Worldwide, the coronavirus has intensified the management problems of health services, significantly harming patients. Some of the most affected processes have been cancer patients’ prevention, diagnosis, and treatment. Breast cancer is the most affected, with more than 20 million cases and at least 10 million deaths by 2020. Various studies have been carried out to support the management of this disease globally. This paper presents a decision support strategy for health teams based on machine learning (ML) tools and explainability algorithms (XAI). The main methodological contributions are: first, the evaluation of different ML algorithms that allow classifying patients with and without cancer from the available dataset; and second, an ML methodology mixed with an XAI algorithm, which makes it possible to predict the disease and interpret the variables and how they affect the health of patients. The results show that first, the XGBoost Algorithm has a better predictive capacity, with an accuracy of 0.813 for the train data and 0.81 for the test data; and second, with the SHAP algorithm, it is possible to know the relevant variables and their level of significance in the prediction, and to quantify the impact on the clinical condition of the patients, which will allow health teams to offer early and personalized alerts for each patient.

Currently, in Chile, more than a quarter-million of patients are waiting for an elective surgical intervention. This is a worldwide reality, and it occurs as the demand for healthcare is vastly superior to the clinical resources in public systems. Moreover, this phenomenon has worsened due to the COVID-19 sanitary crisis. In order to reduce the impact of this situation, patients in the waiting lists are ranked according to a priority. However, the existing prioritization strategies are not necessarily systematized, and they usually respond only to clinical criteria, excluding other dimensions such as the personal and social context of patients. In this paper, we present a decision-support system designed for the prioritization of surgical waiting lists based on biopsychosocial criteria. The proposed system features three methodological contributions; first, an ad-hoc medical record form that captures the biopsychosocial condition of the patients; second, a dynamic scoring scheme that recognizes that patients’ conditions evolve differently while waiting for the required elective surgery; and third, a methodology for prioritizing and selecting patients based on the corresponding dynamic scores and additional clinical criteria. The designed decision-support system was implemented in the otorhinolaryngology unit in the Hospital of Talca, Chile, in 2018. When compared to the previous prioritization methodology, the results obtained from the use of the system during 2018 and 2019 show that this new methodology outperforms the previous prioritization method quantitatively and qualitatively. As a matter of fact, the designed system allowed a decrease, from 2017 to 2019, in the average number of days in the waiting list from 462 to 282 days.

Patient satisfaction and operational efficiency are critical in healthcare. Long waiting times negatively affect patient experience and hospital performance. Addressing these issues requires accurate system time predictions and actionable strategies. This paper presents a hybrid framework combining predictive modeling and optimization to reduce system times and enhance satisfaction, focusing on registration, vitals, and doctor consultation. We evaluated three predictive models: multiple linear regression (MLR), log-transformed regression (LTMLR), and artificial neural networks (ANN). The MLR model had the best performance, with an $R^2$ of 0.93, an MAE of 7.29 min, and an RMSE of 9.57 min. MLR was chosen for optimization due to its accuracy and efficiency, making it ideal for implementation. The hybrid framework combines the MLR model with a simulation-based optimization system to reduce waiting and processing times, considering resource constraints like staff and patient load. Simulating various scenarios, the framework identifies key bottlenecks and allocates resources effectively. Reducing registration and doctor consultation wait times were identified as primary areas for improvement. Efficiency factors were applied to optimize waiting and processing times. These factors include increasing staff during peak hours, improving workflows, and automating tasks. As a result, registration wait time decreased by 15%, vitals by 20%, and doctor consultation by 25%. Processing times improved by 10–15%, leading to an average reduction of 22.5 min in total system time. This paper introduces a hybrid decision support system that integrates predictive analytics with operational improvements. By combining the MLR model with simulation, healthcare managers can predict patient times and test strategies in a risk-free, simulated environment. This approach allows real-time decision-making and scenario exploration without disrupting operations. This methodology highlights how reducing waiting times has a direct impact on patient satisfaction and hospital operational efficiency, offering an applicable solution that does not require significant structural changes. The results are practical and implementable in resource-constrained healthcare environments, allowing for optimized staff management and patient flow.

Pharmacy inventory management is a critical process in healthcare centers. On the one hand, effective drug procurement is fundamental for fulfilling the therapeutic requirements of patients. On the other hand, as hospital pharmacies’ purchasing and storage costs comprise an important share in the hospital budgets, efficient inventory management may play a central role in operational cost containment. Therefore, healthcare centers should design and implement decision-aid strategies for planning the purchase of drugs with the aim of avoiding excessive purchasing volumes and optimizing warehouse capacity, while also meeting forecast demand and ensuring critical stock levels. In this study, we present the methodological features of a decision-aid tool for planning the purchases and inventory levels for the controlled medication pharmacy of the Regional Hospital of Talca, Chile. We report the results obtained after 1 year of operation; these results show that our strategy produced more than 7% savings compared to the regular inventory planning strategy and was more effective in preserving critical stock levels. Furthermore, from a computational point of view, our strategy outperforms a recently published approach for a similar application.