Climate change is increasingly altering hydrological processes through rising temperatures, shifting precipitation regimes, and increasing atmospheric evaporative demand. These changes threaten water security, ecosystem resilience, and the provision of essential hydrological ecosystem services. This publication combines multiple management objectives with climate change considerations by viewing hydrological systems as interconnected networks of water storage, retention, infiltration, and release processes operating across multiple spatial and temporal scales. It introduces the Slow Hydrology (SH) framework, a climate-informed, catchment-scale approach that integrates climate projections, hydrological process understanding, ecosystem services, and adaptive management to strengthen resilience to climatic extremes. SH aims to reduce (slow down) the propagation of climatic stress by enhancing the capacity of landscapes to retain, store, infiltrate, and gradually release water. Rather than introducing new management concepts, its novelty lies in operationally linking future climate information with catchment-scale hydrological functioning, nature-based interventions, ecosystem service objectives, and adaptive decision-making within a single framework. The approach is illustrated through four contrasting European Living Labs established in the INTERLAYER project, demonstrating its applicability across diverse hydroclimatic settings. By explicitly connecting climate adaptation, water retention, ecosystem restoration, and adaptive management, the SH framework provides a transferable basis for translating European water policy objectives into catchment-scale planning. It supports the identification of interventions that simultaneously enhance water resilience, ecosystem functioning, and multiple societal benefits under uncertain future climate conditions.