This paper discusses rapid flow and stage fluctuations in a large lowland river downstream from a large hydropower plant (HPP) in Lithuania. The main problem arises when the HPP is operating in peak mode. Such operation of HPP causes rapid flow and stage fluctuations, which can have a certain impact on river ecosystems. The study analyzes general abiotic indicators such as upramping and downramping rates and stage fluctuations downstream of the HPP. The main idea was to assess recorded stage upramping and downramping rates along the river downstream of large HPP. To assess stage fluctuation statistics, COSH software was used. A maximum upramping rate of 1.04 m/h and maximum downramping rate of 0.88 m/h were identified using data from temporary and permanent gauging stations. Obtained results revealed that stage fluctuations exceed ecologically acceptable rates up to 20 km downstream of HPP. The effect of hydropeaking fades out only at a chainage of 45 km downstream of HPP. In mountainous regions, ecologically acceptable rates are reached at much smaller distances. The study shows that the traditional coefficient of variation of stage fluctuation data can be used to describe hydropeaking indicators. The main results of this study can be used for environmental impact assessment downstream from HPPs.