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Objectives: The purpose of conducted study was to understand the role of cognitive processes like habitual worry in relation to depressive mood among patients with type 1 diabetes mellitus (T1DM) and the significance of illness acceptance in the form of personal resource and mediator in relation between worry and depression. Methods: The study involved 229 participants with diagnosed T1DM, who completed a set of self-description questionnaires. Assessment methods included The Anxious Thoughts Inventory (AnTI), The Acceptance of Illness Scale (AIS) and The Center for Epidemiologic Studies Depression Scale (CES-D). Results: The results show that worry is positively correlated with depression. What is more, relationship between habitual worry and depression was mediated through acceptance of illness. Conclusions: Impact of habitual worry on mental health in T1DM cannot be omitted. Moreover, the observed dependence suggests that depressive mood occurring among people with T1DM may persist because overly worried patients do not accept their own illness. Strengthening patients’ acceptance of illness and raising the topic of worry during diabetes education, can be a valuable direction in preventing depression. Further research is advisable.
Julia Krawczyk; Michał Ziarko; Dorota Zozulińska-Ziółkiewicz; Ewa Mojs. Worry and the level of depression among patients with type 1 diabetes mellitus. The mediating role of illness acceptance. Journal of Medical Science 2021, 90, e509 -e509.
AMA StyleJulia Krawczyk, Michał Ziarko, Dorota Zozulińska-Ziółkiewicz, Ewa Mojs. Worry and the level of depression among patients with type 1 diabetes mellitus. The mediating role of illness acceptance. Journal of Medical Science. 2021; 90 (2):e509-e509.
Chicago/Turabian StyleJulia Krawczyk; Michał Ziarko; Dorota Zozulińska-Ziółkiewicz; Ewa Mojs. 2021. "Worry and the level of depression among patients with type 1 diabetes mellitus. The mediating role of illness acceptance." Journal of Medical Science 90, no. 2: e509-e509.
: The most common cause of mortality among people with type 1 diabetes is cardiovascular diseases. Arterial stiffness allows predicting cardiovascular complications, cardiovascular mortality, and all-cause mortality. There are different ways to measure arterial stiffness; the gold standard is pulse wave velocity. Arterial stiffness is increased in people with type 1 diabetes compared to healthy controls. It increases with age and duration of type 1 diabetes. Arterial stiffness among people with type 1 diabetes has a positive association with systolic blood pressure, obesity, glycated hemoglobin, waist circumference, and waist to hip ratio. It has a negative correlation with estimated glomerular filtration rate, high-density lipoprotein, and the absence of carotid plaques. The increased arterial stiffness could be the result of insulin resistance, collagen increase due to inadequate enzymatic glycation, endothelial and autonomic dysfunction. The insulin-induced decrease in arterial stiffness is impaired in type 1 diabetes. There are not enough proofs to use pharmacotherapy in the prevention of arterial stiffness, but some of the medicaments have obtained promising results in single studies, for example, renin-angiotensin-aldosterone system inhibitors, statins, and SGLT2 inhibitors. The main form of prevention of arterial stiffness progression remains glycemic control and a healthy lifestyle.
Michal Kulecki; Aleksandra Uruska; Dariusz Naskret; Dorota Zozulinska-Ziolkiewicz. Arterial Stiffness and Type 1 Diabetes: The Current State of Knowledge. Current Diabetes Reviews 2021, 17, 1 -1.
AMA StyleMichal Kulecki, Aleksandra Uruska, Dariusz Naskret, Dorota Zozulinska-Ziolkiewicz. Arterial Stiffness and Type 1 Diabetes: The Current State of Knowledge. Current Diabetes Reviews. 2021; 17 ():1-1.
Chicago/Turabian StyleMichal Kulecki; Aleksandra Uruska; Dariusz Naskret; Dorota Zozulinska-Ziolkiewicz. 2021. "Arterial Stiffness and Type 1 Diabetes: The Current State of Knowledge." Current Diabetes Reviews 17, no. : 1-1.
Long-term insulin treatment can slow the growth process and decrease physical fitness level in children. In diabetic children, these two developments should be constantly monitored. The aim of the present study was to examine differences in somatic and physical fitness characteristics between soccer-training boys with type 1 diabetes and healthy boys of the same age (reference values based on Polish population norms for somatic and motor parameters). The participants were 94 boys (8–17 years), diagnosed with diabetes, who participated in soccer training on a regular basis and received routine medical care. The study involved (a) anthropometric and body composition measurements, (b) general motor ability assessments, and (c) comparison of those characteristics with the healthy Polish population. The diabetic boys were found to have lower levels of almost all somatic traits and motor abilities as compared with the healthy boys (p ≤ 0.05). Handgrip strength was a variable with the smallest difference between the two groups. The observed differences indicate the necessity to design an appropriate control and assessment system based on simple medical and fitness field tests for diabetic children and adolescents. It will allow optimizing advanced training as well as minimize health risks before, during, or after exercise.
Magdalena Krzykała; Katarzyna Domaszewska; Małgorzata Woźniewicz-Dobrzyńska; Jakub Kryściak; Agata Konarska; Aleksandra Araszkiewicz; Dorota Zozulińska-Ziółkiewicz; Andrzej Gawrecki; Grzegorz Biegański; Jan Konarski. Characteristics of Selected Somatic and Motor Abilities of Youth Soccer Players with Diabetes Type 1 Treated with Insulin Pump Therapy. International Journal of Environmental Research and Public Health 2021, 18, 3493 .
AMA StyleMagdalena Krzykała, Katarzyna Domaszewska, Małgorzata Woźniewicz-Dobrzyńska, Jakub Kryściak, Agata Konarska, Aleksandra Araszkiewicz, Dorota Zozulińska-Ziółkiewicz, Andrzej Gawrecki, Grzegorz Biegański, Jan Konarski. Characteristics of Selected Somatic and Motor Abilities of Youth Soccer Players with Diabetes Type 1 Treated with Insulin Pump Therapy. International Journal of Environmental Research and Public Health. 2021; 18 (7):3493.
