Andrei Nicolau

Dr. Andrei Nicolau

UMF Grigore T Popa Iasi, Iaşi, Romania
orcid

Research Focus & Metrics

Academic Career Length

8Years (2019-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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21 April 2022 in Medicina
Verified
Journal Article
Open access
PDF file
ACAlexandra Carp
Alexandra Carp
ANAndrei Nicolau
Andrei Nicolau
MMMihaela Moscalu
Mihaela Moscalu
EPEugenia Popescu
Eugenia Popescu
Background: Oral squamous cell carcinoma (OSCC) registered an alarming fall in the average age of individuals diagnosed in the last decade. Objectives: The aim of our study is to assess the main risk factors for OSCC specific to Romania and to identify patients at risk for this pathology. The purpose is to implement in the future a screening and early diagnosis program for OSCC in our country. Materials and Methods: A ten-year case-control study was conducted on patients selected from “St. Spiridon” Hospital-Iaşi, Romania. The study contained 1780 individuals diagnosed with oral squamous cell carcinoma. Results: For the patients under 46 years old: APC = −2.8 percent (95% CI: −24.4 to −7.1; p = 0.0012), with the observed rate of 30.18 percent. The incidence increased in patients aged 46 to 49 years (APC = 9.6%; 95% CI: 6.7 to −10.4; p = 0.0081). For the age group 49 to 64 years old: APC = −2.4 percent (95% CI: −5.3 to −1.6, p = 0.1239). For the age group 64–74: APC = −4.6, (95% CI: 1.4 to 6.9, p = 0.0108). The incidence of incidents was lower in the age group 74–80 (p = 0.0025). For the age group 80–91: APC = 8.1 (95% CI: 6.4 to 14.2, p = 0.0024), with the incidence of cases: APC = 8.1 (95% CI: 6.4 to 14.2, p = 0.0024). Univariate analysis revealed a substantially higher risk of developing oral carcinoma in males (OR = 4.43; CI: 3.84 to 5.80). Age above 60, cigarette usage and alcohol abuse are significant risk factors for OSCC. Patients with lymph node dissemination, ulcero-vegetant form, stages II and IV, whose therapeutic approach consisted of radiotherapy and chemotherapy or radiotherapy only had a worse rate of survival at 24 months post-therapy. Conclusions: Our study highlights the increase in the incidence of OSCC in Romania during the research period, the decrease in the average age of diagnosed patients, as well as the degree to which the studied population is exposed to the main risk factors specific to this geographical area.

9 April 2025 in Medicina
Verified
Journal Article
Open access
PDF file
AAAdina Oana Armencia
Adina Oana Armencia
IBIrina Bamboi
Irina Bamboi
BTBianca Tiron
Bianca Tiron
ARAnca Rapis
Anca Rapis
ANAndrei Nicolau
Andrei Nicolau
Tinela PanaiteTinela Panaite
Tinela Panaite
Background and Objectives: Dental anxiety influences quality of life, causing emotional and physical discomfort. The aim of this study was to identify the prevalence of dental anxiety among young adults and how it influences the dimensions of quality of life, especially in terms of physical and psychological health. Material and Methods: This study was conducted between March and July 2024, within the Community Dentistry Discipline at the “Grigore T. Popa” University of Medicine and Pharmacy in Iași, on a group of 180 students to assess dental anxiety and its impact on their quality of life. Participants completed questionnaires using scales such as the IDAF, DAS-R CORAH, and WHOQOL-BREF. Results: Most participants presented a moderate level of dental anxiety, with 59.4% without anxiety and 6.1% with severe anxiety. Significant correlations were established between dental anxiety and physical and psychological dimensions of quality of life. In contrast, there were no significant correlations between dental anxiety and social relationships or the environment. Anxiety and fear were negatively correlated with perceived physical well-being, but positive correlations were also identified between sensitivity to dental stimuli and more favorable perceptions of physical and psychological health. Discussion: Dental anxiety has a significant impact on patients’ physical and psychological health, especially on their perception of their well-being. This study confirms previous research showing that dental anxiety is related to certain dental procedures. Conclusions: Dental anxiety has a significant impact on psychological and physical perception but does not significantly affect social interactions.

1 August 2025 in Medicina
Verified
Journal Article
Open access
PDF file
AAAdina Oana Armencia
Adina Oana Armencia
ANAndrei Nicolau
Andrei Nicolau
IBIrina Bamboi
Irina Bamboi
BTBianca Tiron
Bianca Tiron
ARAnca Rapis
Anca Rapis
CBCarina Balcoş
Carina Balcoş
Students, particularly those in the medical field, are exposed to various stressors that can affect their health-related behaviors, including smoking habits, with implications for oral health and quality of life. Background and Objectives: to analyze the relationship between smoking, oral health, perceived stress level, and self-assessed quality of life in a sample of dental students. Materials and Methods: The cross-sectional study included 338 students, who completed validated questionnaires and were clinically examined. Lifestyle was assessed using a smoking behavior questionnaire, stress levels were measured with the Student Stress Inventory (SSI), and quality of life was evaluated using the EQ-5D-5L instrument. The DMFT index was calculated to determine oral health status. Results: Among the 338 participating students, 53.8% were smokers. The lifestyle analysis revealed slightly higher average scores among non-smokers across all domains—social (3.26 vs. 3.09), attitudinal (2.75 vs. 2.97), and behavioral (3.82 vs. 3.49), but without statistically significant differences (p > 0.25). The mean DMFT score was 12.48, with no significant differences between smokers and non-smokers (p = 0.554). The SSI total score averaged 83.15, indicating a moderate level of perceived stress, again with no statistically significant differences between the groups (p > 0.05). However, slightly higher average stress scores among smokers may suggest the use of smoking as a coping mechanism. In contrast, quality of life as measured by EQ-5D-5L showed significantly worse outcomes for smokers across all five dimensions, including mobility (78.6% vs. 95.5%, p = 0.000) and self-care (93.4% vs. 100%, p = 0.001). Multivariable logistic regression identified smoking (OR = 1.935; p = 0.047) and moderate stress levels (OR = 0.258; p < 0.001) as independent predictors of oral health status. Conclusions: The results obtained suggest that smoking may function as a stress management strategy among students, supporting the relevance of integrating specific psychobehavioral interventions that address stress reduction and oral health promotion among student populations.

