de novo synthesis in mammary gland that are, in turn, influenced by diet, could explain the relationships between fatty acids within each PC. The discriminant analyses showed that the PC2 included the fatty acids profile that best discriminated between the two farming systems, followed by PC3 and, lastly, PC1. This model, if validated, could be an important tool to the dairy industry.

ACS Style

Stella Agradi; Giulio Curone; Daniele Negroni; Daniele Vigo; Gabriele Brecchia; Valerio Bronzo; Sara Panseri; Luca Maria Chiesa; Tanja Peric; Doina Danes; Laura Menchetti. Determination of Fatty Acids Profile in Original Brown Cows Dairy Products and Relationship with Alpine Pasture Farming System. Animals 2020, 10, 1231 .

AMA Style

Stella Agradi, Giulio Curone, Daniele Negroni, Daniele Vigo, Gabriele Brecchia, Valerio Bronzo, Sara Panseri, Luca Maria Chiesa, Tanja Peric, Doina Danes, Laura Menchetti. Determination of Fatty Acids Profile in Original Brown Cows Dairy Products and Relationship with Alpine Pasture Farming System. Animals. 2020; 10 (7):1231.

Chicago/Turabian Style

Stella Agradi; Giulio Curone; Daniele Negroni; Daniele Vigo; Gabriele Brecchia; Valerio Bronzo; Sara Panseri; Luca Maria Chiesa; Tanja Peric; Doina Danes; Laura Menchetti. 2020. "Determination of Fatty Acids Profile in Original Brown Cows Dairy Products and Relationship with Alpine Pasture Farming System." Animals 10, no. 7: 1231.

Journal article
Published: 22 May 2020 in Animal Reproduction Science
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This study was conducted to evaluate the changing concentrations of metabolic hormones and metabolites in pregnant (P) and pseudopregnant (PP) rabbit does. Twenty-five New Zealand White rabbit does were submitted to artificial insemination (AI) and then classified as P (n = 15) or PP (n = 10). Blood samples were collected weekly until day 32 post AI. During pregnancy, leptin concentrations were greater on Days 14 and 21 (P < 0.05), while insulin was greater on days 21 and 32 post AI (P < 0.05) compared to PP does. The triiodothyronine/thyroxine (T3/T4) ratio was greater in the first and last week (P < 0.001); whereas, cortisol concentrations were greater in the last week of pregnancy and after parturition (P < 0.01) compared with that of PP does. Non-esterified fatty acids (NEFA) concentrations increased from day 7 until day 32 post AI (P < 0.05). Glucose concentrations were unchanged throughout pregnancy although concentrations were positively associated with litter size. These results indicate concentrations of hormones and metabolites change during pregnancy to ensure energy requirements are met for both the foetuses and the maternal tissues. Physiological hyperleptinemia, hyperinsulinemia, and changes in cortisol as well as thyroid hormones indicate there is an adaptation of metabolic functions induced by pregnancy. These adaptations could be mediated by gonadal steroids because changes mainly occur in the second half of pregnancy when the profile of the sex hormones differs between P and PP does.

ACS Style

Laura Menchetti; Egon Andoni; Olimpia Barbato; Claudio Canali; Alda Quattrone; Daniele Vigo; Michela Codini; Giulio Curone; Gabriele Brecchia. Energy homeostasis in rabbit does during pregnancy and pseudopregnancy. Animal Reproduction Science 2020, 218, 106505 .

AMA Style

Laura Menchetti, Egon Andoni, Olimpia Barbato, Claudio Canali, Alda Quattrone, Daniele Vigo, Michela Codini, Giulio Curone, Gabriele Brecchia. Energy homeostasis in rabbit does during pregnancy and pseudopregnancy. Animal Reproduction Science. 2020; 218 ():106505.

Chicago/Turabian Style

Laura Menchetti; Egon Andoni; Olimpia Barbato; Claudio Canali; Alda Quattrone; Daniele Vigo; Michela Codini; Giulio Curone; Gabriele Brecchia. 2020. "Energy homeostasis in rabbit does during pregnancy and pseudopregnancy." Animal Reproduction Science 218, no. : 106505.

