New resveratrol–thiophene and resveratrol–maltol hybrids were synthesized as cholinesterase inhibitors and antioxidants. As with photostability experiments, biological tests also found remarkable differences in the properties and behavior of thiophene and maltol hybrids. While resveratrol–thiophene hybrids have excellent inhibitory and antioxidant properties (similar to the activity of reference drug galantamine), maltols have been proven to be weaker inhibitors and antioxidants. The molecular docking of selected active ligands gave insight into the structures of docked enzymes. It enabled the identification of interactions between the ligand and the active site of both cholinesterases. The maltols that proved to be active cholinesterase inhibitors were able to coordinate Fe³⁺ ion, forming complexes of 1:1 composition. Their formation constants, determined by spectrophotometry, are very similar, lgK = 11.6–12.6, suggesting that Fe³⁺ binds to the common hydroxy-pyranone moiety and is hardly affected by the other aromatic part of the ligand. Accordingly, the characteristic bands in their individual absorption spectra are uniformly red-shifted relative to those of the free ligands. The crystal structures of two new resveratrol–maltol hybrids were recorded, giving additional information on the molecules’ intermolecular hydrogen bonds and packing. In this way, several functionalities of these new resveratrol hybrids were examined as a necessary approach to finding more effective drugs for complicated neurodegenerative diseases.

Nowadays, the study of environmentally friendly ways of producing hydrogen as a green energy source is an increasingly important challenge. One of these potential processes is the heterogeneous photocatalytic splitting of water or other hydrogen sources such as H₂S or its alkaline solution. The most common catalysts used for H₂ production from Na₂S solution are the CdS-ZnS type catalysts, whose efficiency can be further enhanced by Ni-modification. In this work, the surface of Cd_0.5Zn_0.5S composite was modified with Ni(II) compound for photocatalytic H₂ generation. Besides two conventional methods, impregnation was also applied, which is a simple but unconventional modification technique for the CdS-type catalysts. Among the catalysts modified with 1% Ni(II), the impregnation method resulted in the highest activity, for which a quantum efficiency of 15.8% was achieved by using a 415 nm LED and Na₂S-Na₂SO₃ sacrificial solution. This corresponded to an outstanding rate of 170 mmol H₂/h/g under the given experimental conditions. The catalysts were characterized by DRS, XRD, TEM, STEM-EDS, and XPS analyses, which confirmed that Ni(II) is mainly present as Ni(OH)₂ on the surface of the CdS-ZnS composite. The observations from the illumination experiments indicated that Ni(OH)₂ was oxidized during the reaction, and that it therefore played a hole-trapping role.

Considering our previous experience in the design of new cholinesterase inhibitors, especially resveratrol analogs, in this research, the basic stilbene skeleton was used as a structural unit for new carbamates designed as potentially highly selective butyrylcholinesterase (BChE) inhibitors with excellent absorption, distribution, metabolism, excretion and toxicity ADMET properties. The inhibitory activity of newly prepared carbamates 1–13 was tested toward the enzymes acetylcholinesterase (AChE) and BChE. In the tested group of compounds, the leading inhibitors were 1 and 7, which achieved excellent selective inhibitory activity for BChE with IC₅₀ values of 0.12 ± 0.09 μM and 0.38 ± 0.01 μM, respectively. Both were much more active than the standard inhibitor galantamine against BChE. Molecular docking of the most promising inhibitor candidates, compounds 1 and 7, revealed that stabilizing interactions between the active site residues of BChE and the ligands involve π-stacking, alkyl-π interactions, and, when the carbamate orientation allows, H-bond formation. MD analysis confirmed the stability of the obtained complexes. Some bioactive resveratrol-based carbamates displayed complex-forming capabilities with Fe³⁺ ions as metal centers. Spectrophotometric investigation indicated that they coordinate one or two metal ions, which is in accordance with their chemical structure, offering two binding sites: an amine and a carboxylic group in the carbamate moiety. Based on the obtained in silico, experimental and computational results on biological activity in the present work, new carbamates 1 and 7 represent potential selective BChE inhibitors as new therapeutics for neurological disorders.

Hydrogen as an environmentally friendly fuel can be produced by photocatalytic procedures from aqueous systems, utilizing H₂S, an industrial side-product, by conversion and storage of renewable solar energy. Although composites of CdS and ZnS prepared by co-precipitation are very efficient in heterogeneous photocatalytic H₂ generation, the optimal conditions for their synthesis and the effects of the various influencing factors are still not fully clarified. In this work, we investigated how the efficiency of Cd₀.₂₅Zn₀.₇₅S composites modified with Ni(II) was affected by the doping method, Ni-content, hydrothermal treatment, and presence of a complexing agent (ammonia) used in the preparation. The composition, optical, and structural properties of the photocatalysts prepared were determined by ICP, DRS, XRD, TEM, and STEM-EDS. Although hydrothermal treatment proved preferable for Ni-free composites, Ni-modification was more efficient for untreated composites precipitated from ammonia-containing media. The best efficiency (14.9% quantum yield at 380 nm irradiation, 109.8 mmol/g/h hydrogen evolution rate) achieved by surface modification with 0.1–0.3% Ni(II) was 15% and 20% better than those for hydrothermally treated catalyst and similarly prepared Pt-modified one, respectively. Structural characterization of the composites clearly confirmed that the Ni²⁺ ions were not embedded into the CdS-ZnS crystal lattice but were enriched on the surface of particles of the original catalyst in the form of NiO or Ni(OH)₂. This co-catalyst increased the efficiency by electron-trapping, but its too high amount caused an opposite effect by diminishing the excitable surface of the CdS-ZnS particles.

The influence of ionic strength variation and of exciplex formation between silver ions and triplet excited RuL₃²⁺ (L=bipyridine, phenanthroline) on the photo electron transfer kinetics of the complex with methylviologen and the magnetic field dependence of free radical formation efficiency has been studied by laser flash spectroscopy. The magnetic field effect consisting in a decrease of the efficiency of cage escape η_ce in the Ru(bpy)₃²⁺/MV²⁺ system is enhanced by 40% when exciplex formation between Ag⁺ ions and triplet excited RuL₃²⁺ complexes takes place. The relevant kinetic parameters have been determined by magnetokinetic model calculations.