Chicago/Turabian StyleMagdalena Krzykała; Katarzyna Domaszewska; Małgorzata Woźniewicz-Dobrzyńska; Jakub Kryściak; Agata Konarska; Aleksandra Araszkiewicz; Dorota Zozulińska-Ziółkiewicz; Andrzej Gawrecki; Grzegorz Biegański; Jan Konarski. 2021. "Characteristics of Selected Somatic and Motor Abilities of Youth Soccer Players with Diabetes Type 1 Treated with Insulin Pump Therapy." International Journal of Environmental Research and Public Health 18, no. 7: 3493.
Introduction: Protein profiling allows the determination of the presence of proteins marking various stages of the disease, and differentiates between people at risk of various diseases. In type 1 diabetes, protein profiling had been previously used to find blood markers other than islet autoantibodies to indicate the pancreatic beta cell destruction process and to reflect the progression of type 1 diabetes mellitus (T1DM). However, T1DM is an auto-immune disease and its clinical presentation changes in time of its duration. The aim of the study: To find differences in protein profiles in patients with type 1 diabetes according to diabetes control (HbA1c > 7%) and with presence of diabetic complications or obesity. It may help to identify subgroups of patients who may need a better clinical supervision and individualized treatment. Material and methods: A group of 103 patients with auto-immunologically confirmed T1DM, and meeting the following inclusion criteria: Caucasian race, duration of diabetes >5 years, were used in the study. Criteria of exclusion: past or present cancer (treated with chemo-/radiotherapy), diseases of the liver (ALT > 3 × ULN) except for people with simple hepatic steatosis, chronic renal disease (eGFR < 30 mL/1.73 m2/min), and acute inflammation (CRP > 5 mg/dL). The study group was divided in terms of the presence of chronic complications, obesity, or poor metabolic control (HbA1c > 7%). Protein profiling was completed by using the MALDI-TOF MS (matrix-assisted laser desorption/ionization-time of flight mass spectrometry) analyzer. Results: Differentiating proteins were identified in all of the groups. The groups burdened with complications, obesity, and poor metabolic control were characterized by increased levels of fibrinogen, complement C4 and C3. Conclusion: The groups of type 1 diabetes patients burdened with complications, obesity, and poor metabolic control were characterized by increased levels of fibrinogen, complement C4 and C3. Further detailed studies are necessary to determine more subtle changes in the proteomic profile of patients with type 1 diabetes.
Agnieszka Zawada; Dariusz Naskręt; Eliza Matuszewska; Zenon Kokot; Marian Grzymisławski; Dorota Zozulińska-Ziółkiewicz; Agnieszka Dobrowolska; Jan Matysiak. MALDI-TOF Protein Profiling Reflects Changes in Type 1 Diabetes Patients Depending on the Increased Amount of Adipose Tissue, Poor Control of Diabetes and the Presence of Chronic Complications. International Journal of Environmental Research and Public Health 2021, 18, 2263 .
AMA StyleAgnieszka Zawada, Dariusz Naskręt, Eliza Matuszewska, Zenon Kokot, Marian Grzymisławski, Dorota Zozulińska-Ziółkiewicz, Agnieszka Dobrowolska, Jan Matysiak. MALDI-TOF Protein Profiling Reflects Changes in Type 1 Diabetes Patients Depending on the Increased Amount of Adipose Tissue, Poor Control of Diabetes and the Presence of Chronic Complications. International Journal of Environmental Research and Public Health. 2021; 18 (5):2263.
Chicago/Turabian StyleAgnieszka Zawada; Dariusz Naskręt; Eliza Matuszewska; Zenon Kokot; Marian Grzymisławski; Dorota Zozulińska-Ziółkiewicz; Agnieszka Dobrowolska; Jan Matysiak. 2021. "MALDI-TOF Protein Profiling Reflects Changes in Type 1 Diabetes Patients Depending on the Increased Amount of Adipose Tissue, Poor Control of Diabetes and the Presence of Chronic Complications." International Journal of Environmental Research and Public Health 18, no. 5: 2263.
The process of protein glycation described by Brownlee et al. is a crucial pathogenic mechanism in the development of chronic complications of diabetes. To assess advanced glycation end products (AGEs) in the skin of patients with type 1 diabetes (DM1) and excess body fat (EBF) accumulation. The study group consisted of 227 DM1 patients (121 women and 106 men) whose mean age was 31 ±9.2 years; the mean duration of diabetes was 12 ±7.7 years; and the mean HbA1c was 8.9 ±1.8%. The inclusion criteria were as follows: age 18-65 years, DM1, and lack of acute inflammations and uncontrolled chronic diseases. The exclusion criteria were: anemia (hemoglobin (Hb) <11 g/dL), chronic kidney disease (CKD) (glomerular filtration rate (eGFR) <30 mL/min/1.73 m2) and elevated aminotransferase levels (more than twice the upper normal limits). Total adipose tissue content was assessed using the electrical bioimpedance method, with the Tanita BC-418 MA analyzer (Tanita Corp., Tokyo, Japan). The Tanita ViScan AB 140 (Tanita Corp.) was used to evaluate visceral fat tissue (VTF). The content of glycation end products in the skin was assessed using a DiagnOptics AGE Reader device (type 214D00102; DiagnOptics, Groningen, the Netherlands). The group with normal body fat (NBF) consisted of 123 subjects, whereas 104 subjects had EBF. No significant statistical differences were found between the NBF and EBF groups with regard to age, duration of diabetes, current HbA1C value, and tobacco use. A significantly higher AGE score was observed in the EBF group. Increased body fat affects the amount of AGE in the skin, which correlates with a higher risk of developing chronic diabetes complications.
Agnieszka Ewa Zawada; Dariusz Naskret; Paweł Niedźwiecki; Marian Grzymisławski; Dorota Anna Zozulińska-Ziółkiewicz; Agnieszka Dobrowolska. Excess body fat increases the accumulation of advanced glycation end products in the skin of patients with type 1 diabetes. Advances in Clinical and Experimental Medicine 2020, 29, 1193 -1199.