Journal article
Published: 15 March 2020 in Animals
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This study investigated the effects of a short-term administration of bovine colostrum (BC) in a TNBS model of induced colitis. Colitis was induced by TNBS treatment after seven days of BC (BC group, n = 12) or saline (control group, n = 12) administration in mice. Clinical signs, histopathological characteristics, expression levels of Toll-like receptor 4 (TLR4), pro- and anti-inflammatory cytokines, and microbial composition were assessed. BC was well tolerated and did not induce any histological damage or clinical symptoms. After TNBS treatment, the BC group showed a reduction in body weight (BW) loss compared to Control (p < 0.05). Moreover, expression levels of TLR4 (p < 0.01), Interleukin-1β (IL-1β; p < 0.001), Interleukin-8 (IL-8; p < 0.001), and Interleukin-10 (IL-10; p < 0.001) were lower in mice administered with BC. Finally, Escherichia coli were higher (p < 0.05), while Enterococci (p < 0.001), Lactobacillus spp. (p < 0.001), and Bifidobacterium spp. (p < 0.05) were lower in Control than BC group. This study confirms that pre-treatment with BC modulates the expression of genes and the count of microbes involved in the etiopathogenesis of colitis.

ACS Style

Laura Menchetti; Giulio Curone; Iulia Elena Filipescu; Olimpia Barbato; Leonardo Leonardi; Gabriella Guelfi; Giovanna Traina; Patrizia Casagrande-Proietti; Federica Riva; Anna Beatrice Casano; Federica Piro; Daniele Vigo; Alda Quattrone; Gabriele Brecchia. The Prophylactic Use of Bovine Colostrum in a Murine Model of TNBS-Induced Colitis. Animals 2020, 10, 492 .

AMA Style

Laura Menchetti, Giulio Curone, Iulia Elena Filipescu, Olimpia Barbato, Leonardo Leonardi, Gabriella Guelfi, Giovanna Traina, Patrizia Casagrande-Proietti, Federica Riva, Anna Beatrice Casano, Federica Piro, Daniele Vigo, Alda Quattrone, Gabriele Brecchia. The Prophylactic Use of Bovine Colostrum in a Murine Model of TNBS-Induced Colitis. Animals. 2020; 10 (3):492.

Chicago/Turabian Style

Laura Menchetti; Giulio Curone; Iulia Elena Filipescu; Olimpia Barbato; Leonardo Leonardi; Gabriella Guelfi; Giovanna Traina; Patrizia Casagrande-Proietti; Federica Riva; Anna Beatrice Casano; Federica Piro; Daniele Vigo; Alda Quattrone; Gabriele Brecchia. 2020. "The Prophylactic Use of Bovine Colostrum in a Murine Model of TNBS-Induced Colitis." Animals 10, no. 3: 492.

