Emmanuel Frimpong Gyekye

Mr. Emmanuel Frimpong Gyekye

Epidemiology, Noguchi Memorial Institute for Medical Research, Accra, Greater Accra, Ghana
+1
orcid

Research Focus & Metrics

Academic Career Length

2Years (2025-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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1 January 2025 in BioMed Research International
Verified
Journal Article
Open access
JKJonathan Klutse
Jonathan Klutse
YTYeena Abla Tay
Yeena Abla Tay
DADzidzor Aku Attoh
Dzidzor Aku Attoh
Emmanuel Frimpong GyekyeEmmanuel Frimpong Gyekye
Emmanuel Frimpong Gyekye
CBCharlotte Borteley Bortey
Charlotte Borteley Bortey
EBEvelyn Yayra Bonney
Evelyn Yayra Bonney
Cervical cancer is preventable; however, it remains the leading cause of death in low‐ and middle‐income countries (LMICs). Women with HIV (WWHs) have a sixfold higher risk of developing and dying from cervical cancer than women without HIV. Cervical cancer can be prevented by vaccination against high‐risk human papillomaviruses (hrHPVs) and by screening for and treating precancer cervical lesions. While these preventive measures are routinely available to WWHs in developed countries, they are lacking in most LMICs, where the burden of HIV and cervical cancer is the highest. To prevent cervical cancer deaths among WWHs in LMICs, it is imperative to determine the dual burden of HIV and cervical cancer in LMICs. This narrative review synthesized scientific papers and policy documents on the intersection of HIV and cervical cancer in LMICs published between August 2006 and July 2025. We searched PubMed, Scopus, Web of Science, and Google Scholar for articles and official reports from the World Health Organization (WHO) and the US Centers for Disease Control and Prevention (CDC) on cervical cancer burden, prevention strategies, barriers, and outcomes among WWHs. Despite its proven effectiveness, HPV vaccination coverage in LMICs is under 30%, and screening uptake is below 20%. Weak health systems, workforce shortages, stigma, reliance on donor funding, and late‐stage case presentation are major challenges in curbing cervical cancer in LMICs. Urgent political commitment is required to integrate precancer screening and HPV testing into routine HIV care and scale‐up HPV vaccination to achieve the WHO′s triple‐intervention targets to eliminate cervical cancer among WWHs in LMICs.

28 March 2025 in Viruses
Verified
Journal Article
Open access
PDF file
ELELVIS SUATEY LOMOTEY
ELVIS SUATEY LOMOTEY
JAJewelna Akorli
Jewelna Akorli
MOMillicent Opoku
Millicent Opoku
DODaniel Adjei Odumang
Daniel Adjei Odumang
KNKojo Nketia
Kojo Nketia
IDIrene Owusu Donkor
Irene Owusu Donkor
A significant proportion of SARS-CoV-2 infections in Africa were identified as asymptomatic. With the surge of the Omicron variant, asymptomatic participants in epidemiological surveys were key to accurately estimating seroprevalence and true infections in the population. This study assessed seroprevalence, active infections, and circulating variants in Accra, Ghana, during the Omicron wave. Secondary objectives included assessing the association between seroprevalence and sociodemographic factors, vaccination, and adherence to recommended SARS-CoV-2 prevention and control measures. We conducted a cross-sectional survey in Greater Accra in December 2021 using a standardized questionnaire. Serum and naso-oropharyngeal swab samples were collected from 1027 individuals aged ≥ 5 years for the estimation of total antibodies and detection of infection. The study found an overall seroprevalence of 86.8% [95% CI: 84.53–88.77]. PCR test positivity of SARS-CoV-2 was 10%, with the Omicron and Delta variants accounting for 44.1% and 8.8% of infections, respectively. Vaccination (cOR = 10.5, 95% CI: 4.97–26.9, p < 0.001) and older age, particularly the 60+ age group (cOR = 6.05, 95% CI: 2.44–20.2, p < 0.001), were associated with an increase in odds of seropositivity among participants. High seropositivity of SARS-CoV-2 in Accra was an indication of high exposure and transmission rates and/or high vaccine-induced seroprevalence.

