Let be a unital ∗-algebra containing a nontrivial projection P. In this paper, we introduce the notion of a nonlinear mixed skew Jordan-type derivation (that is, , where and for all ) and show that if a map : satisfies , for all and all , then is an additive ∗-derivation. Furthermore, we generalize this result to higher derivable maps on . As applications, the above result is applied to several special classes of unital ∗-algebras such as prime ∗-algebras, factor von Neumann algebras and standard operator algebras.