Research article
Published: 22 January 2020 in Oxidative Medicine and Cellular Longevity
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Infections of the genital tract can perturb the fertility in humans and animals. Pathogen recognition and activation of innate immunity onset through the pattern recognition receptor activation, such as Toll-like receptor 4 (TLR4), leading to the production of proinflammatory cytokines and mediators. TLR4 is expressed both on leukocytes and nonimmune cells. Rabbit TLR4 shows great similarity to its human counterpart. Moreover, the TLR4 signalling pathway could be modulated by long-chain polyunsaturated fatty acids (LC-PUFA). The objectives of this study were (i) to determine the expression levels of TLR4 and proinflammatory cytokines in the reproductive hypothalamic-gonadal axis of the male rabbit and (ii) to evaluate if the n-3 PUFA-enriched diets can modify their expression levels in the tissues and LC-PUFA profiles in seminal plasma. Fifteen rabbit bucks ( n = 5 /experimental group) were fed with different diets: commercial standard (group C), rich in extruded linseed (10%, group L), and in fish oil (3%, group FO) for 110 days. TLR4, TNF-α, and IL-1βmRNA were ubiquitously expressed throughout the hypothalamic-gonadal axis. However, TLR4 mRNA expression was lower in the hypothalamus than the epididymis ( P < 0.01 ), seminal vesicles ( P < 0.01 ), and pituitary gland ( P < 0.05 ). Dietary enrichment in PUFA did not modify the gene expression profile nor the histological characteristics of the tissues. Conversely in seminal plasma, rabbits fed with L and FO had lower n-6 ( P < 0.05 ), LC-PUFA n-6 ( P < 0.05 ), and n-6/n-3 ratio ( P < 0.05 ) but higher n-3 ( P < 0.001 ) and LC-PUFA n-3 ( P < 0.01 ) compared to the control group. Our study builds a map of the gene expression of TRL4 and proinflammatory cytokines in the reproductive hypothalamic-gonadal axis of the male rabbit, fundamental step for understanding the immune defence mechanisms. Diets enriched in LC-PUFA did not affect basal gene expression but modulated sperm fatty acid composition. Finally, rabbit may be an excellent animal model to study the relationship between inflammation and infertility, and the nutritional modulation of immune functions.

ACS Style

Laura Menchetti; Olimpia Barbato; Monica Sforna; Daniele Vigo; Simona Mattioli; Giulio Curone; Marco Tecilla; Federica Riva; Gabriele Brecchia. Effects of Diets Enriched in Linseed and Fish Oil on the Expression Pattern of Toll-Like Receptors 4 and Proinflammatory Cytokines on Gonadal Axis and Reproductive Organs in Rabbit Buck. Oxidative Medicine and Cellular Longevity 2020, 2020, 1 -10.

AMA Style

Laura Menchetti, Olimpia Barbato, Monica Sforna, Daniele Vigo, Simona Mattioli, Giulio Curone, Marco Tecilla, Federica Riva, Gabriele Brecchia. Effects of Diets Enriched in Linseed and Fish Oil on the Expression Pattern of Toll-Like Receptors 4 and Proinflammatory Cytokines on Gonadal Axis and Reproductive Organs in Rabbit Buck. Oxidative Medicine and Cellular Longevity. 2020; 2020 ():1-10.

Chicago/Turabian Style

Laura Menchetti; Olimpia Barbato; Monica Sforna; Daniele Vigo; Simona Mattioli; Giulio Curone; Marco Tecilla; Federica Riva; Gabriele Brecchia. 2020. "Effects of Diets Enriched in Linseed and Fish Oil on the Expression Pattern of Toll-Like Receptors 4 and Proinflammatory Cytokines on Gonadal Axis and Reproductive Organs in Rabbit Buck." Oxidative Medicine and Cellular Longevity 2020, no. : 1-10.

Research article
Published: 16 December 2019 in Oxidative Medicine and Cellular Longevity
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In the last two decades, the human sperm count linearly decreased in Western countries. Health problems, lifestyle, pollutants, and dietary behaviours are considered as the main risk factors, and the unbalance of dietary n ‐ 6 / n ‐ 3 fatty acids is one of the most relevant. The aim of the present research is to study the effect of different dietary sources of n ‐ 3 polyunsaturated fatty acids (PUFA) on reproductive traits using rabbit buck as the animal model. Fifteen rabbit bucks were assigned to three experimental groups: the control group, the FLAX group fed 10% extruded flaxseed, and the FISH group fed 3.5% fish oil for 110 days (50-day adaptation and 60-day experimental periods). Semen samples were collected weekly, whereas blood was collected every two weeks for the analytical determination of semen traits, oxidative status, fatty acid profiles, isoprostanes, neuroprostanes, and the immunocytochemistry of docosahexaenoic acid (DHA) and eicosapentaenoic (EPA) acid. At the end of the trial, the rabbits were killed and the testes were removed and stored for the analysis of fatty acid profile and immunocytochemistry. Results showed that dietary administration of n ‐ 3 PUFA improved the track speed of the sperm and increased the n ‐ 3 long-chain PUFA mainly confined in the sperm tail. Seminal plasma increased the thiobarbituric reactive substances (TBARs) by three times in the groups fed supplemental n ‐ 3 , whereas the F2-isoprotanes (F2-IsoPs) and F4-neuroprostanes (F4-NeuroPs) were lower and higher, respectively, in both supplemented groups than in the control. The testes and sperm showed a higher DHA and EPA distribution in rabbits from the n ‐ 3 supplemented groups compared with the control. In conclusion, supplemental dietary n ‐ 3 PUFA improved sperm motion traits and resulted in an enrichment of membrane fatty acid in the sperm and testes of the rabbits. However, such an increased amount of PUFA negatively affected the sperm oxidative status, which was mainly correlated with the generation of F4-NeuroPs with respect to F2-IsoPs. Accordingly, the latter cannot be considered a good marker of oxidation when diets rich in n ‐ 3 PUFA are provided.