24 March 2022 in Diagnostics
Verified
Journal Article
Open access
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SMStefana Maria Moisa
Stefana Maria Moisa
ANAndrei Nicolau
Andrei Nicolau
RBRaluca-Daniela Balcan
Raluca-Daniela Balcan
IMIngrith Miron
Ingrith Miron
ELENA TARCAELENA TARCA
ELENA TARCA
LTlaura trandafir
laura trandafir
Pediatric sialolithiasis is a rare condition causing tumefaction, induration, redness, and pain of the affected gland. When the submandibular gland is involved, the lesion can be mistaken for an adenopathy. As there are few studies to elucidate this condition in children, we present a rare case of a 16-year-old female with suggestive symptoms, in which initial clinical examination and two ultrasound examinations mistook the lesion for an adenopathy. A computed tomography examination was performed and the correct diagnosis was established. The patient was sent for oro-maxilo-facial examination and sialolithotomy was performed. A 10-mm yellow calculus was extracted and postoperative case evolution was favorable under wide spectrum antibiotherapy, oral nonsteroidal anti-inflammatory therapy and silagog alimentation. Although submandibular adenopathies are much more frequent in the pediatric age group, when faced with a firm, immobile submandibular lesion, the pediatrician should consider the sialolithiasis diagnosis.

15 July 2026 in Dentistry Journal
Verified
Journal Article
Open access
PDF file
AAAdina Oana Armencia
Adina Oana Armencia
RVRoxana-Ionela Vasluianu
Roxana-Ionela Vasluianu
ANAndrei Nicolau
Andrei Nicolau
SMScutariu Mihaela Monica
Scutariu Mihaela Monica
MMmurariu_alice MURARIU
murariu_alice MURARIU
CBCarina Balcoş
Carina Balcoş
Background/Objectives: Health literacy is closely related to preventive behaviors, but its connection with actual oral health practices is still not fully clear, especially in the digital context. This study aimed to assess the association between general health literacy, digital oral health literacy, and oral health behaviors among dental medicine students. Methods: An observational cross-sectional study was conducted on a sample of 304 students. General health literacy was assessed using HLS-EU-Q16, digital oral health literacy using SMOHLQ, and oral health behaviors using HU-DBI. Statistical analyses included descriptive statistics, Spearman correlations, and linear regression models. Results: Oral health behaviors were moderate, while general literacy ranged from problematic to adequate, and digital literacy was high. No significant associations were identified between general health literacy and oral health behaviors (p > 0.05). Digital oral health literacy showed weak negative correlations with behaviors (r = −0.136, p = 0.018). Place of residence was a significant predictor (β = −0.394, p < 0.001), with the model explaining 16.2% of the variance. Conclusions: In this sample of dental medicine students, health literacy was not clearly related to better oral health behaviors. Digital oral health literacy was generally high, but its association with oral health behaviors was weak. Place of residence was associated with oral health behaviors, suggesting that preventive educational approaches for dental medicine students should also consider contextual factors.

13 April 2026 in Dentistry Journal
Verified
Journal Article
Open access
PDF file
AAAdina Oana Armencia
Adina Oana Armencia
ANAndrei Nicolau
Andrei Nicolau
LFLaurian Lucian Francu
Laurian Lucian Francu
GPGalina Pancu
Galina Pancu
RVRoxana-Ionela Vasluianu
Roxana-Ionela Vasluianu
SBStefan Lucian Burlea
Stefan Lucian Burlea
Background/Objectives: Online environment and social media platforms have become major sources of health information, influencing behaviors and decision-making related to oral health. The Aim of This Study was to culturally adapt and psychometrically validate the Romanian version of the Social Media Oral Health Literacy Questionnaire (SMOHLQ) and to assess oral health literacy levels among dental students. Material and Methods: An observational cross-sectional study was conducted among 304 fourth- and fifth-year dental students. The Romanian version of the SMOHLQ underwent cultural adaptation and psychometric evaluation using descriptive statistics, exploratory factor analysis (principal axis factoring with oblimin rotation), Cronbach’s alpha coefficient, intraclass correlation coefficient (ICC), Pearson correlations, and ANOVA analysis. Results: Exploratory factor analysis confirmed a three-dimensional structure consisting of access and understanding, critical appraisal, and behavioral impact domains. Internal consistency was high for the overall scale (Cronbach’s α = 0.856) and good across subscales (α = 0.744–0.836). Pearson correlations showed significant associations between dimensions (r = 0.162–0.603, p < 0.001). ICC values indicated good score stability. ANOVA analyses revealed significant differences across demographic subgroups (p < 0.05). Mean scores were higher for cognitive dimensions (MS = 4.20–4.54) compared with behavioral impact (MS = 2.87). Conclusions: The Romanian version of the SMOHLQ demonstrated satisfactory psychometric properties, supporting its reliability and construct validity as a tool for assessing digital oral health literacy in the context of social media use.