29 June 2026 in Research Square
Verified
Preprint
Open access
PDF file
GGGrace Opoku Gyamfi
Grace Opoku Gyamfi
YAYvonne A Ashong
Yvonne A Ashong
MOMillicent Opoku
Millicent Opoku
MAMillicent Selassie Afatodzie
Millicent Selassie Afatodzie
Emmanuel Frimpong GyekyeEmmanuel Frimpong Gyekye
Emmanuel Frimpong Gyekye
DSDziedzom De Souza
Dziedzom De Souza
Background Strongyloidiasis, caused by Strongyloides spp ., is a neglected tropical disease with significant but underreported public health impact. In Ghana, particularly in the Volta and Oti regions, data on prevalence is limited due to inadequate surveillance and low sensitivity diagnostics. Methods This cross-sectional study analyzed 1,392 archived human stool samples from seven communities across three districts (Adaklu, Hohoe, Nkwanta North). Samples were pooled (up to 10 per pool) for DNA extraction and PCR targeting the 18S rRNA gene. Positive pools were unpooled for individual testing. Results Overall pooled prevalence was 7.2% (95% CI: 5.5–9.3), while individual prevalence was 18.5% (95% CI: 16.5–20.6), with notable variation across communities. Lancha (27.9%) and Dawanu (27.4%) showed the highest rates. Logistic regression found no significant associations with sex, age, or district. Conclusion The pooling strategy proved sensitive and resource efficient, supporting its use in Strongyloides surveillance. This study highlights the need for sensitive diagnostics and integrated surveillance to guide targeted public health interventions.

EOEdmond Kwaku Ocloo
Edmond Kwaku Ocloo
AAAdwoa Asante-Poku
Adwoa Asante-Poku
ISIshaque Mintah Siam
Ishaque Mintah Siam
Nii Arku LaryeaNii Arku Laryea
Nii Arku Laryea
Emmanuel Frimpong GyekyeEmmanuel Frimpong Gyekye
Emmanuel Frimpong Gyekye
MYMichelle Korama Yeboah-Manu
Michelle Korama Yeboah-Manu
Introduction: Tuberculosis [TB] and diabetes mellitus (DM) remain major public health concerns worldwide. TB negatively affects an individual’s glucose tolerance, increasing the risk of developing DM. Similarly, DM reduces the host’s ability to fight TB infection and increases the likelihood of developing TB and poor response to TB medication. This study analysed stigma and health-seeking behaviour in a sub-district of Accra Metropolis. Methods: We used a mixed-methods research approach involving a cross-sectional survey and in-depth interviews to explore community knowledge, stigma, and health-seeking behaviour related to TB and DM. A total of 437 individuals were selected for a survey using a simple random sampling technique, while 22 participants, including three TB patients, four nurses, one medical doctor, four students from a nursing and midwifery school, five students from a school of hygiene, and five community members, were involved in the study. Healthcare providers and patients were purposively selected, while students and community members were recruited through convenience sampling. Descriptive and logistic regression analyses were performed on the quantitative data using STATA, while the qualitative data were thematically analysed using the MAXQDA software. Results: Participants’ age, sex, and educational levels were significantly associated with their knowledge of TB and DM. Males were 0.600 times as likely as females to be knowledgeable about DM (95% CI: 0.386–0.934, p = 0.024). Social determinants of health, such as poverty, local beliefs, stigma, and negative attitudes from healthcare workers, may influence TB patients’ preference for traditional remedies over biomedical treatment. Conclusion: Therefore, we observed that addressing cultural barriers, stigma, and financial costs related to TB and diabetes care will help increase patients’ willingness for biomedical treatment.

21 August 2026 in BMC Infectious Diseases
Verified
Journal Article
Open access
PDF file
GGGrace Opoku Gyamfi
Grace Opoku Gyamfi
YAYvonne A Ashong
Yvonne A Ashong
MOMillicent Opoku
Millicent Opoku
MAMillicent Selassie Afatodzie
Millicent Selassie Afatodzie
Emmanuel Frimpong GyekyeEmmanuel Frimpong Gyekye
Emmanuel Frimpong Gyekye
DSDziedzom De Souza
Dziedzom De Souza
Background: Strongyloidiasis, caused by Strongyloides spp., is a neglected tropical disease with significant but underreported public health impact. In Ghana, particularly in the Volta and Oti regions, data on prevalence is limited due to inadequate surveillance and low sensitivity diagnostics. Methods: This cross-sectional study analyzed 1,392 archived human stool samples from seven communities across three districts (Adaklu, Hohoe, Nkwanta North). Samples were pooled (up to 10 samples per pool) for DNA extraction and PCR targeting the 18 S rRNA gene. Samples from positive pools were tested individually. Results: Overall pooled prevalence was 7.2% (95% CI: 5.5–9.3), while individual prevalence was 18.5% (95% CI: 16.5–20.6), with notable variation across communities. Lancha (27.9%) and Dawanu (27.4%) showed the highest rates. Logistic regression found no significant associations with sex, age, or district. Conclusion: The pooling strategy proved sensitive and resource efficient, supporting its use in Strongyloidiasis surveillance, despite underestimating the prevalence of infection. This study highlights the need for sensitive diagnostics and integrated surveillance to guide targeted public health interventions.