ACS Style

Cesare Castellini; Simona Mattioli; Cinzia Signorini; Elisa Cotozzolo; Daria Noto; Elena Moretti; Gabriele Brecchia; Alessandro Dal Bosco; Giuseppe Belmonte; Thierry Durand; Claudio De Felice; Giulia Collodel. Effect of Dietaryn‐3Source on Rabbit Male Reproduction. Oxidative Medicine and Cellular Longevity 2019, 2019, 1 -13.

AMA Style

Cesare Castellini, Simona Mattioli, Cinzia Signorini, Elisa Cotozzolo, Daria Noto, Elena Moretti, Gabriele Brecchia, Alessandro Dal Bosco, Giuseppe Belmonte, Thierry Durand, Claudio De Felice, Giulia Collodel. Effect of Dietaryn‐3Source on Rabbit Male Reproduction. Oxidative Medicine and Cellular Longevity. 2019; 2019 ():1-13.

Chicago/Turabian Style

Cesare Castellini; Simona Mattioli; Cinzia Signorini; Elisa Cotozzolo; Daria Noto; Elena Moretti; Gabriele Brecchia; Alessandro Dal Bosco; Giuseppe Belmonte; Thierry Durand; Claudio De Felice; Giulia Collodel. 2019. "Effect of Dietaryn‐3Source on Rabbit Male Reproduction." Oxidative Medicine and Cellular Longevity 2019, no. : 1-13.

Short communication
Published: 22 November 2019 in Meat Science
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This study evaluated the effect of different dietary concentrations of Goji berries (GB) on the meat quality of rabbit. At weaning, 60 New Zealand male rabbits were assigned to three groups and fed with a commercial standard diet (C), C supplemented with 1% (LG) or 3% Goji berries (HG) until slaughter. Supplementation did not affect colour, water holding capacity, and tenderness but regression analyses showed linear relationships between pH (P < .05), Thiobarbituric Acid Reactive Substances (TBARS; P < .001), Oxygen Radical Absorbance Capacity (ORAC; P < .001), Redox Index (RI; P < .001), and phenolic content (P < .001) of Longissimus thoracis et lumborum muscle and the rate of GB in the feed. However, by pairwise comparisons emerged that acidification (pH: P < .05), antioxidant/oxidant status (TBARS, ORAC, RI; P < .001), and phenolic content (P < .01) of muscle significantly improved only in HG compared with C group. Then, a dose-dependent relation was found but only the higher dose of GB guaranteed an increase in protection against oxidative phenomena of meat.

ACS Style

Laura Menchetti; Gabriele Brecchia; Raffaella Branciari; Olimpia Barbato; Bernard Fioretti; Michela Codini; Enrico Bellezza; Massimo Trabalza-Marinucci; Dino Miraglia. The effect of Goji berries (Lycium barbarum) dietary supplementation on rabbit meat quality. Meat Science 2019, 161, 108018 .