AMA StyleAgnieszka Ewa Zawada, Dariusz Naskret, Paweł Niedźwiecki, Marian Grzymisławski, Dorota Anna Zozulińska-Ziółkiewicz, Agnieszka Dobrowolska. Excess body fat increases the accumulation of advanced glycation end products in the skin of patients with type 1 diabetes. Advances in Clinical and Experimental Medicine. 2020; 29 (10):1193-1199.
Chicago/Turabian StyleAgnieszka Ewa Zawada; Dariusz Naskret; Paweł Niedźwiecki; Marian Grzymisławski; Dorota Anna Zozulińska-Ziółkiewicz; Agnieszka Dobrowolska. 2020. "Excess body fat increases the accumulation of advanced glycation end products in the skin of patients with type 1 diabetes." Advances in Clinical and Experimental Medicine 29, no. 10: 1193-1199.
The prevalence of diabetes mellitus is increasing worldwide, including the nation of Poland. The aim of this prospective and observational study was to determine risk factors and the predictors of diabetes incidence in elderly women, and to calculate the diabetes incidence ratio in this population. Two-hundred women, aged 65–74, who were non-diabetic at baseline in 2012 were followed for 6.5 years. All women were checked for incident diabetes. In non-diabetic subjects, diagnostic procedures for diabetes were performed according to Poland’s Diabetes recommendations. Between April 2012 and September 2018, 25 women developed diabetes and the next 11 cases were diagnosed based on FPG or oral glucose tolerance test. Women with incident diabetes had significantly higher baseline FPG, triglycerides (TG), TG/HDL cholesterol ratio and visceral adiposity index (VAI) score, and lower abdominal aorta diameter (AAD), HDL cholesterol and eGFR. In the Cox proportional hazard regression analysis, only AAD < 18 mm and VAI score ≥ 3.8 were independently associated with diabetes risk, hazard ratio (HR) 2.47 (95% confidence interval 1.21–5.02), P = 0.013 and HR 2.83 (1.35–5.94), P = 0.006 respectively. In the backward stepwise regression analysis including all variables, diabetes incidence could be predicted from a linear combination of the independent variables: AAD < 18 mm (P = 0.002), VAI score ≥ 3.8 (P < 0.001) and FPG ≥ 5.6 mmol/L (P = 0.011). The calculated incidence of diabetes was 2769.2 new cases/100,000 persons per year. AAD below 18 mm seem to be a novel, independent marker of diabetes risk in elderly women, and AAD assessment during routine abdomen ultrasound may be helpful in identifying females at early elderliness with high risk of diabetes incidence.
Tadeusz Dereziński; Dorota Zozulińska-Ziółkiewicz; Aleksandra Uruska; Mariusz Dąbrowski. Abdominal aorta diameter as a novel marker of diabetes incidence risk in elderly women. Scientific Reports 2020, 10, 1 -8.
AMA StyleTadeusz Dereziński, Dorota Zozulińska-Ziółkiewicz, Aleksandra Uruska, Mariusz Dąbrowski. Abdominal aorta diameter as a novel marker of diabetes incidence risk in elderly women. Scientific Reports. 2020; 10 (1):1-8.
Chicago/Turabian StyleTadeusz Dereziński; Dorota Zozulińska-Ziółkiewicz; Aleksandra Uruska; Mariusz Dąbrowski. 2020. "Abdominal aorta diameter as a novel marker of diabetes incidence risk in elderly women." Scientific Reports 10, no. 1: 1-8.
Clinical remission of type 1 diabetes is not only associated with regeneration of beta cells and preserved insulin secretion, but also with increased insulin sensitivity. The aim of the study was to determine the association between presence of remission in the first year of type 1 diabetes and insulin resistance at seven years from diagnosis of the disease. A total of 108 consecutive patients with newly diagnosed type 1 diabetes were followed prospectively. During the follow-up time, the onset and duration of clinical remission were registered. Seventy-four patients were included in the final analysis. Insulin sensitivity was assessed by the glucose disposal rate (GDR), determined using the hyperinsulinemic-euglycemic clamp, performed at seven years from diagnosis of diabetes. Patients were divided into groups with GDR <4.5mg/kg/min (G1-lower insulin sensitivity group) and GDR≥4.5mg/kg/min (G2-higher insulin sensitivity group). Higher insulin sensitivity was observed in the remission group [GDR 6.2 (IQR 4.2-7.0) vs 3.8 (IQR 3.0-4.8) mg/kg/min; p=0.01]. Furthermore, in G2 group, the duration of remission was longer than in G1 group: [351 (IQR206-561) vs 70 (IQR0-289) days; p=0.002]. Also, the GDR value correlated positively with duration of remission (r=0.42; p=0.002). In the multivariate logistic regression model including age, sex, body mass index at diagnosis and presence of remission, the remission period was independently associated with a higher GDR value [Odds Ratio (OR) 10,88; 95%CI: 1,70-69,50; p=0.009]. Patients with type 1 diabetes who entered remission at the beginning of the disease, despite its ending, have higher insulin sensitivity at seven years after diagnosis of diabetes than non-remitters.
Pawel Niedzwiecki; Stanislaw Pilacinski; Aleksandra Uruska; Dorota Zozulinska-Ziolkiewicz. Clinical Remission of Type 1 Diabetes Predicts Higher Insulin Sensitivity at 7 Years from Diagnosis of the Disease. Diabetes Technology & Therapeutics 2020, 22, 577 -583.
AMA StylePawel Niedzwiecki, Stanislaw Pilacinski, Aleksandra Uruska, Dorota Zozulinska-Ziolkiewicz. Clinical Remission of Type 1 Diabetes Predicts Higher Insulin Sensitivity at 7 Years from Diagnosis of the Disease. Diabetes Technology & Therapeutics. 2020; 22 (8):577-583.
Chicago/Turabian StylePawel Niedzwiecki; Stanislaw Pilacinski; Aleksandra Uruska; Dorota Zozulinska-Ziolkiewicz. 2020. "Clinical Remission of Type 1 Diabetes Predicts Higher Insulin Sensitivity at 7 Years from Diagnosis of the Disease." Diabetes Technology & Therapeutics 22, no. 8: 577-583.
