Currently, the role of the nanoparticles in the structure of the composites and their benefits for the health of the body is valuable. In this study, the effects of the doping on the structural and morphological properties of the hydrogels using a Mg co-doped ZnO hydrogel, which has been fabricated by the sol–gel process, have been investigated. Then, a hydrogel containing nanoparticle and a hydrogel without any nanoparticles was produced as a control. The hydrogels were loaded with catechin and the related characterization was evolved based on the new structure of the matrices. The Mg_0.99Zn_0.01O nanoparticles were synthesized using a green synthesis method. To investigate the properties of the nanoparticles, zeta potential and XRD were studied. The field emission scanning electron microscopy (FESEM), FTIR, TGA, swelling Ratio, and compression tests were investigated for the hydrogels. Based on the results, FESEM showed a more compressed structure for hydrogels including nanoparticles rather than the hydrogels without a nanoparticle. The TGA showed a higher decomposition temperature in the hydrogels including nanoparticles. The swelling ratio of hydrogels containing a nanoparticle was higher than the control hydrogel. κ-Carrageenan/ Mg_0.99Zn_0.01O/NaCMC/Catechin had the highest swelling ratio (44.15%) rather than the κ-Carrageenan/NaCMC (33.22%). Mg_0.99Zn_0.01O nanoparticles presented a stronger structure of hydrogels in the compression test. It is concluded that the role of the synthesized nanoparticle is critical in the structure of the hydrogel.

In the current study, nanocomposites were prepared by combining $k$-carrageenan, polyvinyl alcohol (PVA), and doped nanoparticles (Magnesium oxide) MgO, (Magnesium Zinc oxide) MgZnO 1%, MgZnO 3%, and MgZnO 5%. The nanoparticles were synthesized by a sol–gel method and mixed with a mixture of $k$-carrageenan/PVA (Ca/PVA) in various ratios. The structure of the composites was analyzed using thermogravimetric analysis (TGA), X-ray diffraction (XRD), and Fourier transform infrared spectroscopy (FTIR). The Ca/PVA mixture was then mixed with nanoparticles and loaded with active ingredient, catechin. Scanning electron microscope (SEM) and texture analysis were performed to analyze the nanocomposites. Entrapment efficiency (EE%) and drug release studies confirmed that $k$-carrageenan/PVA/MgZnO 5% had the highest EE% at 81.58% and a drug release of 75.21% $\pm$ 0.94. The EE% of $k$-carrageenan/PVA/MgO was 55.21% and its drug release was 45%. This indicates that ZnO plays an effective role in the structure and performance of Ca/PVA composites. The SEM images of MgO composites show smoother surfaces compared to MgZnO composites. This may be one of the reasons for the increased EE% and drug release of MgZnO composites. The addition of ZnO to the composite structure can lead to the appearance of pores on the surface of the composite, increasing entrapment and drug release.

Silver doped zinc oxide nanoparticles (ZANPs) were synthesized by the gelatin mediated and polymerized sol-gel method, and a calcination temperature of 700 °C was applied for 2 h. X-ray diffraction (XRD), FESEM, TGA, DSC, and EDS were performed to study the structure of the prepared nano-powders. Both cubic silver and hexagonal ZnO diffraction peaks were detected in the XRD patterns. The XRD results, analyzed by the size strain plot (SSP) and Scherrer methods, showed that the crystalline sizes of these nanoparticles increased as the Ag concentration increased. The results were observed via transition electron microscopy (TEM), where the particle size of the prepared samples was increased in the presence of silver. Catechin was chosen as a drug model and was loaded into the hydrogels for release studies. The drug content percentage of catechin in the hydrogels showed a high loading of the drug, and the highest rate was 98.59 ± 2.11%, which was attributed to the Zn_0.97Ag_0.03O hydrogels. The swelling of the samples and in vitro release studies were performed. The results showed that Zn_0.91Ag_0.09O showed the highest swelling ratio (68$\pm$ 3.40%) and, consequently, the highest release (84$\pm 2.18\%$) within 300 min. The higher amount of silver ions in the hydrogel structure causes it to enhance the osmotic pressure of the inner structure and increases the relaxation of the structure chain.