AMA Style

Laura Menchetti, Gabriele Brecchia, Raffaella Branciari, Olimpia Barbato, Bernard Fioretti, Michela Codini, Enrico Bellezza, Massimo Trabalza-Marinucci, Dino Miraglia. The effect of Goji berries (Lycium barbarum) dietary supplementation on rabbit meat quality. Meat Science. 2019; 161 ():108018.

Chicago/Turabian Style

Laura Menchetti; Gabriele Brecchia; Raffaella Branciari; Olimpia Barbato; Bernard Fioretti; Michela Codini; Enrico Bellezza; Massimo Trabalza-Marinucci; Dino Miraglia. 2019. "The effect of Goji berries (Lycium barbarum) dietary supplementation on rabbit meat quality." Meat Science 161, no. : 108018.

Journal article
Published: 14 January 2019 in Veterinary Sciences
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: The main objective of this study was to assess PAG2 mRNA expression in maternal blood cells at the peri-implantation period in water buffalo; moreover, we wanted to evaluate the earliest time in which PAG-2 could be detected in maternal blood. Thirty-two lactating buffaloes artificially inseminated (AI) were utilized. Blood was collected at Days 0, 14, 18, 28, 40 after AI (AI = day 0). Pregnancy was diagnosed by ultrasound at Days 28 and 40 post AI. Out of 32 buffaloes, 14 were pregnant (P group) and 18 were not pregnant (NP group). The plasma PAG-2 threshold of 1.0 ng/mL in the P group was reached at day 40 post AI. PAG2 mRNA expression differed between the P and NP groups, and was either evaluated in Peripheral Blood Mononuclear Cells (PBMC) or Polymorphonuclear Leukocytes (PMN), starting from day 14. However, both the estimated marginal means and multiple comparisons showed that PAG2 mRNA expression was higher in PMN than PBMC. In the present study, PAG-2 appeared in the blood (40 Days post AI), and an early expression of PAG2 mRNA at Day 14 post AI was also observed. Although further research is undoubtedly required, PAG2 mRNA in peripheral blood leukocytes could be using to better understand the role that PAGs play during pregnancy in buffalo.

ACS Style

Olimpia Barbato; Gabriella Guelfi; Laura Menchetti; Gabriele Brecchia; Noelita Melo De Sousa; Claudio Canali; Francesco Grandoni; Maria Carmela Scatà; Giovanna De Matteis; Anna Beatrice Casano; Jean François Beckers; Vittoria Lucia Barile. Investigation of PAG2 mRNA Expression in Water Buffalo Peripheral Blood Mononuclear Cells and Polymorphonuclear Leukocytes from Maternal Blood at the Peri-Implantation Period. Veterinary Sciences 2019, 6, 8 .

AMA Style

Olimpia Barbato, Gabriella Guelfi, Laura Menchetti, Gabriele Brecchia, Noelita Melo De Sousa, Claudio Canali, Francesco Grandoni, Maria Carmela Scatà, Giovanna De Matteis, Anna Beatrice Casano, Jean François Beckers, Vittoria Lucia Barile. Investigation of PAG2 mRNA Expression in Water Buffalo Peripheral Blood Mononuclear Cells and Polymorphonuclear Leukocytes from Maternal Blood at the Peri-Implantation Period. Veterinary Sciences. 2019; 6 (1):8.

Chicago/Turabian Style

Olimpia Barbato; Gabriella Guelfi; Laura Menchetti; Gabriele Brecchia; Noelita Melo De Sousa; Claudio Canali; Francesco Grandoni; Maria Carmela Scatà; Giovanna De Matteis; Anna Beatrice Casano; Jean François Beckers; Vittoria Lucia Barile. 2019. "Investigation of PAG2 mRNA Expression in Water Buffalo Peripheral Blood Mononuclear Cells and Polymorphonuclear Leukocytes from Maternal Blood at the Peri-Implantation Period." Veterinary Sciences 6, no. 1: 8.

