Biodesign holds the potential for radically increasing the sustainability of the built environment and our material culture but comes with new challenges. One of these is the bridging of the vast differences of scale between microbiological processes and architecture. We propose that a transcalar design approach, which weaves together nonlinear dependencies using computational design tools and design methodologies through the biological generation of architectural components, is a way towards successful design implementations. Such design processes were explored in a laboratory-based fabrication and study of a column element. This column, named Protomycokion, serves to illustrate how design methodologies, particularly through the use of a demonstrator artefact, can serve to navigate the multiple scales, disciplines, and experiments that are necessary to engage the complexities of biodesign. Transcalar design processes embrace the adaptability, variability and interdependence of biological organisms and show possible gains with regard to material sustainability and increased performativity.

Biomaterials represent a potential means for the construction industry to reduce its negative ecological impact. These materials require substantially different approaches from conventional construction materials to maximise their potential. In this paper we have outlined four principles of biological design that we argue are central for the successful implementation of a new construction paradigm through biodesign. These principles are: Diversity, complexity and specificity (of form), durability through resilience, and feedback and adaptation. Diversity of material is necessary to maintain the sustainability of biomaterials when scaled up to construction industry volumes. Complexity and specificity of form enable high performativity of the built environments when using low-impact materials. Durability through resilience allows designers to work with materials that would otherwise be considered too weak. Finally, feedback and adaptation are core principles of biological design that allow plants and animals to constantly evolve in response to changing conditions, across multiple time scales, and to manage design in complex systems. In conclusion we have argued that many of these principles are found in vernacular architectural traditions, but that emerging design and fabrication technologies can enable broader implementation that can combine the benefits of modern and vernacular buildings practice.