The goal of this review is to offer an all-encompassing evaluation of an integrated solar energy system within the framework of solar energy utilization. This holistic assessment encompasses photovoltaic technologies, solar thermal systems, and energy storage solutions, providing a comprehensive understanding of their interplay and significance. It emphasizes the importance of solar energy as a renewable resource and its role in addressing global energy demand and mitigating climate change. The review highlights the significance of advancements in various solar energy technologies, focusing on their environmental benefits, including greenhouse gas emissions reduction and air and water pollution mitigation. It explores the evolution of photovoltaic technologies, categorizing them into first-, second-, and third-generation photovoltaic cells, and discusses the applications of solar thermal systems such as water heaters, air heaters, and concentrators. The paper examines key advancements in energy storage solutions for solar energy, including battery-based systems, pumped hydro storage, thermal storage, and emerging technologies. It references recent published literature to present findings on energy payback time, carbon footprint, and performance metrics. Challenges to widespread adoption are discussed, including cost and economic viability, intermittency, environmental impacts, and grid integration. Strategies to overcome these challenges, such as cost reduction, policy support, energy storage integration, and sustainable practices, are presented based on published literature. By bridging gaps in existing literature, this comprehensive resource aims to equip researchers, policymakers, and industry professionals with insights into forging a sustainable and renewable energy future.

Micrococcus luteus, also known as M. luteus, is a bacterium that inhabits mucous membranes, human skin, and various environmental sources. It is commonly linked to infections, especially among individuals who have compromised immune systems. M. luteus is capable of synthesizing the enzyme superoxide dismutase (SOD) as a component of its protective response to reactive oxygen species (ROS). This enzyme serves as a promising target for drug development in various diseases. The current study utilized a subtractive genomics approach to identify potential therapeutic targets from M. luteus. Additionally, genome mining was employed to identify and characterize the biosynthetic gene clusters (BGCs) responsible for the production of secondary metabolites in Bacillus licheniformis (B. licheniformis), a bacterium known for its production of therapeutically relevant secondary metabolites. Subtractive genomics resulted in identification of important extracellular protein SOD as a drug target that plays a crucial role in shielding cells from damage caused by ROS. Genome mining resulted in identification of five potential ligands (secondary metabolites) from B. licheniformis such as, Bacillibactin (BAC), Paenibactin (PAE), Fengycin (FEN), Surfactin (SUR) and Lichenysin (LIC). Molecular docking was used to predict and analyze the binding interactions between these five ligands and target protein SOD. The resulting protein–ligand complexes were further analyzed for their motions and interactions of atoms and molecules over 250 ns using molecular dynamics (MD) simulation analysis. The analysis of MD simulations suggests, Bacillibactin as the probable candidate to arrest the activities of SOD. All the five compounds reported in this study were found to act by directly/indirectly interacting with ROS molecules, such as superoxide radicals (O₂–) and hydrogen peroxide (H₂O₂), and transforming them into less reactive species. This antioxidant activity contributes to its protective effects against oxidative stress-induced damage in cells making them likely candidate for various applications, including in the development of antioxidant-based therapies, nutraceuticals, and functional foods.