Journal article
Published: 01 January 2019 in Animal
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To evaluate how rearing programmes could affect resources allocation and reproductive performance of primiparous rabbit females, a total of 118 rabbit females were used to evaluate the effects of five rearing feeding programmes on their performance from 1st to 2nd parturition: CAL, fed ad libitum C diet (11.0 MJ digestible energy (DE), 114 g digestible protein (DP) and 358 g NDF/kg dry matter (DM) until 1st parturition; CR, fed ad libitum with C diet until 12 weeks of age and then C diet restricted (140 g/day) until 1st parturition; F, fed ad libitum with F diet (8.7 MJ DE, 88 g DP and 476 NDF/kg DM) until 1st parturition; FC, fed with F diet ad libitum until 16 weeks of age, and C diet ad libitum until 1st parturition; FCF, fed with F diet ad libitum until 16 weeks of age, then C diet ad libitum until 20 weeks and then F diet ad libitum until 1st parturition. From 1st parturition, C diet was ad libitum offered to all the experimental groups until 2nd parturition. CAL females presented lower feed intake than females of F, FC and FCF groups in the 1st week of lactation (on av. −16.6%; P<0.05). During 1st lactation, the perirenal fat thickness change in CAL females was not different from 0 (+0.02 mm), while in the other four groups it increased (on av. +0.44 mm; P<0.05). Plasma of females fed with F diet during rearing (F, FC and FCF) had lower non-esterified fatty acids content than those exclusively fed with C diet (–0.088 and –0.072 mmol/l compared to CAL and CR, respectively; P<0.05). FCF litters had higher weight than F litters at day 21 of lactation (+247 g; P<0.05), but FCF litter had significantly lower weight than FC litters at weaning (+170 g; P<0.05). CR females had the shortest average interval between the 1st and 2nd parturition (49 days) and FCF females the longest (+ 9 days compared to CR; P<0.05). At 2nd parturition, liveborn litters of F females were larger and heavier than litters of FCF females (+2.22 kits and +138 g; P<0.05), probably due to the lower mortality at birth of F litters (–16.5 percentage points; P<0.05). In conclusion, rearing females on fibrous diets seems to increase the ability of primiparous rabbit females to obtain resources, especially at the onset of lactation.

ACS Style

E. Martínez-Paredes; D. Savietto; L. Ródenas; C. Cervera; E. Blas; Gabriele Brecchia; C. Boiti; J. J. Pascual. Consequences of rearing feeding programme on the performance of rabbit females from 1st to 2nd parturition. Animal 2019, 13, 2173 -2182.

AMA Style

E. Martínez-Paredes, D. Savietto, L. Ródenas, C. Cervera, E. Blas, Gabriele Brecchia, C. Boiti, J. J. Pascual. Consequences of rearing feeding programme on the performance of rabbit females from 1st to 2nd parturition. Animal. 2019; 13 (10):2173-2182.

Chicago/Turabian Style

E. Martínez-Paredes; D. Savietto; L. Ródenas; C. Cervera; E. Blas; Gabriele Brecchia; C. Boiti; J. J. Pascual. 2019. "Consequences of rearing feeding programme on the performance of rabbit females from 1st to 2nd parturition." Animal 13, no. 10: 2173-2182.

