Non-steroidal anti-inflammatory drugs (NSAIDs) are one of the most widely used classes of medicines in the treatment of inflammation, fever, and pain. However, evidence has demonstrated that these drugs can induce significant toxicity. In the search for innovative strategies to overcome NSAID-related problems, the incorporation of drugs into cyclodextrins (CDs) has demonstrated promising results. This study aims to review the impact of cyclodextrin incorporation on the biopharmaceutical and pharmacological properties of non-steroidal anti-inflammatory drugs. A systematic search for papers published between 2010 and 2020 was carried out using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) protocol and the following search terms: “Complexation”; AND “Cyclodextrin”; AND “non-steroidal anti-inflammatory drug”. A total of 24 different NSAIDs, 12 types of CDs, and 60 distinct inclusion complexes were identified, with meloxicam and β-CD appearing in most studies. The results of the present review suggest that CDs are drug delivery systems capable of improving the pharmacological and biopharmaceutical properties of non-steroidal anti-inflammatory drugs.

Objetivo: Analisar a faceta que avalia a Qualidade de Vida (QV) geral do instrumento WHOQOL-BREF em indivíduos após hospitalização por COVID-19 em município do sudeste de Mato Grosso. Metodologia: Estudo prospectivo, transversal e de abordagem quantitativa com indivíduos hospitalizados por COVID-19 admitidos em um hospital municipal de referência para doença em Rondonópolis, MT. Os dados foram coletados por meio de instrumento semi-estruturado, de junho a dezembro de 2022. Para avaliar a QV geral, foi utilizado o instrumento WHOQOL-BREF. Para avaliar os fatores associados à QV geral aplicou-se um modelo de regressão linear múltipla. Resultados: A maioria dos pesquisados avaliaram sua QV como boa (50,5%) e se consideram satisfeitos (34,07%) com sua saúde no pós-COVID-19. Observou-se diferença estatística para a variável sexo (p=0,008) e renda (p=0,014) em que mulheres e indivíduos com menor renda apresentaram menor média na QV Geral. A variável que esteve associada à menor escore de QV Geral foi uso contínuo de medicamentos antes do diagnóstico da COVID-19 (coeficiente β: 1,85; IC 95%: -0,002-3,707). Conclusão: Através do WHOQOL-BREF foi possível avaliar a QV no pós-COVID-19. Os indivíduos estão satisfeitos com sua saúde e QV, todavia, o uso de medicamentos repercute de forma negativa na QV dessa população.

The COVID-19 pandemic promoted adaptations in several areas in Brazil and around the world. Based on the novelty of the virus, behavioral adjustments were required and information about the prevention/severity of the disease was suggested and disseminated by different sources. Based on this phenomenon, the Professional Master's Degree in Family Health (PROFSAÚDE) developed the research project “Prevention and control of COVID-19: a multicenter study on the perception and daily practices of medical-scientific guidelines by the population in the territories covered by the Care Primary to Health”. Four teaching-learning strategies (two related to collection and quantitative analysis and two related to qualitative analysis) were offered by the national coordination of this multicenter study, aiming to support the learning of PROFSAÚDE's student-researchers in scientific investigation and data analysis. Therefore, the objective of this text is to describe the teaching-learning strategies developed in the network of professional training and multicentric research. The active methodology was adopted, following the pedagogical concept of the program, centered on the subject's learning and, therefore, all the offers had as a method, the flipped classroom. Through an integrated and collective process, the training strategies supported the direction and standardization of the stages of the study nationally, promoted the deepening of the content in mixed methods and the reduction of bias in data collection. Participants positively evaluated the courses, signaling the achievement of learning objectives. The experience showed the aggregating character produced by the research and the potential for the qualification of these health professionals who work in the Unified Health System.

O objetivo deste estudo foi caracterizar as principais publicações que avaliaram o perfil dos estudantes brasileiros que utilizam álcool e outras drogas entre 2012 e 2022. Trata-se de uma Revisão de Escopo, realizada a partir de buscas nos bancos de dados virtuais: BVS, Scielo, Scopus, Web of Science e PubMed. Foram obtidos 31 artigos que analisaram os perfis dos estudantes usuários de drogas lícitas e ilícitas no território educacional brasileiro. Os resultados demonstraram que os prejuízos sociais, psíquicos e biológicos são consequências da utilização de álcool e outras drogas entre os adolescentes. Essa classe, por sua vez, revelou-se vulnerável ao início precoce e manutenção do uso dessas substâncias. Ademais, o uso de drogas lícitas e ilícitas relacionou-se a estudantes com renda salarial baixa, declarados não brancos, com núcleo familiar ruim e, em alguns casos, com comportamentos mais agressivos.