Type 1 diabetes mellitus is a disease involving changes to energy metabolism. Chronic hyperglycemia is a major cause of diabetes complications. Hyperglycemia induces mechanisms that generate the excessive production of reactive oxygen species, leading to the development of oxidative stress. Studies with animal models have indicated the involvement of mitochondrial dysfunction in the pathogenesis of diabetic cardiomyopathy. In the current review, we aimed to collect scientific reports linking disorders in mitochondrial functioning with the development of diabetic cardiomyopathy in type 1 diabetes mellitus. We also aimed to present therapeutic approaches counteracting the development of mitochondrial dysfunction and diabetic cardiomyopathy in type 1 diabetes mellitus.
Aleksandra Cieluch; Aleksandra Uruska; Dorota Zozulinska-Ziolkiewicz. Can We Prevent Mitochondrial Dysfunction and Diabetic Cardiomyopathy in Type 1 Diabetes Mellitus? Pathophysiology and Treatment Options. International Journal of Molecular Sciences 2020, 21, 2852 .
AMA StyleAleksandra Cieluch, Aleksandra Uruska, Dorota Zozulinska-Ziolkiewicz. Can We Prevent Mitochondrial Dysfunction and Diabetic Cardiomyopathy in Type 1 Diabetes Mellitus? Pathophysiology and Treatment Options. International Journal of Molecular Sciences. 2020; 21 (8):2852.
Chicago/Turabian StyleAleksandra Cieluch; Aleksandra Uruska; Dorota Zozulinska-Ziolkiewicz. 2020. "Can We Prevent Mitochondrial Dysfunction and Diabetic Cardiomyopathy in Type 1 Diabetes Mellitus? Pathophysiology and Treatment Options." International Journal of Molecular Sciences 21, no. 8: 2852.
Diabetes and its chronic complications still represent a great clinical problem, despite improvements made in the diagnosis and treatment of the disease. People with diabetes have a much higher risk of impaired brain function and psychiatric disorders. Neurotrophins are factors that protect neuronal tissue and improve the function of the central nervous system, and among them is brain-derived neurotrophic factor (BDNF). The level and function of BDNF in diabetes seems to be disturbed by and connected with the presence of insulin resistance. On the other hand, there is evidence for the highly beneficial impact of physical activity on brain function and BDNF level. However, it is not clear if this protective phenomenon works in the presence of diabetes. In this review, we summarize the current available research on this topic and find that the results of published studies are ambiguous.
Olga Rozanska; Aleksandra Uruska; Dorota Zozulinska-Ziolkiewicz. Brain-Derived Neurotrophic Factor and Diabetes. International Journal of Molecular Sciences 2020, 21, 841 .
AMA StyleOlga Rozanska, Aleksandra Uruska, Dorota Zozulinska-Ziolkiewicz. Brain-Derived Neurotrophic Factor and Diabetes. International Journal of Molecular Sciences. 2020; 21 (3):841.
Chicago/Turabian StyleOlga Rozanska; Aleksandra Uruska; Dorota Zozulinska-Ziolkiewicz. 2020. "Brain-Derived Neurotrophic Factor and Diabetes." International Journal of Molecular Sciences 21, no. 3: 841.
Half of the individuals with type 1 diabetes (T1DM) may present Vitamin D (VD) deficiency. There is little known about factors determining a decision on VD supplementation. The study aimed to determine the factors affecting vitamin D supplementation in people with T1DM. A cross-sectional survey study using the authors’ questionnaire paper and its digital version was performed. The questions involved data on the basic characteristics of the respondent, medical history, VD supplementation status, influence of the social environment, self-education, and the most important personal motivator for VD supplement use. Multivariate logistic regression analysis was performed. We collected a total of n = 184 papers and n = 550 digital complete surveys. From 734 total respondents, 62.0% declared VD supplementation. The main personal rationale for VD supplementation were recommendation of medical specialist 172 (37.8%) and self-education 135 (29.7%). The main reasons for non-supplementation of VD were lack of knowledge about VD 159 (57.0%) and lack of motivation 77 (27.6%). VD supplementation was independently associated with a family doctor (odds ratio (OR), 95% confidence interval (CI): 4.67, 2.32–9.40) or medical specialist recommendation (16.20, 9.57–27.43), and self-education (5.97, 3.90–9.13). Most Polish individuals with T1DM use VD supplements, and the decision is related to physicians’ recommendations and self-education.
Mikołaj Kamiński; Magdalena Molenda; Agnieszka Banaś; Aleksandra Uruska; Dorota Zozulińska-Ziółkiewicz. Determinants of Vitamin D Supplementation among Individuals with Type 1 Diabetes. International Journal of Environmental Research and Public Health 2020, 17, 715 .
AMA StyleMikołaj Kamiński, Magdalena Molenda, Agnieszka Banaś, Aleksandra Uruska, Dorota Zozulińska-Ziółkiewicz. Determinants of Vitamin D Supplementation among Individuals with Type 1 Diabetes. International Journal of Environmental Research and Public Health. 2020; 17 (3):715.
Chicago/Turabian StyleMikołaj Kamiński; Magdalena Molenda; Agnieszka Banaś; Aleksandra Uruska; Dorota Zozulińska-Ziółkiewicz. 2020. "Determinants of Vitamin D Supplementation among Individuals with Type 1 Diabetes." International Journal of Environmental Research and Public Health 17, no. 3: 715.
