A possible inhibitor of proteases, which contains an indole core and an aromatic polar acetylene, was designed and synthesized. This indole derivative has a molecular architecture kindred to biologically relevant species and was obtained through five synthetic steps with an overall yield of 37% from the 2,2′-(phenylazanediyl)di(ethan-1-ol). The indole derivative was evaluated through docking assays using the main protease (SARS-CoV-2-M^pro) as a molecular target, which plays a key role in the replication process of this virus. Additionally, the indole derivative was evaluated as an inhibitor of the enzyme kallikrein 5 (KLK5), which is a serine protease that can be considered as an anticancer drug target.

Excellent quadratic non-linear optical (ONL-2) properties of the poly(2,5-bis(but-2-ynyloxy) benzoate, containing a polar diacetylene as a chromophore, were found. According with the Maker fringes method, oriented polymer films showing an order parameter of ∼0.23 can display outstanding and stable Second Harmonic Generation (SHG) effects under off-resonant conditions (SHG-532 nm). Also, the macroscopic non-linear optical (NLO)-coefficients were evaluated under the rod-like molecular approximation, obtaining: χ_zzz⁽²⁾ and χ_zxx⁽²⁾ in the order of 280 ± 10 and 100 ± 10 pm V⁻¹, respectively. The mechanical and chemical properties, in addition to the large ONL-2 coefficients exhibited by this polymer, make it a promising organic material in the development of optoelectronic/photonic devices.

The presented research demonstrates the dissolving capacity of different commercial chemicals known as irrigants in dentistry to dissolve organic tissue and their evaluation. The aim is to demonstrate that, through a chemical kinetic study, the dissolving capacity of different oxidizing agents such as NaClO, ClO₂, and H₂O₂ to dissolve organic tissue (shrimp pulp) could be measured with different volumes of the aforementioned irrigants as a function of time and pH.