In this study, we present a united sign coherence factor beamformer for coherent plane-wave compounding (CPWC). CPWC is capable of reaching an image quality comparable to the conventional B-mode with a much higher frame rate. Conventional coherence factor (CF) based beamformers for CPWC are based on one-dimensional (1D) frameworks, either in the spatial coherence dimension or angular coherence dimension. Both 1D frameworks do not take into account the coherence information of the dimensions of each other. In order to take full advantage of the radio-frequency (RF) data, this paper proposes a united framework containing both spatial and angular information for CPWC. A united sign coherence factor beamformer (uSCF), which combines the conventional sign coherence factor (SCF) and the united framework, is introduced in the paper as well. The proposed beamformer is compared with the conventional 1D SCF beamformers (spatial and angular dimension beamformers) using simulation, phantom and in vivo studies. In the in vivo images, the proposed method improves the contrast ratio (CR) and generalized contrast-to-noise ratio (gCNR) by 197% and 20% over CPWC. Compared with other 1D methods, uSCF also shows an improved contrast and lateral resolution on all datasets.

Chirp coded excitation is an effective method to improve the signal-to-noise ratio (SNR) and penetration depth of high-frequency endoscopic ultrasound (EUS) imaging. In coded excitation, pulse compression is applied to compress the elongated coded signals into a short pulse, which determines the final imaging performance, including spatial resolution and SNR. However, with the current pulse compression methods, it is hard to get high performance in the peak sidelobe level (PSL), image contrast, and axial resolution at the same time. To solve this problem, in this article, a new method named compressed pulse weighting method (CPWM) was proposed based on the combination of two kinds of pulse compression signals. A brief theoretical derivation proved the feasibility of method. The proposed method was evaluated by the simulation and phantom experiments. Compared with traditional method, the results showed that the proposed adaptive weighting method can provide increases of 32.42% in the penetration depth, 9.48 dB in the SNR, 5.60 dB in the contrast ratio (CR), 5.46 in the contrast-to-noise ratio (CNR), and 0.13 mm in the axial imaging resolution for 12-MHz EUS. Therefore, this method can effectively improve the ultrasound penetration depth and imaging quality, which made it have good potential for high-frequency ultrasound imaging.

We present a united coherence factor beamformer for coherent plane-wave compounding (CPWC). CPWC is capable to reach an image quality comparable to the conventional B-mode imaging with a much higher frame rate and could be further applied to Doppler imaging. Conventional coherence factor (CF) based beamformers for CPWC use only either the spatial coherence or angular coherence information, which limits the image quality. To take full advantage of the radio frequency (RF) data for better image quality, this paper proposes a united coherence factor (uCF) using both spatial and angular information for CPWC. The proposed uCF is applied to simulated, phantom and in vivo imaging data. We evaluate the performance of the proposed method by lateral resolution and contrast. For simulated images, the contrast ratio (CR) improvements are over 80%. In the phantom images, the maximum improvements of the lateral full width at half maximum (FWHM) and CR are 10% and 105%, respectively. To compare the most core differences, the spatial and angular methods are also presented in this paper. uCF is superior in lateral resolution improvement and contrast among the beamformers. In addition, the proposed uCF performance also shows good performance in the power Doppler experiment with improved image quality, which is further verified by the spatial similarity matrix of the Doppler image. Thus, the proposed method (uCF) has a great potential to be applied in CPWC for image quality improvement.

Ultrafast compound Doppler imaging (UCDI), which can be used to acquire Doppler information at very high spatial and temporal sampling rates, provides a great improvement to the characterization of the vasculature. The singular value decomposition (SVD) technique takes advantage of the different features of tissue and blood motion in terms of spatiotemporal coherence and strongly outperforms conventional clutter rejection filters in small animals. However, a major challenge of conventional UCDI with SVD clutter filtering for small vessel imaging is that it is not sensitive enough to detect the hemodynamic changes in deep tissue where the majority of the remaining signal is usually noise-saturated. In this study, with the first attempt to apply ultrasonic tissue characterization techniques to UCDI, we propose an H-scan subtraction Doppler imaging method to bypass the limitations associated with the high-order singular value thresholding selection and improve the image quality of fine vessels. The flow phantom experiments with different blood concentrations show that H-Scan is capable of estimating the relative size and spatial distribution of acoustic scattering objects. In the in vivo rabbit brain experiment, the H-Doppler method, together with the global and block-wise local SVD clutter filtering, are proposed to facilitate better power Doppler images with a significant improvement of background noise suppression. These results demonstrate that the contrast-to-noise-ratio (CNR) of the H-scan subtraction Doppler imaging is 15% to 65% higher than that of the conventional UCDI methods. Therefore, this approach can be potentially applied to the clinical applications of the functional ultrasound (fUS) imaging method.

Ultrasound plane wave imaging technology has been applied to more clinical situations than ever before because of its rapid imaging speed and stable imaging quality. Most transducers used in plane wave imaging are linear arrays, but their structures limit the application of plane wave imaging technology in some special clinical situations, especially in the endoscopic environment. In the endoscopic environment, the size of the linear array transducer is strictly miniaturized, and the imaging range is also limited to the near field. Meanwhile, the near field of a micro linear array has serious mutual interferences between elements, which is against the imaging quality of near field. Therefore, we propose a new structure of a micro ultrasound linear array for plane wave imaging. In this paper, a theoretical comparison is given through sound field and imaging simulations. On the basis of primary work and laboratory technology, micro uniform and non-uniform linear arrays were made and experimented with the phantom setting. We selected appropriate evaluation parameters to verify the imaging results. Finally, we concluded that the micro non-uniform linear array eliminated the artifacts better than the micro uniform linear array without the additional use of signal processing methods, especially for target points in the near-field. We believe this study provides a possible solution for plane wave imaging in cramped environments like endoscopy.