Type 1 diabetes mellitus (T1DM) is associated with chronic complications, which are the result of neurovascular changes. There is still a lack of universal biochemical markers of microvascular damage. The present study aimed to investigate whether selected inflammatory proteins are related to the prevalence of microvascular complications in adult T1DM patients. The following markers were determined in a group of 100 T1DM participants: epidermal growth factor (EGF), metalloproteinase 2 (MMP-2), growth/differentiation factor 15 (GDF-15), and interleukin 29 (IL-29). Screening for microvascular complications, such as autonomic and peripheral neuropathy, diabetic kidney disease, and retinopathy, was conducted. The group was divided according to the occurrence of microvascular complications. At least one complication was required for the patient to be included in the microangiopathy group. The median EGF concentration in the microangiopathy group was higher than in the group without microangiopathy (p = 0.03). Increasing EGF concentration was a statistically significant predictor of the presence of microangiopathy in multivariate logistic regression analysis (p < 0.0001). Additionally, a higher GDF-15 level was associated with diabetic kidney disease, peripheral neuropathy, and proliferative retinopathy vs. nonproliferative retinopathy. GDF-15 concentration correlated negatively with estimated glomerular filtration rate (eGFR) (r = −0.28; p = 0.02). To conclude, higher EGF concentration is an independent predictor of the presence of microvascular complications in T1DM patients. Besides the relation between GDF-15 and diabetic kidney disease, it may be also associated with peripheral neuropathy and retinopathy.
Bogusz Falkowski; Anita Rogowicz-Frontczak; Ewelina Szczepanek-Parulska; Aleksandra Krygier; Elzbieta Wrotkowska; Aleksandra Uruska; Aleksandra Araszkiewicz; Marek Ruchala; Dorota Zozulinska-Ziolkiewicz. Novel Biochemical Markers of Neurovascular Complications in Type 1 Diabetes Patients. Journal of Clinical Medicine 2020, 9, 198 .
AMA StyleBogusz Falkowski, Anita Rogowicz-Frontczak, Ewelina Szczepanek-Parulska, Aleksandra Krygier, Elzbieta Wrotkowska, Aleksandra Uruska, Aleksandra Araszkiewicz, Marek Ruchala, Dorota Zozulinska-Ziolkiewicz. Novel Biochemical Markers of Neurovascular Complications in Type 1 Diabetes Patients. Journal of Clinical Medicine. 2020; 9 (1):198.
Chicago/Turabian StyleBogusz Falkowski; Anita Rogowicz-Frontczak; Ewelina Szczepanek-Parulska; Aleksandra Krygier; Elzbieta Wrotkowska; Aleksandra Uruska; Aleksandra Araszkiewicz; Marek Ruchala; Dorota Zozulinska-Ziolkiewicz. 2020. "Novel Biochemical Markers of Neurovascular Complications in Type 1 Diabetes Patients." Journal of Clinical Medicine 9, no. 1: 198.
Type 1 diabetes (T1DM) often coexists with other autoimmune diseases, most commonly with hypothyroidism. To date, the influence of coexisting autoimmune hypothyroidism (AHT) on the course of chronic neurovascular complications of autoimmune diabetes has not been established. The aim of the study was to assess the relationship between AHT and the occurrence of chronic T1DM complications. The study group comprised 332 European Caucasian participants with T1DM [165 (49.7%) men]. AHT was recognized in subclinical and overt hypothyroidism and confirmed by the presence of anti-thyroid autoantibodies: anti-peroxidase (ATPO) and/or anti-thyroglobulin (ATg) and ultrasonography (hypoechogenicity, parenchymal heterogeneity, lymph nodes assessment). In the analyzed group, 48.5% of patients were diagnosed with at least one neurovascular complication. At the time of enrollment, 16.3% of participants were diagnosed with AHT. Patients with AHT, compared to those without AHT, were characterized by a higher prevalence of neurovascular complications (64.8 vs. 45.3%; P = 0.009) and retinopathy (55.6 vs. 38.9%; P = 0.02). There were significant differences between groups with and without neurovascular complications, with regard to classic risk factors for chronic diabetes complications: age, T1DM duration, SBP, DBP, HbA1c, TG, eGFR and hypertension prevalence. In the multivariate logistic regression analysis, AHT was an independent predictor of neurovascular complications after adjusting for age, DBP, HbA1c and TG (odds ratio, 2.40; 95% confidence interval, 1.17–4.92; P = 0.02). AHT coexisting with T1DM was associated with a higher incidence of neurovascular complications.
A. Rogowicz-Frontczak; B. Falkowski; A. Grzelka-Wozniak; A. Uruska; A. Araszkiewicz; Dorota Zozulinska-Ziolkiewicz. Does autoimmune hypothyroidism increase the risk of neurovascular complications in type 1 diabetes? Journal of Endocrinological Investigation 2020, 43, 833 -839.
AMA StyleA. Rogowicz-Frontczak, B. Falkowski, A. Grzelka-Wozniak, A. Uruska, A. Araszkiewicz, Dorota Zozulinska-Ziolkiewicz. Does autoimmune hypothyroidism increase the risk of neurovascular complications in type 1 diabetes? Journal of Endocrinological Investigation. 2020; 43 (6):833-839.
Chicago/Turabian StyleA. Rogowicz-Frontczak; B. Falkowski; A. Grzelka-Wozniak; A. Uruska; A. Araszkiewicz; Dorota Zozulinska-Ziolkiewicz. 2020. "Does autoimmune hypothyroidism increase the risk of neurovascular complications in type 1 diabetes?" Journal of Endocrinological Investigation 43, no. 6: 833-839.
Purpose: To assess glycemic control and safety of children and adolescents with type 1 diabetes participating in a 2-day football tournament. Methods: In total, 189 children with type 1 diabetes from 11 diabetes care centers, in Poland, participated in a football tournament in 3 age categories: 7–9 (21.2%), 10–13 (42.9%), and 14–17 (36%) years. Participants were qualified and organized in 23 football teams, played 4 to 6 matches of 30 minutes, and were supervised by a medical team. Data on insulin dose and glycemia were downloaded from personal pumps, glucose meters, continuous glucose monitoring, and flash glucose monitoring systems. Results: The median level of blood glucose before the matches was 6.78 (4.89–9.39) mmol/L, and after the matches, it was 7.39 (5.5–9.87) mmol/L (P = .001). There were no episodes of severe hypoglycemia or ketoacidosis. The number of episodes of low glucose value (blood glucose ≤3.9 mmol/L) was higher during the tournament versus 30 days before: 1.2 (0–1.5) versus 0.7 (0.3–1.1) event/person/day, P < .001. Lactate levels increased during the matches (2.2 [1.6–4.0] mmol/L to 4.4 [2.6–8.5] mmol/L after the matches, P < .001). Conclusions: Large football tournaments can be organized safely for children with type 1 diabetes. For the majority of children, moderate mixed aerobic–anaerobic effort did not adversely affect glycemic results and metabolic safety.