Journal article
Published: 18 December 2018 in Livestock Science
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Recognized by the traditional medicine and recent scientific research studies, Lycium barbarum berries (Goji berries) have beneficial effects on human and animal health. The aim of our study was to evaluate the effects of Goji berries on the productive performance of rabbits. One month before insemination, 60 New Zealand White does were randomly assigned to one of the following 3 dietary treatments: commercial standard diet (C); C supplemented with 1% Goji berries (LG); and C supplemented with 3% Goji berries (HG). After weaning up to 91 days of age, 15 randomly selected rabbits/group were fed the same diet as the mothers (C, LG, and HG). Non-pregnant and lactating does of C group showed the highest feed intake (P<0.01), although no significant differences in body weight (BW) were observed between groups. Nutritional treatment did not affect the offspring's feed intake. However, the rabbits fed with Goji supplementation showed not only higher mean BW both during growth (P<0.001) and at slaughter (P<0.01), but also better feed conversion ratio (FCR; P<0.01) than the control group. Rabbits of LG group showed the best performances in the pre-weaning period which was probably related to the highest milk production of the LG does (P<0.001). Indeed, LG group showed lower pre-weaning mortality (P<0.05), higher litter size (P<0.05), and higher litter weight (P<0.05) at day 18 as well as higher litter size at weaning (P=0.05) compared to C group. In conclusion, the present study demonstrates that a low percentage of dietary supplementation with Goji berry improves both reproductive and productive traits of rabbits. Although further studies are needed, our study paves the way for the use of Goji berries in the rabbit nutrition.

ACS Style

L. Menchetti; L. Vecchione; I. Filipescu; V.F. Petrescu; Bernard Fioretti; T. Beccari; M.R. Ceccarini; M. Codini; A. Quattrone; M. Trabalza-Marinucci; O. Barbato; Gabriele Brecchia. Effects of Goji berries supplementation on the productive performance of rabbit. Livestock Science 2018, 220, 123 -128.

AMA Style

L. Menchetti, L. Vecchione, I. Filipescu, V.F. Petrescu, Bernard Fioretti, T. Beccari, M.R. Ceccarini, M. Codini, A. Quattrone, M. Trabalza-Marinucci, O. Barbato, Gabriele Brecchia. Effects of Goji berries supplementation on the productive performance of rabbit. Livestock Science. 2018; 220 ():123-128.

Chicago/Turabian Style

L. Menchetti; L. Vecchione; I. Filipescu; V.F. Petrescu; Bernard Fioretti; T. Beccari; M.R. Ceccarini; M. Codini; A. Quattrone; M. Trabalza-Marinucci; O. Barbato; Gabriele Brecchia. 2018. "Effects of Goji berries supplementation on the productive performance of rabbit." Livestock Science 220, no. : 123-128.

Journal article
Published: 05 December 2018 in Nutrients
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Resveratrol, because of its low solubility in water and its high membrane permeability, is collocated in the second class of the biopharmaceutical classification system, with limited bioavailability due to its dissolution rate. Solid dispersion of resveratrol supported on Magnesium DiHydroxide ([email protected]) was evaluated to improve solubility and increase bioavailability of resveratrol. Fluorimetric microscopy analysis displays three types of microparticles with similar size: Type 1 that emitted preferably fluorescence at 445 nm with bandwidth of 50 nm, type 2 that emitted preferably fluorescence at 605 nm with bandwidth of 70 nm and type 3 that is non-fluorescent. Micronized pure resveratrol displays only microparticles type 1 whereas type 3 are associated to pure magnesium dihydroxide. Dissolution test in simulated gastric environment resveratrol derived from [email protected] in comparison to resveratrol alone displayed better solubility. A 3-fold increase of resveratrol bioavailability was observed after oral administration of 50 mg/kg of resveratrol from [email protected] in rabbits. We hypothesize that type 2 microparticles represent magnesium dihydroxide microparticles with a resveratrol shell and that they are responsible for the improved resveratrol solubility and bioavailability of [email protected]

ACS Style

Roberto Spogli; Maria Bastianini; Francesco Ragonese; Rossana Giulietta Iannitti; Lorenzo Monarca; Federica Bastioli; Irina Nakashidze; Gabriele Brecchia; Laura Menchetti; Michela Codini; Cataldo Arcuri; Loretta Mancinelli; Bernard Fioretti. Solid Dispersion of Resveratrol Supported on Magnesium DiHydroxide ([email protected]) Microparticles Improves Oral Bioavailability. Nutrients 2018, 10, 1925 .

