Félix Machín

Dr. Félix Machín

Unidad de Investigación, Hospital Universitario Nuestra Señora de Candelaria, Santa Cruz de Tenerife, Spain
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Research Focus & Metrics

Academic Career Length

26Years (2001-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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6 August 2006 in Nature Cell Biology
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Journal Article
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GPGiacomo De Piccoli
Giacomo De Piccoli
FCFelipe Cortes-Ledesma
Felipe Cortes-Ledesma
GIGregory Ira
Gregory Ira
JTJordi Torres-Rosell
Jordi Torres-Rosell
SUStefan Uhle
Stefan Uhle
LALuis Aragón
Luis Aragón

27 March 2005 in Nature Cell Biology
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Journal Article
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JTJordi Torres-Rosell
Jordi Torres-Rosell
Félix MachínFélix Machín
Félix Machín
SFSarah Farmer
Sarah Farmer
AJAdam Jarmuz
Adam Jarmuz
TETrevor Eydmann
Trevor Eydmann
LALuis Aragón
Luis Aragón

9 March 2007 in Science
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Journal Article
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JTJordi Torres-Rosell
Jordi Torres-Rosell
GPGiacomo De Piccoli
Giacomo De Piccoli
VCVioleta Cordon-Preciado
Violeta Cordon-Preciado
SFSarah Farmer
Sarah Farmer
AJAdam Jarmuz
Adam Jarmuz
LALuis Aragón
Luis Aragón
Cellular checkpoints prevent mitosis in the presence of stalled replication forks. Whether checkpoints also ensure the completion of DNA replication before mitosis is unknown. Here, we show that in yeast smc5-smc6 mutants, which are related to cohesin and condensin, replication is delayed, most significantly at natural replication-impeding loci like the ribosomal DNA gene cluster. In the absence of Smc5-Smc6, chromosome nondisjunction occurs as a consequence of mitotic entry with unfinished replication despite intact checkpoint responses. Eliminating processes that obstruct replication fork progression restores the temporal uncoupling between replication and segregation in smc5-smc6 mutants. We propose that the completion of replication is not under the surveillance of known checkpoints.

21 January 2009 in Nature
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ABAndrés Clemente Blanco
Andrés Clemente Blanco
MMMaria D. Mayan
Maria D. Mayan
DSDavid Schneider
David Schneider
Félix MachínFélix Machín
Félix Machín
AJAdam Jarmuz
Adam Jarmuz
LALuis Aragón
Luis Aragón

25 September 2008 in Journal of Medicinal Chemistry
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Journal Article
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SJSandra Jiménez-Alonso
Sandra Jiménez-Alonso
HCHaydee Chavez
Haydee Chavez
Ana Estévez-BraunAna Estévez-Braun
Ana Estévez-Braun
ARAngel G. Ravelo
Angel G. Ravelo
EPElisa Pérez-Sacau
Elisa Pérez-Sacau
Félix MachínFélix Machín
Félix Machín

2 April 2004 in Cell Cycle
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Journal Article
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JTJordi Torres-Rosell
Jordi Torres-Rosell
Félix MachínFélix Machín
Félix Machín
AJAdam Jarmuz
Adam Jarmuz
LALuis Aragón
Luis Aragón
In order to transmit a full genetic complement cells must ensure that all chromosomes are accurately split and distributed during anaphase. Chromosome XII in S. cerevisiae contains the site of nucl...