Wagner Luiz Ramos Barbosa

Prof. Dr. Wagner Luiz Ramos Barbosa

Universidade Federal do Pará, Brazil
orcid

Research Focus & Metrics

Academic Career Length

25Years (2002-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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TAThaís Barbosa Alberti
Thaís Barbosa Alberti
Wagner Luiz Ramos BarbosaWagner Luiz Ramos Barbosa
Wagner Luiz Ramos Barbosa
JVjose luiz F Vieira
jose luiz F Vieira
NRNádia Rezende Barbosa Raposo
Nádia Rezende Barbosa Raposo
Rafael Cypriano DutraRafael Cypriano Dutra
Rafael Cypriano Dutra
(−)-β-caryophyllene (BCP), a cannabinoid receptor type 2 (CB2)-selective phytocannabinoid, has already been shown in precedent literature to exhibit both anti-inflammatory and analgesic effects in mouse models of inflammatory and neuropathic pain. Herein, we endeavored to investigate the therapeutic potential of BCP on experimental autoimmune encephalomyelitis (EAE), a murine model of multiple sclerosis (MS). Furthermore, we sought to demonstrate some of the mechanisms that underlie the modulation BCP exerts on autoimmune activated T cells, the pro-inflammatory scenery of the central nervous system (CNS), and demyelination. Our findings demonstrate that BCP significantly ameliorates both the clinical and pathological parameters of EAE. In addition, data hereby presented indicates that mechanisms underlying BCP immunomodulatory effect seems to be linked to its ability to inhibit microglial cells, CD4+ and CD8+ T lymphocytes, as well as protein expression of pro-inflammatory cytokines. Furthermore, it diminished axonal demyelination and modulated Th1/Treg immune balance through the activation of CB2 receptor. Altogether, our study represents significant implications for clinical research and strongly supports the effectiveness of BCP as a novel molecule to target in the development of effective therapeutic agents for MS.

3 June 2004 in Chromatographia
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SGS. Gallori
S. Gallori
ABA. R. Bilia
A. R. Bilia
Maria Camilla BergonziMaria Camilla Bergonzi
Maria Camilla Bergonzi
Wagner Luiz Ramos BarbosaWagner Luiz Ramos Barbosa
Wagner Luiz Ramos Barbosa
FVF. F. Vincieri
F. F. Vincieri

1 August 2016 in Journal of Photochemistry and Photobiology B: Biology
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FMFrancislene J. Martins
Francislene J. Martins
CCCésar A. Caneschi
César A. Caneschi
JVJosé L.F. Vieira
José L.F. Vieira
Wagner Luiz Ramos BarbosaWagner Luiz Ramos Barbosa
Wagner Luiz Ramos Barbosa
NRNádia R.B. Raposo
Nádia R.B. Raposo

1 December 2008 in Revista Brasileira de Farmacognosia
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Wagner Luiz Ramos BarbosaWagner Luiz Ramos Barbosa
Wagner Luiz Ramos Barbosa
LPLucianna Do Nascimento Pinto
Lucianna Do Nascimento Pinto
EQEtienne Quignard
Etienne Quignard
JVJosé Maria dos Santos Vieira
José Maria dos Santos Vieira
JJJosé Otávio Carrera Silva Jr.
José Otávio Carrera Silva Jr.
SASérgio Albuquerque
Sérgio Albuquerque
Arrabidaea chica (HBK.) Verlot (Bignoniaceae) vernacular name "Pariri", is a climbing shrub, widespread from South Mexico to Guyana and central Brazil and is traditionally indicated to treat symptoms of inflammations and skin affections. Its ethanol extract was chemically investigated and tested against yeasts and dermatophytic fungi. The trypanocidal activity of the same extract was also evaluated. This work reports the isolation of three flavonoids, the total growth inhibition of Trichophyton mentagrophytes and a significant trypanocidal effect of the ethanol extract and its fractions. No relevant acute toxicity was detected even at a dose of 1000 mg/kg. Arrabidaea chica (HBK.) Verlot (Bignoniaceae) popularmente, "Pariri", é um arbusto escandente, distribuído do sul do México até a Guiana e Brasil central e é tradicionalmente indicado para tratar sintomas de inflamações e afecções da pele. Seu extrato etanólico foi quimicamente investigado e testado contra leveduras e fungos dermatófitos. A atividade tripanocida do mesmo extrato foi também avaliada. Este trabalho reporta o isolamento de três flavonóides, a inibição total do crescimento de Trichophyton mentagrophytes e um significante efeito tripanocida do extrato etanólico e de suas frações. Não foi detectada qualquer toxicidade aguda relevante, mesmo a uma dose de 1000 mg/kg

18 July 2022 in Polymers
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LFLindalva Maria de Meneses Costa Ferreira
Lindalva Maria de Meneses Costa Ferreira
RPRayanne Rocha Pereira
Rayanne Rocha Pereira
FCFernanda Brito de Carvalho
Fernanda Brito de Carvalho
MRMyrth Soares Do Nascimento Remígio
Myrth Soares Do Nascimento Remígio
Wagner Luiz Ramos BarbosaWagner Luiz Ramos Barbosa
Wagner Luiz Ramos Barbosa
JJJosé Otávio Silva Júnior
José Otávio Silva Júnior
The industrial processing of fruits in the Amazon region, such as tucuma, generates a large amount of coproducts with great nutritional potential. In this work, phenolic compounds from tucuma coproduct almonds were extracted and microencapsulated by spray drying using maltodextrin as the encapsulating agent and verified its antioxidant activity. Phenolic compounds were determined by UV spectroscopy and identified by Ultraefficiency Liquid Chromatography. Antioxidant activity was measured by ABTS and DPPH assay. Thermogravimetric techniques, infrared spectroscopy, scanning electron microscopy, moisture content and water activity were applied to characterize the microparticle. The crude extract and microparticle had total polyphenols of 135.1 mg/g ± 0.078 and 130.5 mg/g ± 0.024, respectively. Caffeic and gallic acids were identified. The crude extract and the microparticle showed good antioxidant activity by ABTS and DPPH assay, justified by the presence of the phenolic compounds found. The microparticle showed spherical and heterogeneous structures and good encapsulation efficiency from the spray drying process using maltodextrin. The results show that the extract of the tucuma almond coproduct can be used as a phenolic compound-rich source and microencapsulated with possible application for functional food production.

9 December 2011 in Journal of Thermal Analysis and Calorimetry
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RCRussany Silva da Costa
Russany Silva da Costa
CNCharles Alberto Brito Negrão
Charles Alberto Brito Negrão
SCSarah Regina Pereira Camelo
Sarah Regina Pereira Camelo
RCRoseane Maria Ribeiro Costa
Roseane Maria Ribeiro Costa
Wagner Luiz Ramos BarbosaWagner Luiz Ramos Barbosa
Wagner Luiz Ramos Barbosa
JJJosé Otávio Silva Júnior
José Otávio Silva Júnior