AMA Style

Roberto Spogli, Maria Bastianini, Francesco Ragonese, Rossana Giulietta Iannitti, Lorenzo Monarca, Federica Bastioli, Irina Nakashidze, Gabriele Brecchia, Laura Menchetti, Michela Codini, Cataldo Arcuri, Loretta Mancinelli, Bernard Fioretti. Solid Dispersion of Resveratrol Supported on Magnesium DiHydroxide ([email protected]) Microparticles Improves Oral Bioavailability. Nutrients. 2018; 10 (12):1925.

Chicago/Turabian Style

Roberto Spogli; Maria Bastianini; Francesco Ragonese; Rossana Giulietta Iannitti; Lorenzo Monarca; Federica Bastioli; Irina Nakashidze; Gabriele Brecchia; Laura Menchetti; Michela Codini; Cataldo Arcuri; Loretta Mancinelli; Bernard Fioretti. 2018. "Solid Dispersion of Resveratrol Supported on Magnesium DiHydroxide ([email protected]) Microparticles Improves Oral Bioavailability." Nutrients 10, no. 12: 1925.

Journal article
Published: 12 September 2018 in Reproduction in Domestic Animals
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This is the first time that PAG determination using two different antisera raised against PAG molecules purified from both caprine (RIA-706) and bubaline placentas (RIA-860) is reported in water buffalo. Ninety-eight buffalo cows, belonging to a buffalo herd subjected to a synchronization and artificial insemination (AI) programme, were enrolled in this study. Blood samples were taken on days 0 (AI), 23, 25, 28, 30 and 45. Pregnancy was confirmed by ultrasonography on days 28 and 45. The blood of 20 buffaloes that had calved was tested every five days from the day of calving until day 50 postcalving. Differences in PAG concentrations were observed between pregnant and nonpregnant buffaloes starting from day 23 post AI using both RIA-706 and RIA-860 (p < 0.001). However, estimated mean concentrations of PAG measured by RIA-706 were higher than RIA-860 (p < 0.001) and Bland-Altman analysis showed biases ranged from 0.0 ng/ml at day 23 to 0.79 ng/ml at day 28 post AI. Moreover, RIA-706 showed greater sensitivity and accuracy both at 23 and 25 days of pregnancy. RIA-706 and RIA-860 decreased below 1 ng/ml from 40 and 30 days postpartum, respectively, suggesting that PAG are better recognized by the antisera raised against the caprine PAG in the postpartum period also. This is essential when using PAG as an appropriate marker of early pregnancy after postpartum for detecting new pregnancies. The results of this study show that the ability of RIA systems to recognize early PAG could be improved using antisera raised against PAG molecules isolated from caprine placenta.

ACS Style

Olimpia Barbato; Laura Menchetti; Noelita M. Sousa; Gabriele Brecchia; Alessandro Malfatti; Claudio Canali; Jean‐Francois Beckers; Vittoria L. Barile. Correlation of two radioimmunoassay systems for measuring plasma pregnancy‐associated glycoproteins concentrations during early pregnancy and postpartum periods in water buffalo. Reproduction in Domestic Animals 2018, 53, 1483 -1490.

AMA Style

Olimpia Barbato, Laura Menchetti, Noelita M. Sousa, Gabriele Brecchia, Alessandro Malfatti, Claudio Canali, Jean‐Francois Beckers, Vittoria L. Barile. Correlation of two radioimmunoassay systems for measuring plasma pregnancy‐associated glycoproteins concentrations during early pregnancy and postpartum periods in water buffalo. Reproduction in Domestic Animals. 2018; 53 (6):1483-1490.

Chicago/Turabian Style

Olimpia Barbato; Laura Menchetti; Noelita M. Sousa; Gabriele Brecchia; Alessandro Malfatti; Claudio Canali; Jean‐Francois Beckers; Vittoria L. Barile. 2018. "Correlation of two radioimmunoassay systems for measuring plasma pregnancy‐associated glycoproteins concentrations during early pregnancy and postpartum periods in water buffalo." Reproduction in Domestic Animals 53, no. 6: 1483-1490.