Black cumin, or Nigella sativa, is a medicinal plant that is extensively recognised and used on a global scale. This study examines the historical use of black seed in both traditional and modern medicine, as well as its antibacterial, antifungal, antiviral, and anti-parasitic properties. Methods: Data were collected by employing a variety of reputable scientific search engines, such as Google Scholar, ScienceDirect, Taylor & Francis, and Wiley Library…etc. The data was processed and analysed by the author's team to reach the following conclusion: We strongly encourage medical personnel to investigate the integrated application of black cumin as a therapeutic agent alongside contemporary compounds, given the comprehensive antimicrobial efficacy of black seed against pathogenic bacteria, viruses, fungi, and parasites. ABSTRAK Jintan hitam, atau Nigella sativa, merupakan tanaman obat yang dikenal luas dan digunakan dalam skala global. Studi ini meneliti penggunaan jintan hitam secara historis dalam pengobatan tradisional dan modern, serta khasiatnya sebagai antibakteri, antijamur, antivirus, dan antiparasit. Data dikumpulkan dengan menggunakan berbagai mesin pencari ilmiah terkemuka, seperti Google Scholar, ScienceDirect, Taylor & Francis, dan Wiley Library…dll. Data tersebut diproses dan dianalisis oleh tim penulis untuk mencapai kesimpulan berikut: Kami sangat menganjurkan tenaga medis untuk menyelidiki aplikasi terpadu jintan hitam sebagai agen terapeutik bersama senyawa kontemporer, mengingat khasiat antimikroba jintan hitam yang komprehensif terhadap bakteri patogen, virus, jamur, dan parasit.

Ahmed A. Rawwash, Emad Ahmed Fathy Hussein, Omar Mohammad Atta. J Pharmacopuncture 2025;28:255-68. https://doi.org/10.3831/KPI.2025.28.4.255

Zamzam water, originating from the well in Mecca, Saudi Arabia, holds significant spiritual and health-related importance for Muslims worldwide. This systematic review synthesizes existing literature on its chemical composition, therapeutic benefits, mechanisms of action, and safety. Key findings indicate that Zamzam water contains elevated levels of essential minerals all within permissible limits set by international regulatory agencies like the World Health Organization (WHO) and the United States Environmental Protection Agency (US EPA). Its alkaline pH and rich mineral profile contribute to its antioxidant properties, supporting hyperglycemia control, renal protection, cancer prevention, dental health, wound healing, and immune modulation. Despite concerns about heavy metals and nitrates, rigorous testing confirms its safety for consumption. Further research is needed to fully understand its unique characteristics and potential nutraceutical benefits.

A honey's quality is determined mostly by the activity of its enzymes. The objective of this work is to compare the quality of seven kinds of honey from three countries by measuring the activity of diastase enzyme activity number using UV / VIS Spectroscopy devices. All types are found all over the Kingdom of Saudi Arabia markets. These types were represented by Sidr honey; Saudi Sidr honey (wild and south), Yemen Sidr honey Kashmiri Sidr honey, and Talh honey including Saudi Talh and Yemen Talh honey. Black acacia honey was included Saudi type only. The obtained result revealed a remarkably significant increase in the average value of diastase number (DN) activity (estimated by using UV / VIS Spectroscopy devices) in Saudi Talh honey (STH) and Saudi Sidr wild honey (SSWH) were 70.66, 60.13 respectively. However, the average DN activity in Saudi Sidr South honey (SSSH) had approximately the half number of SSWH (32.16), while the DN activity of Saudi black acacia (SBAH) and Yemen Talh honey (YTH) was approximately the same (26.74,24,53) respectively. The lowest average value of DN activity was recorded in Yemen Sidr honey (YSH) and Kashmiri Sidr honey (17.17, 17.4) respectively. In conclusion, STH and SSWH have the greatest DN activity which reflects their potential vital role among different kinds of honey in K.S.A. The DN activity is necessary to enhance the nutritional the honey.

Hantaviruses (HTVs) are lethal zoonotic pathogens responsible for hemorrhagic fever with renal syndrome and HTV cardiopulmonary syndrome; however, no specific antiviral treatments or vaccines have been approved. Bee products, such as propolis, honey, royal jelly, bee venom, and bee pollen, demonstrate extensive antiviral, anti-inflammatory, antioxidant, and immunomodulatory properties against various RNA and DNA viruses. No published research has directly evaluated bee products in relation to HTV infection. This review proposes a hypothesis-driven mechanistic framework suggesting that bioactive compounds from bee products may concurrently inhibit HTV replication, alleviate the cytokine storm, diminish oxidative stress, and maintain endothelial barrier integrity. We explicitly recognize the lack of direct experimental evidence regarding bee products’ efficacy against HTVs. Considering the mechanistic similarities with other enveloped viral infections and the recognized functions of NF-κB, Nrf2, and endothelial signaling pathways in HTV pathogenesis, we present a scientifically substantiated rationale for forthcoming research endeavors. The diverse bioactive compounds present in bee products including bee pollen, bee venom, honey, propolis, and royal jelly could provide a multifaceted strategy for inhibiting HTV pathology. We propose systematic in vitro, in silico, and in vivo investigations to assess the potential of bee-derived flavonoids, peptides, and fatty acids as adjunctive therapeutic strategies for HTV disease.