Andrzej Gawrecki; Aleksandra Araszkiewicz; Agnieszka Szadkowska; Grzegorz Biegański; Jan Konarski; Katarzyna Domaszewska; Arkadiusz Michalak; Bogda Skowrońska; Anna Adamska; Dariusz Naskręt; Przemysława Jarosz-Chobot; Agnieszka Szypowska; Tomasz Klupa; Dorota Zozulinska-Ziolkiewicz. Assessment of Safety and Glycemic Control During Football Tournament in Children and Adolescents With Type 1 Diabetes—Results of GoalDiab Study. Pediatric Exercise Science 2019, 31, 401 -407.
AMA StyleAndrzej Gawrecki, Aleksandra Araszkiewicz, Agnieszka Szadkowska, Grzegorz Biegański, Jan Konarski, Katarzyna Domaszewska, Arkadiusz Michalak, Bogda Skowrońska, Anna Adamska, Dariusz Naskręt, Przemysława Jarosz-Chobot, Agnieszka Szypowska, Tomasz Klupa, Dorota Zozulinska-Ziolkiewicz. Assessment of Safety and Glycemic Control During Football Tournament in Children and Adolescents With Type 1 Diabetes—Results of GoalDiab Study. Pediatric Exercise Science. 2019; 31 (4):401-407.
Chicago/Turabian StyleAndrzej Gawrecki; Aleksandra Araszkiewicz; Agnieszka Szadkowska; Grzegorz Biegański; Jan Konarski; Katarzyna Domaszewska; Arkadiusz Michalak; Bogda Skowrońska; Anna Adamska; Dariusz Naskręt; Przemysława Jarosz-Chobot; Agnieszka Szypowska; Tomasz Klupa; Dorota Zozulinska-Ziolkiewicz. 2019. "Assessment of Safety and Glycemic Control During Football Tournament in Children and Adolescents With Type 1 Diabetes—Results of GoalDiab Study." Pediatric Exercise Science 31, no. 4: 401-407.
Patients in an insulin‑deficient state show reduced high‑density lipoprotein cholesterol (HDL‑C) levels. Insulin treatment affects lipid metabolism in this population. There have been no prospective studies evaluating changes in lipid profile after the diagnosis of type 1 diabetes (T1D). We investigated the effect of subcutaneous insulin therapy initiation on quantitative changes in HDL‑C levels and other components of lipid profile in patients with newly diagnosed T1D. A total of 127 patients with newly diagnosed T1D aged 28 years (interquartile range, 23-34 years) were enrolled in the InLipoDiab1 study. The lipid profile was assessed before the first injection of insulin (baseline) and after 3 and 12 months of insulin therapy. The daily dose of insulin (DDI) was defined as the requirement for insulin per kilogram body weight per day. The DDI was calculated at hospital discharge and during visits in an outpatient clinic at 3 and 12 months. We observed a persistent increase in HDL‑C levels at 3 and 12 months versus baseline (P <0.001) in men and women. Moreover, a reduction was observed in triglyceride levels (P <0.001) and the ratio of triglycerides to HDL‑C (P <0.001) in men and women. In contrast, a decrease was observed in low‑density lipoprotein cholesterol and non‑HDL‑C levels (P <0.001), but only in men. Subcutaneous insulin therapy reverses the impaired phenotype of lipoproteins during the first year of treatment. Changes in lipoprotein levels in newly diagnosed T1D differ depending on sex.
Aleksandra Cieluch; Aleksandra Uruska; Agata Grzelka-Woźniak; Paweł Niedźwiecki; Justyna Flotyńska; Dorota Zozulinska-Ziolkiewicz. Changes in high-density lipoprotein cholesterol (HDL-C) level and the ratio of triglycerides to HDL-C during the first year of type 1 diabetes. Polish Archives of Internal Medicine 2019, 129, 598 -604.
AMA StyleAleksandra Cieluch, Aleksandra Uruska, Agata Grzelka-Woźniak, Paweł Niedźwiecki, Justyna Flotyńska, Dorota Zozulinska-Ziolkiewicz. Changes in high-density lipoprotein cholesterol (HDL-C) level and the ratio of triglycerides to HDL-C during the first year of type 1 diabetes. Polish Archives of Internal Medicine. 2019; 129 (9):598-604.
Chicago/Turabian StyleAleksandra Cieluch; Aleksandra Uruska; Agata Grzelka-Woźniak; Paweł Niedźwiecki; Justyna Flotyńska; Dorota Zozulinska-Ziolkiewicz. 2019. "Changes in high-density lipoprotein cholesterol (HDL-C) level and the ratio of triglycerides to HDL-C during the first year of type 1 diabetes." Polish Archives of Internal Medicine 129, no. 9: 598-604.
To analyze physical performance and diabetes-related outcomes in adolescents with type 1 diabetes (T1DM) during two semi-competitive football matches utilising precise physical activity monitoring. The study was conducted during an annual summer camp for adolescents with T1DM. After physical examination and glycated hemoglobin measurement, 16 adolescent players completed Cooper's 12-min running test and, in the following days, took part in two football matches while wearing heart rate (HR) monitors coupled with global positioning system (GPS) tracking. Both matches were comparable in terms of covered distances, number of sprints, achieved velocities and heart rate responses. During both games, capillary blood lactate increased significantly (Match 1: 1.75 ± 0.16-6.13 ± 1.73 mmol/l; Match 2: 1.77 ± 0.18-3.91 ± 0.63 mmol/l, p = 0.004). No significant differences in blood glucose were observed between the matches (p = 0.83) or over each match (p = 0.78). Clinically significant hypoglycemia (< 54 mg/dl) occurred in two children during the first match. None of the players experienced severe hypoglycemia. Despite similar workloads, players consumed significantly less carbohydrates during Match 2 [median difference: - 20 g (25-75%: - 40 to 0), p = 0.006]. HR monitoring and GPS-based tracking can effectively parameterize physical activity during a football match. In T1DM patients, exercise workload and glycemic changes during similar matches are comparable, which provides an opportunity to develop individual recommendations for players with T1DM.
