Infections pose a serious global public health problem and are a major cause of premature mortality worldwide. One of the most challenging objectives faced by modern medicine is timely and accurate laboratory-based diagnostics of infectious diseases. Being a key factor of timely initiation and success of treatment, it may potentially provide reduction in incidence of a disease, as well as prevent outbreak and spread of dangerous epidemics. The traditional methods of laboratory-based diagnostics of infectious diseases are quite time- and labor-consuming, require expensive equipment and qualified personnel, which restricts their use in case of limited resources. Over the past six decades, diagnostic technologies based on lateral flow immunoassay (LFIA) have been and remain true alternatives to modern laboratory analyzers and have been successfully used to quickly detect molecular ligands in biosubstrates to diagnose many infectious diseases and septic conditions. These devices are considered as simplified formats of modern biosensors. Recent advances in the development of label-free biosensor technologies have made them promising diagnostic tools that combine rapid pathogen indication, simplicity, user-friendliness, operational efficiency, accuracy, and cost effectiveness, with a trend towards creation of portable platforms. These qualities exceed the generally accepted standards of microbiological and immunological diagnostics and open up a broad range of applications of these analytical systems in clinical practice immediately at the site of medical care (point-of-care concept, POC). A great variety of modern nanoarchitectonics of biosensors are based on the use of a broad range of analytical and constructive strategies and identification of various regulatory and functional molecular markers associated with infectious bacterial pathogens. Resolution of the existing biosensing issues will provide rapid development of diagnostic biotechnologies.

Fiber-optic sensors have several features that determine the effectiveness of their use for diagnostics of polymer composite materials (PCM). These feature

Mass of macroscopic object is easily measured by a suitable balance. However, this approach becomes inapplicable if mass of microscopic object is to be determined. Alternative approach for mass measurement is based on using the micromechanical resonator as an inertial balance where oscillation frequency is shifted by small quantities of adsorbed mass. In this work we present experimental results of applying an adaptive interferometry technique based on dynamic hologram recorded in photorefractive CdTe crystal for measuring picogram mass adsorbed on micromechanical resonators with dimensions 215×40×15 μm ³ . It is also shown that the resonance micro-weighing system based on adaptive interferometer has potential for reducing the threshold of mass detection down to 10 ^-17 g in the case of using a resonator with sub-micron dimensions

A significant part of the life of bacteria takes place as part of organized microbial communities—biofilms, the importance of which for the microworl

The results of an experimental study of the operation of fiber optic sensors (FOS) of acoustic emission introduced into the structure of polymer composite materials (PCM) are presented. The reliability and fault tolerance of FOS under critical mechanical loads on PCM was assessed, and the influence of the presence of FOS embedded into the structure of PCM on the mechanical characteristics of the material was investigated. For demodulation of FOS output signals, the principles of adaptive holographic interferometry based on two-wave mixing at dynamic hologram formed in a photorefractive crystal are used.