Since 2013, China has implemented a series of strict Air Pollution Control Strategies (APCS) to mitigate environmental and health risks associated with ambient fine particulate matter (PM_2.5). However, while APCS sets clear targets for PM_2.5 concentration, it lacks quantitative control over O₃ levels. Most existing studies have focused on nation-wide health assessments. Therefore, by conducting a coupled framework using health assessment and decomposition method, the spatiotemporal variation in deaths attributable to PM_2.5 pollution, as well as the role of APCS and the synergies between PM_2.5 and O₃ on PM_2.5 concentration and health impacts in the Beijing-Tianjin-Hebei (BTH) region have been explored. The result showed that: (1) PM_2.5 concentration in the BTH region decreased by 68.2%, with a reduction of 45,833 (95% Confidence Interval [CI]: 33,808, 50,069) deaths over the period. However, both concentrations and mortality remained high, indicating a need for faster reductions. (2) End-of-pipe control contributed the most to reducing PM_2.5 concentrations and deaths, though the gaps between source control and end-of-pipe control is narrowing. (3) The synergistic effects of O₃ and PM_2.5 in reducing concentration and mortality have increased, becoming a significant driver of PM_2.5-related health impacts. Our study emphasizes the future importance of implementing refined, diverse emission reduction measures and coordinating efforts to reduce both O₃ and PM_2.5 emissions, which are crucial for achieving the Sustainable Development Goals (SDGs) and advancing the "Beautiful China" and "Healthy China" initiatives.