Andrzej Gawrecki; Arkadiusz Michalak; Szymon Gałczyński; Iwona Dachowska; Dorota Zozulinska-Ziolkiewicz; Agnieszka Szadkowska. Physical workload and glycemia changes during football matches in adolescents with type 1 diabetes can be comparable. International Journal of Earth Sciences 2019, 56, 1191 -1198.
AMA StyleAndrzej Gawrecki, Arkadiusz Michalak, Szymon Gałczyński, Iwona Dachowska, Dorota Zozulinska-Ziolkiewicz, Agnieszka Szadkowska. Physical workload and glycemia changes during football matches in adolescents with type 1 diabetes can be comparable. International Journal of Earth Sciences. 2019; 56 (11):1191-1198.
Chicago/Turabian StyleAndrzej Gawrecki; Arkadiusz Michalak; Szymon Gałczyński; Iwona Dachowska; Dorota Zozulinska-Ziolkiewicz; Agnieszka Szadkowska. 2019. "Physical workload and glycemia changes during football matches in adolescents with type 1 diabetes can be comparable." International Journal of Earth Sciences 56, no. 11: 1191-1198.
The aim of this study was to assess the blood vessel density and maturity in the skin of adults with type 1 diabetes in relation to the presence of late neurovascular complications. We included 148 patients (87 men) with a median (interquartile range) age of 41 (31–49) and median diabetes duration of 21 (17–30) years. Microvessel (CD133, CD34, CD31 and von Willebrand factor) markers were evaluated by indirect immunohistochemistry assay in material from a skin biopsy. Diabetic retinopathy was diagnosed using direct ophthalmoscopy, and diabetic kidney disease was estimated in people with increased albuminuria and a 10-year duration of diabetes or evidence of diabetic retinopathy . Diabetic peripheral neuropathy diagnosis was based on Toronto definition, cardiac autonomic neuropathy on validated ProSciCard III program. Microvessel density, assessed by CD34 and CD133, was significantly higher in patients with cardiac autonomic neuropathy [160 (125–175) vs 121 (100–154)/1 mm2, p = 0.001 and 92 (83–104) vs 79 (63–92)/1 mm2, p = 0.007, respectively] and CD34 in patients with diabetic peripheral neuropathy [135 (106–168) vs 121 (95–145)/1 mm2, p = 0.018], as compared with subjects without complications. In multivariate logistic regression, density of CD34 and CD133 positive vessels was associated with presence of cardiac autonomic neuropathy [odds ratio 1.016 (95% confidence interval: 1.002–1.029), p = 0.019 and odds ratio 1.037 (95% confidence interval: 1.008–1.067), p = 0.011, respectively]. It was independent from age, sex, diabetes duration, smoking status, body mass index and HbA1c value. Density of CD34 positive vessels was also associated with diabetic peripheral neuropathy, independently from sex and diabetes duration [odds ratio 1.009 (95% confidence interval: 1.001–1.020), p = 0.037]. Skin microvessel density is increased in adults with clinical evidence of neurovascular complications of type 1 diabetes. This is associated with predominance of the vessels of low maturity.
Anna Adamska; Stanislaw Pilacinski; Dorota Zozulinska-Ziolkiewicz; Agnieszka Gandecka; Agata Grzelka; Aneta Konwerska; Agnieszka Malinska; Michal Nowicki; Aleksandra Araszkiewicz. An increased skin microvessel density is associated with neurovascular complications in type 1 diabetes mellitus. Diabetes and Vascular Disease Research 2019, 16, 513 -522.
AMA StyleAnna Adamska, Stanislaw Pilacinski, Dorota Zozulinska-Ziolkiewicz, Agnieszka Gandecka, Agata Grzelka, Aneta Konwerska, Agnieszka Malinska, Michal Nowicki, Aleksandra Araszkiewicz. An increased skin microvessel density is associated with neurovascular complications in type 1 diabetes mellitus. Diabetes and Vascular Disease Research. 2019; 16 (6):513-522.
Chicago/Turabian StyleAnna Adamska; Stanislaw Pilacinski; Dorota Zozulinska-Ziolkiewicz; Agnieszka Gandecka; Agata Grzelka; Aneta Konwerska; Agnieszka Malinska; Michal Nowicki; Aleksandra Araszkiewicz. 2019. "An increased skin microvessel density is associated with neurovascular complications in type 1 diabetes mellitus." Diabetes and Vascular Disease Research 16, no. 6: 513-522.
The aim of the study was to analyze the relationship between the presence of type 1 diabetes and sexual dysfunction among young women. The study group consisted of 230 women, including 70 healthy and 160 with diabetes mellitus type 1 (DM1). All the participants voluntarily filled anonymous questionnaire. The results regarding sexual function were obtained using a Female Sexual Function Index (FSFI) questionnaire. Statistical analysis was performed for sexually active people. In the study group, 180 women declared sexual activity: 62 healthy (88%) and 118 with DM1 (82.5%). Women with DM1 in comparison with healthy women were older, had higher BMI, weight, and had more pack-years of cigarette smoking. Women with DM1 had lower results in FSFI and more often achieved scores below the clinical cutoff point. In a multiple linear regression model, the presence of diabetes predicted lower FSFI results. DM1 is independently associated with the presence of impaired sexual function. Sexual dysfunctions are more common among young women with DM1 than in healthy controls. The relationship is significant despite of the age, duration of diabetes, body weight, and presence of angiopathy.
Justyna Flotynska; Aleksandra Uruska; Anna Michalska; Aleksandra Araszkiewicz; Dorota Zozulinska-Ziolkiewicz. Sexual Dysfunction Is a More Common Problem in Young Women with Type 1 Diabetes than in Healthy Women. Journal of Sex & Marital Therapy 2019, 45, 643 -651.
AMA StyleJustyna Flotynska, Aleksandra Uruska, Anna Michalska, Aleksandra Araszkiewicz, Dorota Zozulinska-Ziolkiewicz. Sexual Dysfunction Is a More Common Problem in Young Women with Type 1 Diabetes than in Healthy Women. Journal of Sex & Marital Therapy. 2019; 45 (7):643-651.
Chicago/Turabian StyleJustyna Flotynska; Aleksandra Uruska; Anna Michalska; Aleksandra Araszkiewicz; Dorota Zozulinska-Ziolkiewicz. 2019. "Sexual Dysfunction Is a More Common Problem in Young Women with Type 1 Diabetes than in Healthy Women." Journal of Sex & Marital Therapy 45, no. 7: 643-651.
Dorota Zozulinska-Ziolkiewicz; Aleksandra Araszkiewicz. Peripheral diabetic neuropathy: better prevent than cure. Polish Archives of Internal Medicine 2019, 129, 151 -153.
AMA StyleDorota Zozulinska-Ziolkiewicz, Aleksandra Araszkiewicz. Peripheral diabetic neuropathy: better prevent than cure. Polish Archives of Internal Medicine. 2019; 129 (3):151-153.
Chicago/Turabian StyleDorota Zozulinska-Ziolkiewicz; Aleksandra Araszkiewicz. 2019. "Peripheral diabetic neuropathy: better prevent than cure." Polish Archives of Internal Medicine 129, no. 3: 151-153.
Andrzej Gawrecki; Tomasz Klupa; Aleksandra Araszkiewicz; Bartłomiej Matejko; Agnieszka Szadkowska; Bogumił Wolnik; Elektra Szymańska-Garbacz; Przemysława Jarosz-Chobot; Malgorzata Mysliwiec; Leszek Czupryniak; Maciej T. Małecki; Dorota Zozulinska-Ziolkiewicz. Utilization of do-it-yourself artificial pancreas systems in the management of patients with type 1 diabetes: a position statement of the Pump School Education Initiative by Diabetes Poland. Polish Archives of Internal Medicine 2019, 129, 937 -938.
AMA StyleAndrzej Gawrecki, Tomasz Klupa, Aleksandra Araszkiewicz, Bartłomiej Matejko, Agnieszka Szadkowska, Bogumił Wolnik, Elektra Szymańska-Garbacz, Przemysława Jarosz-Chobot, Malgorzata Mysliwiec, Leszek Czupryniak, Maciej T. Małecki, Dorota Zozulinska-Ziolkiewicz. Utilization of do-it-yourself artificial pancreas systems in the management of patients with type 1 diabetes: a position statement of the Pump School Education Initiative by Diabetes Poland. Polish Archives of Internal Medicine. 2019; 129 (2):937-938.
Chicago/Turabian StyleAndrzej Gawrecki; Tomasz Klupa; Aleksandra Araszkiewicz; Bartłomiej Matejko; Agnieszka Szadkowska; Bogumił Wolnik; Elektra Szymańska-Garbacz; Przemysława Jarosz-Chobot; Malgorzata Mysliwiec; Leszek Czupryniak; Maciej T. Małecki; Dorota Zozulinska-Ziolkiewicz. 2019. "Utilization of do-it-yourself artificial pancreas systems in the management of patients with type 1 diabetes: a position statement of the Pump School Education Initiative by Diabetes Poland." Polish Archives of Internal Medicine 129, no. 2: 937-938.
The University of Texas Wound Classification is a tool assesing risk of amputation of patients with Diabetic Foot Ulceration (DFU). Negative Pressure Wound Therapy (NPWT) is a nonivasive system which was shown to be effective in healing chronic wounds. The aim of the study was to assess utility of long-term NPWT in healing diabetic foot wounds among Polish patients with diabetes. In the study, we retrospectively analysed data of patients of DFU ambulatory using NPWT. Collected data included sex, age, type of DFU, duration of NPWT, history of previous minor amputation and characteristic of the healed wound in The University of Texas Wound Classification before and after NPWT. Total number of participants counted 21 (male = 16, 76%). The wound significantly improved in 17 (81%) patients. Group with successful treatment reached median 92% decrease of risk of amputation (-8.5 to -92%; p < 0.001). Group with successful treatment differed from group with unsuccessful treatment in count of angiopathic DFU (Chi2, 4[24%] vs. 3[75%]; p = 0.049). No significant differences in age, sex, history of previous minor amputation, presence of infection, depth of the ulcer were found. No NPWT adverse effect were reported. Logistic regression model revealed significant relationship between unsuccessful outcome of NPWT and presence of ischemic ulcer adjusted to presence of infection, depth of a wound and sex (OR = 27.5; CI: 1.1-716.7; p = 0.046). NPWT significantly decraeses risk of amputation in Texas Score. NPWT may not help healing wounds simultaneously infected and ischeamic. Presence of ischemic wound decreases chance for successful outcome.
Adam Węgrzynowski; Mikołaj Kamiński; Piotr Liszkowski; Jacek Soska; Aleksandra Araszkiewicz; Dorota Zozulinska-Ziolkiewicz. Long-term negative pressure wound therapy decreases a risk of diabetic foot amputation assessed in the university of Texas wound classification. Wound Medicine 2019, 24, 33 -35.
AMA StyleAdam Węgrzynowski, Mikołaj Kamiński, Piotr Liszkowski, Jacek Soska, Aleksandra Araszkiewicz, Dorota Zozulinska-Ziolkiewicz. Long-term negative pressure wound therapy decreases a risk of diabetic foot amputation assessed in the university of Texas wound classification. Wound Medicine. 2019; 24 (1):33-35.
Chicago/Turabian StyleAdam Węgrzynowski; Mikołaj Kamiński; Piotr Liszkowski; Jacek Soska; Aleksandra Araszkiewicz; Dorota Zozulinska-Ziolkiewicz. 2019. "Long-term negative pressure wound therapy decreases a risk of diabetic foot amputation assessed in the university of Texas wound classification." Wound Medicine 24, no. 1: 33-35.